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Conserved domains on  [gi|1468990966|ref|XP_026100935|]
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clavesin-2-like [Carassius auratus]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 10661176)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to phosphatidylinositol transfer proteins

CATH:  3.40.525.10|1.10.8.20|1.20.5.1200
Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 101-188 7.05e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 60.81  E-value: 7.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468990966 101 KDGFPGVLSNLDRYGRKILVLFAANWDQSRYTFVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASklTPSML 180
Cdd:cd00170     7 LLGGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLL 84


                  ....*...
gi 1468990966 181 RLAIEGLQ 188
Cdd:cd00170    85 KKLLKILQ 92
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
29-75 5.62e-09

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 50.24  E-value: 5.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1468990966   29 QDIQEVRDMIITRPDIGFLRTDDAFILRFLRARKFNHFEAFRLLAQY 75
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 101-188 7.05e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 60.81  E-value: 7.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468990966 101 KDGFPGVLSNLDRYGRKILVLFAANWDQSRYTFVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASklTPSML 180
Cdd:cd00170     7 LLGGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLL 84


                  ....*...
gi 1468990966 181 RLAIEGLQ 188
Cdd:cd00170    85 KKLLKILQ 92
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
29-75 5.62e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 50.24  E-value: 5.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1468990966   29 QDIQEVRDMIITRPDIGFLRTDDAFILRFLRARKFNHFEAFRLLAQY 75
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 50-72 6.97e-03

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 33.79  E-value: 6.97e-03
                          10        20
                  ....*....|....*....|...
gi 1468990966  50 DDAFILRFLRARKFNHFEAFRLL 72
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKML 51
 
Name Accession Description Interval E-value
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 101-188 7.05e-12

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 60.81  E-value: 7.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468990966 101 KDGFPGVLSNLDRYGRKILVLFAANWDQSRYTFVDILRAILLSLEAMIEDPELQVNGFVLIIDWSNFTFKQASklTPSML 180
Cdd:cd00170     7 LLGGIGYLGGRDKEGRPVLVFRAGWDPPKLLDLEELLRYLVYLLEKALRELEEQVEGFVVIIDLKGFSLSNLS--DLSLL 84


                  ....*...
gi 1468990966 181 RLAIEGLQ 188
Cdd:cd00170    85 KKLLKILQ 92
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
29-75 5.62e-09

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 50.24  E-value: 5.62e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1468990966   29 QDIQEVRDMIITRPDIGFLRTDDAFILRFLRARKFNHFEAFRLLAQY 75
Cdd:smart01100   2 EALEELRELLEKHPDLLPPRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
 50-72 6.97e-03

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 33.79  E-value: 6.97e-03
                          10        20
                  ....*....|....*....|...
gi 1468990966  50 DDAFILRFLRARKFNHFEAFRLL 72
Cdd:pfam03765  29 DDVCLLRFLRARKWDVEKAIKML 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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