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Conserved domains on  [gi|148696829|gb|EDL28776|]
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splicing factor 4, isoform CRA_c, partial [Mus musculus]

Protein Classification

Surp and G-patch domain-containing protein( domain architecture ID 10485244)

protein containing domains Surp, kgd, and G-patch

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 235-286 4.16e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  235 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 286
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 310-361 1.22e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.22e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  310 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 361
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 610-654 9.38e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 9.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148696829  610 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 654
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
kgd super family cl39092
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 342-465 1.62e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


The actual alignment was detected with superfamily member PRK12270:

Pssm-ID: 476867 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829  342 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 416
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148696829  417 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 465
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 235-286 4.16e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  235 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 286
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 234-288 1.85e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.69  E-value: 1.85e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696829   234 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 288
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 310-361 1.22e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.22e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  310 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 361
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 610-654 9.38e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 9.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148696829  610 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 654
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 607-653 2.83e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 64.49  E-value: 2.83e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 148696829   607 LTVENIGYQMLMKMGWKEGEGLGTEGQGIKNPVnKGATTIDGAGFGI 653
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPI-SAEIKKDRKGLGA 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 309-363 3.63e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 64.15  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696829   309 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 363
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 342-465 1.62e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829  342 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 416
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148696829  417 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 465
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
 
Name Accession Description Interval E-value
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 235-286 4.16e-18

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 78.33  E-value: 4.16e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  235 RVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSREFLYYRRKVAEI 286
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 234-288 1.85e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.69  E-value: 1.85e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696829   234 RRVIEKLARFVAEGGPELEKVAMEDYKDNPAFTFLHDKNSReFLYYRRKVAEIRK 288
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 310-361 1.22e-14

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 68.31  E-value: 1.22e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148696829  310 NLAEKLARFIADGGPEVETIALQNNRENQAFSFLYDPNSQGYRYYRQKLDEF 361
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 610-654 9.38e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 65.61  E-value: 9.38e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148696829  610 ENIGYQMLMKMGWKEGEGLGTEGQGIKNPVNKGATTiDGAGFGID 654
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKK-DRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 607-653 2.83e-13

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 64.49  E-value: 2.83e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 148696829   607 LTVENIGYQMLMKMGWKEGEGLGTEGQGIKNPVnKGATTIDGAGFGI 653
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPI-SAEIKKDRKGLGA 46
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 309-363 3.63e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 64.15  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 148696829   309 KNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYdPNSQGYRYYRQKLDEFRK 363
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLK-PNDPYHAYYRKKLAEYRQ 54
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 342-465 1.62e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 45.27  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829  342 FLYDPNSqgyryyrqkLDE-----FRKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSI 416
Cdd:PRK12270   18 YLADPNS---------VDPswrefFADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAA 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148696829  417 PGKPTATAAVKRKRKSRWGPEEDKVEL-------PPAELAqRDIDAS---PSPLSVQDL 465
Cdd:PRK12270   89 AAAAAAAPAAPPAAAAAAAPAAAAVEDevtplrgAAAAVA-KNMDASlevPTATSVRAV 146
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 609-639 2.52e-04

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 39.57  E-value: 2.52e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 148696829  609 VENIGYQMLMKMGWKEGEGLGTEGQGIKNPV 639
Cdd:pfam12656  14 VEEFGAAMLRGMGWKPGQGIGKNKKGDVKPK 44
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
362-459 1.48e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829 362 RKAKAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKV 441
Cdd:PRK12323 417 RAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496

                         90       100
                 ....*....|....*....|....
gi 148696829 442 ----ELPP--AELAQRDIDASPSP 459
Cdd:PRK12323 497 ppweELPPefASPAPAQPDAAPAG 520
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 364-459 1.61e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829 364 AKAGSTGSFPAPAPNPSLRRKSAPEAlsgAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKRKSRWGPEEDKVEL 443
Cdd:PRK14951 378 KKTPARPEAAAPAAAPVAQAAAAPAP---AAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQ 454

                         90
                 ....*....|....*.
gi 148696829 444 PPAELAQRDIDASPSP 459
Cdd:PRK14951 455 AAPETVAIPVRVAPEP 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 373-459 4.58e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829  373 PAPAPNP---SLRRKSAPEALSGAVPPITACPTPVAPA--PAVNPTPSIPGKPTATAAVKRKR--KSRWGPEEDKVELPP 445
Cdd:PHA03247 2708 PEPAPHAlvsATPLPPGPAAARQASPALPAAPAPPAVPagPATPGGPARPARPPTTAGPPAPAppAAPAAGPPRRLTRPA 2787

                          90
                  ....*....|....
gi 148696829  446 AELAQRDIDASPSP 459
Cdd:PHA03247 2788 VASLSESRESLPSP 2801
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 365-459 9.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 9.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148696829 365 KAGSTGSFPAPAPNPSLRRKSAPEALSGAVPPITACPTPVAPAPAVNPTPSIPGKPTATAAVKRKrksrwgPEEDKVELP 444
Cdd:PRK14951 365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAP------AAAAPAAAP 438

                         90
                 ....*....|....*
gi 148696829 445 PAELAQRDIDASPSP 459
Cdd:PRK14951 439 AAAPAAVALAPAPPA 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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