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Conserved domains on  [gi|148887383|sp|O35345|]
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RecName: Full=Importin subunit alpha-7; AltName: Full=Importin alpha-S2; AltName: Full=Karyopherin subunit alpha-6

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 622.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 116 IDEVINTpGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064  107 IQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 196 GDSSLCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRK 354
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 433 MDSKIVQVALNGLENILRLGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 148887383 513 PQV--------DETQQQFIFQ 525
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 622.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 116 IDEVINTpGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064  107 IQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 196 GDSSLCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRK 354
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 433 MDSKIVQVALNGLENILRLGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 148887383 513 PQV--------DETQQQFIFQ 525
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 469-514 2.77e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.10  E-value: 2.77e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 148887383  469 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 514
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 7.00e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 7.00e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148887383   156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 256-371 5.04e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  256 VLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMH-NDYKVASPALRAVGNIVTGDDIQTQVILN 334
Cdd:PLN03200  193 ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVRAEAAGALEALSSQSKEAKQAIAD 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 148887383  335 CSALPCLLH-LLSSSKESIRKE--------ACWTISNITAGNRAQI 371
Cdd:PLN03200  273 AGGIPALINaTVAPSKEFMQGEfaqalqenAMGALANICGGMSALI 318
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
36-525 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 622.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  36 IQLRKQKREQQLFKRRNVELINEEAamfdsllMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPP 115
Cdd:COG5064   34 VELRKQKREELLNKRRNLADVSEEA-------ESSFIPMEQQFYSELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPP 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 116 IDEVINTpGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG5064  107 IQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 196 GDSSLCRDYVLNCSILNPLLTLLTKSTR-LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACW 274
Cdd:COG5064  186 GDSEGCRDYVLQCGALEPLLGLLLSSAIhISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDACW 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 275 ALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSSKESIRK 354
Cdd:COG5064  266 AISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRK 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 355 EACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGT--PEQIRYLVSLGCIKPLCDLLTV 432
Cdd:COG5064  346 EACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLnrPDIIRYLVSQGFIKPLCDLLDV 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 433 MDSKIVQVALNGLENILRLGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSSLA 512
Cdd:COG5064  426 VDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDELA 505

                        490       500
                 ....*....|....*....|.
gi 148887383 513 PQV--------DETQQQFIFQ 525
Cdd:COG5064  506 PETagntftfgSNVNQQGNFN 526
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 469-514 2.77e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 81.10  E-value: 2.77e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 148887383  469 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVED--DDSSLAPQ 514
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEeeDDENLAPE 49
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-102 3.79e-18

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 79.12  E-value: 3.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383   13 RMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLmdsyvssttgeSVITREMVEMLFSD 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQL-----------LESLPEMVQGVNSD 69

                          90
                  ....*....|
gi 148887383   93 DSDLQLATTQ 102
Cdd:pfam01749  70 DPELQLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 1.16e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.39  E-value: 1.16e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148887383  156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
228-402 6.78e-11

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 60.03  E-value: 6.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 228 RNAVWALSNLcrgknpppefaKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDgpnekIQAVidsgvcRRLVELLMHND 307
Cdd:COG1413    3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD-----PRAV------PALLEALKDPD 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 308 YKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSSKESIRKEACWTISNITagnraqiqaviDANIFPVLIEIL 387
Cdd:COG1413   61 PEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                        170
                 ....*....|....*
gi 148887383 388 QKAEFRTRKEAAWAI 402
Cdd:COG1413  119 KDPDWEVRRAAARAL 133
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 156-195 7.00e-10

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 54.36  E-value: 7.00e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148887383   156 TSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 328-365 8.69e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.00  E-value: 8.69e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 148887383  328 QTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITA 365
Cdd:pfam00514   4 NKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
145-321 2.09e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.79  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 145 AAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSlcrdyvlncsiLNPLLTLLtKSTRL 224
Cdd:COG1413    5 AARALGRLGD-----------PAAVPALIAALADEDPDVRAAAARALGRLGDPRA-----------VPALLEAL-KDPDP 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 225 TMTRNAVWALSNLcrgKNPPPefakvspcLPVLSRLLFSSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLM 304
Cdd:COG1413   62 EVRAAAAEALGRI---GDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGD------PAAVP-----ALLEALK 119

                        170
                 ....*....|....*..
gi 148887383 305 HNDYKVASPALRAVGNI 321
Cdd:COG1413  120 DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
183-363 3.96e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.32  E-value: 3.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 183 VQEQAVWALGNIAGDSSLcrdyvlncsilnPLLTLLTKSTRLTMTRNAVWALSNLcrgknpppefaKVSPCLPVLSRLLF 262
Cdd:COG1413    1 VRRAAARALGRLGDPAAV------------PALIAALADEDPDVRAAAARALGRL-----------GDPRAVPALLEALK 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383 263 SSDSDLLADACWALSYLSDgpnekiQAVIDsgvcrRLVELLMHNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLL 342
Cdd:COG1413   58 DPDPEVRAAAAEALGRIGD------PEAVP-----ALIAALKDEDPEVRRAAAEALGRL--GDP---------AAVPALL 115

                        170       180
                 ....*....|....*....|.
gi 148887383 343 HLLSSSKESIRKEACWTISNI 363
Cdd:COG1413  116 EALKDPDWEVRRAAARALGRL 136
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 141-194 4.25e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 49.67  E-value: 4.25e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 148887383  141 LQFEAAWALTNIASGTSQQTKIVIEAgAVPIFIELLNSDFEDVQEQAVWALGNI 194
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 325-365 6.07e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 6.07e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148887383   325 DDIQTQVILNCSALPCLLHLLSSSKESIRKEACWTISNITA 365
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.12e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 1.12e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148887383  367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-323 5.85e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148887383  283 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVT 323
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-450 8.66e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 8.66e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148887383  410 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILR 450
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 198-239 9.01e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.52  E-value: 9.01e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 148887383  198 SSLCRDYVLNCSILNPLLTLLtKSTRLTMTRNAVWALSNLCR 239
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 126-235 4.90e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 45.02  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  126 VDRFVEFLKRNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSlcrdyv 205
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKIGDPEA------ 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 148887383  206 lncsiLNPLLTLLTKSTRLTMTRNAVWALS 235
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 283-322 6.92e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.80  E-value: 6.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 148887383   283 PNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIV 322
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 112-154 1.68e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.68e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 148887383  112 PSPPIDEVINtPGVVDRFVEFLKrNENCTLQFEAAWALTNIAS 154
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-407 1.83e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 148887383   367 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATS 407
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 242-281 2.02e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.67  E-value: 2.02e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 148887383  242 NPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSD 281
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 314-363 1.12e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.04  E-value: 1.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148887383  314 ALRAVGNI--VTGDDIQTQVIlncSALPCLLHLLSSSKESIRKEACWTISNI 363
Cdd:pfam13513   7 AALALGSLaeGGPDLLAPAVP---ELLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 410-448 1.34e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 148887383   410 TPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENI 448
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT COG1413
HEAT repeat [General function prediction only];
120-195 1.72e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.54  E-value: 1.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148887383 120 INTPGVVDRFVEFLKrNENCTLQFEAAWALTNIASgtsqqtkivieAGAVPIFIELLNSDFEDVQEQAVWALGNIA 195
Cdd:COG1413   74 IGDPEAVPALIAALK-DEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 183-237 1.16e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 37.35  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 148887383  183 VQEQAVWALGNIA-GDSSLCRDYVLNcsILNPLLTLLTKSTRLTMtRNAVWALSNL 237
Cdd:pfam13513   3 VREAAALALGSLAeGGPDLLAPAVPE--LLPALLPLLNDDSDLVR-EAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 112-154 2.90e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.48  E-value: 2.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 148887383   112 PSPPIDEVINTpGVVDRFVEFLKRnENCTLQFEAAWALTNIAS 154
Cdd:smart00185   1 DDENKQAVVDA-GGLPALVELLKS-EDEEVVKEAAWALSNLSS 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 299-399 4.25e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 4.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  299 LVELLM-HNDYKVASPALRAVGNIvtGDDiqtqvilncSALPCLLHLLSSSKESIRKEACWTISNItaGNRAQIqavida 377
Cdd:pfam13646   4 LLQALLrDPDPEVRAAAIRALGRI--GDP---------EAVPALLELLKDEDPAVRRAAAEALGKI--GDPEAL------ 64

                          90       100
                  ....*....|....*....|..
gi 148887383  378 nifPVLIEILQKAEFRTRKEAA 399
Cdd:pfam13646  65 ---PALLELLRDDDDDVVRAAA 83
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 256-371 5.04e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148887383  256 VLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMH-NDYKVASPALRAVGNIVTGDDIQTQVILN 334
Cdd:PLN03200  193 ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVRAEAAGALEALSSQSKEAKQAIAD 272

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 148887383  335 CSALPCLLH-LLSSSKESIRKE--------ACWTISNITAGNRAQI 371
Cdd:PLN03200  273 AGGIPALINaTVAPSKEFMQGEfaqalqenAMGALANICGGMSALI 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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