SHC (Src homology 2 domain containing) family, member 4, isoform CRA_b [Mus musculus]
PH domain-containing protein( domain architecture ID 106840)
Pleckstrin homology (PH) domain-containing protein may be involved in targeting a protein to the appropriate cellular location or interacting with a binding partner
List of domain hits
Name | Accession | Description | Interval | E-value | ||
PH-like super family | cl17171 | Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ... |
181-219 | 6.34e-20 | ||
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins. The actual alignment was detected with superfamily member cd01209: Pssm-ID: 473070 Cd Length: 170 Bit Score: 83.03 E-value: 6.34e-20
|
||||||
Name | Accession | Description | Interval | E-value | ||
PTB_Shc | cd01209 | Shc-like phosphotyrosine-binding (PTB) domain; Shc is a substrate for receptor tyrosine ... |
181-219 | 6.34e-20 | ||
Shc-like phosphotyrosine-binding (PTB) domain; Shc is a substrate for receptor tyrosine kinases, which can interact with phosphoproteins at NPXY motifs. Shc contains an PTB domain followed by an SH2 domain. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This cd is part of the Shc-like subgroup. Pssm-ID: 269920 Cd Length: 170 Bit Score: 83.03 E-value: 6.34e-20
|
||||||
PID | pfam00640 | Phosphotyrosine interaction domain (PTB/PID); |
192-219 | 2.72e-03 | ||
Phosphotyrosine interaction domain (PTB/PID); Pssm-ID: 395515 Cd Length: 133 Bit Score: 36.57 E-value: 2.72e-03
|
||||||
Name | Accession | Description | Interval | E-value | ||
PTB_Shc | cd01209 | Shc-like phosphotyrosine-binding (PTB) domain; Shc is a substrate for receptor tyrosine ... |
181-219 | 6.34e-20 | ||
Shc-like phosphotyrosine-binding (PTB) domain; Shc is a substrate for receptor tyrosine kinases, which can interact with phosphoproteins at NPXY motifs. Shc contains an PTB domain followed by an SH2 domain. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This cd is part of the Shc-like subgroup. Pssm-ID: 269920 Cd Length: 170 Bit Score: 83.03 E-value: 6.34e-20
|
||||||
PID | pfam00640 | Phosphotyrosine interaction domain (PTB/PID); |
192-219 | 2.72e-03 | ||
Phosphotyrosine interaction domain (PTB/PID); Pssm-ID: 395515 Cd Length: 133 Bit Score: 36.57 E-value: 2.72e-03
|
||||||
Blast search parameters | ||||
|