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Conserved domains on  [gi|14591904|ref|NP_002898|]
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ATP-dependent DNA helicase Q1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
recQ_fam TIGR00614
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ...
81-543 0e+00

ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 129701 [Multi-domain]  Cd Length: 470  Bit Score: 767.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    81 DILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:TIGR00614   1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   161 LNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKMFMSRLEkayEARRFTRIAVDEVHCCSQWGHDFRPDYKALGI 240
Cdd:TIGR00614  81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   241 LKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNtedFIEDIVKLINGRYKGQSGIIY 320
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTPK---ILEDLLRFIRKEFEGKSGIIY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   321 CFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQ 400
Cdd:TIGR00614 233 CPSRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQ 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   401 ESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQ-----KLYEMVSYCQNISKCRRVLMAQHFDEVWN-----SEA 470
Cdd:TIGR00614 313 ESGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGNFrtyklKLYEMMEYCLNSSTCRRLILLSYFGEKGFnksfcIMG 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904   471 CNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEE----LNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL-PREDLE 543
Cdd:TIGR00614 393 TEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSavgrLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLyGRGKDE 470
 
Name Accession Description Interval E-value
recQ_fam TIGR00614
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ...
81-543 0e+00

ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129701 [Multi-domain]  Cd Length: 470  Bit Score: 767.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    81 DILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:TIGR00614   1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   161 LNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKMFMSRLEkayEARRFTRIAVDEVHCCSQWGHDFRPDYKALGI 240
Cdd:TIGR00614  81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   241 LKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNtedFIEDIVKLINGRYKGQSGIIY 320
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTPK---ILEDLLRFIRKEFEGKSGIIY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   321 CFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQ 400
Cdd:TIGR00614 233 CPSRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQ 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   401 ESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQ-----KLYEMVSYCQNISKCRRVLMAQHFDEVWN-----SEA 470
Cdd:TIGR00614 313 ESGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGNFrtyklKLYEMMEYCLNSSTCRRLILLSYFGEKGFnksfcIMG 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904   471 CNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEE----LNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL-PREDLE 543
Cdd:TIGR00614 393 TEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSavgrLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLyGRGKDE 470
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
78-528 1.47e-172

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 500.44  E-value: 1.47e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  78 KVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGIS 157
Cdd:COG0514   4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 158 ATMLNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKmFMSRLEKAyearRFTRIAVDEVHCCSQWGHDFRPDYKA 237
Cdd:COG0514  84 AAFLNSSLSAEERREVLRAL--RAGELKLLYVAPERLLNPR-FLELLRRL----KISLFAIDEAHCISQWGHDFRPDYRR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 238 LGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSntEDFIEDIVKLINGRyKGQSG 317
Cdd:COG0514 157 LGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPP--DDKLAQLLDFLKEH-PGGSG 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 318 IIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMEN 397
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEA 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 398 YYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMEN-------VGQQKLYEMVSYCQnISKCRRVLMAQHFDEVwNSEA 470
Cdd:COG0514 314 YYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPpdeerkrVERAKLDAMLAYAE-TTGCRRQFLLRYFGEE-LAEP 391
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904 471 CNKmCDNCCKDSafERKNITEYCRdliKILKQAEELNEKLTPLKLIDSWMGKGAAKLR 528
Cdd:COG0514 392 CGN-CDNCLGPP--ETFDGTEAAQ---KALSCVYRTGQRFGAGHVIDVLRGSKNEKIR 443
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
74-282 8.66e-155

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 444.50  E-value: 8.66e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  74 PWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQ 153
Cdd:cd18015   1 PWSGKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 154 LGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRP 233
Cdd:cd18015  81 LGISATMLNASSSKEHVKWVHAALTDKNSELKLLYVTPEKIAKSKRFMSKLEKAYNAGRLARIAIDEVHCCSQWGHDFRP 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 14591904 234 DYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd18015 161 DYKKLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
63-505 3.73e-151

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 467.84  E-value: 3.73e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    63 SSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLIS 142
Cdd:PLN03137  432 SNDKKWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVS 511
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   143 LMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVH 222
Cdd:PLN03137  512 LIQDQIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAH 591
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   223 CCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKpsnTEDFIE 302
Cdd:PLN03137  592 CVSQWGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPK---TKKCLE 668
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   303 DIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPD 382
Cdd:PLN03137  669 DIDKFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPD 748
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   383 VRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQ---------------------QKLY 441
Cdd:PLN03137  749 VRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISQGGVEQspmamgynrmassgriletntENLL 828
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14591904   442 EMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEE 505
Cdd:PLN03137  829 RMVSYCENEVDCRRFLQLVHFGEKFDSTNCKKTCDNCSSSKSLIDKDVTEIARQLVELVKLTGE 892
DpdF NF041063
protein DpdF;
105-423 3.30e-39

protein DpdF;


Pssm-ID: 468990 [Multi-domain]  Cd Length: 813  Bit Score: 154.68  E-value: 3.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  105 AGKEVFLVMPTGGGKSLCYQLPALCS---DGFTLVICPLISL---MEDQLM-VLKQLGISATMLNA---SSSKEhvkwVH 174
Cdd:NF041063 157 PGSTLIVNLPTGSGKSLVAQAPALLAsrqGGLTLVVVPTVALaidQERRAReLLRRAGPDLGGPLAwhgGLSAE----ER 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  175 AEMVN--KNSELKLIYVTPEKIAKSkmFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIG 252
Cdd:NF041063 233 AAIRQriRDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLRRSLLRLAPSG 310
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  253 -------LTATATNHVLTDAQKILCIEKCFT-FTASFNRPNLYYEVRQKPSnTEDFIEDIVKLIngRYKGQSGIIYCFSQ 324
Cdd:NF041063 311 rpfrtllLSATLTESTLDTLETLFGPPGPFIvVSAVQLRPEPAYWVAKCDS-EEERRERVLEAL--RHLPRPLILYVTKV 387
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  325 KDSEQVTVSLQNLGIH-AGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESG 403
Cdd:NF041063 388 EDAEAWLQRLRAAGFRrVALFHGDTPDAERERLIEQWRENELDIVVATSAFGLGMDKSDVRTVIHACVPETLDRFYQEVG 467
                        330       340
                 ....*....|....*....|
gi 14591904  404 RAGRDDMKADCILYYGFGDI 423
Cdd:NF041063 468 RGGRDGKASLSLLIYTPDDL 487
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
93-258 2.72e-27

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 108.10  E-value: 2.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    93 RPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPAL------CSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSS 166
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   167 KEHVKWvhaEMVNKNSELKLIYVTPEKIAKskmfMSRLEKAYEARRFtrIAVDEVHCCSQWGhdFRPDYKAlgILKRQFP 246
Cdd:pfam00270  81 GGDSRK---EQLEKLKGPDILVGTPGRLLD----LLQERKLLKNLKL--LVLDEAHRLLDMG--FGPDLEE--ILRRLPK 147
                         170
                  ....*....|..
gi 14591904   247 NASLIGLTATAT 258
Cdd:pfam00270 148 KRQILLLSATLP 159
DEXDc smart00487
DEAD-like helicases superfamily;
87-291 2.77e-23

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 97.95  E-value: 2.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904     87 FKLEKFRPLQLETINVTMAG-KEVFLVMPTGGGKSLCYQLPALC-----SDGFTLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:smart00487   4 FGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEalkrgKGGRVLVLVPTRELAEQWAEELKKLGPSLGL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    161 LNASSSKEHVKWVHAEMVNKNsELKLIYVTPEkiakskMFMSRLEKAY-EARRFTRIAVDEVHCCSQWGhdFRPDYKalG 239
Cdd:smart00487  84 KVVGLYGGDSKREQLRKLESG-KTDILVTTPG------RLLDLLENDKlSLSNVDLVILDEAHRLLDGG--FGDQLE--K 152
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 14591904    240 ILKRQFPNASLIGLTATATNHVLTDAQKILciEKCFTFTASFnRPNLYYEVR 291
Cdd:smart00487 153 LLKLLPKNVQLLLLSATPPEEIENLLELFL--NDPVFIDVGF-TPLEPIEQF 201
 
Name Accession Description Interval E-value
recQ_fam TIGR00614
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ...
81-543 0e+00

ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129701 [Multi-domain]  Cd Length: 470  Bit Score: 767.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    81 DILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:TIGR00614   1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   161 LNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKMFMSRLEkayEARRFTRIAVDEVHCCSQWGHDFRPDYKALGI 240
Cdd:TIGR00614  81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   241 LKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNtedFIEDIVKLINGRYKGQSGIIY 320
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTPK---ILEDLLRFIRKEFEGKSGIIY 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   321 CFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQ 400
Cdd:TIGR00614 233 CPSRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQ 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   401 ESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQ-----KLYEMVSYCQNISKCRRVLMAQHFDEVWN-----SEA 470
Cdd:TIGR00614 313 ESGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGNFrtyklKLYEMMEYCLNSSTCRRLILLSYFGEKGFnksfcIMG 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904   471 CNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEE----LNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTL-PREDLE 543
Cdd:TIGR00614 393 TEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSavgrLNQKFGMGYPVDFLRGSNSQKIRDGGFRKHSLyGRGKDE 470
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
78-528 1.47e-172

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 500.44  E-value: 1.47e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  78 KVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGIS 157
Cdd:COG0514   4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 158 ATMLNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKmFMSRLEKAyearRFTRIAVDEVHCCSQWGHDFRPDYKA 237
Cdd:COG0514  84 AAFLNSSLSAEERREVLRAL--RAGELKLLYVAPERLLNPR-FLELLRRL----KISLFAIDEAHCISQWGHDFRPDYRR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 238 LGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSntEDFIEDIVKLINGRyKGQSG 317
Cdd:COG0514 157 LGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPP--DDKLAQLLDFLKEH-PGGSG 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 318 IIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMEN 397
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDKPDVRFVIHYDLPKSIEA 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 398 YYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMEN-------VGQQKLYEMVSYCQnISKCRRVLMAQHFDEVwNSEA 470
Cdd:COG0514 314 YYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPpdeerkrVERAKLDAMLAYAE-TTGCRRQFLLRYFGEE-LAEP 391
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904 471 CNKmCDNCCKDSafERKNITEYCRdliKILKQAEELNEKLTPLKLIDSWMGKGAAKLR 528
Cdd:COG0514 392 CGN-CDNCLGPP--ETFDGTEAAQ---KALSCVYRTGQRFGAGHVIDVLRGSKNEKIR 443
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
74-282 8.66e-155

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 444.50  E-value: 8.66e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  74 PWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQ 153
Cdd:cd18015   1 PWSGKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 154 LGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRP 233
Cdd:cd18015  81 LGISATMLNASSSKEHVKWVHAALTDKNSELKLLYVTPEKIAKSKRFMSKLEKAYNAGRLARIAIDEVHCCSQWGHDFRP 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 14591904 234 DYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd18015 161 DYKKLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
63-505 3.73e-151

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 467.84  E-value: 3.73e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    63 SSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLIS 142
Cdd:PLN03137  432 SNDKKWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVS 511
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   143 LMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVH 222
Cdd:PLN03137  512 LIQDQIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAH 591
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   223 CCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKpsnTEDFIE 302
Cdd:PLN03137  592 CVSQWGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPK---TKKCLE 668
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   303 DIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPD 382
Cdd:PLN03137  669 DIDKFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPD 748
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   383 VRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQ---------------------QKLY 441
Cdd:PLN03137  749 VRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISQGGVEQspmamgynrmassgriletntENLL 828
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14591904   442 EMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEE 505
Cdd:PLN03137  829 RMVSYCENEVDCRRFLQLVHFGEKFDSTNCKKTCDNCSSSKSLIDKDVTEIARQLVELVKLTGE 892
recQ TIGR01389
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ...
80-478 1.41e-129

ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273594 [Multi-domain]  Cd Length: 591  Bit Score: 394.05  E-value: 1.41e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    80 KDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISAT 159
Cdd:TIGR01389   2 QQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAAA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   160 MLNASSSKEHVKwvHAEMVNKNSELKLIYVTPEkiakskmfmsRLEKAYEARRFTR-----IAVDEVHCCSQWGHDFRPD 234
Cdd:TIGR01389  82 YLNSTLSAKEQQ--DIEKALVNGELKLLYVAPE----------RLEQDYFLNMLQRipialVAVDEAHCVSQWGHDFRPE 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   235 YKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKpSNTEDFIEDIVKlingRYKG 314
Cdd:TIGR01389 150 YQRLGSLAERFPQVPRIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKK-NNKQKFLLDYLK----KHRG 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   315 QSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKS 394
Cdd:TIGR01389 225 QSGIIYASSRKKVEELAERLESQGISALAYHAGLSNKVRAENQEDFLYDDVKVMVATNAFGMGIDKPNVRFVIHYDMPGN 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   395 MENYYQESGRAGRDDMKADCILYYGFGDI----FRISSMVVMENVGQ---QKLYEMVSYCqNISKCRRVLMAQHFDEVwN 467
Cdd:TIGR01389 305 LESYYQEAGRAGRDGLPAEAILLYSPADIallkRRIEQSEADDDYKQierEKLRAMIAYC-ETQTCRRAYILRYFGEN-E 382
                         410
                  ....*....|.
gi 14591904   468 SEACNKmCDNC 478
Cdd:TIGR01389 383 VEPCGN-CDNC 392
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
80-478 2.25e-116

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 360.57  E-value: 2.25e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   80 KDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISAT 159
Cdd:PRK11057  14 KQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGVAAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  160 MLNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAKSKmFMSRLEKAyearRFTRIAVDEVHCCSQWGHDFRPDYKALG 239
Cdd:PRK11057  94 CLNSTQTREQQLEVMAGC--RTGQIKLLYIAPERLMMDN-FLEHLAHW----NPALLAVDEAHCISQWGHDFRPEYAALG 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  240 ILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEV--RQKPsntedfIEDIVKLINGRyKGQSG 317
Cdd:PRK11057 167 QLRQRFPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLveKFKP------LDQLMRYVQEQ-RGKSG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  318 IIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMEN 397
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  398 YYQESGRAGRDDMKADCILYYGFGDIFRISSMVVMENVGQQ------KLYEMVSYCQnISKCRRVLMAQHFDEvWNSEAC 471
Cdd:PRK11057 320 YYQETGRAGRDGLPAEAMLFYDPADMAWLRRCLEEKPAGQQqdierhKLNAMGAFAE-AQTCRRLVLLNYFGE-GRQEPC 397

                 ....*..
gi 14591904  472 NKmCDNC 478
Cdd:PRK11057 398 GN-CDIC 403
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
80-282 9.36e-96

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 292.90  E-value: 9.36e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  80 KDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISAT 159
Cdd:cd17920   1 EQILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 160 MLNASSSKEHVKWVHAEMvnKNSELKLIYVTPEKIAkSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALG 239
Cdd:cd17920  81 ALNSTLSPEEKREVLLRI--KNGQYKLLYVTPERLL-SPDFLELLQRLPERKRLALIVVDEAHCVSQWGHDFRPDYLRLG 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 14591904 240 ILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd17920 158 RLRRALPGVPILALTATATPEVREDILKRLGLRNPVIFRASFD 200
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
283-418 1.19e-73

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 232.87  E-value: 1.19e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 283 RPNLYYEVRQKPSNTEDFieDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSA 362
Cdd:cd18794   1 RPNLFYSVRPKDKKDEKL--DLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLR 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 14591904 363 NEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYY 418
Cdd:cd18794  79 DKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
DEXHc_RecQ2_BLM cd18016
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ...
76-282 4.93e-72

DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.


Pssm-ID: 350774 [Multi-domain]  Cd Length: 208  Bit Score: 231.25  E-value: 4.93e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  76 SGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLG 155
Cdd:cd18016   2 SKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 156 ISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDY 235
Cdd:cd18016  82 IPATYLTGDKTDAEATKIYLQLSKKDPIIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPDY 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 14591904 236 KALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd18016 162 KRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
82-282 3.59e-52

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 178.60  E-value: 3.59e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  82 ILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALC----SDGFTLVICPLISLMEDQLMVLKQLgIS 157
Cdd:cd18018   3 LLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDALPRA-IK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 158 ATMLNaSSSKEHVKWVHAEMVNKNsELKLIYVTPEKIAkSKMFMSRLEkayEARRFTRIAVDEVHCCSQWGHDFRPDYKA 237
Cdd:cd18018  82 AAALN-SSLTREERRRILEKLRAG-EVKILYVSPERLV-NESFRELLR---QTPPISLLVVDEAHCISEWSHNFRPDYLR 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 14591904 238 LGILKRQFPNA-SLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd18018 156 LCRVLRELLGApPVLALTATATKRVVEDIASHLGIPESGVVRGPLY 201
DEXHc_RecQ3 cd18017
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ...
81-282 2.28e-51

DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.


Pssm-ID: 350775 [Multi-domain]  Cd Length: 193  Bit Score: 176.12  E-value: 2.28e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  81 DILQNVFKLEKFRPLQLETI-NVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISAT 159
Cdd:cd18017   2 NALNEYFGHSSFRPVQWKVIrSVLEERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPAC 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 160 MLNASSSKEHVKwvhaemVNKNSELKLIYVTPEKIAKSKMFMSRLEKayearRFTRIAVDEVHCCSQWGHDFRPDYKALG 239
Cdd:cd18017  82 FLGSAQSQNVLD------DIKMGKIRVIYVTPEFVSKGLELLQQLRN-----GITLIAIDEAHCVSQWGHDFRSSYRHLG 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 14591904 240 ILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFN 282
Cdd:cd18017 151 SIRNRLPNVPIVALTATATPSVRDDIIKNLNLRNPQITCTSFD 193
DEXHc_RecQ5 cd18014
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ...
80-280 3.82e-48

DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350772 [Multi-domain]  Cd Length: 205  Bit Score: 167.65  E-value: 3.82e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  80 KDILQNVFKLEKFR-PLQLETINVTMAGK-EVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGIS 157
Cdd:cd18014   1 RSTLKKVFGHSDFKsPLQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 158 ATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKiAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKA 237
Cdd:cd18014  81 VDSLNSKLSAQERKRIIADLESEKPQTKFLYITPEM-AATSSFQPLLSSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLR 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 14591904 238 LGILKRQFPNASLIGLTATATNHVLTDAQKILCIEK-CFTFTAS 280
Cdd:cd18014 160 LGALRSRYGHVPWVALTATATPQVQEDIFAQLRLKKpVAIFKTP 203
DpdF NF041063
protein DpdF;
105-423 3.30e-39

protein DpdF;


Pssm-ID: 468990 [Multi-domain]  Cd Length: 813  Bit Score: 154.68  E-value: 3.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  105 AGKEVFLVMPTGGGKSLCYQLPALCS---DGFTLVICPLISL---MEDQLM-VLKQLGISATMLNA---SSSKEhvkwVH 174
Cdd:NF041063 157 PGSTLIVNLPTGSGKSLVAQAPALLAsrqGGLTLVVVPTVALaidQERRAReLLRRAGPDLGGPLAwhgGLSAE----ER 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  175 AEMVN--KNSELKLIYVTPEKIAKSkmFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIG 252
Cdd:NF041063 233 AAIRQriRDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLRRSLLRLAPSG 310
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  253 -------LTATATNHVLTDAQKILCIEKCFT-FTASFNRPNLYYEVRQKPSnTEDFIEDIVKLIngRYKGQSGIIYCFSQ 324
Cdd:NF041063 311 rpfrtllLSATLTESTLDTLETLFGPPGPFIvVSAVQLRPEPAYWVAKCDS-EEERRERVLEAL--RHLPRPLILYVTKV 387
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  325 KDSEQVTVSLQNLGIH-AGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESG 403
Cdd:NF041063 388 EDAEAWLQRLRAAGFRrVALFHGDTPDAERERLIEQWRENELDIVVATSAFGLGMDKSDVRTVIHACVPETLDRFYQEVG 467
                        330       340
                 ....*....|....*....|
gi 14591904  404 RAGRDDMKADCILYYGFGDI 423
Cdd:NF041063 468 RGGRDGKASLSLLIYTPDDL 487
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
106-256 1.01e-31

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 120.20  E-value: 1.01e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 106 GKEVFLVMPTGGGKSLCYQLPALCSD----GFTLVICPLISLMEDQLMVLKQL---GISATMLNASSSKEHVKwvhaemV 178
Cdd:cd00046   1 GENVLITAPTGSGKTLAALLAALLLLlkkgKKVLVLVPTKALALQTAERLRELfgpGIRVAVLVGGSSAEERE------K 74
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904 179 NKNSELKLIYVTPEKIAKSKMFMSRLEKayeaRRFTRIAVDEVHCCSQWGHDFRPDYkaLGILKRQFPNASLIGLTAT 256
Cdd:cd00046  75 NKLGDADIIIATPDMLLNLLLREDRLFL----KDLKLIIVDEAHALLIDSRGALILD--LAVRKAGLKNAQVILLSAT 146
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
93-258 2.72e-27

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 108.10  E-value: 2.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    93 RPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPAL------CSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSS 166
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   167 KEHVKWvhaEMVNKNSELKLIYVTPEKIAKskmfMSRLEKAYEARRFtrIAVDEVHCCSQWGhdFRPDYKAlgILKRQFP 246
Cdd:pfam00270  81 GGDSRK---EQLEKLKGPDILVGTPGRLLD----LLQERKLLKNLKL--LVLDEAHRLLDMG--FGPDLEE--ILRRLPK 147
                         170
                  ....*....|..
gi 14591904   247 NASLIGLTATAT 258
Cdd:pfam00270 148 KRQILLLSATLP 159
DEXDc smart00487
DEAD-like helicases superfamily;
87-291 2.77e-23

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 97.95  E-value: 2.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904     87 FKLEKFRPLQLETINVTMAG-KEVFLVMPTGGGKSLCYQLPALC-----SDGFTLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:smart00487   4 FGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEalkrgKGGRVLVLVPTRELAEQWAEELKKLGPSLGL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    161 LNASSSKEHVKWVHAEMVNKNsELKLIYVTPEkiakskMFMSRLEKAY-EARRFTRIAVDEVHCCSQWGhdFRPDYKalG 239
Cdd:smart00487  84 KVVGLYGGDSKREQLRKLESG-KTDILVTTPG------RLLDLLENDKlSLSNVDLVILDEAHRLLDGG--FGDQLE--K 152
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 14591904    240 ILKRQFPNASLIGLTATATNHVLTDAQKILciEKCFTFTASFnRPNLYYEVR 291
Cdd:smart00487 153 LLKLLPKNVQLLLLSATPPEEIENLLELFL--NDPVFIDVGF-TPLEPIEQF 201
HELICc smart00490
helicase superfamily c-terminal domain;
328-408 6.50e-22

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 89.96  E-value: 6.50e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    328 EQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80

                   .
gi 14591904    408 D 408
Cdd:smart00490  81 A 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
301-407 7.20e-20

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 85.34  E-value: 7.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   301 IEDIVKLINGRYKGQSgIIYCFSQKDSEqVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDK 380
Cdd:pfam00271   3 LEALLELLKKERGGKV-LIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDL 80
                          90       100
                  ....*....|....*....|....*..
gi 14591904   381 PDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:pfam00271  81 PDVDLVINYDLPWNPASYIQRIGRAGR 107
RecQ_Zn_bind pfam16124
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
420-479 5.20e-16

RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.


Pssm-ID: 465031 [Multi-domain]  Cd Length: 66  Bit Score: 72.71  E-value: 5.20e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14591904   420 FGDIFRISSMVVMEN-------VGQQKLYEMVSYCQNISKCRRVLMAQHFDEVWNSEACnKMCDNCC 479
Cdd:pfam16124   1 YQDVVRLRFLIEQSEadeerkeVELQKLQAMVAYCENTTDCRRKQLLRYFGEEFDSEPC-GNCDNCL 66
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
111-417 6.16e-15

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 78.14  E-value: 6.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 111 LVMPTGGGKSL----CYQlpALCSDGFTLVICPLISLMEdQLM--VLKQLGISATMLNASSSKEHVkwvhaemvnknsel 184
Cdd:COG1061 105 VVAPTGTGKTVlalaLAA--ELLRGKRVLVLVPRRELLE-QWAeeLRRFLGDPLAGGGKKDSDAPI-------------- 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 185 klIYVTPEKIAKSKMFmSRLEkayeaRRFTRIAVDEVHccsqwgHDFRPDYKAlgILKRqFPNASLIGLTAT----ATNH 260
Cdd:COG1061 168 --TVATYQSLARRAHL-DELG-----DRFGLVIIDEAH------HAGAPSYRR--ILEA-FPAAYRLGLTATpfrsDGRE 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 261 VLTD---------------AQKILCIEKCFTFTASFNRPNLYYEVRQKP------SNTEDFIEDIVKLINGRYKGQSGII 319
Cdd:COG1061 231 ILLFlfdgivyeyslkeaiEDGYLAPPEYYGIRVDLTDERAEYDALSERlrealaADAERKDKILRELLREHPDDRKTLV 310
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 320 YCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYY 399
Cdd:COG1061 311 FCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFI 390
                       330       340
                ....*....|....*....|..
gi 14591904 400 QesgRAGR----DDMKADCILY 417
Cdd:COG1061 391 Q---RLGRglrpAPGKEDALVY 409
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
362-418 7.62e-12

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 61.18  E-value: 7.62e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 14591904 362 ANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRD-DMKADCILYY 418
Cdd:cd18785  20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGgKDEGEVILFV 77
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
96-407 1.68e-11

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 67.55  E-value: 1.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  96 QLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCS-----DGFTLVICPLISLMEDQLMVLKQL------GISATMLNAS 164
Cdd:COG1205  61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAlledpGATALYLYPTKALARDQLRRLRELaealglGVRVATYDGD 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 165 SSKEHVKWV--HAEmvnknselkLIYVTPEKI--------AKSKMFMSRLekayearRFtrIAVDEVHCcsqwghdfrpd 234
Cdd:COG1205 141 TPPEERRWIreHPD---------IVLTNPDMLhygllphhTRWARFFRNL-------RY--VVIDEAHT----------- 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 235 YK-ALG-----ILKR------------QFpnaslIGLTATATN---HV--LTDaQKILCIEKCF------TFtaSFNRPN 285
Cdd:COG1205 192 YRgVFGshvanVLRRlrricrhygsdpQF-----ILASATIGNpaeHAerLTG-RPVTVVDEDGsprgerTF--VLWNPP 263
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 286 LYYEVRQKPSNTE--DFIEDIVKlingryKGQSGIIYCFSQKDSEQVTVSLQN------LGIHAGAYHANLEPEDKTTVH 357
Cdd:COG1205 264 LVDDGIRRSALAEaaRLLADLVR------EGLRTLVFTRSRRGAELLARYARRalrepdLADRVAAYRAGYLPEERREIE 337
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 14591904 358 RKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:COG1205 338 RGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGR 387
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
286-407 1.92e-11

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 61.75  E-value: 1.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 286 LYYEVrqkpsNTEDFIEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEI 365
Cdd:cd18787   4 LYVVV-----EEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKV 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 14591904 366 QVVVAT-VAfGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:cd18787  79 RVLVATdVA-ARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGR 120
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
287-417 4.12e-10

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 58.72  E-value: 4.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 287 YYEVRQKPSNTEDFIEDIVKLINGRYKGQSgIIYCFSQKDSEQVTVSLQNLGIHagayHANLEPEDKTTVHRKWSANEIQ 366
Cdd:cd18795  17 IKLRVDVMNKFDSDIIVLLKIETVSEGKPV-LVFCSSRKECEKTAKDLAGIAFH----HAGLTREDRELVEELFREGLIK 91
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14591904 367 VVVATVAFGMGIDKPdVRFVIHHSMSK---------SMENYYQESGRAGR---DDmKADCILY 417
Cdd:cd18795  92 VLVATSTLAAGVNLP-ARTVIIKGTQRydgkgyrelSPLEYLQMIGRAGRpgfDT-RGEAIIM 152
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
287-407 5.66e-10

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 61.70  E-value: 5.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 287 YYEVRQKpsnteDFIEDIVKLINgRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQ 366
Cdd:COG0513 220 YYLVDKR-----DKLELLRRLLR-DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIR 293
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 14591904 367 VVVAT-VAfGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:COG0513 294 VLVATdVA-ARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGR 334
COG1202 COG1202
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
241-410 1.83e-09

Superfamily II helicase, archaea-specific [Replication, recombination and repair];


Pssm-ID: 440815 [Multi-domain]  Cd Length: 790  Bit Score: 61.06  E-value: 1.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 241 LKRQFPNASLIGLTATATN-HVLtdAQKILC-----------IEKCFTFTASFNRPNLYYE-VRQKPSNTEDFiedivkl 307
Cdd:COG1202 354 LKYYCPGAQWIYLSATVGNpEEL--AKKLGAklveyeerpvpLERHLTFADGREKIRIINKlVKREFDTKSSK------- 424
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 308 inGrYKGQSgIIYCFSQKDSEQVTvslQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRfVI 387
Cdd:COG1202 425 --G-YRGQT-IIFTNSRRRCHEIA---RALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQ-VI 496
                       170       180
                ....*....|....*....|....*...
gi 14591904 388 HHS--MSK---SMENYYQESGRAGRDDM 410
Cdd:COG1202 497 FDSlaMGIewlSVQEFHQMLGRAGRPDY 524
SF2_C_Hrq cd18797
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ...
318-412 1.99e-09

C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350184 [Multi-domain]  Cd Length: 146  Bit Score: 56.50  E-value: 1.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 318 IIYCFSQKDSEQVTVSLQNLGIHAG-------AYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHS 390
Cdd:cd18797  39 IVFCRSRKLAELLLRYLKARLVEEGplaskvaSYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG 118
                        90       100
                ....*....|....*....|..
gi 14591904 391 MSKSMENYYQESGRAGRDDMKA 412
Cdd:cd18797 119 YPGSLASLWQQAGRAGRRGKDS 140
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
75-407 2.05e-07

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 54.13  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  75 WSGKVKDILQNvFKLEKFRPLQLETI-NVTMAGKEVFLVMPTGGGKSLCYQLP---ALCSDGFTLVICPLISL---MEDQ 147
Cdd:COG1204   7 PLEKVIEFLKE-RGIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAilkALLNGGKALYIVPLRALaseKYRE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 148 LM-VLKQLGISATMlnasSSKEHVkwVHAEMVNKNSelklIYV-TPEKiakskmFMSRLEKAYE-ARRFTRIAVDEVHcc 224
Cdd:COG1204  86 FKrDFEELGIKVGV----STGDYD--SDDEWLGRYD----ILVaTPEK------LDSLLRNGPSwLRDVDLVVVDEAH-- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 225 sQWGHDFR-PDYK-ALGILKRQFPNASLIGLTATATNhvltdAQKILCIEKCFTFTASFnRPN-----LYY----EVRQK 293
Cdd:COG1204 148 -LIDDESRgPTLEvLLARLRRLNPEAQIVALSATIGN-----AEEIAEWLDAELVKSDW-RPVplnegVLYdgvlRFDDG 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 294 PSNTEDFIEDIV-KLINGRykGQSgIIYCFSQKDSEQ-----------------------VTVSLQNLGIHAG------- 342
Cdd:COG1204 221 SRRSKDPTLALAlDLLEEG--GQV-LVFVSSRRDAESlakkladelkrrltpeereeleeLAEELLEVSEETHtneklad 297
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14591904 343 ------AYH-ANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMEN-----YYQESGRAGR 407
Cdd:COG1204 298 clekgvAFHhAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMVPipvleFKQMAGRAGR 374
PTZ00424 PTZ00424
helicase 45; Provisional
318-407 8.78e-07

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 51.75  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  318 IIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMEN 397
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPEN 350
                         90
                 ....*....|
gi 14591904  398 YYQESGRAGR 407
Cdd:PTZ00424 351 YIHRIGRSGR 360
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
96-222 2.19e-06

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 48.35  E-value: 2.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  96 QLETINVTMAGKEVFLVMPTGGGKSLCYQLP---ALCSDGFT--LVICPLISLMEDQLMVLKQL------GISATMLNAS 164
Cdd:cd17923   5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileALLRDPGSraLYLYPTKALAQDQLRSLRELleqlglGIRVATYDGD 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14591904 165 SSKEHVKWVHAEMVNknselkLIYVTPEKI--------AKSKMFMSRLekayearRFtrIAVDEVH 222
Cdd:cd17923  85 TPREERRAIIRNPPR------ILLTNPDMLhyallphhDRWARFLRNL-------RY--VVLDEAH 135
PTZ00110 PTZ00110
helicase; Provisional
94-411 5.76e-06

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 49.39  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   94 PLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALC----------SDG-FTLVICPLISLMEDqlmvlkqlgISATMLN 162
Cdd:PTZ00110 155 PIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVhinaqpllryGDGpIVLVLAPTRELAEQ---------IREQCNK 225
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  163 -ASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAY-EARRFTRIAVDEVHCCSQWGhdFRPDYKAlgI 240
Cdd:PTZ00110 226 fGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVtNLRRVTYLVLDEADRMLDMG--FEPQIRK--I 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  241 LKRQFPNASLIGLTATATNHVLTDAQKiLCIEK-------CFTFTASFN-RPNLY-YEVRQKPSNTEDFIEDIVKlingr 311
Cdd:PTZ00110 302 VSQIRPDRQTLMWSATWPKEVQSLARD-LCKEEpvhvnvgSLDLTACHNiKQEVFvVEEHEKRGKLKMLLQRIMR----- 375
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  312 yKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHAnlepeDKTTVHRKWSANEIQ-----VVVATVAFGMGIDKPDVRFV 386
Cdd:PTZ00110 376 -DGDKILIFVETKKGADFLTKELRLDGWPALCIHG-----DKKQEERTWVLNEFKtgkspIMIATDVASRGLDVKDVKYV 449
                        330       340
                 ....*....|....*....|....*
gi 14591904  387 IHHSMSKSMENYYQESGRAGRDDMK 411
Cdd:PTZ00110 450 INFDFPNQIEDYVHRIGRTGRAGAK 474
ResIII pfam04851
Type III restriction enzyme, res subunit;
91-256 5.99e-06

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 46.90  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904    91 KFRPLQLETINVTMAG-----KEVFLVMPTGGGKSLCY-QLPALCSDGF----TLVICPLISLMEDQLMVLKQLGISATM 160
Cdd:pfam04851   3 ELRPYQIEAIENLLESikngqKRGLIVMATGSGKTLTAaKLIARLFKKGpikkVLFLVPRKDLLEQALEEFKKFLPNYVE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   161 LNASSSKEhvkwvhaEMVNKNSELKLIYVTPEKIAKSKMfMSRLEKAYEARRFtrIAVDEVHccsqwgHDFRPDYKAlgi 240
Cdd:pfam04851  83 IGEIISGD-------KKDESVDDNKIVVTTIQSLYKALE-LASLELLPDFFDV--IIIDEAH------RSGASSYRN--- 143
                         170
                  ....*....|....*.
gi 14591904   241 LKRQFPNASLIGLTAT 256
Cdd:pfam04851 144 ILEYFKPAFLLGLTAT 159
RQC pfam09382
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ...
484-590 4.85e-05

RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.


Pssm-ID: 462780 [Multi-domain]  Cd Length: 108  Bit Score: 42.91  E-value: 4.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   484 FERKNITEYCRDLIKILKqaeELNEKLTPLKLID--------SWMGKGAAKLRVAGVVAPtLPREDLEKIIAHFLIQQYL 555
Cdd:pfam09382   2 PETVDVTEEAQKILSCVY---RTGQRFGAGHLIDvlrgsknkKIRQLGHDKLSTFGIGKD-LSKKEWRRIIRQLIAEGYL 77
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 14591904   556 KEDYSFTayatiSYLKIGPKA-NLLNNEAHaITMQV 590
Cdd:pfam09382  78 EVDIEFY-----SVLKLTPKArEVLKGEEK-VMLRV 107
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
92-259 5.06e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 44.56  E-value: 5.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  92 FRPLQLETINVTM-AGKEVFLVMPTGGGKSLCYQLPAL----CSDGFTLVICPLISLMEDQLM----VLKQLGISATMLN 162
Cdd:cd17921   2 LNPIQREALRALYlSGDSVLVSAPTSSGKTLIAELAILralaTSGGKAVYIAPTRALVNQKEAdlreRFGPLGKNVGLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 163 ASSSkehvkwvhaemVNKNSELKL-IYV-TPEKIAkskmFMSRLEKAYEARRFTRIAVDEVHCCSQwghdfrPDYKA--- 237
Cdd:cd17921  82 GDPS-----------VNKLLLAEAdILVaTPEKLD----LLLRNGGERLIQDVRLVVVDEAHLIGD------GERGVvle 140
                       170       180
                ....*....|....*....|....
gi 14591904 238 --LGILKRQFPNASLIGLTATATN 259
Cdd:cd17921 141 llLSRLLRINKNARFVGLSATLPN 164
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
92-256 7.87e-05

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 43.06  E-value: 7.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  92 FRPLQLETINVtMAGKEVF----LVMPTGGGKSLC-YQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSS 166
Cdd:cd17926   1 LRPYQEEALEA-WLAHKNNrrgiLVLPTGSGKTLTaLALIAYLKELRTLIVVPTDALLDQWKERFEDFLGDSSIGLIGGG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 167 KehvkwvhaemvNKNSELKLIYV-TPEKIakskmfmSRLEKAYEA--RRFTRIAVDEVH--CCSQWGHdfrpdykalgIL 241
Cdd:cd17926  80 K-----------KKDFDDANVVVaTYQSL-------SNLAEEEKDlfDQFGLLIVDEAHhlPAKTFSE----------IL 131
                       170
                ....*....|....*
gi 14591904 242 KRqFPNASLIGLTAT 256
Cdd:cd17926 132 KE-LNAKYRLGLTAT 145
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
345-445 9.47e-05

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 43.10  E-value: 9.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 345 HANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVR-FVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGfgdi 423
Cdd:cd18811  68 HGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATvMVIEDAERFGLSQLHQLRGRVGRGDHQSYCLLVYK---- 143
                        90       100
                ....*....|....*....|..
gi 14591904 424 frissmVVMENVGQQKLYEMVS 445
Cdd:cd18811 144 ------DPLTETAKQRLRVMTE 159
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
338-407 1.81e-04

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 44.54  E-value: 1.81e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14591904 338 GIhaGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPdVRFVIHHSMSK----SMEN-----YYQESGRAGR 407
Cdd:COG4581 301 GI--AVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMP-ARTVVFTKLSKfdgeRHRPltareFHQIAGRAGR 376
Cas3 COG1203
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ...
9-371 2.37e-04

CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440816 [Multi-domain]  Cd Length: 535  Bit Score: 44.30  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904   9 EELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWnkeDFPWSGKVKDILQNVFK 88
Cdd:COG1203  47 LLLAALELALLLLLLLLLLLLLLLLLLDLLLDDLAFLFLLLLIDADWLDSANFDMARQAL---DHLLAERLERLLPKKSK 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  89 LEKFR-PLQLE----TINVTMAGKEVFLVM-PTGGGK---SLCY---QLPALCSDGFTLVIcPLISLMEDQLMVLKQLG- 155
Cdd:COG1203 124 PRTPInPLQNEalelALEAAEEEPGLFILTaPTGGGKteaALLFalrLAAKHGGRRIIYAL-PFTSIINQTYDRLRDLFg 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 156 --I----SATMLNASSSKEHVKWVHAEMVNkNSEL---KLIYVTPEKIAKSkMFMSRleKAYEaRRFTRIA-----VDEV 221
Cdd:COG1203 203 edVllhhSLADLDLLEEEEEYESEARWLKL-LKELwdaPVVVTTIDQLFES-LFSNR--KGQE-RRLHNLAnsviiLDEV 277
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 222 HCCSQwgHDFRPDYKALGILKRQfpNASLIGLTAT---ATNHVLTDAQKILCIEKC--FTFTASFNRPNlyYEVRQKPSN 296
Cdd:COG1203 278 QAYPP--YMLALLLRLLEWLKNL--GGSVILMTATlppLLREELLEAYELIPDEPEelPEYFRAFVRKR--VELKEGPLS 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 297 TEDFIEDIVKLINgryKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAY--HANLEPEDKTTVHRKW----SANEIQVVVA 370
Cdd:COG1203 352 DEELAELILEALH---KGKSVLVIVNTVKDAQELYEALKEKLPDEEVYllHSRFCPADRSEIEKEIkerlERGKPCILVS 428

                .
gi 14591904 371 T 371
Cdd:COG1203 429 T 429
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
79-139 1.40e-03

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 40.65  E-value: 1.40e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14591904  79 VKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALC-----------SDG-FTLVICP 139
Cdd:cd17949   1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQrllsleprvdrSDGtLALVLVP 73
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
327-417 2.43e-03

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 40.93  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904  327 SEQVTVSLqnlGIHAGAYHANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAG 406
Cdd:PLN00206 384 ANAITVVT---GLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRAS 460
                         90
                 ....*....|.
gi 14591904  407 RDDMKADCILY 417
Cdd:PLN00206 461 RMGEKGTAIVF 471
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
106-259 3.51e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 38.85  E-value: 3.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 106 GKEVFLVMPTGGGKSLCYQL---PALCSDGFTLVICPLISLMEDQLMVLKQL-------GISATMLNassskEHVKWVHa 175
Cdd:cd18028  17 GENLLISIPTASGKTLIAEMamvNTLLEGGKALYLVPLRALASEKYEEFKKLeeiglkvGISTGDYD-----EDDEWLG- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 176 emvnknsELKLIYVTPEKIAkskmFMSRLEKAYeARRFTRIAVDEVHCCSqwghdfrpDYK-------ALGILKRQFPNA 248
Cdd:cd18028  91 -------DYDIIVATYEKFD----SLLRHSPSW-LRDVGVVVVDEIHLIS--------DEErgptlesIVARLRRLNPNT 150
                       170
                ....*....|.
gi 14591904 249 SLIGLTATATN 259
Cdd:cd18028 151 QIIGLSATIGN 161
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
76-128 4.33e-03

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 39.28  E-value: 4.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 14591904  76 SGKVKDILQNvFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPAL 128
Cdd:cd17953  20 SEKVLDLIKK-LGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMF 71
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
293-407 4.51e-03

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 38.01  E-value: 4.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14591904 293 KPSNTEDFIEDIVKLINgryKGQSGIIYCFSQKDSEQVTVSLQNL------GIHAGAYHANLEPEDKTTVHRKWSANEIQ 366
Cdd:cd18796  20 AGESGADAYAEVIFLLE---RHKSTLVFTNTRSQAERLAQRLRELcpdrvpPDFIALHHGSLSRELREEVEAALKRGDLK 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 14591904 367 VVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGR 407
Cdd:cd18796  97 VVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
SF2_C_RecG_TRCF cd18792
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ...
345-419 4.83e-03

C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350179 [Multi-domain]  Cd Length: 160  Bit Score: 38.40  E-value: 4.83e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14591904 345 HANLEPEDKTTVHRKWSANEIQVVVATVAFGMGIDKPDVR-FVIHHSMSKSMENYYQESGRAGRDDMKADCILYYG 419
Cdd:cd18792  67 HGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANtMIIEDADRFGLSQLHQLRGRVGRGKHQSYCYLLYP 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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