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Conserved domains on  [gi|148679722|gb|EDL11669|]
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carbonic anhydrase 5a, mitochondrial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 55-251 4.23e-142

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03118:

Pssm-ID: 469577  Cd Length: 236  Bit Score: 402.68  E-value: 4.23e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDS--------------------------- 107
Cdd:cd03118    1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSgisggplenhyrlkqfhfhwgannewg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 ------------ELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCL 175
Cdd:cd03118   81 sehtvdghtypaELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 176 MPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03118  161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 274-356 6.58e-18

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03122:

Pssm-ID: 469577 [Multi-domain]  Cd Length: 253  Bit Score: 82.40  E-value: 6.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 274 QVAMGPFDPSCLLPACRD-YWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEE--DVMVNNYRPLQ 350
Cdd:cd03122  165 EVELPPFPLSDLLPPFTDkYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLTRRQDGVMsgDYLPNNGRPQQ 244


                 ....*.
gi 148679722 351 PLRDRK 356
Cdd:cd03122  245 PLGSRT 250
 
Name Accession Description Interval E-value
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 55-251 4.23e-142

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 402.68  E-value: 4.23e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDS--------------------------- 107
Cdd:cd03118    1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSgisggplenhyrlkqfhfhwgannewg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 ------------ELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCL 175
Cdd:cd03118   81 sehtvdghtypaELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 176 MPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03118  161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
46-251 4.19e-82

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 250.65  E-value: 4.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   46 WTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVS-YDAA-SCRYLWNTGYFFQVEFDDS-------------------- 103
Cdd:pfam00194   6 WGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQgYDVPpGKNTLTNNGHTVQVSLDDGdpstisggplatryrlvqfh 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  104 ----------CEDS--------ELHLVHWNStKYENYKKASVGENGLAVIGVFLKLG-AHHQALQKLVDVLPEVRHKDTQ 164
Cdd:pfam00194  86 fhwgstdsrgSEHTidgkrypaELHIVHYNS-KYKSFDEAAKHPDGLAVLGVFFEVGdENNPYLQPIVSALDNIKYKGKS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  165 VAMGPFDPSCLMPAC-RDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLR 243
Cdd:pfam00194 165 VLLPPFDLSDLLPEDlTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNFRPTQPLN 244


                  ....*...
gi 148679722  244 DRKLRSSF 251
Cdd:pfam00194 245 GRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 33-246 1.74e-77

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 238.75  E-value: 1.74e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722    33 CAEEHSNCARHPLWTGPvsSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSC-------- 104
Cdd:smart01057   2 GYEGKNGPEHWGKLDPP--FCGGKRQSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDDDGstlsggpl 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   105 ---------------------E--------DSELHLVHWNSTKyeNYKKASVGENGLAVIGVFLKLGAHH-QALQKLVDV 154
Cdd:smart01057  80 pgryrlkqfhfhwggsdsegsEhtidgkrfPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDH 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   155 LPEVRHKDTQVAMGPFDPSCLMPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFsgrGEEEDVMV 233
Cdd:smart01057 158 LPLIKYKGQETELTPFDLSSLLPAsTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLP---MEGNEPLV 234

                          250
                   ....*....|...
gi 148679722   234 NNYRPLQPLRDRK 246
Cdd:smart01057 235 NNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
53-250 1.59e-45

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 156.20  E-value: 1.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIqwkDSVYDPQLAPLRVSYDAASCRyLWNTGYFFQVEFDDS--------------------CE------- 105
Cdd:COG3338   50 ATGKNQSPIDI---RTAIKADLPPLKFDYKPTPLE-IVNNGHTIQVNVDPGstltvdgkryelkqfhfhtpSEhtingks 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 106 -DSELHLVHwnstkyenykKASVGEngLAVIGVFLKLGAHHQALQKLVDVLPEVRHkDTQVAMGPFDPSCLMPACRDYWT 184
Cdd:COG3338  126 yPMEAHLVH----------KDADGE--LAVVGVLFEEGAENPALAKLWANLPLEAG-EEVALDATIDLNDLLPEDRSYYR 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 185 YPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLlfsgrgeeedvMVNNYRPLQPLRDRKLRSS 250
Cdd:COG3338  193 YSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL-----------YPNNARPVQPLNGRLILES 247
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 274-356 6.58e-18

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 82.40  E-value: 6.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 274 QVAMGPFDPSCLLPACRD-YWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEE--DVMVNNYRPLQ 350
Cdd:cd03122  165 EVELPPFPLSDLLPPFTDkYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLTRRQDGVMsgDYLPNNGRPQQ 244


                 ....*.
gi 148679722 351 PLRDRK 356
Cdd:cd03122  245 PLGSRT 250
PLN02202 PLN02202
carbonate dehydratase
 53-247 3.61e-13

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 69.32  E-value: 3.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIQWKDSVYDPQLAPLRVSY---DAASCRYLWNTGYFFQVEFDDSCEDSE---LHLVHWNS--------TK 118
Cdd:PLN02202  53 AVGKLQSPIDIQRRQIFYNHKLESIHRDYyftNATLVNHVCNVAMFFGEGAGDVIIDNKnytLLQMHWHTpsehhlhgVQ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 119 Y--ENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHK------DTQVAMGPFDPSCLMPACRDYWTYPGSLT 190
Cdd:PLN02202 133 YaaELHMVHQAKDGSFAVVASLFKIGTEEPFLSQMKDKLVKLKEErfkgnhTAQVEVGKIDTRHIERKTRKYFRYIGSLT 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148679722 191 TPPLAESVTWIVQKTPVEVSPSQLSMFRTLLfsgrgeeEDVMVNNYRPLQPLRDRKL 247
Cdd:PLN02202 213 TPPCSENVSWTILGKVRSMSKEQVELLRSPL-------DKSFKNNSRPCQPLNGRRV 262
PLN02202 PLN02202
carbonate dehydratase
 271-357 1.48e-07

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 52.37  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 271 QDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLfsgrgeeEDVMVNNYRPLQ 350
Cdd:PLN02202 183 HTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPL-------DKSFKNNSRPCQ 255


                 ....*..
gi 148679722 351 PLRDRKL 357
Cdd:PLN02202 256 PLNGRRV 262
 
Name Accession Description Interval E-value
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 55-251 4.23e-142

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 402.68  E-value: 4.23e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDS--------------------------- 107
Cdd:cd03118    1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSgisggplenhyrlkqfhfhwgannewg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 ------------ELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCL 175
Cdd:cd03118   81 sehtvdghtypaELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 176 MPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03118  161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 53-251 1.66e-84

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 256.98  E-value: 1.66e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDD--------------------------SCED 106
Cdd:cd03119   23 AKGDRQSPIDIKTKDAKHDPSLKPLSVSYDPATAKTILNNGHSFNVEFDDtddrsvlrggpltgsyrlrqfhfhwgSSDD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 107 -------------SELHLVHWNStKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPS 173
Cdd:cd03119  103 hgsehtvdgvkyaAELHLVHWNS-KYGSFGEAAKQPDGLAVVGVFLKVGEANPELQKVLDALDSIKTKGKQAPFTNFDPS 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148679722 174 CLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03119  182 CLLPASLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGEPPCPMVDNWRPPQPLKGRKVRASF 259
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
46-251 4.19e-82

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 250.65  E-value: 4.19e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   46 WTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVS-YDAA-SCRYLWNTGYFFQVEFDDS-------------------- 103
Cdd:pfam00194   6 WGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQgYDVPpGKNTLTNNGHTVQVSLDDGdpstisggplatryrlvqfh 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  104 ----------CEDS--------ELHLVHWNStKYENYKKASVGENGLAVIGVFLKLG-AHHQALQKLVDVLPEVRHKDTQ 164
Cdd:pfam00194  86 fhwgstdsrgSEHTidgkrypaELHIVHYNS-KYKSFDEAAKHPDGLAVLGVFFEVGdENNPYLQPIVSALDNIKYKGKS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  165 VAMGPFDPSCLMPAC-RDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLR 243
Cdd:pfam00194 165 VLLPPFDLSDLLPEDlTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNFRPTQPLN 244


                  ....*...
gi 148679722  244 DRKLRSSF 251
Cdd:pfam00194 245 GRVVFASF 252
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 55-251 2.02e-80

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 245.90  E-value: 2.02e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCED---------------------------- 106
Cdd:cd03149    1 GNRQSPIDIVSSEAVYDPKLKPLSLSYDPCTSLSISNNGHSVMVEFDDSDDKtvitggplenpyrlkqfhfhwgakhgsg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 107 -----------SELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCL 175
Cdd:cd03149   81 sehtvdgktfpSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGDEHPGLNRLTDALYMVRFKGTKAQFLDFNPKCL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 176 MPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03149  161 LPKSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNHMVNNFRPPQPLKGRTVRASF 236
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 33-246 1.74e-77

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 238.75  E-value: 1.74e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722    33 CAEEHSNCARHPLWTGPvsSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSC-------- 104
Cdd:smart01057   2 GYEGKNGPEHWGKLDPP--FCGGKRQSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDDDGstlsggpl 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   105 ---------------------E--------DSELHLVHWNSTKyeNYKKASVGENGLAVIGVFLKLGAHH-QALQKLVDV 154
Cdd:smart01057  80 pgryrlkqfhfhwggsdsegsEhtidgkrfPLELHLVHYNSKG--SFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDH 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722   155 LPEVRHKDTQVAMGPFDPSCLMPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFsgrGEEEDVMV 233
Cdd:smart01057 158 LPLIKYKGQETELTPFDLSSLLPAsTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLP---MEGNEPLV 234

                          250
                   ....*....|...
gi 148679722   234 NNYRPLQPLRDRK 246
Cdd:smart01057 235 NNARPLQPLNGRV 247
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 55-248 5.41e-74

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 229.09  E-value: 5.41e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSC-----------------------EDS---- 107
Cdd:cd00326    1 GKRQSPINIVTSAVVYDPSLPPLNFDYYPTTSLTLVNNGHTVQVNFDDDGgtlsggglpgryklvqfhfhwgsENSpgse 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 ----------ELHLVHWNSTKYENykKASVGENGLAVIGVFLKLG-AHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLM 176
Cdd:cd00326   81 htidgkryplELHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGeKENPFLKKILDALPKIKYKGKETTLPPFDLSDLL 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148679722 177 PAC-RDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSgrgeEEDVMVNNYRPLQPLRDRKLR 248
Cdd:cd00326  159 PSSlRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDR----EGKPLVNNYRPVQPLNGRVVY 227
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
53-250 1.59e-45

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 156.20  E-value: 1.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIqwkDSVYDPQLAPLRVSYDAASCRyLWNTGYFFQVEFDDS--------------------CE------- 105
Cdd:COG3338   50 ATGKNQSPIDI---RTAIKADLPPLKFDYKPTPLE-IVNNGHTIQVNVDPGstltvdgkryelkqfhfhtpSEhtingks 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 106 -DSELHLVHwnstkyenykKASVGEngLAVIGVFLKLGAHHQALQKLVDVLPEVRHkDTQVAMGPFDPSCLMPACRDYWT 184
Cdd:COG3338  126 yPMEAHLVH----------KDADGE--LAVVGVLFEEGAENPALAKLWANLPLEAG-EEVALDATIDLNDLLPEDRSYYR 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148679722 185 YPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLlfsgrgeeedvMVNNYRPLQPLRDRKLRSS 250
Cdd:COG3338  193 YSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL-----------YPNNARPVQPLNGRLILES 247
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 23-246 2.32e-43

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 149.73  E-value: 2.32e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  23 GPQRWrfqHSCAEEHSNCArhplwtgpvssaEGTRQSPINIQWKDSVYDpQLAPLRVSYDAASCRYLwNTGYFFQVEFDD 102
Cdd:cd03124    1 GPEHW---GNLDPEFALCA------------TGKNQSPIDITTKAVVSD-KLPPLNYNYKPTSATLV-NNGHTIQVNFEG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 103 SC-----------------------------EDSELHLVHWNStkyenykkasvgENGLAVIGVFLKLGAHHQALQKLVD 153
Cdd:cd03124   64 NGgtltidgetyqllqfhfhspsehlingkrYPLEAHLVHKSK------------DGQLAVVAVLFEEGKENPFLKKILD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 154 VLPEVRHKDTQVAMGpFDPSCLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLlfsgrgeeedVMV 233
Cdd:cd03124  132 NMPKKEGTEVNLPAI-LDPNELLPESRSYYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAA----------VYP 200

                        250
                 ....*....|...
gi 148679722 234 NNYRPLQPLRDRK 246
Cdd:cd03124  201 NNARPVQPLNGRE 213
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 53-251 2.65e-42

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 148.08  E-value: 2.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCR--YLWNTGYFFQV------------------------------EF 100
Cdd:cd03120   11 ANGEYQSPINLNSREARYDPSLLEVRLSPNYVVCRdcEVINDGHTIQIilksksvlsggplpqghefelaevrfhwgrEN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 101 DDSCEDS--------ELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDP 172
Cdd:cd03120   91 QRGSEHTvnfkafpmELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNP 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 173 SCLM--PACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEE-----EDVMVNNYRPLQPLRDR 245
Cdd:cd03120  171 NTLLpdPLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAElvegcDGLLGDNFRPTQPLSDR 250


                 ....*.
gi 148679722 246 KLRSSF 251
Cdd:cd03120  251 VIRAAF 256
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 55-251 1.52e-38

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 138.21  E-value: 1.52e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLR-VSYD---AASCRyLWNTGYFFQVEFD-------------------------DSCE 105
Cdd:cd03123   14 GKRQSPIDIQTDIVQFDPSLPPLElVGYDlpgTEEFT-LTNNGHTVQLSLPptmhirggpgteytaaqlhlhwggrGSLS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 106 DSE-----------LHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAH-HQALQKLVDVLPEVRHKDTQVAMGPFDPS 173
Cdd:cd03123   93 GSEhtidgirfaaeLHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGYPeNTYYEKIISHLHEIKYKGQETTVPGFNVR 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148679722 174 CLMPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSgrgEEEDVMVNNYRPLQPLRDRKLRSSF 251
Cdd:cd03123  173 ELLPEdLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLENTLMD---THNKTLQNNYRATQPLNGRVVEASF 248
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 46-251 1.29e-37

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 135.74  E-value: 1.29e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  46 WTGPVSSAEGTRQSPINIQwKDSV-YDPQLAPLR-VSYDAASCR--YLWNTGYFFQVEF--------------------- 100
Cdd:cd03126    5 WPKKYPFCGGVAQSPIDIH-TDILqYDSSLPPLEfHGYNVSGTEqfTLTNNGHTVQLSLpptmhigglpfkytasqlhlh 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 101 ---DDSCEDSE-----------LHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVA 166
Cdd:cd03126   84 wgqRGSPEGSEhtisgkhfaaeLHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGPFNPSYEKIFSHLHEVKYKDQKVS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 167 MGPFDPSCLMPACRD-YWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDR 245
Cdd:cd03126  164 VPGFNVQELLPKRLDeYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQPFNER 243


                 ....*.
gi 148679722 246 KLRSSF 251
Cdd:cd03126  244 LVFASF 249
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 55-245 1.12e-35

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 130.08  E-value: 1.12e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLR-VSYDAAscRYLW---NTGYFFQVEFDDSCEDS----------------------- 107
Cdd:cd03117    1 GKRQSPINIVTKKVQYDENLTPFTfTGYDDT--TTNWtitNNGHTVQVTLPDGAKISggglpgtykalqfhfhwgsngsp 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 -------------ELHLVHWNStKYENYKKASVGENGLAVIGVFLKLGA-HHQALQKLVDVLPEVRHKDTQVAMGPFDPS 173
Cdd:cd03117   79 gsehtidgerypmELHIVHIKE-SYNSLLEALKDSDGLAVLGFFIEEGEeENTNFDPLISALSNIPQKGGSTNLTPFSLR 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148679722 174 CLMPA--CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRgEEEDVMVNNYRPLQPLRDR 245
Cdd:cd03117  158 SLLPSvlLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDT-DNGQPMVNNFRPVQPLNGR 230
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 55-248 3.60e-31

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 118.67  E-value: 3.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  55 GTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDS------------------------CEDS--- 107
Cdd:cd03121   18 GRRQSPVDIEPSRLLFDPFLTPLRIDTGRKVSGTFYNTGRHVSFRPDKDpvvnisggplsyryrleeirlhfgREDEqgs 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 108 -----------ELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLG-AHHQALQKLV--DVLPEVRHKDTQVAMGPFDPS 173
Cdd:cd03121   98 ehtvngqafpgEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGeTSNPELRRLTnrDTITSIRYKGDAYFLQDLSIE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148679722 174 CLMPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLR 248
Cdd:cd03121  178 LLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPMSPNFRPVQPLNNRPVR 252
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 61-246 1.65e-28

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 111.68  E-value: 1.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  61 INIQWKDSVYDPQLAPLRVSYDAASCRYLWNTgyffqvEFDDSCEDS--------ELHLVHWNSTKYENYKKASVGeNGL 132
Cdd:cd03122   60 LRLEGNSSDPFVSGGPLLGRYKFSEITFHWGT------CNSDGSEHSidghkfplEMQILHRNTDFFDSFEAIKSP-GGV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 133 AVIGVFLKLG-AHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLMPACRD-YWTYPGSLTTPPLAESVTWIVQKTPVEVS 210
Cdd:cd03122  133 LALAYLFELShEDNPFLDPIIEGLRNVSRPGKEVELPPFPLSDLLPPFTDkYYSYEGSLTTPPCSETVEWIVFREPVPIS 212

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 148679722 211 PSQLSMFRTLLFSGRGEEE--DVMVNNYRPLQPLRDRK 246
Cdd:cd03122  213 SRQLEAFRELLTRRQDGVMsgDYLPNNGRPQQPLGSRT 250
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 46-251 4.24e-25

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 102.17  E-value: 4.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  46 WTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVS-YDAASCRYLW-NTGYFFQVEFDDS-------------------- 103
Cdd:cd03125    5 WPEKYPACGGKRQSPIDIQRREVRFNPSLLQLELVgYEKEQGEFTMtNNGHTVQIDLPPTmsittgdgtvytavqmhfhw 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 104 ----CEDS-------------ELHLVHWNStKYENYKKASVGENGLAVIGVFLKLG--AHHQALQKLVDVLPEVRHKDTQ 164
Cdd:cd03125   85 ggrdSEISgsehtidgmryvaELHIVHYNS-KYKSYEEAKDKPDGLAVLAFLYKVGhyAENTYYSDFISKLAKIKYAGQT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 165 VAMGPFDPSCLMPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSMFRTLLFSGRGEeedVMVNNYRPLQPLR 243
Cdd:cd03125  164 TTLTSLDVRDMLPEnLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLMDHHNK---TIRNDYRRTQPLN 240


                 ....*...
gi 148679722 244 DRKLRSSF 251
Cdd:cd03125  241 HRVVEANF 248
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 44-251 2.11e-24

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 100.42  E-value: 2.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  44 PLWTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRV-SYD---AASCRyLWNTGYFFQVEFDDSCE-------------- 105
Cdd:cd03150    3 PPWPSVSPACAGRFQSPVDIRPHLVAFCPALRPLELlGFDlppSPSLR-LLNNGHTVQLSLPSGLRmalgpgqeyralql 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 106 ---------------------DSELHLVHWNsTKYENYKKASVGENGLAVIGVFLKLGAH-HQALQKLVDVLPEVRHKDT 163
Cdd:cd03150   82 hlhwgaagrpgsehtvdghrfPAEIHVVHLS-TAFANLDEALGRPGGLAVLAAFLAEGLHeNSAYEQLLSRLSEISEEES 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 164 QVAMGPFDPSCLMPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSmfrTLLFSGRGEEEDVMVNNYRPLQPL 242
Cdd:cd03150  161 ETVVPGLDVSALLPSdLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLH---TLSDSLWGPHDSRLQLNFRATQPL 237


                 ....*....
gi 148679722 243 RDRKLRSSF 251
Cdd:cd03150  238 NGRKIEASF 246
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 274-356 6.58e-18

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 82.40  E-value: 6.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 274 QVAMGPFDPSCLLPACRD-YWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEE--DVMVNNYRPLQ 350
Cdd:cd03122  165 EVELPPFPLSDLLPPFTDkYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLTRRQDGVMsgDYLPNNGRPQQ 244


                 ....*.
gi 148679722 351 PLRDRK 356
Cdd:cd03122  245 PLGSRT 250
PLN02202 PLN02202
carbonate dehydratase
 53-247 3.61e-13

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 69.32  E-value: 3.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722  53 AEGTRQSPINIQWKDSVYDPQLAPLRVSY---DAASCRYLWNTGYFFQVEFDDSCEDSE---LHLVHWNS--------TK 118
Cdd:PLN02202  53 AVGKLQSPIDIQRRQIFYNHKLESIHRDYyftNATLVNHVCNVAMFFGEGAGDVIIDNKnytLLQMHWHTpsehhlhgVQ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 119 Y--ENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHK------DTQVAMGPFDPSCLMPACRDYWTYPGSLT 190
Cdd:PLN02202 133 YaaELHMVHQAKDGSFAVVASLFKIGTEEPFLSQMKDKLVKLKEErfkgnhTAQVEVGKIDTRHIERKTRKYFRYIGSLT 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148679722 191 TPPLAESVTWIVQKTPVEVSPSQLSMFRTLLfsgrgeeEDVMVNNYRPLQPLRDRKL 247
Cdd:PLN02202 213 TPPCSENVSWTILGKVRSMSKEQVELLRSPL-------DKSFKNNSRPCQPLNGRRV 262
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 271-361 3.90e-11

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 62.67  E-value: 3.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 271 QDTQVAMGPFDPSCLLPA-CRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLfsgRGEEEDVMVNNYRPL 349
Cdd:cd03150  158 EESETVVPGLDVSALLPSdLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSDSL---WGPHDSRLQLNFRAT 234

                         90
                 ....*....|..
gi 148679722 350 QPLRDRKLRSSF 361
Cdd:cd03150  235 QPLNGRKIEASF 246
PLN02179 PLN02179
carbonic anhydrase
 106-204 2.11e-09

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 57.30  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 106 DSELHLVHWNSTkyenykkasvgeNGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKdtQVAMGPFDPSCLMPACRDYWTY 185
Cdd:PLN02179 141 DLELHMVHTSAS------------GKTAVVGVLYKLGEPDEFLTKLLNGIKGVGKK--EINLGIVDPRDIRFETNNFYRY 206

                         90
                 ....*....|....*....
gi 148679722 186 PGSLTTPPLAESVTWIVQK 204
Cdd:PLN02179 207 IGSLTIPPCTEGVIWTVVK 225
PLN02202 PLN02202
carbonate dehydratase
 271-357 1.48e-07

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 52.37  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148679722 271 QDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLfsgrgeeEDVMVNNYRPLQ 350
Cdd:PLN02202 183 HTAQVEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPL-------DKSFKNNSRPCQ 255


                 ....*..
gi 148679722 351 PLRDRKL 357
Cdd:PLN02202 256 PLNGRRV 262
PLN02179 PLN02179
carbonic anhydrase
 274-314 3.21e-03

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 38.81  E-value: 3.21e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148679722 274 QVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQK 314
Cdd:PLN02179 185 EINLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTVVK 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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