|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
1-460 |
0e+00 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 953.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 1 MRIGITGKLFMAIFATCMLVLITMHWGVRTSFERGFIDYIKQSNEQRIAMLSHALEGEYQHYGNWDFLRNNDQVIYQIMR 80
Cdd:PRK10549 4 WRPGITGKLFLAIFATCMLVLITMHWGVRISFERGFIDYIKHGNEQRLQMLSDALGEQYQQHGNWRFLRNNDRFVFQILR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 81 SFEQNQNSESRPSMPPRGWRAQFWVVDQDNNLLVGHSGHLPTEASRSAIKVNDQVVGWVISTPSEKLTRNADITFDQQQR 160
Cdd:PRK10549 84 SFEQDNDSKPGPGMPPHGWRTQFWVVDQNNKVLVGPRGPIPPDGTRRPILVNGAEVGWVIASPVERLTRNTDINFDKQQR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 161 RTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDF 240
Cdd:PRK10549 164 RTSWLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 241 MADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIA 320
Cdd:PRK10549 244 MADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 321 SFHGRFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLER 400
Cdd:PRK10549 324 AFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQK 403
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 401 LFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPLFHSIG 460
Cdd:PRK10549 404 LFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQ 463
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
1-454 |
0e+00 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 641.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 1 MRIGITGKLFMAIFATCMLVLITMHWGVRTSFERGFIDYIKQSNEQRIAMLSHALEGEYQHYGNWDFLRNN-DQVIYQIM 79
Cdd:NF012163 1 LRPGITGKLFLAIFATCLLLLIVMHWAVRVSFQRGFIDYIKDGNEQRLQRLSDALGEQYAQHGNWRFLRNNgDRWVRQLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 80 RSFEQ-NQNSESRPSMPPR-GWRAQFWVVDQDNNLLVGHSGHLPTEASRSAIKVNDQVVGWVISTPSEKLTRNADITFDQ 157
Cdd:NF012163 81 RTLEHdNDSDKPGPGLPDHlGWRSRLWLVDANHRFVVGPPDPVSDDGTRRPILVNGQEVGALGASPVERLTRNTDINFDS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 158 QQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMR 237
Cdd:NF012163 161 QQKRASWLIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 238 RDFMADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQV 317
Cdd:NF012163 241 RDFMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 318 AIASFHGRFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQ 397
Cdd:NF012163 321 EGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQ 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1518082090 398 LERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:NF012163 401 LARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
159-455 |
4.44e-84 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 263.72 E-value: 4.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 159 QRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRR 238
Cdd:COG5002 87 ALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 239 DFMADVSHELRTPLAVLRGELEALQDGLRQPTP---ESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLL 315
Cdd:COG5002 167 EFVANVSHELRTPLTSIRGYLELLLDGAADDPEerrEYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 316 QVAIASFHGRFQNKKMTITAHLPEHAV-IFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVS 394
Cdd:COG5002 247 EEVVEELRPLAEEKGIELELDLPEDPLlVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIP 326
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1518082090 395 DEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG5002 327 EEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
151-455 |
3.08e-70 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 225.94 E-value: 3.08e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 151 ADITFDQQQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL 230
Cdd:COG0642 24 LLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 EKNEQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLD 310
Cdd:COG0642 104 EEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 311 VVRLLQVAIASFHGRFQNKKMTITAHLPEHAV-IFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDS 389
Cdd:COG0642 184 LAELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDT 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1518082090 390 KPGVSDEQLERLFERFYRTESSRNraSGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG0642 264 GPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-455 |
1.76e-68 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 218.24 E-value: 1.76e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 224 NQLASSLEKNEQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTP---ESLSSLQAEVAILTKLVNDLHQLSQSDRG 300
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 301 ALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLP-EHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQE 379
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPpELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1518082090 380 ETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRasGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-454 |
1.10e-59 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 190.75 E-value: 1.10e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 346 DPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAI 425
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1518082090 426 CHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
204-453 |
5.73e-50 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 173.16 E-value: 5.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 204 FSTRVAVSSRDELGHLAQDFNQLasslEKNEQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTPES---LSSLQAE 280
Cdd:TIGR02966 85 LEIRIAPYGEEQKLLVARDVTRL----RRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWnraLEIMLEQ 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 281 VAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLEN 360
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 361 SLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAk 440
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEI- 319
|
250
....*....|....
gi 1518082090 441 HSPLG-GLRITVVF 453
Cdd:TIGR02966 320 ESELGkGSTFSFIF 333
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
13-439 |
1.45e-46 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 169.93 E-value: 1.45e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 13 IFAtcMLVLITMH----WGVRtSFERGFIDYIKQSNEQRIAMLSHALEGEYQHYGNWDflRNNDQVIYQIMRSFEQNQNS 88
Cdd:NF033092 12 IYV--LLILIAMQiigvYFVR-QLETQLLNNFKESINLRANLLSYNLEQELSKEDEDD--ETLEEDIRTILNDFNNNDIS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 89 ESRpsmpprgwraqfwVVDQDNNLL----------VGH-----------SGHLPTEASRSAIKVNDQVvgWVISTPSEKL 147
Cdd:NF033092 87 EIQ-------------VIDAKGTILgtsdpsnqsiVGQkttdsdvkralLGGKDNEKILIDPEDNNRV--YVLATPIKSS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 148 TRN--------ADI--TFDQQQRRTSWFIVGlsTLLAAAVTWVL----SRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSR 213
Cdd:NF033092 152 NGEvvgaiyieASMesVYDQMNNINLIFATG--TLIALVITAVLgillARTITRPIKEMRKQALAMAKGDFSRKVKVYGN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 214 DELGHLAQDFNQL--------------------------------------------ASSL------------------- 230
Cdd:NF033092 230 DEIGQLAEAFNNLtkrlqeaqatteserrkldsvlshmtdgviatdrrgrvilindpALEMlnvsretvlgqsildvlgl 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 --------------------------------------------------------EKNEQMRRDFMADVSHELRTPLAV 254
Cdd:NF033092 310 eeeytlrdlleeqdsllldfsteeeplilranfsviqresgfingliavlhdvteqEKIEQERREFVANVSHELRTPLTT 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 255 LRGELEALQDG-LRQPT--PESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKM 331
Cdd:NF033092 390 MRSYLEALADGaWKDPElaPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNI 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 332 TITAHLPEHAV-IFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTES 410
Cdd:NF033092 470 TFKREFPKRDLwVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDK 549
|
570 580
....*....|....*....|....*....
gi 1518082090 411 SRNRASGGSGLGLAICHNIVDAHGGKISA 439
Cdd:NF033092 550 ARSRKMGGTGLGLAIAKEVVEAHGGRIWA 578
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
147-454 |
3.34e-46 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 166.41 E-value: 3.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 147 LTRNADITFDQQQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSR-DELGHLAQDFNQ 225
Cdd:TIGR01386 150 LDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRApAELRELAQSFNA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 226 LASSLEKNEQMRRDFMADVSHELRTPLAVLRGELEALqdgLRQPTP-----ESLSSLQAEVAILTKLVNDLHQLSQSDRG 300
Cdd:TIGR01386 230 MLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVA---LSQPRTgeeyrEVLESNLEELERLSRMVSDMLFLARADNG 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 301 ALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITahLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEE 380
Cdd:TIGR01386 307 QLALERVRLDLAAELAKVAEYFEPLAEERGVRIR--VEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSD 384
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1518082090 381 TLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKhSPLGGLRITVVFP 454
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
181-437 |
3.75e-44 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 158.23 E-value: 3.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 181 LSRGMLAPVKRLVEGTHRLAAGDFSTRV--AVSSRDELGHLAQDFNQLASSLE---KNEQMrrdFMADVSHELRTPLAVL 255
Cdd:NF012226 80 LAQRFIVPINFLADAAKKISQGDLSARAedSQIHSAEISELMHNFNDMAQKLEssvKNAQV---WNAAIAHELRTPITIL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 256 RGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALayrKTQLDVVRLLQVAIAS---FHGRFQNKKMT 332
Cdd:NF012226 157 QGRLQGILDGVFEPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQL---RLNYESVDLKDSIEKVlkmFEDRLEQAQLT 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 333 ITAHLPEHAViFGDPDRLNQLFHNLLENSLRYTNeGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSR 412
Cdd:NF012226 234 IVLNLTATPV-FCDRRRIEQVLIALIDNAIRYAN-AGKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSR 311
|
250 260
....*....|....*....|....*
gi 1518082090 413 NRASGGSGLGLAICHNIVDAHGGKI 437
Cdd:NF012226 312 NKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
165-455 |
5.57e-44 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 159.36 E-value: 5.57e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 165 FIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFN----QLASSLEKNEQMRR-- 238
Cdd:COG5000 13 LIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNrmtdQLKEQREELEERRRyl 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 --------------------------------------------------------------------------------
Cdd:COG5000 93 etilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllv 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 239 ------------------------------DFMADVSHELRTPLAVLRGELEALQDGLRQPTPE-------SLSSLQAEV 281
Cdd:COG5000 173 rasplrddgyvivfdditellraerlaawgELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEdredlerALDTIIRQV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 282 AILTKLVNDLHQLSQSDrgalAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEHA-VIFGDPDRLNQLFHNLLEN 360
Cdd:COG5000 253 DRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKN 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 361 SLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYrteSSRnraSGGSGLGLAICHNIVDAHGGKISAK 440
Cdd:COG5000 329 AIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTK---PKGTGLGLAIVKKIVEEHGGTIELE 402
|
410
....*....|....*
gi 1518082090 441 HSPLGGLRITVVFPL 455
Cdd:COG5000 403 SRPGGGTTFTIRLPL 417
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
161-439 |
1.18e-41 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 154.80 E-value: 1.18e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 161 RTSWFIVGLSTL-LAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASS-------LEK 232
Cdd:NF040691 187 RGTLLLGGLALVvLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERMPVKGEDDLARLARSFNQMADSlqrqirqLEE 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 233 NEQMRRDFMADVSHELRTPLAVLR--GELEALQ-DGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQL 309
Cdd:NF040691 267 LSRLQQRFVSDVSHELRTPLTTIRmaADVIHDSrDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPV 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 310 DVVRLLQVAIASFHGRFQNKKMTITAHLP-EHAVIFGDPDRLNQLFHNLLENSLRYTnEGGALEIIALIQEETLTLHWQD 388
Cdd:NF040691 347 DLRPLVRRVVDALRQLAERAGVELRVDAPgTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRD 425
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 389 SKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAIChnIVDA--HGGKISA 439
Cdd:NF040691 426 HGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIA--LEDArlHGGWLEA 476
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
164-457 |
4.65e-41 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 152.39 E-value: 4.65e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 164 WFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSS-RDELGHLAQDFNQLASSLEK--NEQMRrdF 240
Cdd:PRK09470 169 LLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETgPQEFRQAGASFNQMVTALERmmTSQQR--L 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 241 MADVSHELRTPLAVLRGELeALqdgLRQPTPES--LSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQlDVVRLLQVA 318
Cdd:PRK09470 247 LSDISHELRTPLTRLQLAT-AL---LRRRQGESkeLERIETEAQRLDSMINDLLVLSRNQQKNHLERETF-KANSLWSEV 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 319 I--ASFHGRFQNKKMTITAHlPEHAVIFGDPDRLNQLFHNLLENSLRYTNEggalEIIALI--QEETLTLHWQDSKPGVS 394
Cdd:PRK09470 322 LedAKFEAEQMGKSLTVSAP-PGPWPINGNPNALASALENIVRNALRYSHT----KIEVAFsvDKDGLTITVDDDGPGVP 396
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 395 DEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPLFH 457
Cdd:PRK09470 397 EEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYK 459
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
156-455 |
2.36e-38 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 144.99 E-value: 2.36e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 156 DQQQRRT---SWFIVGLSTLLAAAVTWVLSRgmlaPVKRLVEGTHRLAAGdfsTRVAV--SSRDELGHLAQDFnqlassl 230
Cdd:PRK11100 178 KRSERRIlwaGALLLGIALLIGAGVVWWLNR----SIRRLTRYADAVTEG---KPVPLpkLGSSELRELAQAL------- 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 eknEQMRR---------DFMADVSHELRTPLAVLRGELEALQDglrQPTPES----LSSLQAEVAILTKLVNDLHQLSQ- 296
Cdd:PRK11100 244 ---ESMRVklegkayveQYVQTLTHELKSPLAAIRGAAELLQE---DPPPEDrarfTGNILTQSARLQQLIDRLLELARl 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 297 SDRGALAyRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEHAVIfGDPDRLNQLFHNLLENSLRYTNEGGALEIIAL 376
Cdd:PRK11100 318 EQRQELE-VLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVL-GDPFLLRQALGNLLDNAIDFSPEGGTITLSAE 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 377 IQEETLTLHWQDSKPGVSDEQLERLFERFY---RTESSRNrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:PRK11100 396 VDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
|
..
gi 1518082090 454 PL 455
Cdd:PRK11100 472 PR 473
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
172-455 |
2.12e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 140.32 E-value: 2.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 172 LLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDFM---------- 241
Cdd:COG4191 65 LLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqseklaalge 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 242 --ADVSHELRTPLAVLRGELEALQDGLRQP-----TPESLSSLQAEVAILTKLVNDLHQLSQSDRGalayRKTQLDVVRL 314
Cdd:COG4191 145 laAGIAHEINNPLAAILGNAELLRRRLEDEpdpeeLREALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNEL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 315 LQVAIASFHGRFQNKKMTITAHLPEHA-VIFGDPDRLNQLFHNLLENSLR--YTNEGGALEIIALIQEETLTLHWQDSKP 391
Cdd:COG4191 221 IDEALELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGP 300
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1518082090 392 GVSDEQLERLFERFYRTessrNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG4191 301 GIPPEVLERIFEPFFTT----KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
183-459 |
2.32e-37 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 141.66 E-value: 2.32e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 183 RGMLapvkRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDFMADVSHELRTPLAVLRGELEAL 262
Cdd:PRK10604 162 QDML----KLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMS 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 263 QDglrqPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFhgRFQNKKMTITAHLPEHA- 341
Cdd:PRK10604 238 DN----LSAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADI--QAVTPEKTVRLDTPHQGd 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 342 VIFGDPDRLNQLFHNLLENSLRYTneGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGL 421
Cdd:PRK10604 312 YGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGL 389
|
250 260 270
....*....|....*....|....*....|....*...
gi 1518082090 422 GLAICHNIVDAHGGKISAKHSPLGGLRITVVFPLFHSI 459
Cdd:PRK10604 390 GLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHNL 427
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
152-454 |
1.61e-33 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 132.22 E-value: 1.61e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 152 DITFDQQQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLE 231
Cdd:COG4251 197 LLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 232 K-NEQMRRdFMADVSHELRTPLAVLRGELEALQ----DGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALayRK 306
Cdd:COG4251 277 RsNEELEQ-FAYVASHDLREPLRKISGFSQLLEedygDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQEL--EF 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 307 TQLDVVRLLQVAIASFHGRFQNKKMTIT-AHLPehaVIFGDPDRLNQLFHNLLENSLRYTNEG--GALEIIALIQEETLT 383
Cdd:COG4251 354 EPVDLNELLEEVLEDLEPRIEERGAEIEvGPLP---TVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWV 430
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1518082090 384 LHWQDSKPGVSDEQLERLFERFYRTESSRNRasGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:COG4251 431 FSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
162-451 |
1.76e-33 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 131.31 E-value: 1.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 162 TSWfIVGLSTLLAAaVTWVLSRGmLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDFM 241
Cdd:PRK10337 165 IPW-LVALPIMLII-LMVLLGRE-LAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 242 ADVSHELRTPLAVLRGELEALQdgLRQPTPE----SLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQV 317
Cdd:PRK10337 242 SDAAHELRSPLAALKVQTEVAQ--LSDDDPQarkkALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQS 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 318 AIASFHGRFQNKKMTITAHLPEHAVIF-GDPDRLNQLFHNLLENSLRYTNEGGALEIialiqeeTLT---LHWQDSKPGV 393
Cdd:PRK10337 320 AVMDIYHTAQQAGIDVRLTLNAHPVIRtGQPLLLSLLVRNLLDNAIRYSPQGSVVDV-------TLNarnFTVRDNGPGV 392
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1518082090 394 SDEQLERLFERFYR---TESSrnrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITV 451
Cdd:PRK10337 393 TPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
345-455 |
2.48e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 118.91 E-value: 2.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 345 GDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTeSSRNRASGGSGLGLA 424
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRT-DKRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
214-437 |
3.80e-32 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 126.22 E-value: 3.80e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 214 DELGHLAQDFNQLASSLEKNEQMrrdfMADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQA---EVA-----ILT 285
Cdd:PRK09303 132 DELFVLRQENETLLEQLKFKDRV----LAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEqlqDQArrqleEIE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 286 KLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEH-AVIFGDPDRLNQLFHNLLENSLRY 364
Cdd:PRK09303 208 RLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlPSVYADQERIRQVLLNLLDNAIKY 287
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1518082090 365 TNEGGALEIIALIQeetlTLHW-----QDSKPGVSDEQLERLFERFYRTesSRNRASGGSGLGLAICHNIVDAHGGKI 437
Cdd:PRK09303 288 TPEGGTITLSMLHR----TTQKvqvsiCDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSVCRRIVRVHYGQI 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
207-454 |
4.52e-32 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 126.66 E-value: 4.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 207 RVAVSSRDELGHLAQDFNQLasslEKNEQMRRDFMADVSHELRTPLAVLRGELEALQD-GLRQPTPE-SLSSLQAEVAIL 284
Cdd:PRK11006 178 RVMPYTEGQLLMVARDVTQM----HQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDqPLEGALREkALHTMREQTQRM 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 285 TKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQV----AIAsfhgrFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLEN 360
Cdd:PRK11006 254 EGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVlereAQT-----LSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYN 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 361 SLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAK 440
Cdd:PRK11006 329 AVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIE 408
|
250
....*....|....
gi 1518082090 441 HSPLGGLRITVVFP 454
Cdd:PRK11006 409 SEVGKGTRFSFVLP 422
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
134-455 |
4.97e-31 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 126.68 E-value: 4.97e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 134 QVVGW--VISTPSEKLtrnADITFDQQQRRTSWFIVGLsTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVS 211
Cdd:PRK15347 272 KGPGWqqVTLYPRRNL---ANEALKPALQQLPFALLIL-VLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPEN 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 212 SRDELGHLAQDFNQLASSLEKN----------------------EQMRR---DFMADVSHELRTPLAVLRGELEALQDGl 266
Cdd:PRK15347 348 RLDELGSIAKAYNQLLDTLNEQydtlenkvaertqalaeakqraEQANKrksEHLTTISHEIRTPLNGVLGALELLQNT- 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 267 rQPTPESL----SSLQAEVAILTkLVNDLHQLS--QSDRGALAYRKTQLdvVRLLQVAIASFHGRFQNKKMT----ITAH 336
Cdd:PRK15347 427 -PLTAEQMdladTARQCTLSLLA-IINNLLDFSriESGQMTLSLEETAL--LPLLDQAMLTIQGPAQSKSLTlrtfVGAH 502
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 337 LPEHAVIfgDPDRLNQLFHNLLENSLRYTNEGGALEIIAlIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSrnraS 416
Cdd:PRK15347 503 VPLYLHL--DSLRLRQILVNLLGNAVKFTETGGIRLRVK-RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----S 575
|
330 340 350
....*....|....*....|....*....|....*....
gi 1518082090 417 GGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:PRK15347 576 QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
172-455 |
5.84e-31 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 123.87 E-value: 5.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 172 LLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDFMADVSHELRTP 251
Cdd:PRK09467 164 LLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTP 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 252 LAVLR-------GELEALQDGLRQPTPESlsslqaeVAILTKLVNDLHQLSQSDRgalayrkTQLDVVRLLQVAIASFHG 324
Cdd:PRK09467 244 LTRIRlatemmsEEDGYLAESINKDIEEC-------NAIIEQFIDYLRTGQEMPM-------EMADLNALLGEVIAAESG 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 325 RfqnkKMTITAHLPEHAV-IFGDPDRLNQLFHNLLENSLRYTNegGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFE 403
Cdd:PRK09467 310 Y----EREIETALQPGPIeVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQ 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1518082090 404 RFYRTESSRNraSGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:PRK09467 384 PFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
350-453 |
3.30e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 112.70 E-value: 3.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNraSGGSGLGLAICHNI 429
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE--GGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1518082090 430 VDAHGGKISAKHSPLGGLRITVVF 453
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
207-455 |
7.35e-30 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 123.22 E-value: 7.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 207 RVAVSSRDELGHLAQDfnqlasslekNEQMRRDFMADVSHELRTPLAVLRGELEALQDGL---RQPTPESLSSLQAEVAI 283
Cdd:PRK10490 644 RLTLTASEEQARLASE----------REQLRNALLAALSHDLRTPLTVLFGQAEILTLDLaseGSPHARQASEIRQQVLN 713
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 284 LTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITahLPEHAV-IFGDPDRLNQLFHNLLENSL 362
Cdd:PRK10490 714 TTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLS--LPEPLTlIHVDGPLFERVLINLLENAV 791
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 363 RYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRteSSRNRASGGSGLGLAICHNIVDAHGGKISAKHS 442
Cdd:PRK10490 792 KYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFAR--GNKESAIPGVGLGLAICRAIVEVHGGTIWAENR 869
|
250
....*....|...
gi 1518082090 443 PLGGLRITVVFPL 455
Cdd:PRK10490 870 PEGGACFRVTLPL 882
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
235-455 |
1.92e-28 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 115.27 E-value: 1.92e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 235 QMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTPES-LSSLQAEVAILTKLVNDLhqLSQSDRGALAYRKTQLDvvR 313
Cdd:COG5807 145 SVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEyFNIIISEIDRINTIITEL--LVLSKPKKFNFKKLNLN--D 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 314 LLQVAIASFHGRFQNKKMTITAHLPEHA-VIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPG 392
Cdd:COG5807 221 VLEDVIALLSTEAILKNISIKYDLADDEpVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIG 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 393 VSDEQLERLFERFYRTESSrnrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG5807 301 IPEEVLEKIGEPFFTTKEE------GTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLPL 357
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
169-454 |
1.97e-28 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 117.18 E-value: 1.97e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 169 LSTLLAAAVTWVLSRGMLaPVKRLVEGTHRLAAGDFSTRVAVSSRD-ELGHLAQDFNQLASSLEKNEQMRRDFMADVSHE 247
Cdd:PRK09835 194 ISLLIVFIVLLAVHKGHA-PIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHE 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 248 LRTPLA--VLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGR 325
Cdd:PRK09835 273 IRTPITnlITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAW 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 326 FQNKKMTITAHLPEHAViFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERF 405
Cdd:PRK09835 353 AEERGVELRFVGDPCQV-AGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRF 431
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1518082090 406 YRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKhSPLGGLRITVVFP 454
Cdd:PRK09835 432 YRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVT-SDARGTRFVISLP 479
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-455 |
3.32e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 107.41 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLhwQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNI 429
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITI--TDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 1518082090 430 VDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
225-455 |
8.23e-28 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 113.40 E-value: 8.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 225 QLASSLEKNEQMR--RDFMADVSHELRTPLAVLRGELEALQDGLRQP-TPESLSSLQAEVAILTKLVNDLHQLSQSDRGa 301
Cdd:COG3852 121 RLERELRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLERELPDDeLREYTQLIIEEADRLNNLVDRLLSFSRPRPP- 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 302 layRKTQLDVVRLLQVAIASFHGRFqNKKMTITAH----LPEhavIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIA-- 375
Cdd:COG3852 200 ---EREPVNLHEVLERVLELLRAEA-PKNIRIVRDydpsLPE---VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrv 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 376 --------LIQEETLTLHWQDSKPGVSDEQLERLFERFYRTessrnRAsGGSGLGLAICHNIVDAHGGKISAKHSPLGGL 447
Cdd:COG3852 273 erqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTT-----KE-KGTGLGLAIVQKIVEQHGGTIEVESEPGKGT 346
|
....*...
gi 1518082090 448 RITVVFPL 455
Cdd:COG3852 347 TFRIYLPL 354
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
345-455 |
2.03e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.53 E-value: 2.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 345 GDPDRLNQLFHNLLENSLRYTNEGGALEIIaLIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrnRASGGSGLGLA 424
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
151-443 |
6.32e-27 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 114.49 E-value: 6.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 151 ADITFDQQQRRTSWFIVGLstLLAAAVTWVL----SRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLA------ 220
Cdd:TIGR02956 320 SDLLMTLSVAQFGLLITGM--LGLVILVFIMwrvvYRSVILRLNQHTQALLRLALGDLDISLDARGDDELAHMGraieaf 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 221 ------------------QDFNQLASSLE---------------------KNEQMRRD-----------FMADVSHELRT 250
Cdd:TIGR02956 398 rdtaahnlklqaderqvaQELQEHKESLEqlvaqrtqelaetnerlnaevKNHAKARAeaeeanraksaFLATMSHEIRT 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 251 PLAVLRGELEALQD-GLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNK 329
Cdd:TIGR02956 478 PLNGILGTLELLGDtGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMVSRAQLK 557
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 330 KMTITAHLPEH--AVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFyr 407
Cdd:TIGR02956 558 GIQLRLNIPEQlpNWWQGDGPRIRQVLINLVGNAIKFTDRGSVVLRVSLNDDSSLLFEVEDTGCGIAEEEQATLFDAF-- 635
|
330 340 350
....*....|....*....|....*....|....*.
gi 1518082090 408 TESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSP 443
Cdd:TIGR02956 636 TQADGRRRSGGTGLGLAISQRLVEAMDGELGVESEL 671
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-453 |
6.24e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 102.33 E-value: 6.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 326 FQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEggALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERF 405
Cdd:cd16954 14 YQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRG 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1518082090 406 YRTESSRNrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:cd16954 92 QRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
163-454 |
9.83e-25 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 104.66 E-value: 9.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 163 SWFIVGLSTLLAA-AVTWVLSrgmlaPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRDFM 241
Cdd:PRK10755 67 SLVMVSLTLLICFqAVRWITR-----PLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFT 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 242 ADVSHELRTPLAVLRGELEALQdglRQPTPESlSSLQAEVAILTKLVNDLHQLSQSDRgALA---YRKTQL--DVVRLLQ 316
Cdd:PRK10755 142 ADVAHELRTPLAGIRLHLELLE---KQHHIDV-APLIARLDQMMHTVEQLLQLARAGQ-SFSsghYQTVKLleDVILPSQ 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 317 VAIASFHgrfQNKKMTIT-AHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSD 395
Cdd:PRK10755 217 DELSEML---EQRQQTLLlPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDE 293
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 396 EQLERLFERFYRTESSrnraSGGSGLGLAICHNIVDAHGGKISAK-HSPLGGLRITVVFP 454
Cdd:PRK10755 294 SKCGELSKAFVRMDSR----YGGIGLGLSIVSRITQLHHGQFFLQnRQERSGTRAWVWLP 349
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-455 |
2.67e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 96.73 E-value: 2.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 356 NLLENSLRYTNEggALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGG 435
Cdd:cd16939 7 NLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHGG 84
|
90 100
....*....|....*....|
gi 1518082090 436 KISAKHSPLGGLRITVVFPL 455
Cdd:cd16939 85 HVECDDSELGGACFRLTWPR 104
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
234-460 |
8.34e-24 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 104.28 E-value: 8.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 234 EQMRR--------DFMADVSHELRTPLAVLRGELEALQDGLRQ-PTPESLSSLQAEVAILTKLVNDLHQLSQSDRGALA- 303
Cdd:PRK11360 379 RRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDpPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQp 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 304 YRKTQL--DVVRLLQVAIASFHGRFQnkkMTITAHLPEhavIFGDPDRLNQLFHNLLENSLRYTNEGGALEI-IALIQEE 380
Cdd:PRK11360 459 VSLNALveEVLQLFQTAGVQARVDFE---TELDNELPP---IWADPELLKQVLLNILINAVQAISARGKIRIrTWQYSDG 532
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 381 TLTLHWQDSKPGVSDEQLERLFERFYRTESSrnrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPLFHSIG 460
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
163-453 |
2.73e-23 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 102.02 E-value: 2.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 163 SWFIVGLST--LLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGdfstrvavsSRD--------ELGHLAQDFNQLAssleK 232
Cdd:PRK10815 191 SWFSYVLLAnlLLVIPLLWLAAWWSLRPIEALAKQVRELEEG---------EREqldpnpprELTSLVRNLNRLL----K 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 233 NEQMR----RDFMADVSHELRTPLAVLRGELEALQDGlRQPTPEslsslQAEVAILTKLVN-------DLHQLSQSDRGA 301
Cdd:PRK10815 258 NERERytkyRTTLTDLTHSLKTPLAVLQSTLRSLRSG-KQMSVE-----QAEPIMLEQISRisqqigyYLHRASMRSEHN 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 302 LAYRKTQlDVVRLLQVAIASFHGRFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEggALEIIALIQEET 381
Cdd:PRK10815 332 LLSRELH-SVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEH 408
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1518082090 382 LTLHWQDSKPGVSDEQLERLFERFYRTESSRNrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:PRK10815 409 LHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIF 476
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
101-454 |
5.15e-23 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 102.13 E-value: 5.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 101 AQFWVVDQDNNLLVghsghLPTeasRSAIKVNDQVVGWVI---STPSEKLTRNADITfdqqqrrtSWFIVGLSTLLAAAV 177
Cdd:TIGR03785 358 ASTWRLSPDSKAVI-----LSA---AYPIWIDTEVLGAVIaeqTTNGIRTLRNSALE--------KLFNVILAIMSIGTL 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 178 T------WVLSRgmlapVKRLVEGTHrlAAGDFSTRV-----AVSSRDELGHLAQDFNQLASSLEKNEQMRRDFMADVSH 246
Cdd:TIGR03785 422 AlfgfasWISWR-----IRRLSDDAE--AAIDSQGRIsgaipASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSH 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 247 ELRTPLAVLRGELEALQDG-LRQPTPESLSSLQAEVAILTKLVNDLHQ---LSQSDRGAlayRKTQLDVVRLLQVAIASF 322
Cdd:TIGR03785 495 ELRTPVAVVRSSLENLELQaLEQEKQKYLERAREGTERLSMILNNMSEatrLEQAIQSA---EVEDFDLSEVLSGCMQGY 571
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 323 hgRFQNKKMTITAHLPEHAVIF-GDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERL 401
Cdd:TIGR03785 572 --QMTYPPQRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQL 649
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1518082090 402 FERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLG-GLRITVVFP 454
Cdd:TIGR03785 650 FDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRISLP 703
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
227-455 |
3.75e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 100.19 E-value: 3.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 227 ASSLEKNEQM-----RRDFMADVSHELRTPLAVLRGELEALQ-DGL-RQPTPESLSSLQAEVAILTKLVNDLHQLSQSDR 299
Cdd:PRK09959 697 ALEVERNKAInatvaKSQFLATMSHEIRTPISSIMGFLELLSgSGLsKEQRVEAISLAYATGQSLLGLIGEILDVDKIES 776
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 300 GALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTIT--AHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALI 377
Cdd:PRK09959 777 GNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScsSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLG 856
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 378 Q----EETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRAsgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:PRK09959 857 HiddnHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
..
gi 1518082090 454 PL 455
Cdd:PRK09959 935 PV 936
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-453 |
6.10e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.54 E-value: 6.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 345 GDPDRLNQLFHNLLENSLRYTNEGGALEIIaLIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrnRASGGSGLGLA 424
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLS 84
|
90 100
....*....|....*....|....*....
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
231-455 |
6.90e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 98.12 E-value: 6.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 EKNEQMRR--------DFMADVSHELRTPLAVLRGELEALQDGLrqpTPES-------LSSLQAEVAILTKLvndlhqLS 295
Cdd:COG5809 256 KLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTI---DEEQktyldimLSELDRIESIISEF------LV 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 296 QSDRGALAYRKTQL-----DVVRLLQV-AIasfhgrfQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGG 369
Cdd:COG5809 327 LAKPQAIKYEPKDLntlieEVIPLLQPqAL-------LKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGG 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 370 ALEI-IALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrnrasGGSGLGLAICHNIVDAHGGKISAKhSPLG-GL 447
Cdd:COG5809 400 NITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE------KGTGLGLMVSYKIIEEHGGKITVE-SEVGkGT 472
|
....*...
gi 1518082090 448 RITVVFPL 455
Cdd:COG5809 473 TFSITLPI 480
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
350-455 |
7.70e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.24 E-value: 7.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHW----QDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAI 425
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVSLEEEEEDGVQLrfsvEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 1518082090 426 CHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
166-437 |
4.04e-21 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 96.29 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 166 IVGLSTLLAAAVTWVLSRGMLapVKRLV---EGTHRLAAGDFSTRVAVSSRDELGHLAQ-------DFNQLASSLE---- 231
Cdd:COG4192 331 IALLSLLLAVLINYFYVRRRL--VKRLNalsDAMAAIAAGDLDVPIPVDGNDEIGRIARllrvfrdQAIEKTQELEteie 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 232 ---KNEQMRRDFMAD----------------VSHELRTPLAVLRGEL----EALQDGLRQPTPESLSSLQAEVAILTKLV 288
Cdd:COG4192 409 erkRIEKNLRQTQDEliqaakmavvgqtmtsLAHELNQPLNAMSMYLfsakKALEQENYAQLPTSLDKIEGLIERMDKII 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 289 NDLHQLS-QSDRGALAYRKTQLDVVRLLQVAIasfhgrfQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNE 367
Cdd:COG4192 489 KSLRQFSrKSDTPLQPVDLRQVIEQAWELVES-------RAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVAT 561
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 368 GGALEIIALIQEETLTLHWQDSKPGVSDeqLERLFERFYRTESSrnrasgGSGLGLAICHNIVDAHGGKI 437
Cdd:COG4192 562 QPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEV------GLGLGLSICRSIMQQFGGDL 623
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
157-458 |
2.00e-20 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 94.59 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 157 QQQRR---TSWFIVGLSTLLAAA-VTW-VLSRGMLAPVKRLVEGTHRLAAGDFST----RVAVSSRDELGHLAQDF---- 223
Cdd:PRK11466 323 EKASArgqYSLLLLGMVSLCALIlILWrVVYRSVTRPLAEQTQALQRLLDGDIDSpfpeTAGVRELDTIGRLMDAFrsnv 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 224 -------NQLASSL---------------------EKNEQMRRDFMADVSHELRTPLAVLRGELEALQDglRQPTPESLS 275
Cdd:PRK11466 403 halnrhrEQLAAQVkartaelqelviehrqaraeaEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD--NPALNAQRD 480
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 276 SLQA---EVAILTKLVNDLHQLSQSDRGA--LAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEH--AVIFGDPD 348
Cdd:PRK11466 481 DLRAitdSGESLLTILNDILDYSAIEAGGknVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlpTALMGDPR 560
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 349 RLNQLFHNLLENSLRYTNEGgALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRnrasGGSGLGLAICHN 428
Cdd:PRK11466 561 RIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSR 635
|
330 340 350
....*....|....*....|....*....|
gi 1518082090 429 IVDAHGGKISAKHSPLGGLRITVVFPLFHS 458
Cdd:PRK11466 636 LAQAMGGELSATSTPEVGSCFCLRLPLRVA 665
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
242-455 |
1.33e-19 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 91.00 E-value: 1.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 242 ADVSHELRTPLAVLRGeleaLQDGLRQPTPESLSSLQA------EVAILTKLVNDLHQLSQSDRgaLAYRKTQL-DVVR- 313
Cdd:PRK10364 242 AGVAHEIRNPLSSIKG----LAKYFAERAPAGGEAHQLaqvmakEADRLNRVVSELLELVKPTH--LALQAVDLnDLINh 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 314 LLQVAIASFHGRFQNKKMTITAHLPEhavIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGV 393
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTANDTLPE---IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1518082090 394 SDEQLERLFERFYRTESSrnrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:PRK10364 393 AADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
346-454 |
2.04e-19 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 83.31 E-value: 2.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 346 DPDRLNQLFHNLLENSLRYTNEGGALE-IIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLA 424
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRcILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-439 |
2.22e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 82.82 E-value: 2.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNraSGGSGLGLAICHNI 429
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90
....*....|
gi 1518082090 430 VDAHGGKISA 439
Cdd:cd16923 79 IELHGGSASA 88
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
1.45e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 80.71 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNI 429
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1518082090 430 VDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
242-455 |
1.50e-18 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 87.86 E-value: 1.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 242 ADVSHELRTPLAVLRGELEalqdgLRQPTPES--------LSSL-QAEvAILTKLvndlhqLSQSDRGALAYRKTQL--- 309
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQ-----LLQPGIEDkeeyfdimLSELdRIE-SIISEF------LALAKPQAVNKEKENInel 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 310 --DVVRLLQvAIASFHGrfqnkKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQ 387
Cdd:COG5805 360 iqDVVTLLE-TEAILHN-----IQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVI 433
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1518082090 388 DSKPGVSDEQLERLFERFYRTESSrnrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:COG5805 434 DEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
229-455 |
5.30e-18 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 86.92 E-value: 5.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 229 SLEKNEQMRRDFMADVSHELRTPLAVLRGELEALQDglRQPTPESLSSLQA--EVAI-LTKLVNDLHQLSQSDRgalayR 305
Cdd:PRK11091 275 ALEKASRDKTTFISTISHELRTPLNGIVGLSRILLD--TELTAEQRKYLKTihVSAItLGNIFNDIIDMDKMER-----R 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 306 KTQLDV----VRLLQVAIASFHG--------RFqnkKMTITAHLPEHAVIfgDPDRLNQLFHNLLENSLRYTNEGGALEI 373
Cdd:PRK11091 348 KLQLDNqpidFTDFLADLENLSGlqaeqkglRF---DLEPLLPLPHKVIT--DGTRLRQILWNLISNAVKFTQQGGVTVR 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 374 IALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSR-NRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVV 452
Cdd:PRK11091 423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLT 502
|
...
gi 1518082090 453 FPL 455
Cdd:PRK11091 503 IHA 505
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
203-458 |
1.13e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 85.80 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 203 DFSTRVAVS-SRDELGHLAQDFNQLASslekneqMrrdFMADVSHELRTPLAVLRGELEALQ-DGLRQPTPESLSSLQAE 280
Cdd:PRK10841 422 DVSARVKMEeSLQEMAQAAEQASQSKS-------M---FLATVSHELRTPLYGIIGNLDLLQtKELPKGVDRLVTAMNNS 491
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 281 VAILTKLVNDLHQLSQSDRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKMT----ITAHLPEhaVIFGDPDRLNQLFHN 356
Cdd:PRK10841 492 SSLLLKIISDILDFSKIESEQLKIEPREFSPREVINHITANYLPLVVKKRLGlycfIEPDVPV--ALNGDPMRLQQVISN 569
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 357 LLENSLRYTNEGGaleII--ALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHG 434
Cdd:PRK10841 570 LLSNAIKFTDTGC---IVlhVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMD 646
|
250 260
....*....|....*....|....
gi 1518082090 435 GKISAKHSPLGGLRITVVFPLFHS 458
Cdd:PRK10841 647 GDISVDSEPGMGSQFTIRIPLYGA 670
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
1.15e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 75.51 E-value: 1.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEET-----LTLHWQDSKPGVSDEQLERLFERFYRTESSrnrasgGSGLGLA 424
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIRTSPaddraVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
1.38e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 75.18 E-value: 1.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTneGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNraSGGSGLGLAICHNI 429
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 1518082090 430 VDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
1.77e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 74.67 E-value: 1.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEG--GALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrNRASGGSGLGLAICH 427
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 1518082090 428 NIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-455 |
4.40e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 73.61 E-value: 4.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 347 PDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNrasgGSGLGLAIC 426
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 1518082090 427 HNIVDAHGGKISAKHSPLGGLRITVVFPL 455
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-443 |
1.74e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.55 E-value: 1.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 337 LPEHAVI-FGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRA 415
Cdd:cd16947 7 IPDRPIYaNANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100
....*....|....*....|....*...
gi 1518082090 416 SGGSGLGLAICHNIVDAHGGKISAKHSP 443
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNSKP 114
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
186-230 |
5.47e-15 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 68.63 E-value: 5.47e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1518082090 186 LAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL 230
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-453 |
1.47e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 69.41 E-value: 1.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 346 DPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNraSGG-SGLGLA 424
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR--SGGhYGMGLY 78
|
90 100
....*....|....*....|....*....
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:cd16975 79 IAKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
157-438 |
1.71e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 76.04 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 157 QQQRRT--SWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL---- 230
Cdd:PRK11107 172 QQYREIfiAFLMLLLGIGLALLFAFRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGNMLGELDMLKNGINAMAMSLsayh 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 ---------------EKNEQM-----------RR---------DFMADVSHELRTPL--------AVLRGELEALQ-DGL 266
Cdd:PRK11107 252 eemqqnidqatsdlrETLEQMeiqnveldlakKRaqeaariksEFLANMSHELRTPLngvigftrQTLKTPLTPTQrDYL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 267 RqpTPE-SLSSLqaevaiLTkLVNDLHQLSQSDRGAL-------AYRKTQLDVVRLLQvaiASFHgrfqNKKMTITAHL- 337
Cdd:PRK11107 332 Q--TIErSANNL------LA-IINDILDFSKLEAGKLvlenipfSLRETLDEVVTLLA---HSAH----EKGLELTLNId 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 338 ---PEHAVifGDPDRLNQLFHNLLENSLRYTNEGGALEIIAL--IQEETLTLHWQ--DSKPGVSDEQLERLFERFYRTES 410
Cdd:PRK11107 396 pdvPDNVI--GDPLRLQQIITNLVGNAIKFTESGNIDILVELraLSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADA 473
|
330 340
....*....|....*....|....*...
gi 1518082090 411 SRNRASGGSGLGLAICHNIVDAHGGKIS 438
Cdd:PRK11107 474 SISRRHGGTGLGLVITQKLVNEMGGDIS 501
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-447 |
2.68e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 68.64 E-value: 2.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 346 DPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYrtesSRNRASGG---SGLG 422
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY----SLPRPHSGqksTGLG 76
|
90 100
....*....|....*....|....*
gi 1518082090 423 LAICHNIVDAHGGKISAKHSPLGGL 447
Cdd:cd16945 77 LAFVQEVAQLHGGRITLRNRPDGVL 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
106-455 |
3.59e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 74.28 E-value: 3.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 106 VDQDNNLLVGHSGHLPTEASRSAIKVNDQVVGW--VISTPSEKLTRNAditfdQQQRRTSWFIVGLSTLLAAAVTWVLSR 183
Cdd:COG2972 105 LILLLALLLLLSILLLILGLLLIILLLLSLLGWtlVSLIPKSELFRGL-----FSLRRLILLIILLLLLLALLLSYLLSR 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 184 GMLAPVKRLVEGTHRLAAGDFsTRVAVSSRDELGHLAQDFNQLASSLEKNEQMRRdfmadvshELRtpLAVLRGELEALQ 263
Cdd:COG2972 180 SITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVY--------ELE--LEKKEAELKALQ 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 264 dgLR-QP-----TPESLSSL--QAEVAILTKLVNDL-----HQLSQSDRGALayRKTQLDVVRLLqVAIASFhgRFQNkK 330
Cdd:COG2972 249 --AQiNPhflfnTLNSIRWLaeLEDPEEAEEMLEALskllrYSLSKGDELVT--LEEELELIKSY-LEIQKL--RFGD-R 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 331 MTITAHLPEHAVIFGDPDRLNQlfhNLLENSLRY----TNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFy 406
Cdd:COG2972 321 LEVEIEIDEELLDLLIPKLILQ---PLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL- 396
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1518082090 407 rtessrNRASGGSGLGLAICHNIVDAHGGK---ISAKHSPLGGLRITVVFPL 455
Cdd:COG2972 397 ------SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
151-453 |
8.27e-14 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 73.61 E-value: 8.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 151 ADITFDQQQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL 230
Cdd:COG2770 202 VLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 231 EKNEQMR--------RDFMADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGAL 302
Cdd:COG2770 282 RESIEEAeeeeelaeAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLL 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 303 AYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQEETL 382
Cdd:COG2770 362 LLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELA 441
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1518082090 383 TLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVF 453
Cdd:COG2770 442 AAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLL 512
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
213-455 |
9.45e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 72.57 E-value: 9.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 213 RDELGHLAQdfnQLASSLEKNEQMRRdfmadVSHELRTPLAVLRGELEalqdglrqptpesLSSLQAEVAILTKLVNDLH 292
Cdd:COG3290 173 RTELERLEE---ELEGVKELAEALRA-----QRHDFRNHLHTISGLLQ-------------LGEYDEALEYIDEISEELQ 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 293 QLSQSDRgalayRKTQLDVVR-LLQVAIASFHGRfqNKKMTITAHLPEHAVIFGDPDrLNQLFHNLLENSLRYTNEGGAL 371
Cdd:COG3290 232 ELIDSLL-----SRIGNPVLAaLLLGKAARARER--GIDLTIDIDSDLPDLPLSDTD-LVTILGNLLDNAIEAVEKLPEE 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 372 E----IIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTessrnRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGL 447
Cdd:COG3290 304 ErrveLSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFST-----KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGT 378
|
....*...
gi 1518082090 448 RITVVFPL 455
Cdd:COG3290 379 VFTVRLPK 386
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
236-300 |
1.31e-13 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 65.31 E-value: 1.31e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1518082090 236 MRRDFMADVSHELRTPLAVLRGELEALQDG-LRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRG 300
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEkLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
66-460 |
2.22e-13 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 71.84 E-value: 2.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 66 DFLRNNDQVIYQIMRSFEQNQNSESRPSMPPRGWRAQFWVVDQDNNLLVGHSGHLPTEASRSAIKVNDQVVGWVISTPSE 145
Cdd:COG3850 23 LLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 146 KLTRNADITFDQQQRRTSWFIVGLSTLLAAAVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQ 225
Cdd:COG3850 103 LLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 226 LASSLEK--------NEQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQS 297
Cdd:COG3850 183 MADELQElyaeleeeEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 298 DRGALAYRKTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEHAVIfgDPDRLNQLFHNLLENSLRYTNEGGALEIIALI 377
Cdd:COG3850 263 LELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLL--VELAALLLLLLLQAIANASLLLIALASVVAAL 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 378 QEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFPLFH 457
Cdd:COG3850 341 LELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLI 420
|
...
gi 1518082090 458 SIG 460
Cdd:COG3850 421 VSI 423
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-454 |
4.42e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 65.29 E-value: 4.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYT-NEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYrTESSRNRASG-GSGLGLAICH 427
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 1518082090 428 NIVDAHGGKISAK-HSPLG---GLRITVVFP 454
Cdd:cd16953 80 QIIEAHGGISVAEnHNQPGqviGARFTVQLP 110
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-296 |
8.41e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 63.00 E-value: 8.41e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1518082090 234 EQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTP--ESLSSLQAEVAILTKLVNDLHQLSQ 296
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqrEYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
215-459 |
9.07e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 70.48 E-value: 9.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 215 ELGHLAQDFNQLASSLEKNEQMRR--DFMADVSHELRTPLAVLRGELEALQDGLRQPTP--ESLSSLQAEVAILTKLVND 290
Cdd:PRK13837 426 ERRRLETERDALERRLEHARRLEAvgTLASGIAHNFNNILGAILGYAEMALNKLARHSRaaRYIDEIISAGARARLIIDQ 505
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 291 LhqLSQSDRGAlaYRKTQLDVVRLLQVAIASfhgrfqnkkmtITAHLPEH-----------AVIFGDPDRLNQLFHNLLE 359
Cdd:PRK13837 506 I--LAFGRKGE--RNTKPFDLSELVTEIAPL-----------LRVSLPPGveldfdqdqepAVVEGNPAELQQVLMNLCS 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 360 NSLRYTNEGGALEI----IALIQEETLT-----------LHWQDSKPGVSDEQLERLFERFYRTESsrnrasGGSGLGLA 424
Cdd:PRK13837 571 NAAQAMDGAGRVDIslsrAKLRAPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRA------GGTGLGLA 644
|
250 260 270
....*....|....*....|....*....|....*
gi 1518082090 425 ICHNIVDAHGGKISAKHSPLGGLRITVVFPLFHSI 459
Cdd:PRK13837 645 TVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
236-300 |
1.08e-12 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 62.97 E-value: 1.08e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1518082090 236 MRRDFMADVSHELRTPLAVLRGELEALQDGLRQPTP-ESLSSLQAEVAILTKLVNDLHQLSQSDRG 300
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQrEYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HAMP |
pfam00672 |
HAMP domain; |
180-232 |
1.21e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 62.26 E-value: 1.21e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 180 VLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEK 232
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
183-231 |
1.65e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 59.18 E-value: 1.65e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1518082090 183 RGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLE 231
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLE 49
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
18-230 |
2.91e-11 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 65.43 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 18 MLVLITMHWGVRTSFERGFIDYIKQSNEQRIAMLSHALEGEYQHYGNWDFLRNNDQVIYQIMRSFEQNQNSESRPSMPPR 97
Cdd:COG0840 39 ALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLEL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 98 GWRAQFWVVDQDNNLLVGHSGHLPTEASRSAIKVNDQVVGWVISTPSEKLTRNADITFDQQQRRTSWFIVGLSTLLAAAV 177
Cdd:COG0840 119 LLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIIL 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 178 TWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL 230
Cdd:COG0840 199 ALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-451 |
3.98e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.39 E-value: 3.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTN--EGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrnrASGGSGLGLAICH 427
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKP----VGKGTGLGLSISY 76
|
90 100
....*....|....*....|....
gi 1518082090 428 NIVDAHGGKISAKHSPLGGLRITV 451
Cdd:cd16976 77 GIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-443 |
1.94e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 57.80 E-value: 1.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 350 LNQLFHNLLENSLRYTNEGGALEIIALIQEETLTLHW-----------QDSKPGVSDEQLERLFERFYrteSSRnraSGG 418
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVTLGHprhrlalrvsvIDNGPGIPPDLQDTIFYPMV---SGR---ENG 74
|
90 100
....*....|....*....|....*
gi 1518082090 419 SGLGLAICHNIVDAHGGKISAKHSP 443
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP 99
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-454 |
9.63e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 56.01 E-value: 9.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 346 DPDRLNQLFHNLLENS-------------LRYTNEGGALEIIALIQEetltlhwqDSKPGVSDEQLERLFERFYRTESSr 412
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegrpsdvgeVRIRVEADQDGRIVLIVC--------DNGKGFPREMRHRATEPYVTTRPK- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1518082090 413 nrasgGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16944 72 -----GTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-454 |
1.41e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 55.37 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 357 LLENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYrTESSRNRASGGSGLGLAICHNIVDAHGGK 436
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLVKKLCDKLGHK 91
|
90
....*....|....*...
gi 1518082090 437 ISAKHSPLGGLRITVVFP 454
Cdd:cd16948 92 IDVESEVGEGTTFTITFP 109
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
219-455 |
5.00e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 57.78 E-value: 5.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 219 LAQDFNQLAsslekNEQMRRDFMADVSHELRTPLAVLRGELEALQDGLRQPtpeslsSLQAEVAILtklvndlhqLSQSD 298
Cdd:PRK11073 117 LSQEQLQHA-----QQVAARDLVRGLAHEIKNPLGGLRGAAQLLSKALPDP------ALTEYTKVI---------IEQAD 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 299 R-GALayrktqldVVRLL------QVAIASFHGRFQNKKMTITAHLPEHAVIFGD-----------PDRLNQLFHNLLEN 360
Cdd:PRK11073 177 RlRNL--------VDRLLgpqrpgTHVTESIHKVAERVVQLVSLELPDNVRLIRDydpslpelahdPDQIEQVLLNIVRN 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 361 SLRYTNEGGALEIIALIQEETLTLHWQ-----------DSKPGVSDEQLERLFerfYRTESSRnraSGGSGLGLAICHNI 429
Cdd:PRK11073 249 ALQALGPEGGTITLRTRTAFQLTLHGEryrlaaridieDNGPGIPPHLQDTLF---YPMVSGR---EGGTGLGLSIARNL 322
|
250 260
....*....|....*....|....*.
gi 1518082090 430 VDAHGGKISAKHSPlGGLRITVVFPL 455
Cdd:PRK11073 323 IDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-454 |
5.25e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 50.75 E-value: 5.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 356 NLLENSL----RYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESSRNRasggsGLGLAICHNIVD 431
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 1518082090 432 AHGGKISAKHSPLGGLRITVVFP 454
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
246-423 |
2.43e-05 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 46.36 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 246 HELRTPLA---VLRGELE-ALQDglRQPTPESLSSLQAEVA----ILTKLVndlhqlSQSDRGALAYRktQLDVVRLLQV 317
Cdd:NF033792 211 HELGTPLAtiaLVAKELErELPD--DPPLREDAELLRSQAErcrdILRRLT------SLGEEGDAHLD--RLPLSALIEE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 318 AIASFHGRfqNKKMTITAHLPEHA--VIFGDPDRLNQLfHNLLENSLRYTNEggALEIIALIQEETLTLHWQDSKPGVSD 395
Cdd:NF033792 281 AAAPHRGF--GKEIEVVVAGDPGEepVIRRNPEILYGL-GNLIENAVDFARS--TVTVTASWDAESVTITIEDDGPGFPP 355
|
170 180
....*....|....*....|....*...
gi 1518082090 396 EQLERLFERFYRTESSRNRASGGSGLGL 423
Cdd:NF033792 356 DVLSRIGEPYVTTRRGEERRPGGGGLGL 383
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
165-230 |
6.94e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 45.05 E-value: 6.94e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1518082090 165 FIVGLSTLLAAAVTWvLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSL 230
Cdd:PRK10600 130 FAVFMALLLVFTIIW-LRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
293-455 |
8.15e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.90 E-value: 8.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 293 QLSQSDRGalayrkTQLDVVRLLQVAIASFHGRFQNKKMTITAHLPEhavIFGDPDRLNQL---FHNLLENSLRY---TN 366
Cdd:COG3920 349 LLYQSEDW------EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---VELPADAAVPLgliLNELVTNALKHaflSG 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 367 EGGALEIIALIQEETLTLHWQDSKPGVSDEqlerlferfyrtessrNRASGGSGLGLAICHNIVDAHGGKISAKHSPlgG 446
Cdd:COG3920 420 EGGRIRVSWRREDGRLRLTVSDNGVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--G 481
|
....*....
gi 1518082090 447 LRITVVFPL 455
Cdd:COG3920 482 TRVRITFPL 490
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
225-455 |
1.70e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 44.15 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 225 QLASSL-EKNEQMRRDFMADVSHELRTPLAVLRGELEALQDGL--RQPTP---------ESLSSLQAEVAILTKLVNDLH 292
Cdd:PRK10618 437 QQAQREyEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSdeEQQQPeldqlaeqsDVLVRLVDNIQLLNMLETQDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 293 QLSQSDrgalaYRKTQL--DVVRLLQVAIasfhgrfQNK--KMTITAHLPEHAVIFGDPDRLNQLFHNLLENSLRYTNEG 368
Cdd:PRK10618 517 KPEQEL-----FSLQDLidEVLPEVLPAI-------KRKglQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAYG 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 369 GaleiIALI------QEETLTLHWQDSKPGVSDEQLERLfeRF-YRTESSRNRASGGSGLGLAICHNIVDAHGGK--ISA 439
Cdd:PRK10618 585 K----ITLEvdqdesSPDRLTIRILDTGAGVSIKELDNL--HFpFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHltIKS 658
|
250
....*....|....*.
gi 1518082090 440 KHSPlgGLRITVVFPL 455
Cdd:PRK10618 659 REGL--GTRYSIHLKM 672
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
337-452 |
2.70e-04 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 40.90 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 337 LPEhaVIFGDPDRLNQLFHNLLENSLRYTNEGGALEIIALIQ---EETLTLHWQDSKPGVSDEQLERLFE---------- 403
Cdd:cd16938 1 LPD--VVVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEggsEDRSDRDWGPWRPSMSDESVEIRFEveindsgsps 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1518082090 404 ---RFYRTESSR--NRASGGSGLGLAICHNIVDAHGGKISAKHSPLGGLRITVV 452
Cdd:cd16938 79 iesASMRNSLNRryNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLL 132
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|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
166-232 |
4.59e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 42.53 E-value: 4.59e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 166 IVGLSTLLAAA--VTWVLSRGMLAPVKRLVEGTHRLAAGDFST-RVAVSSRDELGHLAQDFNQLASSLEK 232
Cdd:PRK10935 155 LLGLILILTLVffTVRFTRRQVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK 224
|
|
| PRK15041 |
PRK15041 |
methyl-accepting chemotaxis protein; |
164-301 |
4.20e-03 |
|
methyl-accepting chemotaxis protein;
Pssm-ID: 185001 [Multi-domain] Cd Length: 554 Bit Score: 39.55 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 164 WFIVG-LSTLLAA--AVTWVLSRGMLAPVKRLVEGTHRLAAGDFSTRVAVSSRDELGHLAQDFNQLASSLEKNeqmrrdf 240
Cdd:PRK15041 194 WILVGvMIVVLAVifAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRT------- 266
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1518082090 241 MADVSHELRtplAVLRG--ELEALQDGLRQPTPESLSSLQAEVAILTKLVNDLHQLSQSDRGA 301
Cdd:PRK15041 267 VGDVRNGAN---AIYSGasEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNAENARQA 326
|
|
| PIN_Nob1-like |
cd09876 |
VapC-like PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein ... |
243-312 |
6.06e-03 |
|
VapC-like PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs; PIN (PilT N terminus) domain of the Saccharomyces cerevisiae ribosome assembly factor, Nob1 (Nin one binding) protein, the Thermoplasma acidophilum DSM 1728, UPF0129 protein Ta0041, and similar eukaryotic and archaeal homologs are included in this family. The Nob1 PIN domain binds the single-stranded cleavage site D at the 3-prime end of 18S rRNA. Recombinant Nob1 binds as a tetramer to pre-18S rRNA fragments containing cleavage site D and believed to cleave at this site. This subgroup belongs to the VapC (virulence-associated protein C)-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Matelska et al. recently classified PIN-like domains into distinct groups; this subgroup includes some sequences belonging to one of these, PIN_6.
Pssm-ID: 350224 Cd Length: 112 Bit Score: 36.34 E-value: 6.06e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1518082090 243 DVSHELRTPLAVLRgeLEALQDGL--RQPTPESLsslqAEVAILTKLVNDLHQLSQSDRG--ALAYrktQLDVV 312
Cdd:cd09876 26 EVLEEIRDKKSRLR--LELLPGKLkvREPSEESI----KAVKEFAKKTGDYGSLSATDIKvlALAL---ELEAE 90
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
358-454 |
6.90e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 36.59 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1518082090 358 LENSLRYTNEGGALEIIALIQEETLTLHWQDSKPGVSDEQLERLFERFYRTESsrnrASGGSGLGLAICHNIVDAHGGKI 437
Cdd:cd16919 24 IETSNQRVDADYALNYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE----VGKGTGLGLSMVYGFVKQSGGHL 99
|
90
....*....|....*...
gi 1518082090 438 SAkHSPLG-GLRITVVFP 454
Cdd:cd16919 100 RI-YSEPGvGTTVRIYLP 116
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