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Conserved domains on  [gi|1562262172|ref|WP_128700908|]
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nucleoside-diphosphate kinase [Candidatus Velamenicoccus archaeovorus]

Protein Classification

nucleoside-diphosphate kinase( domain architecture ID 10000602)

nucleoside-diphosphate kinase catalyzes the exchange of phosphate groups between different nucleoside diphosphates

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 1-148 7.81e-59

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 439875  Cd Length: 140  Bit Score: 179.49  E-value: 7.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   1 METqaTLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGefhdrRKVMAL 80
Cdd:COG0105     2 MER--TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTS-----GPVVAM 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562262172  81 IYWGEGAITKCRSLAGATNPEEADSVSIRGSYGrittRGVYENVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:COG0105    75 VLEGENAVAVVRKLMGATNPAEAAPGTIRGDFA----LSIGENAVHGSDSPESAEREIALFFSEEEIV 138
 
Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 1-148 7.81e-59

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 179.49  E-value: 7.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   1 METqaTLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGefhdrRKVMAL 80
Cdd:COG0105     2 MER--TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTS-----GPVVAM 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562262172  81 IYWGEGAITKCRSLAGATNPEEADSVSIRGSYGrittRGVYENVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:COG0105    75 VLEGENAVAVVRKLMGATNPAEAAPGTIRGDFA----LSIGENAVHGSDSPESAEREIALFFSEEEIV 138
NDK pfam00334
Nucleoside diphosphate kinase;
4-147 2.15e-51

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 160.73  E-value: 2.15e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLM-GefhdrrKVMALIY 82
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTsG------PVVAMVL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172  83 WGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEI 147
Cdd:pfam00334  75 EGENAISKWRELMGATNPAEAAPGTIRGDFAVSIGR----NAVHGSDSPESAEREIALFFPEEEI 135
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 6-145 1.04e-48

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 153.72  E-value: 1.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:PRK00668    4 TFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSG-----PVVVMVLEGE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGrITTRgvyENVVHVSAIPEDAEREIKLWFEPD 145
Cdd:PRK00668   79 NAIAKVRELMGATNPAEAAPGTIRGDFA-LSIG---ENVVHGSDSPESAAREIALFFSEE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 6-142 1.96e-48

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 153.01  E-value: 1.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:cd04413     3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSG-----PVVAMVLEGE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd04413    78 NAVKTVRKLMGATNPADAAPGTIRGDFALSIGR----NIVHGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 4-147 3.74e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 150.01  E-value: 3.74e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172    4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLM-GEfhdrrkVMALIY 82
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTsGP------VVAMVL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172   83 WGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEI 147
Cdd:smart00562  75 EGEDAVKTWRTLMGPTDPREAAPGTIRGDFGLDIGR----NAVHGSDSPESAEREIALFFPESEI 135
 
Name Accession Description Interval E-value
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 1-148 7.81e-59

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 179.49  E-value: 7.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   1 METqaTLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGefhdrRKVMAL 80
Cdd:COG0105     2 MER--TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTS-----GPVVAM 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1562262172  81 IYWGEGAITKCRSLAGATNPEEADSVSIRGSYGrittRGVYENVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:COG0105    75 VLEGENAVAVVRKLMGATNPAEAAPGTIRGDFA----LSIGENAVHGSDSPESAEREIALFFSEEEIV 138
NDK pfam00334
Nucleoside diphosphate kinase;
4-147 2.15e-51

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 160.73  E-value: 2.15e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLM-GefhdrrKVMALIY 82
Cdd:pfam00334   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTsG------PVVAMVL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172  83 WGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEI 147
Cdd:pfam00334  75 EGENAISKWRELMGATNPAEAAPGTIRGDFAVSIGR----NAVHGSDSPESAEREIALFFPEEEI 135
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 6-145 1.04e-48

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 153.72  E-value: 1.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:PRK00668    4 TFSIIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSG-----PVVVMVLEGE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGrITTRgvyENVVHVSAIPEDAEREIKLWFEPD 145
Cdd:PRK00668   79 NAIAKVRELMGATNPAEAAPGTIRGDFA-LSIG---ENVVHGSDSPESAAREIALFFSEE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 6-142 1.96e-48

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 153.01  E-value: 1.96e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:cd04413     3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSG-----PVVAMVLEGE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd04413    78 NAVKTVRKLMGATNPADAAPGTIRGDFALSIGR----NIVHGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 4-147 3.74e-47

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 150.01  E-value: 3.74e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172    4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLM-GEfhdrrkVMALIY 82
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTsGP------VVAMVL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172   83 WGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEI 147
Cdd:smart00562  75 EGEDAVKTWRTLMGPTDPREAAPGTIRGDFGLDIGR----NAVHGSDSPESAEREIALFFPESEI 135
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 6-148 8.18e-39

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 129.07  E-value: 8.18e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLmgefhDRRKVMALIYWGE 85
Cdd:PTZ00093    5 TFIMVKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYI-----SSGPVVCMVWEGK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:PTZ00093   80 NVVKQGRKLLGATNPLESAPGTIRGDFCVDVGR----NVIHGSDSVESAKREIALWFKPEELV 138
PLN02619 PLN02619
nucleoside-diphosphate kinase
 2-148 8.56e-32

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 113.79  E-value: 8.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   2 ETQATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLmgefhDRRKVMALI 81
Cdd:PLN02619   87 EMERTFIAIKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFL-----SSGPVVAMV 161

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1562262172  82 YWGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:PLN02619  162 WEGEGVIKYGRKLIGATDPQKSEPGTIRGDLAVVVGR----NIIHGSDGPETAKDEINLWFKPEELV 224
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 4-142 9.47e-32

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 110.52  E-value: 9.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYW 83
Cdd:cd00595     1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSG-----PVVAMILE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1562262172  84 GEGAITKCRSLAGATNPEEADSV---SIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd00595    76 KDNAVGEWREMLGPTNPEIARHLapgSLRADFGTDVLR----NAVHGSDSVESAAREIAFFF 133
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 2-142 3.43e-31

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 109.14  E-value: 3.43e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   2 ETQATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALI 81
Cdd:PRK14540    1 EKERTFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSG-----RIVAMV 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1562262172  82 YWGEGAITKCRSLAGATNPEEADSVSIRGSYGRITTrgvyENVVHVSAIPEDAEREIKLWF 142
Cdd:PRK14540   76 IEGENAISTVRKMIGKTNPAEAEPGTIRGDFGLYTP----ANIIHASDSKESAEREIKLFF 132
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 4-148 3.49e-26

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 97.66  E-value: 3.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYrhLKDKPFF---EDVLRYLMgEFHDRRKVMAL 80
Cdd:PRK14543    6 QKTLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY--LYDDIAVrhgEAVWKSLI-KFISSSPVFVF 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172  81 IYWGEGAITKCRSLAGATNPEEADSVSIRG-------SYGRITTRGVYeNVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:PRK14543   83 VVEGVESVEVVRKFCGSTEPKLAIPGTIRGdfsyhsfNYANEKGFSVY-NVIHASANEDDALREIPIWFKDNEIL 156
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 1-148 1.97e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 90.64  E-value: 1.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   1 METQATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYrhlkdkPFFEDVLRYL----------MG- 69
Cdd:PRK14544    1 MPIERTLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFY------PSSEEWYRSVgnkllkayqeLGi 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172  70 -----------------------EFHDRRKVMALIYWGEGAITKCRSLAGATNPEEADSVSIRGSY-------GRITTRG 119
Cdd:PRK14544   75 dprarlgtddpvevgkkvkeslvKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDYsidspdlAAEEGRV 154

                         170       180
                  ....*....|....*....|....*....
gi 1562262172 120 VYeNVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:PRK14544  155 VY-NLVHASDSPEEAEREIKFWFREEEIL 182
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 1-142 5.03e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 80.72  E-value: 5.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   1 METQATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLrylmgEFHDRRKVMAL 80
Cdd:PRK14545    1 MAGNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELV-----EFMSRGPIVAA 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1562262172  81 IYWGEGAITKCRSLAGATNPEEADSVSIRGSYGrittRGVYENVVHVSAIPEDAEREIKLWF 142
Cdd:PRK14545   76 ILEKENAVEDFRTLIGATNPADAAEGTIRKKYA----KSIGENAVHGSDSDENAQIEGAFHF 133
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 4-142 7.17e-19

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 77.67  E-value: 7.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDK----PFFEDVLRYLMgefhdrrkVMA 79
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVvpelPAMVDELTSGP--------CIA 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1562262172  80 LIYWGEGAITKCRSLAGATNPEEADSV---SIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd04412    73 LEIAGENAVKTFREFCGPFDPEIAKQLrpnTLRARYGKDKVQ----NAVHCTDLPEDGPLELKFFF 134
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 6-148 2.80e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 76.53  E-value: 2.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLrylmgEFHDRRKVMALIYWGE 85
Cdd:PRK14541    4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELV-----EFMSSGPCVPMILEKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGriTTRGvyENVVHVSAIPEDAEREIKLWFEPDEII 148
Cdd:PRK14541   79 NAVADFRTLIGATDPAEAAEGTVRKLYA--DSKG--ENIVHGSDSAENAAIEAGFFFSAEEVV 137
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 6-147 3.17e-17

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 73.55  E-value: 3.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:PRK14542    4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSG-----PIVAAALERD 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1562262172  86 GAITKCRSLAGATNPEEADSVSIRGSYGRITTrgvyENVVHVSAIPEDAEREIKLWFEPDEI 147
Cdd:PRK14542   79 NAVLHWREVIGATDPKEAAAGTIRALYAESKE----ANAVHGSDSDANAALEISFFFKGNEL 136
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 4-142 4.80e-16

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 70.32  E-value: 4.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLKrSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMgefhdRRKVMALIYW 83
Cdd:cd04416     1 EYTLALIKPDAVA-EKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMT-----SGPSLILVLS 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1562262172  84 GEGAITKCRSLAGATNPEEADSV---SIRGSYGRittrGVYENVVHVSAIPEDAEREIKLWF 142
Cdd:cd04416    75 KENAVEEWRELMGPTDPEEAKEEkpdSLRAQFAR----DHLSNAVHGSSSAEEAEKEIDFFF 132
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 4-142 8.58e-16

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 69.78  E-value: 8.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   4 QATLILIKPDGLkrSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEFhdrrkVMALIYW 83
Cdd:cd04415     1 EKTLALIKPDAY--SKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGP-----IVAMELV 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1562262172  84 GEGAITKCRSLAGATNPEEADS---VSIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd04415    74 GDDAISEWRKLLGPTNSSVARSdapNSIRALFGTDGTR----NAAHGSDSVASAARELEFFF 131
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 2-143 8.53e-14

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 65.62  E-value: 8.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   2 ETQATLILIKPDGLKRSLTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALI 81
Cdd:PLN02931   28 EEERTLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSG-----PVLVMV 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1562262172  82 YWGEGAITKCRSLAGATNPEEADSV---SIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWFE 143
Cdd:PLN02931  103 LEKENAVSDWRTLIGPTDARKAKIShpnSIRAMCGLDSEK----NCVHGSDSPESAEREISFFFG 163
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 6-142 5.85e-11

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 57.06  E-value: 5.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172   6 TLILIKPDGLKRslTGNILTRLSETKLEIVAAKMVRVSRELAAEHYRHLKDKPFFEDVLRYLMGEfhdrrKVMALIYWGE 85
Cdd:cd04418     3 TLAIIKPDAVHK--AEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSG-----PIVAMVLARH 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562262172  86 GAITKCRSLAGATNPEEADSV---SIRGSYGRITTRgvyeNVVHVSAIPEDAEREIKLWF 142
Cdd:cd04418    76 NAISYWKELLGPTNSLKAKEThpdSLRAIYGTDDLR----NAVHGSDSFSSAEREIRFMF 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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