NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1565722138|ref|WP_129068930|]
View 

carbonic anhydrase [Halorientalis pallida]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.11e-31

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 112.60  E-value: 2.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   28 DAQHPEAVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVQrtaVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPP---YDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  108 TYDAlthgvsEPDGIGHCLDLLKPQLEPGVDRLPADlsrpdsiNHLVEYNVDRQVQFLRESDDVPDSVTA-----VGTVY 182
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTSPAIREAVAKgklkvHGWVY 144

                          170
                   ....*....|....*.
gi 1565722138  183 DFQDvyggrrGEIHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.11e-31

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 112.60  E-value: 2.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   28 DAQHPEAVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVQrtaVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPP---YDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  108 TYDAlthgvsEPDGIGHCLDLLKPQLEPGVDRLPADlsrpdsiNHLVEYNVDRQVQFLRESDDVPDSVTA-----VGTVY 182
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTSPAIREAVAKgklkvHGWVY 144

                          170
                   ....*....|....*.
gi 1565722138  183 DFQDvyggrrGEIHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-186 2.42e-31

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 112.22  E-value: 2.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  34 AVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVqrtAVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVP---PYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565722138 114 HGVSEPDGIGHCLDLLKPQLEPGVDRLPADLSRPDSINHLVEYNVDRQVQFLRESDDVPDSVTA-----VGTVYDFQD 186
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTFPIVREAVAKgklkiHGWVYDLET 153
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-207 1.23e-30

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 111.79  E-value: 1.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   2 DQTFVDLLARN----ADHAATFDARFDDVQDAQHPEAVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVqrtAVGET 77
Cdd:COG0288     1 MEALKRLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGNVVP---PYDPG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  78 VSGDVLYPIEHTGTEIAVVVGHTGCGAVTATYDALTHgvSEPDGIGHCLDLLKPQLEPgVDRLPADLSRPDSINHLVEYN 157
Cdd:COG0288    77 VLASIEYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVER-VRAELPAADGEERLDRLVELN 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1565722138 158 VDRQVQFLRESDDVPDSVTA-----VGTVYDFQDvyggrrGEIHVVNVDGERDVE 207
Cdd:COG0288   154 VREQVENLRTSPIVREAVAAgklkvHGWVYDLAT------GRVEFLDPEGGGFEP 202
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 21-166 1.52e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 71.80  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  21 ARFDDVQDAQHPEAVTVCCSDSRVLQDHIWGNDePGHLFTCGNIGNRVVQRTAVGE--TVSGDVLYPIEHTGTEIAVVVG 98
Cdd:cd00884    15 ELFEKLAKGQSPKALFIACSDSRVVPALITQTQ-PGELFVVRNVGNLVPPYEPDGGfhGTSAAIEYAVAVLKVEHIVVCG 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565722138  99 HTGCGAVTATYDaLTHGVSEPDGIGHCLDLLKPQLEPGVDRLPaDLSRPDSINHLVEYNVDRQVQFLR 166
Cdd:cd00884    94 HSDCGGIRALLS-PEDLLDKLPFIGKWLRIAEPAKEVVLAELS-HADFDDQLRALEKENVLLSLENLL 159
PLN00416 PLN00416
carbonate dehydratase
 21-105 6.06e-10

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 57.74  E-value: 6.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  21 ARFDDVQDAQHPEAVTVCCSDSRVLQDHIWgNDEPGHLFTCGNIGNRV-----VQRTAVGETVSgdvlYPIEHTGTEIAV 95
Cdd:PLN00416   69 TLFNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVppfdqKRHSGVGAAVE----YAVVHLKVENIL 143

                          90
                  ....*....|
gi 1565722138  96 VVGHTGCGAV 105
Cdd:PLN00416  144 VIGHSCCGGI 153
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-198 2.11e-31

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 112.60  E-value: 2.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   28 DAQHPEAVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVQrtaVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFG-LGPGDLFVIRNAGNIVPP---YDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  108 TYDAlthgvsEPDGIGHCLDLLKPQLEPGVDRLPADlsrpdsiNHLVEYNVDRQVQFLRESDDVPDSVTA-----VGTVY 182
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTSPAIREAVAKgklkvHGWVY 144

                          170
                   ....*....|....*.
gi 1565722138  183 DFQDvyggrrGEIHVV 198
Cdd:smart00947 145 DIET------GKLEVL 154
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-186 2.42e-31

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 112.22  E-value: 2.42e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  34 AVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVqrtAVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTATYDAlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFD-TGPGDLFVVRNAGNLVP---PYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565722138 114 HGVSEPDGIGHCLDLLKPQLEPGVDRLPADLSRPDSINHLVEYNVDRQVQFLRESDDVPDSVTA-----VGTVYDFQD 186
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTFPIVREAVAKgklkiHGWVYDLET 153
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-207 1.23e-30

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 111.79  E-value: 1.23e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   2 DQTFVDLLARN----ADHAATFDARFDDVQDAQHPEAVTVCCSDSRVLQDHIWGnDEPGHLFTCGNIGNRVVqrtAVGET 77
Cdd:COG0288     1 MEALKRLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGNVVP---PYDPG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  78 VSGDVLYPIEHTGTEIAVVVGHTGCGAVTATYDALTHgvSEPDGIGHCLDLLKPQLEPgVDRLPADLSRPDSINHLVEYN 157
Cdd:COG0288    77 VLASIEYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVER-VRAELPAADGEERLDRLVELN 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1565722138 158 VDRQVQFLRESDDVPDSVTA-----VGTVYDFQDvyggrrGEIHVVNVDGERDVE 207
Cdd:COG0288   154 VREQVENLRTSPIVREAVAAgklkvHGWVYDLAT------GRVEFLDPEGGGFEP 202
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 21-166 1.52e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 71.80  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  21 ARFDDVQDAQHPEAVTVCCSDSRVLQDHIWGNDePGHLFTCGNIGNRVVQRTAVGE--TVSGDVLYPIEHTGTEIAVVVG 98
Cdd:cd00884    15 ELFEKLAKGQSPKALFIACSDSRVVPALITQTQ-PGELFVVRNVGNLVPPYEPDGGfhGTSAAIEYAVAVLKVEHIVVCG 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565722138  99 HTGCGAVTATYDaLTHGVSEPDGIGHCLDLLKPQLEPGVDRLPaDLSRPDSINHLVEYNVDRQVQFLR 166
Cdd:cd00884    94 HSDCGGIRALLS-PEDLLDKLPFIGKWLRIAEPAKEVVLAELS-HADFDDQLRALEKENVLLSLENLL 159
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 5-108 2.94e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 70.25  E-value: 2.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138   5 FVDLLARNADHAAtfdARFDDVQDAQHPEAVTVCCSDSRVlqdhiwgndEPGHLFTCGnIGNRVVQRTAvGETVSGDVL- 83
Cdd:cd03378    15 FVSGKPLHPDQDL---ARRRELAKGQKPFAVILSCSDSRV---------PPEIIFDQG-LGDLFVVRVA-GNIVDDDVLg 80

                          90       100
                  ....*....|....*....|....*...
gi 1565722138  84 ---YPIEHTGTEIAVVVGHTGCGAVTAT 108
Cdd:cd03378    81 sleYAVEVLGVPLVVVLGHESCGAVAAA 108
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-107 1.29e-14

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 67.53  E-value: 1.29e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1565722138  30 QHPEAVTVCCSDSRVLQDHIWGNdEPGHLFTCGNIGNRVvqrTAVGETVSGDVLYPIEHTGTEIAVVVGHTGCGAVTA 107
Cdd:cd00382     1 QKPKALIIGCSDSRVPPELIFGL-GPGDLFVVRNAGNLV---PPYDLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA 74
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-186 8.86e-11

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 58.73  E-value: 8.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  30 QHPEAVTVCCSDSRVLQDHIWGNdEPGHLFTCGNIGNRVVQRtavgETVSGDVL-YPIEHTGTEIAVVVGHTGCGAVTAT 108
Cdd:cd00883    23 QTPEYLWIGCSDSRVPENTILGL-LPGEVFVHRNIANLVSPT----DLNCLSVLqYAVDVLKVKHIIVCGHYGCGGVKAA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138 109 YDALTHGVSEPdGIGHCLDLLKPQLEpgvdRLPADLSRPDSINHLVEYNVDRQVQFLRESDDVPDSVTAV------GTVY 182
Cdd:cd00883    98 LTGKRLGLLDN-WLRPIRDVYRLHAA----ELDALEDEEERVDRLVELNVVEQVKNLCKTPIVQDAWKRGqelevhGWVY 172


                  ....
gi 1565722138 183 DFQD 186
Cdd:cd00883   173 DLGD 176
PLN00416 PLN00416
carbonate dehydratase
 21-105 6.06e-10

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 57.74  E-value: 6.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  21 ARFDDVQDAQHPEAVTVCCSDSRVLQDHIWgNDEPGHLFTCGNIGNRV-----VQRTAVGETVSgdvlYPIEHTGTEIAV 95
Cdd:PLN00416   69 TLFNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVppfdqKRHSGVGAAVE----YAVVHLKVENIL 143

                          90
                  ....*....|
gi 1565722138  96 VVGHTGCGAV 105
Cdd:PLN00416  144 VIGHSCCGGI 153
PRK10437 PRK10437
carbonic anhydrase; Provisional
 23-186 7.73e-09

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 53.78  E-value: 7.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  23 FDDVQDAQHPEAVTVCCSDSRVLQDHIWGNdEPGHLFTCGNIGNRVVQRTAVGETVsgdVLYPIEHTGTEIAVVVGHTGC 102
Cdd:PRK10437   26 FEKLAQAQKPRFLWIGCSDSRVPAERLTGL-EPGELFVHRNVANLVIHTDLNCLSV---VQYAVDVLEVEHIIICGHYGC 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138 103 GAVTATYDALTHGVSEpDGIGHCLDLLKPQlepgvDRLPADLSRPDSINHLVEYNVDRQVQFLRESDDVPDS------VT 176
Cdd:PRK10437  102 GGVQAAVENPELGLIN-NWLLHIRDIWFKH-----SSLLGEMPQERRLDTLCELNVMEQVYNLGHSTIMQSAwkrgqkVT 175

                         170
                  ....*....|
gi 1565722138 177 AVGTVYDFQD 186
Cdd:PRK10437  176 IHGWAYGIHD 185
PLN03014 PLN03014
carbonic anhydrase
 18-105 2.19e-07

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 50.50  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  18 TFDARFDDVQDAQHPEAVTVCCSDSRVLQDHIWgNDEPGHLFTCGNIGNRV-----VQRTAVGETVSgdvlYPIEHTGTE 92
Cdd:PLN03014  146 TNPALYGELAKGQSPKYMVFACSDSRVCPSHVL-DFQPGDAFVVRNIANMVppfdkVKYGGVGAAIE----YAVLHLKVE 220

                          90
                  ....*....|...
gi 1565722138  93 IAVVVGHTGCGAV 105
Cdd:PLN03014  221 NIVVIGHSACGGI 233
PLN03019 PLN03019
carbonic anhydrase
 18-105 8.29e-07

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 48.60  E-value: 8.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  18 TFDARFDDVQDAQHPEAVTVCCSDSRVLQDHIWgNDEPGHLFTCGNIGNRV-----VQRTAVGETVSgdvlYPIEHTGTE 92
Cdd:PLN03019  141 TNPALYGELAKGQSPKYMVFACSDSRVCPSHVL-DFHPGDAFVVRNIANMVppfdkVKYAGVGAAIE----YAVLHLKVE 215

                          90
                  ....*....|...
gi 1565722138  93 IAVVVGHTGCGAV 105
Cdd:PLN03019  216 NIVVIGHSACGGI 228
PLN03006 PLN03006
carbonate dehydratase
 23-107 8.93e-07

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 48.58  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  23 FDDVQDAQHPEAVTVCCSDSRVLQDHIWGNdEPGHLFTCGNIGNRVVQRTAVGETVSGDVLYPIEHTGTEIAVVVGHTGC 102
Cdd:PLN03006  104 YKNLADAQAPKFLVIACADSRVCPSAVLGF-QPGDAFTVRNIANLVPPYESGPTETKAALEFSVNTLNVENILVIGHSRC 182


                  ....*
gi 1565722138 103 GAVTA 107
Cdd:PLN03006  183 GGIQA 187
PLN02154 PLN02154
carbonic anhydrase
 22-114 1.02e-06

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 48.20  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  22 RFDDVQDAQHPEAVTVCCSDSRVLQDHIWGNdEPGHLFTCGNIGNrVVQRTAVGETVSGDVL-YPIEHTGTEIAVVVGHT 100
Cdd:PLN02154   97 KFKALAIAQSPKVMVIGCADSRVCPSYVLGF-QPGEAFTIRNVAN-LVTPVQNGPTETNSALeFAVTTLQVENIIVMGHS 174

                          90
                  ....*....|....
gi 1565722138 101 GCGAVTATYDALTH 114
Cdd:PLN02154  175 NCGGIAALMSHQNH 188
PRK15219 PRK15219
carbonic anhydrase; Provisional
 28-183 4.75e-06

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 45.98  E-value: 4.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  28 DAQHPEAVTVCCSDSRVlqdhiwgndePGHLFTCGNIGNRVVQRTAvGETVSGDVLYPIEH----TGTEIAVVVGHTGCG 103
Cdd:PRK15219   86 AGQYPAAVILSCIDSRA----------PAEIILDTGIGETFNSRVA-GNISNDDLLGSMEFacavAGAKVVLVMGHTACG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138 104 AVTATYDALTHGvsepdGIGHCLDLLKPQLEpgVDRLPADLS--RPDSINHLVEYNVDRQVQFLRESDDV------PDSV 175
Cdd:PRK15219  155 AVKGAIDNVELG-----NLTGLLDRIKPAIE--VTEFDGERSskNYKFVDAVARKNVELTIENIRKNSPIlrkleqEGKI 227


                  ....*...
gi 1565722138 176 TAVGTVYD 183
Cdd:PRK15219  228 KIVGSMYN 235
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-183 6.87e-06

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 44.16  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138  37 VCCSDSRVLQDHIWGNdEPGHLFTCGNIGNRVVQ---RTAVgetVSGDVLypiehtGTEIAVVVGHTGCGAVTATYDALT 113
Cdd:cd03379     8 VTCMDARLDPEKALGL-KLGDAKVIRNAGGRVTDdaiRSLV---VSVYLL------GTREIIVIHHTDCGMLTFTDEELK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1565722138 114 HGVSEpDGIGHcldllkpqlEPGVDRLPADLsrpDSINHLVEyNVDRQVQFLRESDDVPDSVTAVGTVYD 183
Cdd:cd03379    78 EKMKE-RGIAE---------AYGGIDKEFWF---LGFDDLEE-SVREDVERIRNHPLIPDDVPVHGYVYD 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH