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Conserved domains on  [gi|148682434|gb|EDL14381|]
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minichromosome maintenance deficient 3 (S. cerevisiae), isoform CRA_a, partial [Mus musculus]

Protein Classification

minichromosome maintenance family protein( domain architecture ID 1003676)

minichromosome maintenance (MCM) family protein similar to minichromosome maintenance protein, a DNA-dependent ATPase required for the initiation of eukaryotic DNA replication, and MCM domain-containing protein 2 (mcmdc2), which plays an important role in meiotic recombination and associated DNA double-strand break repair

Gene Ontology:  GO:0032508|GO:0003677|GO:0005524
PubMed:  15007098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 16-305 5.66e-153

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17754:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 436.51  E-value: 5.66e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  16 PGPFPPRGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:cd17754   66 PLAIATTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYrapgeqdgdalplgs 175
Cdd:cd17754  146 NARCSVLAAANPVYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY--------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgtkkkkekmvsAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQD 254
Cdd:cd17754  211 ------------------------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDD 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148682434 255 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17754  249 NTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
 
Name Accession Description Interval E-value
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 16-305 5.66e-153

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 436.51  E-value: 5.66e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  16 PGPFPPRGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:cd17754   66 PLAIATTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYrapgeqdgdalplgs 175
Cdd:cd17754  146 NARCSVLAAANPVYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY--------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgtkkkkekmvsAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQD 254
Cdd:cd17754  211 ------------------------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDD 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148682434 255 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17754  249 NTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM smart00350
minichromosome maintenance proteins;
23-307 8.18e-137

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 403.18  E-value: 8.18e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434    23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:smart00350 268 GKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVL 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDalplgssvdilat 182
Cdd:smart00350 348 AAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHPEEDEAF------------- 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   183 ddpdftqddqqdtriyekhdsllhgtkkkkEKMVSAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQDSmSSDTA 261
Cdd:smart00350 415 ------------------------------EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESR 463

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 148682434   262 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 307
Cdd:smart00350 464 SSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 21-310 7.00e-97

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 305.96  E-value: 7.00e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  21 PR-----GRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHAR 94
Cdd:COG1241  340 PRgvytsGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVAT 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  95 LNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHqyrapgeqdgdalplg 174
Cdd:COG1241  420 LNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVH---------------- 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 175 ssvdilatddpdftqddqqdtRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQ 253
Cdd:COG1241  484 ---------------------RAGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKK 542

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148682434 254 DSMSSDTArtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYaYFKKV 310
Cdd:COG1241  543 GEDEDSPV---PITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS-CLKDV 595
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
21-310 6.69e-89

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 284.90  E-value: 6.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  21 PR-----GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:NF040949 349 PRavytsGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATL 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQyrapgeqdgdalplgs 175
Cdd:NF040949 429 NARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHS---------------- 492

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgTKKKKEKMVSAAFMKKYIHVA-KIIKPTLTQESAAYIAEEYSRLRSQD 254
Cdd:NF040949 493 --------------------------------GKEKVKPEIDPDLLKKYIAYArKYVRPKLTEEAKKLIEDFYVEMRKSS 540

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148682434 255 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELvQYAYFKKV 310
Cdd:NF040949 541 KSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRL-MLAFLESV 595
MCM pfam00493
MCM P-loop domain;
23-158 3.21e-82

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 253.22  E-value: 3.21e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:pfam00493  89 GKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSIL 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148682434  103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 158
Cdd:pfam00493 169 AAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 23-312 2.26e-51

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 186.74  E-value: 2.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSV 101
Cdd:PTZ00111 524 GKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAI 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 102 LAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhQYRAPGEQDGDAlplgssvdila 181
Cdd:PTZ00111 604 LASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK--DFLLPHMTGSGN----------- 670

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 182 tddpDFTQDDQQDTRIYEkhDSLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRSQDSMSSDT 260
Cdd:PTZ00111 671 ----DEDTYDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMRQGNFQTSNL 742

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148682434 261 --------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLE 312
Cdd:PTZ00111 743 delehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVD 814
 
Name Accession Description Interval E-value
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 16-305 5.66e-153

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 436.51  E-value: 5.66e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  16 PGPFPPRGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:cd17754   66 PLAIATTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYrapgeqdgdalplgs 175
Cdd:cd17754  146 NARCSVLAAANPVYGRYDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY--------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgtkkkkekmvsAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQD 254
Cdd:cd17754  211 ------------------------------------------IKFLRKYIHYAKeRIKPKLTQEAAEYIAEEYADLRNDD 248

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148682434 255 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17754  249 NTKTDKARTSPITARTLETLIRLATAHAKARLSKTVDKVDAEVALNLLRFA 299
MCM smart00350
minichromosome maintenance proteins;
23-307 8.18e-137

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 403.18  E-value: 8.18e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434    23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:smart00350 268 GKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSDRTAIHEAMEQQTISIAKAGITTTLNARCSVL 347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDalplgssvdilat 182
Cdd:smart00350 348 AAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELAKHVVDLHRYSHPEEDEAF------------- 414

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   183 ddpdftqddqqdtriyekhdsllhgtkkkkEKMVSAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQDSmSSDTA 261
Cdd:smart00350 415 ------------------------------EPPLSQEKLRKYIAYAReKIKPKLSEEAADKLVKAYVDLRKEDS-QTESR 463

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 148682434   262 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYF 307
Cdd:smart00350 464 SSIPITVRQLESIIRLSEAHAKMRLSDVVEEADVEEAIRLLRESII 509
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 23-303 5.59e-103

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 309.66  E-value: 5.59e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17706   73 GKGSSGAGLTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSIL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDgdalplgssvdilat 182
Cdd:cd17706  153 AAANPKGGRYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSDPEEQV--------------- 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 ddpdftqddqqdtriyekhdsllhgTKKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQdsmsSDTAR 262
Cdd:cd17706  218 -------------------------KPEEDGIPIDIELLRKYILYARQIHPKISEEAREKLVRWYVELRKE----SERRS 268

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 148682434 263 TSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 303
Cdd:cd17706  269 TIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVR 309
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 21-310 7.00e-97

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 305.96  E-value: 7.00e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  21 PR-----GRGSSGVGLTAAVTTDQE-TGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHAR 94
Cdd:COG1241  340 PRgvytsGKGSTAAGLTAAAVRDDFgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVAT 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  95 LNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHqyrapgeqdgdalplg 174
Cdd:COG1241  420 LNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVH---------------- 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 175 ssvdilatddpdftqddqqdtRIYEKHDSLLHGTKKKKEKMVSAAFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQ 253
Cdd:COG1241  484 ---------------------RAGELLEQEIEEETEEVKPEIDPDLLRKYIAYARrNVFPVLTEEAKDLIEDFYVDMRKK 542

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148682434 254 DSMSSDTArtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYaYFKKV 310
Cdd:COG1241  543 GEDEDSPV---PITARQLEALIRLAEASARMRLSDTVTEEDAERAIRLVDS-CLKDV 595
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
21-310 6.69e-89

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 284.90  E-value: 6.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  21 PR-----GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:NF040949 349 PRavytsGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATL 428

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQyrapgeqdgdalplgs 175
Cdd:NF040949 429 NARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHS---------------- 492

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgTKKKKEKMVSAAFMKKYIHVA-KIIKPTLTQESAAYIAEEYSRLRSQD 254
Cdd:NF040949 493 --------------------------------GKEKVKPEIDPDLLKKYIAYArKYVRPKLTEEAKKLIEDFYVEMRKSS 540

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148682434 255 SMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELvQYAYFKKV 310
Cdd:NF040949 541 KSSEDPDSPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERAIRL-MLAFLESV 595
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 23-305 4.69e-88

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 271.21  E-value: 4.69e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17758   72 GRGSSGVGLTAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSIL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYrapgeqdgdalplgssvdilaT 182
Cdd:cd17758  152 AAANPAYGRYNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQH---------------------N 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 DDPDftqddqqdtriyekhdsllhgtkkKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRSQDSMSSDTAR 262
Cdd:cd17758  211 KQPD------------------------SDFEPLDPKLLRAYIALAKRKRPTVPPALADYIVQAYVEMRQEAKRSKDFTF 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 148682434 263 TSPvtaRTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17758  267 TTP---RTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 23-303 2.14e-84

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 262.32  E-value: 2.14e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17756   73 GKGSSAAGLTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDAlplgssvdilat 182
Cdd:cd17756  153 AAANPVFGRYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARKASQSQEN------------ 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 ddpdftqddqqdtriyekhdsllhgtkkkkEKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRS---QDSMSS 258
Cdd:cd17756  221 ------------------------------EGEIPISKLKRYIAYCRAkCAPRLSEEAAEKLSNHYVTIRKdvrQNELES 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 148682434 259 DTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 303
Cdd:cd17756  271 DNRSSIPITVRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQ 315
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 19-302 1.30e-82

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 257.30  E-value: 1.30e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  19 FPPR-----GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHA 93
Cdd:cd17757   64 FSPRavytsGKASSAAGLTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  94 RLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRApgeqdgdalpl 173
Cdd:cd17757  144 TLNARTSILAAANPVGGRYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIVDLHSKRE----------- 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 174 gssvdilATDDPDFTQDDqqdtriyekhdsllhgtkkkkekmvsaafMKKYIHVAKIIKPTLTQESAAYIAEEYSRLRsQ 253
Cdd:cd17757  213 -------EAIEPPFTAEQ-----------------------------LKRYIAYARTFKPKLTKEAKDELVEQYKELR-Q 255

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 148682434 254 DSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELV 302
Cdd:cd17757  256 DDASGSTRSSYRITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLL 304
MCM pfam00493
MCM P-loop domain;
23-158 3.21e-82

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 253.22  E-value: 3.21e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434   23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:pfam00493  89 GKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSIL 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148682434  103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMH 158
Cdd:pfam00493 169 AAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 23-305 2.55e-77

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 243.88  E-value: 2.55e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17755   74 GKGSSAVGLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSIL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQYRAPGEQDGDALPlgssvdilat 182
Cdd:cd17755  154 ASANPIGSRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYLEDTPEHIQDEVLD---------- 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 ddpdftqddqqdtriyekhdsllhgtkkkkekmvsAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRsqdSMSSDTA 261
Cdd:cd17755  224 -----------------------------------VEVLTDYISYAREhIHPKLSEEAAQELVQAYVDMR---KMGSDAR 265

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 148682434 262 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17755  266 KRITATPRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLIREA 309
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 23-303 1.57e-76

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 241.59  E-value: 1.57e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17761   74 GKGSTAAGLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHQyrapgeqdgdalpLGSSVDILAT 182
Cdd:cd17761  154 AAANPKFGRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHS-------------GGEMREIKPE 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 DDPDftqddqqdtriyekhdsllhgtkkkkekmvsaaFMKKYIHVA-KIIKPTLTQESAAYIAEEYSRLRSQdsmSSDTA 261
Cdd:cd17761  221 IDPD---------------------------------LLRKYIAYArKNVRPVLTEEAKQLIKDFYVEMRKS---GQETP 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 148682434 262 RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQ 303
Cdd:cd17761  265 SPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIML 306
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 23-302 3.24e-72

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 231.18  E-value: 3.24e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17753   73 GQGASAVGLTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHqyrapgeqdgdalplgssvdilAT 182
Cdd:cd17753  153 AAANPIGGRYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGSH----------------------VR 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 DDPDFTQDDQQDTRIYEKHDSllhgtKKKKEKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRsQDSMSSDTA 261
Cdd:cd17753  211 SHPENDEDREGEEEKNQRQRP-----KETKVEPIPQELLRKYIHYAREkVRPKLNQMDMDKVSRVYADLR-KESMATGSL 284

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 148682434 262 rtsPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELV 302
Cdd:cd17753  285 ---PITVRHLESIIRISEAHAKMHLREYVSEEDVDMAIRVM 322
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 23-305 4.45e-53

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 180.43  E-value: 4.45e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTaaVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVL 102
Cdd:cd17760   73 GIGSTSAGLT--VTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTIL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 103 AAANPvYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLrmhqyrapgEQDGDAlplgssvdilat 182
Cdd:cd17760  151 AATNP-KGQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL---------ENKGEP------------ 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 183 ddpdftqddqqdtriyekhdsllhgtkKKKEKMVSAAFMKKYIHVAKIIKPTLTQESAAyIAEEYSRLRSQdsmsSDTAR 262
Cdd:cd17760  209 ---------------------------SKSSKLWSMEKMRTYFCLIKNLRPVLSDEANA-ILLRYYQLQRQ----SDCRN 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 148682434 263 TSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17760  257 AARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 23-312 2.26e-51

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 186.74  E-value: 2.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  23 GRGSSGVGLTAAVT-TDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSV 101
Cdd:PTZ00111 524 GKSSSSVGLTASIKfNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETAI 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 102 LAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRmhQYRAPGEQDGDAlplgssvdila 181
Cdd:PTZ00111 604 LASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK--DFLLPHMTGSGN----------- 670

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 182 tddpDFTQDDQQDTRIYEkhDSLLHgtKKKKEKMVSAAFMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRSQDSMSSDT 260
Cdd:PTZ00111 671 ----DEDTYDRSNTMHVE--DESLR--SEKDYNKNDLDMLRMYIKFSKLhCFPKLSDEAKKVITREYVKMRQGNFQTSNL 742

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148682434 261 --------------------ARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLE 312
Cdd:PTZ00111 743 delehaqedddddlyyqssgTRMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSSTFQSLVD 814
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 21-305 1.52e-47

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 165.40  E-value: 1.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  21 PRGRGSSG-----VGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDmDRTAIHEVMEQGRVTIAKAGIHARL 95
Cdd:cd17759   68 PRGVYVCGnttttSGLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  96 NARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHvlrmHQyrapgeqdgdalplgs 175
Cdd:cd17759  147 PARTSVIAAANPVGGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH----HQ---------------- 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434 176 svdilatddpdftqddqqdtriyekhdsllhgtkkkkekmvsaaFMKKYIHVAK-IIKPTLTQESAAYIAEEYSRLRSQd 254
Cdd:cd17759  207 --------------------------------------------LLRKYISYARqYVNPVLSKDASEALQEFYLELRKQ- 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148682434 255 smsSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYA 305
Cdd:cd17759  242 ---NQLADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 220-303 1.02e-22

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 91.84  E-value: 1.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  220 FMKKYIHVAKI-IKPTLTQESAAYIAEEYSRLRSqdsMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEA 298
Cdd:pfam17855   2 LLRKYIAYAREkIKPKLSEEAREKLVDAYVELRK---ESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEA 78


                  ....*
gi 148682434  299 VELVQ 303
Cdd:pfam17855  79 IRLLK 83
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 49-107 8.41e-05

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 43.68  E-value: 8.41e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148682434   49 GAMVLADRGVVCIDEfdkMSDMDRTAI---HEVMEQGRVTIAKAGIHARLNARCSVLAAANP 107
Cdd:pfam01078 100 GEISLAHNGVLFLDE---LPEFKRRVLeslRQPLEDGEITISRARAKVTFPARFQLVAAMNP 158
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 38-165 6.06e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 41.69  E-value: 6.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148682434  38 DQETGERRLEAGAmVLAdrGVVCIDEFDKMSDmdRT--AIHEVMEQGRVTIakAGIHARLNARCSVLAAANPVygrydqy 115
Cdd:COG0714   80 DQQTGEFEFRPGP-LFA--NVLLADEINRAPP--KTqsALLEAMEERQVTI--PGGTYKLPEPFLVIATQNPI------- 145

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148682434 116 ktpmENIG---LQDSLLSRFdLLFIMLDQMDPEQDREIsdhvLRMHQYRAPGE 165
Cdd:COG0714  146 ----EQEGtypLPEAQLDRF-LLKLYIGYPDAEEEREI----LRRHTGRHLAE 189
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 49-107 8.09e-04

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 41.56  E-value: 8.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148682434  49 GAMVLADRGVVCIDEfdkMSDMDRTAIhEV----MEQGRVTIAKAGIHARLNARCSVLAAANP 107
Cdd:COG0606  290 GEISLAHNGVLFLDE---LPEFSRRVL-EAlrqpLEDGEVTISRANGSVTYPARFQLVAAMNP 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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