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Conserved domains on  [gi|148696827|gb|EDL28774|]
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splicing factor 4, isoform CRA_a, partial [Mus musculus]

Protein Classification

SURP domain-containing protein( domain architecture ID 10485192)

SURP domain-containing protein may bind RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 191-242 1.67e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.71  E-value: 1.67e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  191 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 242
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 266-317 5.58e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.70  E-value: 5.58e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  266 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 317
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 298-412 1.82e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696827  298 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 372
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 148696827  373 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS 412
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDAS 134
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 191-242 1.67e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.71  E-value: 1.67e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  191 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 242
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 190-244 1.64e-16

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 73.39  E-value: 1.64e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696827   190 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 244
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 266-317 5.58e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.70  E-value: 5.58e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  266 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 317
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 265-319 3.80e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 66.46  E-value: 3.80e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696827   265 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 319
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 298-412 1.82e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696827  298 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 372
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 148696827  373 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS 412
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDAS 134
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 191-242 1.67e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.71  E-value: 1.67e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  191 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 242
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 190-244 1.64e-16

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 73.39  E-value: 1.64e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696827   190 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 244
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 266-317 5.58e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.70  E-value: 5.58e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696827  266 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 317
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 265-319 3.80e-14

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 66.46  E-value: 3.80e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696827   265 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 319
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 298-412 1.82e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696827  298 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 372
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 148696827  373 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS 412
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDAS 134
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 320-415 2.05e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696827 320 AKAGSTGSFPAPAPNPSLRRKSAPEAlsgAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKVEL 399
Cdd:PRK14951 378 KKTPARPEAAAPAAAPVAQAAAAPAP---AAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ 454

                         90
                 ....*....|....*.
gi 148696827 400 PPAELAQRDIDASPSP 415
Cdd:PRK14951 455 AAPETVAIPVRVAPEP 470
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
318-415 3.27e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696827 318 RKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKV 397
Cdd:PRK12323 417 RAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496

                         90       100
                 ....*....|....*....|....
gi 148696827 398 ----ELPP--AELAQRDIDASPSP 415
Cdd:PRK12323 497 ppweELPPefASPAPAQPDAAPAG 520
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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