NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148718313|gb|ABQ99440|]
View 

cytidylate kinase [Haemophilus influenzae PittGG]

Protein Classification

(d)CMP kinase( domain architecture ID 10794419)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-217 4.23e-127

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


:

Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 357.89  E-value: 4.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    1 MGMIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNGEVNILLA 80
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   81 GMDVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQ 160
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148718313  161 NKGINGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYI 217
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
 
Name Accession Description Interval E-value
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-217 4.23e-127

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 357.89  E-value: 4.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    1 MGMIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNGEVNILLA 80
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   81 GMDVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQ 160
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148718313  161 NKGINGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYI 217
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
3-222 3.26e-126

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 355.49  E-value: 3.26e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNGEVNILLAGM 82
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  83 DVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNK 162
Cdd:COG0283   81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 163 GINGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEKVS 222
Cdd:COG0283  161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 5-219 8.27e-109

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 311.16  E-value: 8.27e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    5 ITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNgevnILLAGMDV 84
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHTE----VFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   85 SRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKGI 164
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148718313  165 NGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQE 219
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
4-220 4.41e-88

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 273.08  E-value: 4.41e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNgevnILLAGMD 83
Cdd:PRK11860 444 VICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IWLGGED 519

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  84 VSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKG 163
Cdd:PRK11860 520 VTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQLISKG 599

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148718313 164 INGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEK 220
Cdd:PRK11860 600 ISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 4-202 5.93e-67

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 202.72  E-value: 5.93e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGaiyrvtalaalqrktdltnetdlaelarhldiqfipqngevnillagmd 83
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  84 vsrLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKG 163
Cdd:cd02020   32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 148718313 164 INGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDST 202
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
 
Name Accession Description Interval E-value
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-217 4.23e-127

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 357.89  E-value: 4.23e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    1 MGMIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNGEVNILLA 80
Cdd:TIGR00017   1 MAMIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNGEVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   81 GMDVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQ 160
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148718313  161 NKGINGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYI 217
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKILEYA 217
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
3-222 3.26e-126

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 355.49  E-value: 3.26e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNGEVNILLAGM 82
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPGGQRVFLNGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  83 DVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNK 162
Cdd:COG0283   81 DVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELKEK 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 163 GINGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEKVS 222
Cdd:COG0283  161 GISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRERLS 220
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 5-219 8.27e-109

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 311.16  E-value: 8.27e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    5 ITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNgevnILLAGMDV 84
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGHTE----VFLNGEDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   85 SRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKGI 164
Cdd:pfam02224  77 SSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKGL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148718313  165 NGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQE 219
Cdd:pfam02224 157 SVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILELIKQ 211
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
4-220 4.41e-88

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 273.08  E-value: 4.41e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIPQNgevnILLAGMD 83
Cdd:PRK11860 444 VICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRFEGDR----IWLGGED 519

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  84 VSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKG 163
Cdd:PRK11860 520 VTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQLISKG 599

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148718313 164 INGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEK 220
Cdd:PRK11860 600 ISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVLDWWQER 656
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
4-222 4.81e-73

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 230.15  E-value: 4.81e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELARHLDIQFIP-QNGEVNILLAGM 82
Cdd:PRK13477 286 IIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELKPsSGSPQRVWINGE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  83 DVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNK 162
Cdd:PRK13477 366 DVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQRIGEKGGLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQAQ 445

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148718313 163 GING-NFAQILAEIKERDFRDRNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEKVS 222
Cdd:PRK13477 446 GFPViDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIIDLYRDRIP 506
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 4-202 5.93e-67

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 202.72  E-value: 5.93e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGaiyrvtalaalqrktdltnetdlaelarhldiqfipqngevnillagmd 83
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTG------------------------------------------------- 31

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  84 vsrLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKG 163
Cdd:cd02020   32 ---GIRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 148718313 164 INGNFAQILAEIKERDFRDRNREVAPLKPADDALLLDST 202
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 2-223 2.58e-48

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 168.43  E-value: 2.58e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   2 GMIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDLTNETDLAELAR----------HLDIQFIPQ 71
Cdd:PRK09518   1 MIIVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDAELVDEQVVTeavgefftglHFDISVDPD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  72 NGEVniLLAGMDVSRLIRTQEVADAASKVAVFQKVRSALLQLQQD----------FAKNDGLIADGRDMGTVVFPNAQVK 141
Cdd:PRK09518  81 SPGV--FADGEDISEEIRSPEVSSHVSAVAAIPPVRNVLIAAQRAyiareasadsFSGGLGIVAEGRDITTVVAPDAEVR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 142 LFLDASAEERAKRRYKQLQNKgingNFAQILAEIKERDFRDrNREVAPLKPADDALLLDSTTLSIDEVIDQALAYIQEKV 221
Cdd:PRK09518 159 ILLTAREEVRQARRSGQDRSE----TPGVVLEDVAARDEAD-SKVTSFLSAADGVTTLDNSDLDFDETLDLLIGLVEDAI 233


                 ..
gi 148718313 222 SV 223
Cdd:PRK09518 234 EE 235
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 3-212 2.08e-27

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 109.42  E-value: 2.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAALQRKTDL-------TNETDLA------ELARHLDIQFI 69
Cdd:PRK12269  35 VIIALDGPAGSGKSSVCRLLASRLGAQCLNTGSFYRAFTLAALRRVSELavqacspSPDPDAAvgcaavPHATNLDTSYA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  70 PQNGEVNILL------------------AGM------DVSRLIRTQEVADAASKVAVFQKVRSALLQLQQDFAKNDGLIA 125
Cdd:PRK12269 115 PLTAQKKVALfdeaywvsfartvalsyrAGVmyvgeeNVESLLRSDEVESAVSYFAAMPAIRAIMTGKIRSAVCGARVVC 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 126 DGRDMGTVVFPNAQVKLFLDASAEERAKRRYKQLQNKGINGNFAQilaEIKERDFRDRNREVAPLKPADDALLLDSTTLS 205
Cdd:PRK12269 195 EGRDLTTVVFVDADLKCYLDASIEARVARRWAQGTSRLSKQELEQ---RMRARDAHDRARTVGGLRCAPDALYVDTSCLT 271


                 ....*..
gi 148718313 206 IDEVIDQ 212
Cdd:PRK12269 272 IEEVCER 278
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
3-220 3.50e-16

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 73.71  E-value: 3.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDsGAIyrvtalaalqrktdltnetdLAELARHLdiqfipqngevnillaGM 82
Cdd:COG1102    1 MVITISREPGSGGTTIAKRLAEKLGLPLYD-GEI--------------------LREAAKER----------------GL 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  83 DVSRLIRTQEVADA--ASKVAVFQKVRSALLQLQQDFAKNDGLIADGRDMGTVV--FPNAqVKLFLDASAEERAKR---R 155
Cdd:COG1102   44 SEEEFEKLDEKAPSllYRDTAEEDEIDRALDKVIRELARKGNCVIVGRLADWILrdRPNV-LKVFLTAPLEVRVKRiaeR 122

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 156 YkqlqnkgiNGNFAQILAEIKERDFRDRNR--EVAPLKPADDA---LLLDSTTLSIDEVIDQALAYIQEK 220
Cdd:COG1102  123 E--------GISEEEAEKEIKKRDKSRAKYykYYYGIDWGDPSnydLVINTSRLGIEEAVDLILAAIEAR 184
PRK04182 PRK04182
cytidylate kinase; Provisional
 3-220 2.92e-15

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 70.99  E-value: 2.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRvtalaalqrktdltnetdlaELARHLdiqfipqngevnillaGM 82
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR--------------------ELAKER----------------GM 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313  83 DVSRLIRTQEVADAASKvavfqkvrsALLQLQQDFA-KNDGLIADGRDMGTVVFPNAQVKLFLDASAEERAKRrykqlqn 161
Cdd:PRK04182  45 SLEEFNKYAEEDPEIDK---------EIDRRQLEIAeKEDNVVLEGRLAGWMAKDYADLKIWLKAPLEVRAER------- 108

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313 162 kgI----NGNFAQILAEIKERDFRDRNR-------EVAPLKPADdaLLLDSTTLSIDEVIDQALAYIQEK 220
Cdd:PRK04182 109 --IaereGISVEEALEETIEREESEAKRykeyygiDIDDLSIYD--LVINTSRWDPEGVFDIILTAIDKL 174
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 4-154 3.45e-05

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 43.00  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148718313    4 IITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRVTALAalqrktdltnETDLAELARHldiqfipQNGEVnillAGMD 83
Cdd:pfam13189   1 VITISRQYGSGGTTIAKKLAEKLGYPFYDREILDEIAKEL----------GISEEEFELF-------DEKSR----LSSF 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148718313   84 VSRLIRTQEVADAASKVAVFQKVRSALLQLqqdfAKNDGLIADGRDmGTVVF---PNAqVKLFLDASAEERAKR 154
Cdd:pfam13189  60 LYSLAGGRVRGDALSDDRLFDAQSKVIREL----AAEDNCVIVGRG-ADYILkdiPNV-LRVFLTAPLEDRVKR 127
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 3-51 5.60e-04

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 39.73  E-value: 5.60e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYALLDSGAIYRvtalAALQRKTDL 51
Cdd:COG0563    1 MRIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR----AAVKAGTEL 45
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 9-54 1.51e-03

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 38.37  E-value: 1.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 148718313   9 GPSGAGKGTLCYALAEKLGYALLDSGAIYRvtalAALQRKTDLTNE 54
Cdd:cd01428    6 GPPGSGKGTQAERLAKKYGLPHISTGDLLR----EEIASGTELGKK 47
PRK06547 PRK06547
hypothetical protein; Provisional
 3-30 1.59e-03

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 38.18  E-value: 1.59e-03
                         10        20
                 ....*....|....*....|....*...
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLGYAL 30
Cdd:PRK06547  16 ITVLIDGRSGSGKTTLAGALAARTGFQL 43
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 4-27 1.64e-03

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 38.49  E-value: 1.64e-03
                         10        20
                 ....*....|....*....|....
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLG 27
Cdd:cd02030    1 VITVDGNIASGKGKLAKELAEKLG 24
ABC_NikE_OppD_transporters cd03257
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...
 9-72 2.22e-03

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.


Pssm-ID: 213224 [Multi-domain]  Cd Length: 228  Bit Score: 37.87  E-value: 2.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148718313   9 GPSGAGKGTLCYALaekLGYALLDSGAIYRvtalaalqRKTDLTNETDLAELARHLDIQFIPQN 72
Cdd:cd03257   38 GESGSGKSTLARAI---LGLLKPTSGSIIF--------DGKDLLKLSRRLRKIRRKEIQMVFQD 90
AAA_17 pfam13207
AAA domain;
9-38 2.84e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 36.83  E-value: 2.84e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 148718313    9 GPSGAGKGTLCYALAEKLGYALLDSGAIYR 38
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLR 31
aroK PRK00131
shikimate kinase; Reviewed
 1-33 3.64e-03

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 37.09  E-value: 3.64e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 148718313   1 MGMIITVDGPSGAGKGTLCYALAEKLGYALLDS 33
Cdd:PRK00131   3 KGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDT 35
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 3-27 5.20e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 36.74  E-value: 5.20e-03
                         10        20
                 ....*....|....*....|....*
gi 148718313   3 MIITVDGPSGAGKGTLCYALAEKLG 27
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARRLAEQLG 32
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 4-33 5.52e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 36.08  E-value: 5.52e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALLDS 33
Cdd:cd02021    1 IIVVMGVSGSGKSTVGKALAERLGAPFIDG 30
ADK pfam00406
Adenylate kinase;
9-51 5.54e-03

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 36.52  E-value: 5.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148718313    9 GPSGAGKGTLCYALAEKLGYALLDSGAIYRvtalAALQRKTDL 51
Cdd:pfam00406   3 GPPGAGKGTQAEKIVQKYGLPHLSTGDLLR----AEIKSGTEL 41
Gmk COG0194
Guanylate kinase [Nucleotide transport and metabolism];
2-26 6.07e-03

Guanylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 439964  Cd Length: 190  Bit Score: 36.59  E-value: 6.07e-03
                         10        20
                 ....*....|....*....|....*
gi 148718313   2 GMIITVDGPSGAGKGTLCYALAEKL 26
Cdd:COG0194    2 GKLIVLSGPSGAGKTTLVKALLERD 26
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 4-31 7.42e-03

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 36.05  E-value: 7.42e-03
                         10        20
                 ....*....|....*....|....*...
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGYALL 31
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVV 28
gmk PRK00300
guanylate kinase; Provisional
 1-25 7.80e-03

guanylate kinase; Provisional


Pssm-ID: 234719  Cd Length: 205  Bit Score: 36.22  E-value: 7.80e-03
                         10        20
                 ....*....|....*....|....*
gi 148718313   1 MGMIITVDGPSGAGKGTLCYALAEK 25
Cdd:PRK00300   4 RGLLIVLSGPSGAGKSTLVKALLER 28
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 4-66 8.68e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 33.85  E-value: 8.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148718313   4 IITVDGPSGAGKGTLCYALAEKLGY---ALLDSGAIyrVTALAALQRKTDLtNETDLAELARHLDI 66
Cdd:cd02019    1 IIAITGGSGSGKSTVAKKLAEQLGGrsvVVLDEIVI--LEGLYASYKSRDA-RIRDLADLKIYLDA 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH