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Conserved domains on  [gi|156095831|ref|XP_001613950|]
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hypothetical protein, conserved [Plasmodium vivax]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 219-422 2.62e-38

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


:

Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 137.73  E-value: 2.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  219 SINEIHVDMLQNCKNYYIEQIRENIGKIKSLKSNICELDERDREIKNNLSVHSSQNLDMTEKIGALEVKRENLNKDLKFY 298
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  299 SKDFVIFKNLELIYNESNMYIKNLREFAQNSKEKISQVEEAFQELPQGDDQNgdayFEGYFEDIKNKNRLLKKMVQNIDL 378
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAA----IQDVQQKTGLKNLLLEKKLQALGE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 156095831  379 DMDAVNKELTSYINSHHLRDDDVQKVRQGINFCMQTYNKEFDNL 422
Cdd:pfam13851 157 TLEKKEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
CCDC66 super family cl37891
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 28-132 2.53e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


The actual alignment was detected with superfamily member pfam15236:

Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 38.24  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831   28 EVENLVKIQREEllRAVQRKRLLESRLEEKKNELERFKKEYHELKSKIDFlsegcEKYGEKTKEEPKVIKNKSVFYNFQN 107
Cdd:pfam15236  56 EHQNAIKKQLEE--KERQKKLEEERRRQEEQEEEERLRREREEEQKQFEE-----ERRKQKEKEEAMTRKTQALLQAMQK 128

                          90       100
                  ....*....|....*....|....*
gi 156095831  108 AEELKKLDKEKEDIKNMIGEKHEQT 132
Cdd:pfam15236 129 AQELAQRLKQEQRIRELAEKGHDTS 153
 
Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 219-422 2.62e-38

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 137.73  E-value: 2.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  219 SINEIHVDMLQNCKNYYIEQIRENIGKIKSLKSNICELDERDREIKNNLSVHSSQNLDMTEKIGALEVKRENLNKDLKFY 298
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  299 SKDFVIFKNLELIYNESNMYIKNLREFAQNSKEKISQVEEAFQELPQGDDQNgdayFEGYFEDIKNKNRLLKKMVQNIDL 378
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAA----IQDVQQKTGLKNLLLEKKLQALGE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 156095831  379 DMDAVNKELTSYINSHHLRDDDVQKVRQGINFCMQTYNKEFDNL 422
Cdd:pfam13851 157 TLEKKEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 28-132 2.53e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 38.24  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831   28 EVENLVKIQREEllRAVQRKRLLESRLEEKKNELERFKKEYHELKSKIDFlsegcEKYGEKTKEEPKVIKNKSVFYNFQN 107
Cdd:pfam15236  56 EHQNAIKKQLEE--KERQKKLEEERRRQEEQEEEERLRREREEEQKQFEE-----ERRKQKEKEEAMTRKTQALLQAMQK 128

                          90       100
                  ....*....|....*....|....*
gi 156095831  108 AEELKKLDKEKEDIKNMIGEKHEQT 132
Cdd:pfam15236 129 AQELAQRLKQEQRIRELAEKGHDTS 153
 
Name Accession Description Interval E-value
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
 219-422 2.62e-38

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 137.73  E-value: 2.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  219 SINEIHVDMLQNCKNYYIEQIRENIGKIKSLKSNICELDERDREIKNNLSVHSSQNLDMTEKIGALEVKRENLNKDLKFY 298
Cdd:pfam13851   1 ELMKNHEKAFNEIKNYYNDITRNNLELIKSLKEEIAELKKKEERNEKLMSEIQQENKRLTEPLQKAQEEVEELRKQLENY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831  299 SKDFVIFKNLELIYNESNMYIKNLREFAQNSKEKISQVEEAFQELPQGDDQNgdayFEGYFEDIKNKNRLLKKMVQNIDL 378
Cdd:pfam13851  81 EKDKQSLKNLKARLKVLEKELKDLKWEHEVLEQRFEKVERERDELYDKFEAA----IQDVQQKTGLKNLLLEKKLQALGE 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 156095831  379 DMDAVNKELTSYINSHHLRDDDVQKVRQGINFCMQTYNKEFDNL 422
Cdd:pfam13851 157 TLEKKEAQLNEVLAAANLDPDALQAVTEKLEDVLESKNQLIKDL 200
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 28-132 2.53e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 38.24  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156095831   28 EVENLVKIQREEllRAVQRKRLLESRLEEKKNELERFKKEYHELKSKIDFlsegcEKYGEKTKEEPKVIKNKSVFYNFQN 107
Cdd:pfam15236  56 EHQNAIKKQLEE--KERQKKLEEERRRQEEQEEEERLRREREEEQKQFEE-----ERRKQKEKEEAMTRKTQALLQAMQK 128

                          90       100
                  ....*....|....*....|....*
gi 156095831  108 AEELKKLDKEKEDIKNMIGEKHEQT 132
Cdd:pfam15236 129 AQELAQRLKQEQRIRELAEKGHDTS 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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