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Conserved domains on  [gi|148609439|ref|YP_001272570|]
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holin [Enterobacteria phage cdtI]

Protein Classification

class II holin family protein( domain architecture ID 10523107)

class II holin family protein similar to lambdoid phage 21 pinholin, which forms small holes that depolarize the membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Phage_holin_2_1 pfam04971
Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins ...
5-68 1.67e-29

Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis.


:

Pssm-ID: 428228  Cd Length: 64  Bit Score: 99.09  E-value: 1.67e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148609439   5 DKLTTGVAYGTSAGSAGYWFLQLLDKVTPSQWAAIGVLGSLVFGLLTYLTNLYFKIKEDKRKAA 68
Cdd:pfam04971  1 SKIATGVSYGASAGSIGYWLLQLLDKLSPDEWSAIGVLGGLVIGLITYLTNLYFKRKQTRAKRS 64
 
Name Accession Description Interval E-value
Phage_holin_2_1 pfam04971
Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins ...
5-68 1.67e-29

Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis.


Pssm-ID: 428228  Cd Length: 64  Bit Score: 99.09  E-value: 1.67e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148609439   5 DKLTTGVAYGTSAGSAGYWFLQLLDKVTPSQWAAIGVLGSLVFGLLTYLTNLYFKIKEDKRKAA 68
Cdd:pfam04971  1 SKIATGVSYGASAGSIGYWLLQLLDKLSPDEWSAIGVLGGLVIGLITYLTNLYFKRKQTRAKRS 64
 
Name Accession Description Interval E-value
Phage_holin_2_1 pfam04971
Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins ...
5-68 1.67e-29

Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis.


Pssm-ID: 428228  Cd Length: 64  Bit Score: 99.09  E-value: 1.67e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148609439   5 DKLTTGVAYGTSAGSAGYWFLQLLDKVTPSQWAAIGVLGSLVFGLLTYLTNLYFKIKEDKRKAA 68
Cdd:pfam04971  1 SKIATGVSYGASAGSIGYWLLQLLDKLSPDEWSAIGVLGGLVIGLITYLTNLYFKRKQTRAKRS 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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