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Conserved domains on  [gi|148681065|gb|EDL13012|]
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mCG14111 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 154-372 2.45e-139

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17455:

Pssm-ID: 475125  Cd Length: 407  Bit Score: 403.83  E-value: 2.45e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIG 233
Cdd:cd17455  190 VFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMIITHYEGEEVNAGRIG 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 234 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEIT 313
Cdd:cd17455  270 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLGFFMTGYLPLGFEFAVEIT 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148681065 314 YPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNsPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17455  350 YPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYG-PQAGNIFLCAWIFVGIILTALIK 407
 
Name Accession Description Interval E-value
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 154-372 2.45e-139

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 403.83  E-value: 2.45e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIG 233
Cdd:cd17455  190 VFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMIITHYEGEEVNAGRIG 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 234 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEIT 313
Cdd:cd17455  270 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLGFFMTGYLPLGFEFAVEIT 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148681065 314 YPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNsPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17455  350 YPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYG-PQAGNIFLCAWIFVGIILTALIK 407
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
191-377 1.35e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 74.52  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 191 IPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYT-KTYKQTTLIVYVLSF 269
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 270 IGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKItTDYNS 349
Cdd:COG2271  260 LALLLLALLPSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATG 335

                        170       180
                 ....*....|....*....|....*...
gi 148681065 350 PEAGNIFLCAWMFVGIILTALIKSDLRR 377
Cdd:COG2271  336 YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
183-337 1.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.11  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  183 SIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLtLVVAGMVGSILCGLWLDYTKTYKQTTL 262
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148681065  263 IV--YVLSFIGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFT 337
Cdd:pfam07690 271 ALllLILAALGLLLLSLTLSSLWLLLALL---LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 238-348 2.66e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.67  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  238 VAGMVGSILCGlWL---DYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFtGGILGFFMTGYLPLGFEFAVEITY 314
Cdd:TIGR00881 263 LGGLVGTLLAG-WLsdkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIC-LFALGFLVYGPQMLIGVIASELAP 340

                          90       100       110
                  ....*....|....*....|....*....|....
gi 148681065  315 PESEGMSSGLLNTAAQILGIFFTLAQGKITTDYN 348
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
 
Name Accession Description Interval E-value
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 154-372 2.45e-139

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 403.83  E-value: 2.45e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIG 233
Cdd:cd17455  190 VFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLNQMIITHYEGEEVNAGRIG 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 234 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEIT 313
Cdd:cd17455  270 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLGFFMTGYLPLGFEFAVEIT 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148681065 314 YPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNsPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17455  350 YPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYG-PQAGNIFLCAWIFVGIILTALIK 407
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 155-372 4.59e-117

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 347.15  E-value: 4.59e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 155 FKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGL 234
Cdd:cd17456  190 FQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLNRMVIFHYPGEEVNAGRIGL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 235 TLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITY 314
Cdd:cd17456  270 TIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLGFFMTGYLPLGFEFAAELTY 349

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 148681065 315 PESEGMSSGLLNTAAQILGIFFTLAQGKItTDYNSPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17456  350 PESEGTSSGLLNVSAQVFGIIFTISQGQI-IDNFGTKAGNIFLCAFLLVGTILTALIK 406
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 154-372 3.42e-115

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 342.30  E-value: 3.42e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIG 233
Cdd:cd17398  189 FFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTGVYYAISTLLNQMVLEYFPNEEVNAGWIG 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 234 LTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEIT 313
Cdd:cd17398  269 LTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELT 348

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 148681065 314 YPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNsPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17398  349 YPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVG-ALASNIVLSVALLLGTILTAFIK 406
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 154-372 4.75e-70

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 226.51  E-value: 4.75e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVgEEVNAGRIG 233
Cdd:cd17334  187 LFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLAQILLPFGV-SQTSAGWLG 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 234 LTLVVAGMVGSILCGLWLDYTktyKQTTLIVYVLSFIGMLIFTFTLNL-------GYIIVVFFTGGILGFFMTGYLPLGF 306
Cdd:cd17334  266 FFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLvdryglpYVTLAFYLLCGLLGFFQNSMVPIMF 342

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148681065 307 EFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYnSPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17334  343 ELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPT-PTESKYLLWFILCTVGSCLGALFF 407
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 155-354 1.62e-30

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 121.61  E-value: 1.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 155 FKEKPPLPPSQAQAVLRDSPpeeysYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVnAGRIGL 234
Cdd:cd17399  188 VRSSVPPTPPSASAAHESEP-----FFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLEQILCPSGYSNNF-AGICGA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 235 TLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYI-IVVFFTGGILGFFMTGYLPLGFEFAVEIT 313
Cdd:cd17399  262 LMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQsVLLAVLCGLFGFFGFAIYPVGLELAVECT 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148681065 314 YPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNSPEAGN 354
Cdd:cd17399  342 YPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLPI 382
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
 155-370 6.64e-24

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 101.99  E-value: 6.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 155 FKEKPPLPPSQAQAVLRdsppeeYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNqIILTYYVGEEVNAGRIGL 234
Cdd:cd17397  175 FPSKPPTPPSVSASTQR------LSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLD-VNLTPFGVSQVEAGWIGF 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 235 TLVVAGMVGSILCGLWLDY-TKTYKQTTLIVYVLSFIGMLIFTFTLnLGYI----IVVFFTGGILGFFMTGYLPLGFEFA 309
Cdd:cd17397  248 YSTVAGCVGGIIVGRFADRfGGRMKLILLLLFSGATGSFLWFTLIC-LKLLpfstVSLYTSCILLGVFLNGSVPLFYELA 326

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148681065 310 VEITYPESEGMSSGLLNTAAQILGIFFTLaqgkITTDYNSpeaGNIFLcAWMFVGIILTAL 370
Cdd:cd17397  327 VEAAYPVPEGITSGVLTFLNNVFGLVFLL----ILIIPNI---GTSWM-NWCLLGSCLLSV 379
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 160-368 3.50e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 91.33  E-value: 3.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 160 PLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVA 239
Cdd:cd06174  172 VVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 240 GMVGSILCGLWLDYTKtykqTTLIVYVLSFIGMLIFTFTLNLG-YIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESE 318
Cdd:cd06174  252 GALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLApSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR 327

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 148681065 319 GMSSGLLNTAAQILGIFFTLAQGKITTDYNSPEAGNIFLCAWMFVGIILT 368
Cdd:cd06174  328 GTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
191-377 1.35e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 74.52  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 191 IPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYT-KTYKQTTLIVYVLSF 269
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAA 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 270 IGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKItTDYNS 349
Cdd:COG2271  260 LALLLLALLPSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-LDATG 335

                        170       180
                 ....*....|....*....|....*...
gi 148681065 350 PEAGNIFLCAWMFVGIILTALIKSDLRR 377
Cdd:COG2271  336 YQAAFLLLAALALLAALLALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
169-378 2.36e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.90  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 169 VLRDSPPEEYSYK----SSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGS 244
Cdd:COG2223  179 FLRDPPAGAAAAAkaslRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 245 ILCGLWLDYTKTYKqTTLIVYVLSFIGMLIFTFTL-NLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSG 323
Cdd:COG2223  259 PLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALgSLWLFLVLFL---LLGLALGGGNGAVFALVPDIFPTKNAGAVYG 334

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 148681065 324 LLNTAAQILGIFFTLAQGKITTDYNSPEAGNIFLCAWMFVGIILTALIKSDLRRH 378
Cdd:COG2223  335 LVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
174-378 2.81e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 55.68  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 174 PPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNqIILTYYVGEEVN-AGRIGLTLVVAGMVGSILCGLWLD 252
Cdd:COG2211  211 EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL-YYFKYVLGLSAAlVGLLLALYFLAALLGAPLWPRLAK 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 253 -YTKtyKQTTLIVYVLSFIGMLIFTFtLNLGYIIVVFFTGGILGFFMTGYLPLGF-------EFAVEITYPESEGMSSGL 324
Cdd:COG2211  290 rFGK--KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWamladvvDYDEWKTGRRREGLYFGI 366

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148681065 325 LN---TAAQILGIFFTL----AQGKITTDYNSPEAGN-------IFLCAWMFVGIILTALIKSDLRRH 378
Cdd:COG2211  367 FTfaiKLGQALAGALAGlllaLFGYVAGAAQSPSALTgirllffLLPAVLLLLAALLLLFYPLTRERH 434
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
171-333 6.37e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 6.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 171 RDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLW 250
Cdd:COG2814  187 ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 251 LDYTKtYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQ 330
Cdd:COG2814  267 ADRFG-RRRLLLIGLLLLALGLLLLALAGSLWLLLLALF---LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342


                 ...
gi 148681065 331 ILG 333
Cdd:COG2814  343 LGG 345
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 193-371 3.24e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 51.80  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 193 FVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIV--YVLSFI 270
Cdd:cd17319  181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIigLLLAAV 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 271 GMLIFTFTLNLgYIIVVFFTGGilGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNSP 350
Cdd:cd17319  261 GLLLAYLTTSP-VVAVILLSLA--GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSY 337

                        170       180
                 ....*....|....*....|.
gi 148681065 351 EAGNIFLCAWMFVGIILTALI 371
Cdd:cd17319  338 TAAFLFLAAVALLAALLVLLL 358
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 193-371 5.05e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.45  E-value: 5.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 193 FVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTkTYKQTTLIVYVLSFIGM 272
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTLVIGLILSGILA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 273 LIFtFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKIttdynSPEA 352
Cdd:cd17316  258 LPL-FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL-----LAST 331

                        170
                 ....*....|....*....
gi 148681065 353 GNIFLCAWMFVGIILTALI 371
Cdd:cd17316  332 GGTGVPALILALLAIVALI 350
MFS_1 pfam07690
Major Facilitator Superfamily;
183-337 1.06e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.11  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  183 SIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLtLVVAGMVGSILCGLWLDYTKTYKQTTL 262
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148681065  263 IV--YVLSFIGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFT 337
Cdd:pfam07690 271 ALllLILAALGLLLLSLTLSSLWLLLALL---LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 189-369 1.42e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.93  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 189 RNIPFVLLLVSYGIMTGAFYSISTLLnQIILTYYVGEEVNAGRIGLTLV-VAGMVGSILCGLWLDYT-----KTYKQTTL 262
Cdd:cd17475  196 RNRDVWLIAIAGALLVAPQFALLTFL-LLFLHDHLGLSVVAAGALLAVAqLGGALGRIGLGRVSDRVfggrrRPVLVITA 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 263 IVYVLSFIGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGK 342
Cdd:cd17475  275 AIAAAALLVLSLLSPGTPLWLLVLLLI---LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGL 351

                        170       180
                 ....*....|....*....|....*..
gi 148681065 343 ITTDYNSPEAGNIFLCAWMFVGIILTA 369
Cdd:cd17475  352 LVDATHSYAPAWLALALLLVLAALLLL 378
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 154-333 1.08e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 47.24  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 154 AFKEKPPLPPSQAQAVlrdsPPEEYSYKSSIWNLCRNIPFVLLLVSygiMTGAFYSISTLLNQIILTYYVGEE------- 226
Cdd:cd17313  199 FVKEPPLSPEAGEHSE----NPSLGEVLKSLLKLLKIMPRSLLRLL---LVIFFWWIAFFPFELFFTDYMGEEvyhgtsa 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 227 --------VNAGRIGLTLV-VAGMVGSILCGLWLDYTKTyKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGIlGFF 297
Cdd:cd17313  272 asshygagVRMGAWGLLIFsLAFLIFSLPIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGI-GWA 349

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148681065 298 MTGYLPlgFEFAVEIT--YPESEGMSSGLLNTA---AQILG 333
Cdd:cd17313  350 TININP--YPLVSDYHseSGRGQGTDTGLLNLAislAQILV 388
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 192-339 2.99e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 192 PFVLLLVSYGIMTGAFYSISTLLNQIiLTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtYKQTTLIVYVLSFIG 271
Cdd:cd17478  196 ALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFG-RRRVIIASLLLAAPF 273

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148681065 272 MLIFTFTLNLGYIIVVFftggILGFFMTGYLPLGFEFAVEITyPESEGMSSGLlntaaqILGIFFTLA 339
Cdd:cd17478  274 LLLFLLTPGIWSYILLV----LAGFLLFASFPVTVVLAQELL-PGNVGLASGL------MMGLSFGLG 330
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 189-371 6.17e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 41.77  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 189 RNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYyvGEEVNAGRIGLTLV-VAGMVGSILCGLWLDYTKTYKQTTLIVYVL 267
Cdd:cd17352  181 KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGRLYLYIFTLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 268 sFIGMLIFTFTLNLGYIIVVFFtGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKITTDY 347
Cdd:cd17352  259 -ILGLSLLAFPLATTYVGLIVF-SVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336

                        170       180
                 ....*....|....*....|....
gi 148681065 348 NSPEAGNIFLCAWMFVGIILTALI 371
Cdd:cd17352  337 GDYDAAFYFCGACLLLSGVLLFLL 360
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 181-372 1.49e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 40.64  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 181 KSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNqiiltYYVGEEVNAG--RIGLTL---VVAGMVGSILCGlWLDYTK 255
Cdd:cd17325  189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLP-----LYAAELGGLSpaQIGLLFgaqGLASALSQPPAG-KLSDRI 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 256 TYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFtggILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIF 335
Cdd:cd17325  263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA---LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 148681065 336 FTLAQGKItTDYNSPEAGNIFLCAWMFVGIILTALIK 372
Cdd:cd17325  340 GPLLGGFL-YDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 192-331 1.98e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 192 PFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDyTKTYKQTTLIVYVLSFIG 271
Cdd:cd17321  169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD-RFGPRLVLVAGLLLTAVG 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 272 MLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQI 331
Cdd:cd17321  248 LLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 189-345 2.30e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.92  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 189 RNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKqTTLIVYVLS 268
Cdd:cd06179  260 RGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIK-WQLVAGFVL 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065 269 FIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILG-----IFFTLAQGKI 343
Cdd:cd06179  339 FTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGavgtaIFTSILSNRL 418


                 ..
gi 148681065 344 TT 345
Cdd:cd06179  419 SK 420
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 238-348 2.66e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 39.67  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  238 VAGMVGSILCGlWL---DYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFtGGILGFFMTGYLPLGFEFAVEITY 314
Cdd:TIGR00881 263 LGGLVGTLLAG-WLsdkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLIC-LFALGFLVYGPQMLIGVIASELAP 340

                          90       100       110
                  ....*....|....*....|....*....|....
gi 148681065  315 PESEGMSSGLLNTAAQILGIFFTLAQGKITTDYN 348
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
Sugar_tr pfam00083
Sugar (and other) transporter;
200-371 7.75e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.41  E-value: 7.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  200 YGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLT---LVVAGMVGSILCGLWLDYtKTYKQTTLIVYVLSFIGMLIFT 276
Cdd:pfam00083  16 TGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIvsiFSVGCFIGSLFAGKLGDR-FGRKKSLLIANVLFVIGAVLQG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148681065  277 FTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQIlGIFFTLAQGKITTDYNSPEAGNIF 356
Cdd:pfam00083  95 AAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITF-GILLAYIFGLGLNKTSNSDGWRIP 173

                         170
                  ....*....|....*
gi 148681065  357 LcawmFVGIILTALI 371
Cdd:pfam00083 174 L----GLQLVPALLL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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