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Conserved domains on  [gi|147647745|sp|Q5VYY2|]
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RecName: Full=Lipase member M; AltName: Full=Lipase-like abhydrolase domain-containing protein 3; Flags: Precursor

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
50-404 5.73e-58

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 195.09  E-value: 5.73e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  50 SEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTgSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 130 GNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQEKIYYVGYSQGTTMGFIAFsTMPELAQKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 210 FALAPIATVKHAKSPGTK---FLLLpDMMIKGLfgkkeFLYQTRFLRQLVIYLcgqviLDQICSNIML---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHL-DQMVVAM-----GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 284 --MNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSeTKNLEKCNQPTPVRYRVRDM--TVPTAMWTGGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIpkSLPLWMGYGGTDGL 338
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 147647745 360 SNPEDVKMLLSEVTN---LIYHKNipeWAHVDFIWGLDAPHRMYNEII 404
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMI 383
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
50-404 5.73e-58

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 195.09  E-value: 5.73e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  50 SEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTgSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 130 GNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQEKIYYVGYSQGTTMGFIAFsTMPELAQKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 210 FALAPIATVKHAKSPGTK---FLLLpDMMIKGLfgkkeFLYQTRFLRQLVIYLcgqviLDQICSNIML---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHL-DQMVVAM-----GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 284 --MNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSeTKNLEKCNQPTPVRYRVRDM--TVPTAMWTGGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIpkSLPLWMGYGGTDGL 338
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 147647745 360 SNPEDVKMLLSEVTN---LIYHKNipeWAHVDFIWGLDAPHRMYNEII 404
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
49-111 4.71e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 105.31  E-value: 4.71e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147647745   49 ISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNL 111
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
64-216 2.77e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 51.17  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  64 EVATEDGYILSVNriprgLVQPKKTGSRPVVLLQHGlvGGASNWISNLPNNSLgfiLADAGFDVWMGNSRGNAWSRKHkt 143
Cdd:COG1506    1 TFKSADGTTLPGW-----LYLPADGKKYPVVVYVHG--GPGSRDDSFLPLAQA---LASRGYAVLAPDYRGYGESAGD-- 68
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147647745 144 lsidqdefwaFSYDEMArfDLPAVINFILQKTG--QEKIYYVGYSQGttmGFIAFSTMPELAQKIKMYFALAPIA 216
Cdd:COG1506   69 ----------WGGDEVD--DVLAAIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVS 128
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
50-404 5.73e-58

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 195.09  E-value: 5.73e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  50 SEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTgSRPVVLLQHGLVGGASNWISNLPNNSLGFILADAGFDVWM 129
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQ-RGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 130 GNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTgQEKIYYVGYSQGTTMGFIAFsTMPELAQKIKMY 209
Cdd:PLN02872 113 GNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 210 FALAPIATVKHAKSPGTK---FLLLpDMMIKGLfgkkeFLYQTRFLRQLVIYLcgqviLDQICSNIML---LLGGFNTNN 283
Cdd:PLN02872 191 ALLCPISYLDHVTAPLVLrmvFMHL-DQMVVAM-----GIHQLNFRSDVLVKL-----LDSICEGHMDcndLLTSITGTN 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 284 --MNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSeTKNLEKCNQPTPVRYRVRDM--TVPTAMWTGGQDWL 359
Cdd:PLN02872 260 ccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGI-FKNLKLYGQVNPPAFDLSLIpkSLPLWMGYGGTDGL 338
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 147647745 360 SNPEDVKMLLSEVTN---LIYHKNipeWAHVDFIWGLDAPHRMYNEII 404
Cdd:PLN02872 339 ADVTDVEHTLAELPSkpeLLYLEN---YGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
49-111 4.71e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 105.31  E-value: 4.71e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147647745   49 ISEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWISNL 111
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
92-392 7.38e-26

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 104.89  E-value: 7.38e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745   92 PVVLLQHGLVGGASNWISNLPNnslgfiLADAGFDVWMGNSRGNAWSRKHKTLSidqdefwAFSYDEMARFdlpavINFI 171
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  172 LQKTGQEKIYYVGYSQGTTMGFIAFSTMPElaqKIKMYFALAPIatvkhakSPGTKFLLLPDMMIKGLFGKKEFLYQTRF 251
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPD---RVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFA 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  252 LRQLVIYLCGQVILDQICSNIMLLLGGFntnNMNMSRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWgsetknlek 331
Cdd:pfam00561 133 PNPLGRLVAKLLALLLLRLRLLKALPLL---NKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE--------- 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 147647745  332 cnqptpvryrvrdmtvPTAMWTGGQDWLsNPEDVKMLLSEVTNLIYHKNIPEWAHVDFIWG 392
Cdd:pfam00561 201 ----------------PTLIIWGDQDPL-VPPQALEKLAQLFPNARLVVIPDAGHFAFLEG 244
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
64-216 2.77e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 51.17  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  64 EVATEDGYILSVNriprgLVQPKKTGSRPVVLLQHGlvGGASNWISNLPNNSLgfiLADAGFDVWMGNSRGNAWSRKHkt 143
Cdd:COG1506    1 TFKSADGTTLPGW-----LYLPADGKKYPVVVYVHG--GPGSRDDSFLPLAQA---LASRGYAVLAPDYRGYGESAGD-- 68
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147647745 144 lsidqdefwaFSYDEMArfDLPAVINFILQKTG--QEKIYYVGYSQGttmGFIAFSTMPELAQKIKMYFALAPIA 216
Cdd:COG1506   69 ----------WGGDEVD--DVLAAIDYLAARPYvdPDRIGIYGHSYG---GYMALLAAARHPDRFKAAVALAGVS 128
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
61-214 8.18e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 49.62  E-value: 8.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  61 EEYEVATEDGYILSVNRIPRglvqpkKTGSRPVVLLQHGLVGGASNWisnlpnNSLGFILADAGFDVWMGNSRGNAWSRK 140
Cdd:COG2267    4 RLVTLPTRDGLRLRGRRWRP------AGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGRSDG 71
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147647745 141 HKTLsidqdefwAFSYDEMARfDLPAVINFILQKTGQeKIYYVGYSQGttmGFIAFSTMPELAQKIKMYFALAP 214
Cdd:COG2267   72 PRGH--------VDSFDDYVD-DLRAALDALRARPGL-PVVLLGHSMG---GLIALLYAARYPDRVAGLVLLAP 132
YpfH COG0400
Predicted esterase [General function prediction only];
91-230 4.07e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.43  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  91 RPVVLLQHGLVGGASNWIS---NLPNNSLGFILADAGFDVWMGnsrGNAWSRKHKTLSIDQDEFWAFSYDEMARFdlpav 167
Cdd:COG0400    5 APLVVLLHGYGGDEEDLLPlapELALPGAAVLAPRAPVPEGPG---GRAWFDLSFLEGREDEEGLAAAAEALAAF----- 76
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147647745 168 INFILQKTG--QEKIYYVGYSQGTTM-------------GFIAFSTmpelaqkikmYFALAPIATVKHAKSPGTKFLL 230
Cdd:COG0400   77 IDELEARYGidPERIVLAGFSQGAAMalslalrrpellaGVVALSG----------YLPGEEALPAPEAALAGTPVFL 144
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
88-191 3.38e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 37.12  E-value: 3.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745  88 TGSRPVVLLQHGLVGGASNWiSNLPNNslgfiLADAGFDVWmgnsrgnawsrkhkTLSIDQDefwAFSYDEMARfDLPAV 167
Cdd:COG1075    2 AATRYPVVLVHGLGGSAASW-APLAPR-----LRAAGYPVY--------------ALNYPST---NGSIEDSAE-QLAAF 57
                         90       100
                 ....*....|....*....|....
gi 147647745 168 INFILQKTGQEKIYYVGYSQGTTM 191
Cdd:COG1075   58 VDAVLAATGAEKVDLVGHSMGGLV 81
PhaC COG3243
Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];
112-195 6.65e-03

Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];


Pssm-ID: 442475 [Multi-domain]  Cd Length: 545  Bit Score: 38.78  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147647745 112 PNNSLgfI--LADAGFDVWMgNSRGNAwSRKHKTLSIDqdefwafsyDEMARFdLPAVINFILQKTGQEKIYYVGYSQGT 189
Cdd:COG3243  223 PGNSL--VryLVDQGFTVFL-ISWGNP-DAEDRDLGLD---------DYVEDG-ILAAVDAVREITGEDKVNLLGYCLGG 288

                 ....*.
gi 147647745 190 TMGFIA 195
Cdd:COG3243  289 TLLAIY 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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