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Conserved domains on  [gi|154240684|ref|NP_619613|]
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stabilin-1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_Domain super family cl02612
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2208-2300 3.45e-46

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


The actual alignment was detected with superfamily member cd03515:

Pssm-ID: 470631  Cd Length: 93  Bit Score: 161.48  E-value: 3.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2208 GVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 154240684 2288 RKNLSELWDAYCY 2300
Cdd:cd03515    81 RLNLSERWDAYCY 93
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 499-644 6.26e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


:

Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 109.23  E-value: 6.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  499 PPPLPGDSKKTVGQILASTEVFTRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 577
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 154240684  578 HIYNhGQLTVEKLISKGRVLTMANQVLTVNISeEGRILLGpeGIPVRRVDVPAANGVIHMLEGILLP 644
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1737-1867 1.03e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.18  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1737 GYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALQALPPDRKNWLFheDHRDKLAAILRGHMIRNiEALASDLPNLGQ 1816
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 154240684  1817 LRTMHGNTISFSCgltRPGELIVgeDEAHIVQRHLTFEGGLAYGIDQLLEP 1867
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1607-1711 5.21e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 99.25  E-value: 5.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1607 KELKG-DGPFTVFVPHADLISNMSQDELARIRAHRQL---VFRYHVVGCRKLwSQEMLDQGYITTLSGHTLRVSEREGSI 1682
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGRLT-SSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 154240684  1683 YLNDfARVVSSDLEVVNGVLHFIDHVLLP 1711
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1000-1121 2.35e-18

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 83.07  E-value: 2.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1000 AHFSAFSQWFKNSSI--TLP-ADSRVTALVPSESAIRRLSLEDQAFWLQ-PKMLPELARAHFLQGAFSEEELArlNGQQV 1075
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLK--NGGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 154240684  1076 ATLsATTRWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLP 1121
Cdd:pfam02469   79 ATL-QGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1460-1496 1.15e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684  1460 CASGHGGCSPYANCTKVaPGQRTCTCQDGYTGDGELC 1496
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2095-2130 6.17e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 154240684  2095 CQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSC 2130
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2367-2463 2.58e-06

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 48.13  E-value: 2.58e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   2367 TLFVPVNKGF------VDNMT--LSGPDLELHASNATFLSINASRGTLLPAHSGLSLFISDTGPDNTslvplapgaVVVS 2438
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*..
gi 154240684   2439 H--VIVWDIMAFNGIIHALASPLLmPP 2463
Cdd:smart00554   72 GarIVEADIAATNGVVHVIDRVLL-PP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1502-1539 5.02e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1502 CLVHNGGCHVHAECIPTGPqQVSCSCREGYSGDGIqTC 1539
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV-TC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 952-988 1.09e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 1.09e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684   952 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 988
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2136-2173 7.39e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 7.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  2136 CLDGHrGGCSEHADCLNTgPNTRRCECHVGYVGDGLQC 2173
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1545-1582 1.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 1.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1545 CSQNNGGCSPYAVCKSTgDGQRTCSCDATHTvGDGITC 1582
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 915-946 4.17e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 154240684   915 GGCHADALCSYVgPGQSRCTCKLGFAGNGYEC 946
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-860 1.99e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 154240684   831 PCHSDAHCVIQEGVARCVCHDGFEGNGFSC 860
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1992-2021 6.11e-03

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.11e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 154240684   1992 SGQCNCHPGFAGTACELCAPGAFGPQCQAC 2021
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2208-2300 3.45e-46

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 161.48  E-value: 3.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2208 GVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 154240684 2288 RKNLSELWDAYCY 2300
Cdd:cd03515    81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2206-2301 1.26e-34

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 128.61  E-value: 1.26e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   2206 QAGVFHIQATsGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSL 2285
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 154240684   2286 GVRKNLSeLWDAYCYR 2301
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2208-2300 3.72e-34

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 126.92  E-value: 3.72e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  2208 GVFHIQAtSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 154240684  2288 RKNLSELWDAYCY 2300
Cdd:pfam00193   80 RDPLSERYDAYCY 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 499-644 6.26e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 109.23  E-value: 6.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  499 PPPLPGDSKKTVGQILASTEVFTRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 577
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 154240684  578 HIYNhGQLTVEKLISKGRVLTMANQVLTVNISeEGRILLGpeGIPVRRVDVPAANGVIHMLEGILLP 644
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1737-1867 1.03e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.18  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1737 GYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALQALPPDRKNWLFheDHRDKLAAILRGHMIRNiEALASDLPNLGQ 1816
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 154240684  1817 LRTMHGNTISFSCgltRPGELIVgeDEAHIVQRHLTFEGGLAYGIDQLLEP 1867
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1607-1711 5.21e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 99.25  E-value: 5.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1607 KELKG-DGPFTVFVPHADLISNMSQDELARIRAHRQL---VFRYHVVGCRKLwSQEMLDQGYITTLSGHTLRVSEREGSI 1682
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGRLT-SSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 154240684  1683 YLNDfARVVSSDLEVVNGVLHFIDHVLLP 1711
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 520-644 6.91e-21

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 90.39  E-value: 6.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   520 FTRFETILENCGLPSILDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRVLT 598
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 154240684   599 MANQVLTVNIsEEGRILLgpEGIPVRRVDVPAANGVIHMLEGILLP 644
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1609-1711 1.48e-20

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 90.74  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 1609 LKGDGPFTVFVPH------------ADLISNMSQDELARIrahrqlvFRYHVVGcRKLWSQEMLDQGYITTLSGHTLRVS 1676
Cdd:COG2335    59 LSGEGPFTVFAPTdaafaalpagtlDALLKPENKATLTKI-------LTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVT 130

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 154240684 1677 EREGSIYLNDfARVVSSDLEVVNGVLHFIDHVLLP 1711
Cdd:COG2335   131 VSGGGVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
543-645 2.32e-19

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 85.11  E-value: 2.32e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684    543 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRVLTMANQVLTVNISEeGRILLGPEGIP 622
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 154240684    623 VRRVDVPAANGVIHMLEGILLPP 645
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1000-1121 2.35e-18

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 83.07  E-value: 2.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1000 AHFSAFSQWFKNSSI--TLP-ADSRVTALVPSESAIRRLSLEDQAFWLQ-PKMLPELARAHFLQGAFSEEELArlNGQQV 1075
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLK--NGGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 154240684  1076 ATLsATTRWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLP 1121
Cdd:pfam02469   79 ATL-QGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1616-1712 2.45e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 79.33  E-value: 2.45e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1616 TVFVPHADLISNMSQDELARIRAHRQLVFRYHVVGcRKLWSQEMLDQGYITTLSGHTLRVSERE--GSIYLNDfARVVSS 1693
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 154240684   1694 DLEVVNGVLHFIDHVLLPP 1712
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1763-1868 6.29e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 78.17  E-value: 6.29e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1763 TMLWPTDSALQALPPDRKNWLfhedhRDKLAAILRGHMIRNiEALASDLPNLGQLRTMHGNTISFSCgltRPGELIVGED 1842
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR---SGGSGTVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 154240684   1843 EAHIVQRHLTFEGGLAYGIDQLLEPP 1868
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1023-1122 1.19e-13

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 68.93  E-value: 1.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1023 TALVPSESAIRRLSLEDQAFWLQpkMLPELARAHFLQGAFSEEELarLNGQQVATLS-ATTRWQIHNISGKVWVQNATVD 1101
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLAD--KLKNLLLYHVVPGRLSSADL--LNGGTLPTLAgSKLRITRSGGSGTVTVNGARIV 76

                            90       100
                    ....*....|....*....|.
gi 154240684   1102 VPDLLATNGILHIVSQVLLPP 1122
Cdd:smart00554   77 EADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1725-1867 2.26e-13

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 70.32  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 1725 PQRN-VTAAAESFGYKIFSRLLTVAGLLPMLQDAshRPFTMLWPTDSALQALPPDRKNWLFHEDHRDKLAAILRGHMIRN 1803
Cdd:COG2335    29 PTKNiVETAANNPDFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVVPG 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154240684 1804 iEALASDLPNLGQLRTMHGNTISFScglTRPGELIVGedEAHIVQRHLTFEGGLAYGIDQLLEP 1867
Cdd:COG2335   107 -KVTAADLKDGKTLTTLQGQTLTVT---VSGGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 991-1121 1.59e-11

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.93  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  991 DIIQELEANAHFSAFSQWFKNSSI--TLPADSRVTALVPSESAIRRLSLEDQAFWLQPKMLPELAR---AHFLQGAFSEE 1065
Cdd:COG2335    32 NIVETAANNPDFSTLVAALKAAGLvdTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKiltYHVVPGKVTAA 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154240684 1066 ELArlNGQQVATLSATTrWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLP 1121
Cdd:COG2335   112 DLK--DGKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1460-1496 1.15e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684  1460 CASGHGGCSPYANCTKVaPGQRTCTCQDGYTGDGELC 1496
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2095-2130 6.17e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 154240684  2095 CQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSC 2130
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2367-2463 2.58e-06

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 48.13  E-value: 2.58e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   2367 TLFVPVNKGF------VDNMT--LSGPDLELHASNATFLSINASRGTLLPAHSGLSLFISDTGPDNTslvplapgaVVVS 2438
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*..
gi 154240684   2439 H--VIVWDIMAFNGIIHALASPLLmPP 2463
Cdd:smart00554   72 GarIVEADIAATNGVVHVIDRVLL-PP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1502-1539 5.02e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1502 CLVHNGGCHVHAECIPTGPqQVSCSCREGYSGDGIqTC 1539
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV-TC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 952-988 1.09e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 1.09e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684   952 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 988
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2136-2173 7.39e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 7.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  2136 CLDGHrGGCSEHADCLNTgPNTRRCECHVGYVGDGLQC 2173
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1545-1582 1.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 1.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1545 CSQNNGGCSPYAVCKSTgDGQRTCSCDATHTvGDGITC 1582
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 2333-2461 2.07e-04

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 43.40  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  2333 ANFSTFYGMLlgyaNATQrgleFMDFLEDELTYKTLFVPVNKGF------VDNMTLSGPD-----LELHASNATFLSINA 2401
Cdd:pfam02469    1 PGFSTFVALL----KAAG----LVDTLNGSQGPFTVFAPTNEAFaklpagTLNFLLKDKEqlknlLKYHVVPGRLTSSDL 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154240684  2402 SRGTLLPAHSGLSLFISDTGpdntslvplapGAVVV--SHVIVWDIMAFNGIIHALASPLLM 2461
Cdd:pfam02469   73 KNGGTLATLQGSKLRVNVTG-----------GSVTVngARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 915-946 4.17e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 154240684   915 GGCHADALCSYVgPGQSRCTCKLGFAGNGYEC 946
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-860 1.99e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 154240684   831 PCHSDAHCVIQEGVARCVCHDGFEGNGFSC 860
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1992-2021 6.11e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.11e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 154240684   1992 SGQCNCHPGFAGTACELCAPGAFGPQCQAC 2021
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 2325-2462 7.76e-03

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 39.50  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2325 LLDVLAATANFSTFYGMLlgyaNATqrGLEfmDFLEDELTYkTLFVPVNKGF-------VDNMTLSGPDLEL------HA 2391
Cdd:COG2335    33 IVETAANNPDFSTLVAAL----KAA--GLV--DTLSGEGPF-TVFAPTDAAFaalpagtLDALLKPENKATLtkiltyHV 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154240684 2392 SNATFLSINASRGTLLPAHSGLSLFISDTGpdntslvplapGAVVV--SHVIVWDIMAFNGIIHALASpLLMP 2462
Cdd:COG2335   104 VPGKVTAADLKDGKTLTTLQGQTLTVTVSG-----------GGVTVngANVITADIEASNGVIHVIDK-VLLP 164
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1990-2024 8.55e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 154240684 1990 RGSGQCNCHPGFAGTACELCAPGAFGPQCQACRCT 2024
Cdd:cd00055    16 PGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2208-2300 3.45e-46

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 161.48  E-value: 3.45e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2208 GVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 154240684 2288 RKNLSELWDAYCY 2300
Cdd:cd03515    81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2206-2301 1.26e-34

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 128.61  E-value: 1.26e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   2206 QAGVFHIQATsGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSL 2285
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 154240684   2286 GVRKNLSeLWDAYCYR 2301
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2208-2300 3.72e-34

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 126.92  E-value: 3.72e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  2208 GVFHIQAtSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 154240684  2288 RKNLSELWDAYCY 2300
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2208-2300 3.29e-29

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 112.90  E-value: 3.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2208 GVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGV 2287
Cdd:cd01102     1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                          90
                  ....*....|...
gi 154240684 2288 RKNlSELWDAYCY 2300
Cdd:cd01102    81 PAP-SGRYDAYCF 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 499-644 6.26e-27

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 109.23  E-value: 6.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  499 PPPLPGDSKKTVGQILASTEVFTRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELVRY 577
Cdd:COG2335    22 AEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKILTY 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 154240684  578 HIYNhGQLTVEKLISKGRVLTMANQVLTVNISeEGRILLGpeGIPVRRVDVPAANGVIHMLEGILLP 644
Cdd:COG2335   102 HVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1737-1867 1.03e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 101.18  E-value: 1.03e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1737 GYKIFSRLLTVAGLLPMLQDaSHRPFTMLWPTDSALQALPPDRKNWLFheDHRDKLAAILRGHMIRNiEALASDLPNLGQ 1816
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 154240684  1817 LRTMHGNTISFSCgltRPGELIVgeDEAHIVQRHLTFEGGLAYGIDQLLEP 1867
Cdd:pfam02469   78 LATLQGSKLRVNV---TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1607-1711 5.21e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 99.25  E-value: 5.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1607 KELKG-DGPFTVFVPHADLISNMSQDELARIRAHRQL---VFRYHVVGCRKLwSQEMLDQGYITTLSGHTLRVSEREGSI 1682
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGRLT-SSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 154240684  1683 YLNDfARVVSSDLEVVNGVLHFIDHVLLP 1711
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 520-644 6.91e-21

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 90.39  E-value: 6.91e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   520 FTRFETILENCGLPSILDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRVLT 598
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 154240684   599 MANQVLTVNIsEEGRILLgpEGIPVRRVDVPAANGVIHMLEGILLP 644
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 2209-2300 7.73e-21

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 89.29  E-value: 7.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2209 VFHIqatSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGVR 2288
Cdd:cd03520     2 VFYA---TAPEKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGVRTLYRF 78

                          90
                  ....*....|....*...
gi 154240684 2289 KNL------SELWDAYCY 2300
Cdd:cd03520    79 PNQtgfpdpHSRFDAYCF 96
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1609-1711 1.48e-20

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 90.74  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 1609 LKGDGPFTVFVPH------------ADLISNMSQDELARIrahrqlvFRYHVVGcRKLWSQEMLDQGYITTLSGHTLRVS 1676
Cdd:COG2335    59 LSGEGPFTVFAPTdaafaalpagtlDALLKPENKATLTKI-------LTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVT 130

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 154240684 1677 EREGSIYLNDfARVVSSDLEVVNGVLHFIDHVLLP 1711
Cdd:COG2335   131 VSGGGVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
543-645 2.32e-19

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 85.11  E-value: 2.32e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684    543 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRVLTMANQVLTVNISEeGRILLGPEGIP 622
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 154240684    623 VRRVDVPAANGVIHMLEGILLPP 645
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1000-1121 2.35e-18

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 83.07  E-value: 2.35e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  1000 AHFSAFSQWFKNSSI--TLP-ADSRVTALVPSESAIRRLSLEDQAFWLQ-PKMLPELARAHFLQGAFSEEELArlNGQQV 1075
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLK--NGGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 154240684  1076 ATLsATTRWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLP 1121
Cdd:pfam02469   79 ATL-QGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 2209-2300 7.28e-18

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 80.93  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2209 VFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRV--GVVSLG 2286
Cdd:cd03518     2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTvpGLRSYG 81

                          90
                  ....*....|....
gi 154240684 2287 VRKNLSELWDAYCY 2300
Cdd:cd03518    82 ERDKMLSRYDAFCF 95
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 2209-2300 1.39e-17

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 79.76  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2209 VFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNR---VGVVSL 2285
Cdd:cd03517     2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCYGDMdgfPGVRNY 81

                          90
                  ....*....|....*
gi 154240684 2286 GVRkNLSELWDAYCY 2300
Cdd:cd03517    82 GVR-DPDELYDVYCY 95
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1616-1712 2.45e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 79.33  E-value: 2.45e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1616 TVFVPHADLISNMSQDELARIRAHRQLVFRYHVVGcRKLWSQEMLDQGYITTLSGHTLRVSERE--GSIYLNDfARVVSS 1693
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 154240684   1694 DLEVVNGVLHFIDHVLLPP 1712
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 2207-2304 2.65e-17

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 80.97  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2207 AGVFHIQaTSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLG 2286
Cdd:cd03516     6 MGVFLVE-KNGRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYILN 84

                          90
                  ....*....|....*...
gi 154240684 2287 VrkNLSELWDAYCYRVQD 2304
Cdd:cd03516    85 S--NLSSRYDAYCYNSSD 100
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1763-1868 6.29e-17

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 78.17  E-value: 6.29e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1763 TMLWPTDSALQALPPDRKNWLfhedhRDKLAAILRGHMIRNiEALASDLPNLGQLRTMHGNTISFSCgltRPGELIVGED 1842
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR---SGGSGTVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 154240684   1843 EAHIVQRHLTFEGGLAYGIDQLLEPP 1868
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 2218-2300 2.07e-15

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 73.61  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2218 PYGLTFSEAKEACEGQGAVLASLPQLSAAQQL-GFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGVRKNLSELWD 2296
Cdd:cd03519     8 PGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFGFPDKKHKLYG 87


                  ....
gi 154240684 2297 AYCY 2300
Cdd:cd03519    88 VYCY 91
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1023-1122 1.19e-13

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 68.93  E-value: 1.19e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   1023 TALVPSESAIRRLSLEDQAFWLQpkMLPELARAHFLQGAFSEEELarLNGQQVATLS-ATTRWQIHNISGKVWVQNATVD 1101
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLAD--KLKNLLLYHVVPGRLSSADL--LNGGTLPTLAgSKLRITRSGGSGTVTVNGARIV 76

                            90       100
                    ....*....|....*....|.
gi 154240684   1102 VPDLLATNGILHIVSQVLLPP 1122
Cdd:smart00554   77 EADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1725-1867 2.26e-13

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 70.32  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 1725 PQRN-VTAAAESFGYKIFSRLLTVAGLLPMLQDAshRPFTMLWPTDSALQALPPDRKNWLFHEDHRDKLAAILRGHMIRN 1803
Cdd:COG2335    29 PTKNiVETAANNPDFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVVPG 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154240684 1804 iEALASDLPNLGQLRTMHGNTISFScglTRPGELIVGedEAHIVQRHLTFEGGLAYGIDQLLEP 1867
Cdd:COG2335   107 -KVTAADLKDGKTLTTLQGQTLTVT---VSGGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 991-1121 1.59e-11

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.93  E-value: 1.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  991 DIIQELEANAHFSAFSQWFKNSSI--TLPADSRVTALVPSESAIRRLSLEDQAFWLQPKMLPELAR---AHFLQGAFSEE 1065
Cdd:COG2335    32 NIVETAANNPDFSTLVAALKAAGLvdTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKiltYHVVPGKVTAA 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 154240684 1066 ELArlNGQQVATLSATTrWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLP 1121
Cdd:COG2335   112 DLK--DGKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1460-1496 1.15e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684  1460 CASGHGGCSPYANCTKVaPGQRTCTCQDGYTGDGELC 1496
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2095-2130 6.17e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.17e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 154240684  2095 CQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSC 2130
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
2367-2463 2.58e-06

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 48.13  E-value: 2.58e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684   2367 TLFVPVNKGF------VDNMT--LSGPDLELHASNATFLSINASRGTLLPAHSGLSLFISDTGPDNTslvplapgaVVVS 2438
Cdd:smart00554    1 TVFAPTDEAFqklppdLNSLLadKLKNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGT---------VTVN 71

                            90       100
                    ....*....|....*....|....*..
gi 154240684   2439 H--VIVWDIMAFNGIIHALASPLLmPP 2463
Cdd:smart00554   72 GarIVEADIAATNGVVHVIDRVLL-PP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1502-1539 5.02e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 5.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1502 CLVHNGGCHVHAECIPTGPqQVSCSCREGYSGDGIqTC 1539
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGV-TC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 952-988 1.09e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.13  E-value: 1.09e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 154240684   952 CRVGNGGCHGLATCKAVGGgQRVCTCPPHFGGDGFSC 988
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2136-2173 7.39e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 7.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  2136 CLDGHrGGCSEHADCLNTgPNTRRCECHVGYVGDGLQC 2173
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1545-1582 1.09e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 1.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 154240684  1545 CSQNNGGCSPYAVCKSTgDGQRTCSCDATHTvGDGITC 1582
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 2333-2461 2.07e-04

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 43.40  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684  2333 ANFSTFYGMLlgyaNATQrgleFMDFLEDELTYKTLFVPVNKGF------VDNMTLSGPD-----LELHASNATFLSINA 2401
Cdd:pfam02469    1 PGFSTFVALL----KAAG----LVDTLNGSQGPFTVFAPTNEAFaklpagTLNFLLKDKEqlknlLKYHVVPGRLTSSDL 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 154240684  2402 SRGTLLPAHSGLSLFISDTGpdntslvplapGAVVV--SHVIVWDIMAFNGIIHALASPLLM 2461
Cdd:pfam02469   73 KNGGTLATLQGSKLRVNVTG-----------GSVTVngARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 915-946 4.17e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 154240684   915 GGCHADALCSYVgPGQSRCTCKLGFAGNGYEC 946
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-860 1.99e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.99e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 154240684   831 PCHSDAHCVIQEGVARCVCHDGFEGNGFSC 860
Cdd:pfam12947    7 GCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
Link_domain_KIAA0527_like cd03521
Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, ...
 2209-2271 4.83e-03

Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, it is highly similar to the link domain. The link domain is a hyaluronan-binding (HA) domain. KIAA0527 contains a single link module. The KIAA0527 gene was originally cloned from human brain tissue.


Pssm-ID: 239598  Cd Length: 95  Bit Score: 38.76  E-value: 4.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 154240684 2209 VFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLS-AAQQLGFHVCFVGWLANGSAAHPVVTP 2271
Cdd:cd03521     2 LFVLELENGSQGLGLRAARQSCASLGARLASAAELRrAVVECFFSACARGWLADGTVGTTVCNP 65
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1992-2021 6.11e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.91  E-value: 6.11e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 154240684   1992 SGQCNCHPGFAGTACELCAPGAFGPQCQAC 2021
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 2325-2462 7.76e-03

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 39.50  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 154240684 2325 LLDVLAATANFSTFYGMLlgyaNATqrGLEfmDFLEDELTYkTLFVPVNKGF-------VDNMTLSGPDLEL------HA 2391
Cdd:COG2335    33 IVETAANNPDFSTLVAAL----KAA--GLV--DTLSGEGPF-TVFAPTDAAFaalpagtLDALLKPENKATLtkiltyHV 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 154240684 2392 SNATFLSINASRGTLLPAHSGLSLFISDTGpdntslvplapGAVVV--SHVIVWDIMAFNGIIHALASpLLMP 2462
Cdd:COG2335   104 VPGKVTAADLKDGKTLTTLQGQTLTVTVSG-----------GGVTVngANVITADIEASNGVIHVIDK-VLLP 164
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1990-2024 8.55e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.55e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 154240684 1990 RGSGQCNCHPGFAGTACELCAPGAFGPQCQACRCT 2024
Cdd:cd00055    16 PGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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