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Conserved domains on  [gi|148701224|gb|EDL33171|]
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latent transforming growth factor beta binding protein 3, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 466-508 1.05e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148701224  466 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 508
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
281-321 1.07e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   281 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 321
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 197-231 1.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 148701224 197 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 231
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 636-672 4.35e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.49  E-value: 4.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148701224  636 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 672
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
322-362 4.56e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   322 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 362
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
403-436 9.62e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 9.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148701224   403 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 436
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
363-402 2.20e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148701224   363 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 402
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-601 1.16e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148701224   573 DVDECLDESNCRNG-VCENTRGGYRCACTP 601
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-273 3.97e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148701224   240 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 273
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-196 6.56e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 6.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 148701224   153 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 196
Cdd:smart00179   1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 466-508 1.05e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148701224  466 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 508
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
281-321 1.07e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   281 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 321
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 197-231 1.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 148701224 197 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 231
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
197-229 3.86e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.86e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148701224   197 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 229
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 636-672 4.35e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.49  E-value: 4.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148701224  636 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 672
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
322-362 4.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   322 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 362
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-312 8.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 8.85e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 148701224 281 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 312
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
403-436 9.62e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 9.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148701224   403 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 436
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 403-438 1.25e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.25e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 403 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 438
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 322-356 1.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 322 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 356
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
363-402 2.20e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148701224   363 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 402
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 363-402 4.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148701224 363 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 402
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-601 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148701224   573 DVDECLDESNCRNG-VCENTRGGYRCACTP 601
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
363-392 1.90e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148701224  363 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 392
Cdd:pfam07645   1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 573-601 3.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.44e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 148701224 573 DVDECLDESNCRN-GVCENTRGGYRCACTP 601
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-273 3.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148701224   240 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 273
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-196 6.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 6.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 148701224   153 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 196
Cdd:smart00179   1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
322-351 6.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 6.81e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148701224  322 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 351
Cdd:pfam07645   1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 7.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 7.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 148701224 240 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 272
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 153-187 8.85e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 8.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 153 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 187
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 466-508 1.05e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 48.81  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148701224  466 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 508
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
281-321 1.07e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   281 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 321
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 197-231 1.99e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 1.99e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 148701224 197 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 231
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
197-229 3.86e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 3.86e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 148701224   197 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 229
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 636-672 4.35e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 41.49  E-value: 4.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148701224  636 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 672
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
322-362 4.56e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 4.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 148701224   322 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 362
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 281-312 8.85e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 8.85e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 148701224 281 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 312
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
403-436 9.62e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 9.62e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 148701224   403 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 436
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 403-438 1.25e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.25e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 403 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 438
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 322-356 1.56e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 322 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 356
Cdd:cd00054    1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
363-402 2.20e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148701224   363 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 402
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 363-402 4.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 148701224 363 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 402
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 398-441 6.61e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 6.61e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 148701224 398 GRKCQDIDECSqdpglCLPHG---ACENLQGSYVCVCDEGFTLTQDQ 441
Cdd:cd01475  181 GKICVVPDLCA-----TLSHVcqqVCISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
573-601 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.16e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 148701224   573 DVDECLDESNCRNG-VCENTRGGYRCACTP 601
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 320-357 1.75e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 1.75e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 148701224 320 CIDVDECEAG-KVCQDgICTNTPGSFQCQCLSGYHLSRD 357
Cdd:cd01475  184 CVVPDLCATLsHVCQQ-VCISTPGSYLCACTEGYALLED 221
EGF_CA pfam07645
Calcium-binding EGF domain;
363-392 1.90e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148701224  363 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 392
Cdd:pfam07645   1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 573-601 3.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.44e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 148701224 573 DVDECLDESNCRN-GVCENTRGGYRCACTP 601
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
240-273 3.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 3.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 148701224   240 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 273
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-196 6.56e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.92  E-value: 6.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 148701224   153 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 196
Cdd:smart00179   1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
322-351 6.81e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 34.91  E-value: 6.81e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 148701224  322 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 351
Cdd:pfam07645   1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 240-272 7.87e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 7.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 148701224 240 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 272
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 153-187 8.85e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.53  E-value: 8.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 148701224 153 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 187
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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