NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148690168|gb|EDL22115|]
View 

PCI domain containing 2, isoform CRA_a, partial [Mus musculus]

Protein Classification

PCI domain-containing protein( domain architecture ID 2851)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; Similar to Schizosaccharomyces pombe COP9 signalosome complex subunit 7 and Mus musculus PCI domain-containing protein 2

Gene Ontology:  GO:0000338|GO:0003690
PubMed:  9644972

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PINT super family cl02111
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 49-140 8.56e-16

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


The actual alignment was detected with superfamily member COG5600:

Pssm-ID: 470471  Cd Length: 413  Bit Score: 72.52  E-value: 8.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690168  49 DMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRITYK 126
Cdd:COG5600  144 DNLSKISRLLTRMFNSILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFH 223

                         90
                 ....*....|....
gi 148690168 127 YYVGRKAMFDSDFK 140
Cdd:COG5600  224 YYLGIYYLLNENFH 237
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
49-140 8.56e-16

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 72.52  E-value: 8.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690168  49 DMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRITYK 126
Cdd:COG5600  144 DNLSKISRLLTRMFNSILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFH 223

                         90
                 ....*....|....
gi 148690168 127 YYVGRKAMFDSDFK 140
Cdd:COG5600  224 YYLGIYYLLNENFH 237
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
49-140 8.56e-16

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 72.52  E-value: 8.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690168  49 DMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRITYK 126
Cdd:COG5600  144 DNLSKISRLLTRMFNSILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFH 223

                         90
                 ....*....|....
gi 148690168 127 YYVGRKAMFDSDFK 140
Cdd:COG5600  224 YYLGIYYLLNENFH 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH