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Conserved domains on  [gi|146386524]
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Chain C, Liver carboxylesterase 1

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

CATH:  3.40.50.1820
EC:  3.1.1.-
PubMed:  8453375|3163407|8280778|9704093|11099800
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2-526 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524    2 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 81
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   82 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 160
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  161 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 240
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  241 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 318
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  319 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 394
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  395 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 473
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 146386524  474 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 526
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2-526 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524    2 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 81
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   82 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 160
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  161 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 240
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  241 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 318
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  319 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 394
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  395 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 473
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 146386524  474 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 526
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 5-517 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 595.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   5 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 84
Cdd:cd00312    1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  85 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 163
Cdd:cd00312   68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 164 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 243
Cdd:cd00312  147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 244 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 323
Cdd:cd00312  226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 324 VPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLwkSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADV 403
Cdd:cd00312  299 VPLIIGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELL--PYLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 404 MFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANF 482
Cdd:cd00312  377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 146386524 483 ARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 517
Cdd:cd00312  457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
1-530 9.53e-156

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 453.96  E-value: 9.53e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   1 SSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSel 80
Cdd:COG2272   10 AAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGG-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  81 ftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQYRLGIWGFF 158
Cdd:COG2272   82 --------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGALGFL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 159 -----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTs 233
Cdd:COG2272  152 alpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLS- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 234 vLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVIDGMLLLKTP 312
Cdd:COG2272  231 -VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVDGDVLPEDP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 313 EELQAERNFHTVPYMVGINKQEFGWLIPML-MSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYLGGTDdtvk 391
Cdd:COG2272  297 LEAFAAGRAADVPLLIGTNRDEGRLFAALLgDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYPAASP---- 361

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 392 kKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLKEGASEEEI 469
Cdd:COG2272  362 -AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTPADR 437

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146386524 470 RLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 530
Cdd:COG2272  438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
PRK10162 PRK10162
acetyl esterase;
115-203 1.07e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 115 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 192
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 146386524 193 GSVTIFGESAG 203
Cdd:PRK10162 154 SRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
2-526 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524    2 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 81
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   82 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 160
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  161 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 240
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  241 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 318
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  319 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 394
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  395 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 473
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 146386524  474 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 526
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 5-517 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 595.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   5 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 84
Cdd:cd00312    1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  85 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 163
Cdd:cd00312   68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 164 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 243
Cdd:cd00312  147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 244 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 323
Cdd:cd00312  226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 324 VPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLwkSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADV 403
Cdd:cd00312  299 VPLIIGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELL--PYLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 404 MFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANF 482
Cdd:cd00312  377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 146386524 483 ARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 517
Cdd:cd00312  457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
1-530 9.53e-156

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 453.96  E-value: 9.53e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   1 SSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSel 80
Cdd:COG2272   10 AAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGG-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  81 ftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQYRLGIWGFF 158
Cdd:COG2272   82 --------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGALGFL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 159 -----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTs 233
Cdd:COG2272  152 alpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGLS- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 234 vLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVIDGMLLLKTP 312
Cdd:COG2272  231 -VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVDGDVLPEDP 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 313 EELQAERNFHTVPYMVGINKQEFGWLIPML-MSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYLGGTDdtvk 391
Cdd:COG2272  297 LEAFAAGRAADVPLLIGTNRDEGRLFAALLgDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYPAASP---- 361

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 392 kKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLKEGASEEEI 469
Cdd:COG2272  362 -AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTPADR 437

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146386524 470 RLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 530
Cdd:COG2272  438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
101-204 1.06e-20

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 90.32  E-value: 1.06e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 101 IYTPADLTKKnrLPVMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGiwgffstgDEHSrgnW-GHLDQV-A 176
Cdd:COG0657    3 VYRPAGAKGP--LPVVVYFHGGGWVSGSKDTHDPLArrLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                         90       100
                 ....*....|....*....|....*...
gi 146386524 177 ALRWVQDNIASFGGNPGSVTIFGESAGG 204
Cdd:COG0657   70 ALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 116-204 1.41e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 72.63  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  116 MVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLgiwgffstGDEHSrgnW--GHLDQVAALRWVQDNIASFGGN 191
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRL--------APEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 146386524  192 PGSVTIFGESAGG 204
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
101-230 2.30e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.80  E-value: 2.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 101 IYTPADltkKNRLPVMVWIHGGGlmVGAASTYDGLALAAHEN-VVVVTIQYRlgiwgffstGDEHSRGNWGHL---DQVA 176
Cdd:COG1506   14 LYLPAD---GKKYPVVVYVHGGP--GSRDDSFLPLAQALASRgYAVLAPDYR---------GYGESAGDWGGDevdDVLA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 146386524 177 ALRWVqdnIASFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVA 230
Cdd:COG1506   80 AIDYL---AARPYVDPDRIGIYGHSYGG--YMALLAAARHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 99-204 4.73e-09

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 56.42  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   99 LNIYTPAdlTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENV-----VVVTIQYRLgiwgffsTGDEHSRgnwghlD 173
Cdd:pfam20434   1 LDIYLPK--NAKGPYPVVIWIHGGGWNSGDKEADMGFMTNTVKALlkagyAVASINYRL-------STDAKFP------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 146386524  174 QV----AALRWVQDNIASFGGNPGSVTIFGESAGG 204
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
PRK10162 PRK10162
acetyl esterase;
115-203 1.07e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 115 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 192
Cdd:PRK10162  83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                         90
                 ....*....|.
gi 146386524 193 GSVTIFGESAG 203
Cdd:PRK10162 154 SRIGFAGDSAG 164
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 101-204 3.34e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.68  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524 101 IYTPADLTKKNRLPVMVWIHGGGlmvGAASTYD---GL-ALAAHENVVVV----TIQYRLGIWGFFSTGDEHSRGnwGHL 172
Cdd:COG3509   41 LYVPAGYDGGAPLPLVVALHGCG---GSAADFAagtGLnALADREGFIVVypegTGRAPGRCWNWFDGRDQRRGR--DDV 115

                         90       100       110
                 ....*....|....*....|....*....|..
gi 146386524 173 DQVAALrwVQDNIASFGGNPGSVTIFGESAGG 204
Cdd:COG3509  116 AFIAAL--VDDLAARYGIDPKRVYVTGLSAGG 145
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 99-233 5.21e-04

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 41.68  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524   99 LNIYTPADLTKKNRLPVMVWIHGGGL--MVGAASTYDGLALAAH-ENVVVVTIQY-----RLGIWGFfstGDEHSRGNWG 170
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGWfqNGPAKEGLDRLAASGEiPPVIIVGSPRggevsFYSDWDR---GLNATEGPGA 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146386524  171 H--LDQVAA--LRWVQDNiasFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVALTS 233
Cdd:pfam00756  87 YayETFLTQelPPLLDAN---FPTAPDGRALAGQSMGG--LGALYLALKYPDLFGSVSSFSPILNPS 148
COG4099 COG4099
Predicted peptidase [General function prediction only];
73-204 7.95e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 41.11  E-value: 7.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  73 AGQLLSELFTNRKENIPLKlsedclYlNIYTPADLTKKNRLPVMVWIHGGG---------LMVGAAStYDGLALAAHENV 143
Cdd:COG4099   16 QDGFEARTFTDPSDGDTLP------Y-RLYLPKGYDPGKKYPLVLFLHGAGergtdnekqLTHGAPK-FINPENQAKFPA 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146386524 144 VVVTIQYRLGIWgffstgdehsrgnWGHLDQVAAL-RWVQDNIASFGGNPGSVTIFGESAGG 204
Cdd:COG4099   88 IVLAPQCPEDDY-------------WSDTKALDAVlALLDDLIAEYRIDPDRIYLTGLSMGG 136
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
99-228 1.37e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.99  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146386524  99 LNIYTPADLTKKN-RLPVMVWIHGGGL-------MVGAASTYDGLAlAAHE--NVVVVTIQYRLGiwgffSTGDEHSRGN 168
Cdd:COG2382   97 VWVYLPPGYDNPGkKYPVLYLLDGGGGdeqdwfdQGRLPTILDNLI-AAGKipPMIVVMPDGGDG-----GDRGTEGPGN 170

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146386524 169 WGHLDQVAA--LRWVQDNiASFGGNPGSVTIFGESAGG-ESVSVLVLSPlakNLFHRAISESG 228
Cdd:COG2382  171 DAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGlAALYAALRHP---DLFGYVGSFSG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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