NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1570485847|ref|XP_027898385|]
View 

alpha-2,8-sialyltransferase 8E-like [Xiphophorus couchianus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 71-343 2.47e-155

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23971:

Pssm-ID: 480271  Cd Length: 271  Bit Score: 436.69  E-value: 2.47e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  71 NYEKFRLDLRVNVNGFDEAIITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSC 150
Cdd:cd23971     2 EHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 151 GKMINSADFVIRCNLPPLSDgyEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVC 230
Cdd:cd23971    82 GREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 231 MRTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPfNFKNLTNHY 310
Cdd:cd23971   160 LRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHY 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1570485847 311 YDDMKPNTNFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23971   239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 71-343 2.47e-155

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 436.69  E-value: 2.47e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  71 NYEKFRLDLRVNVNGFDEAIITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSC 150
Cdd:cd23971     2 EHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 151 GKMINSADFVIRCNLPPLSDgyEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVC 230
Cdd:cd23971    82 GREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 231 MRTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPfNFKNLTNHY 310
Cdd:cd23971   160 LRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHY 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1570485847 311 YDDMKPNTNFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23971   239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 90-338 3.65e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 298.75  E-value: 3.65e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  90 IITQTNTPVGSRLVYdGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLs 169
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 170 DGYEKDVGTKTNLVTANP-TILFKKFESLVGR--RRPLMEKLSSY--GNSMLLLPAFSFGMNTAVCMRTLYTIQDFESAI 244
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 245 HP---VFINPEYLIKLSKFW-HAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFgihpFNFKNLTNHYYDDMKPNTN- 319
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 1570485847 320 ---FHSMPVEFSILLQLHRNGV 338
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 71-343 2.47e-155

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 436.69  E-value: 2.47e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  71 NYEKFRLDLRVNVNGFDEAIITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSC 150
Cdd:cd23971     2 EHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 151 GKMINSADFVIRCNLPPLSDgyEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVC 230
Cdd:cd23971    82 GREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 231 MRTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPfNFKNLTNHY 310
Cdd:cd23971   160 LRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHHY 238

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1570485847 311 YDDMKPNTNFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23971   239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 72-343 1.00e-112

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 328.64  E-value: 1.00e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  72 YEKFRLDLRVNVNGFDEAIITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCG 151
Cdd:cd23991     3 HENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 152 KMINSADFVIRCNLPPLSDGYEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVCM 231
Cdd:cd23991    83 AEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSF 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 232 RTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGiHPFNFKNLTNHYY 311
Cdd:cd23991   163 KVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFS-KNTEGKPISHHYY 241

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1570485847 312 DDMKPNTNFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23991   242 DNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 90-338 3.65e-101

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 298.75  E-value: 3.65e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  90 IITQTNTPVGSRLVYdGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLs 169
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 170 DGYEKDVGTKTNLVTANP-TILFKKFESLVGR--RRPLMEKLSSY--GNSMLLLPAFSFGMNTAVCMRTLYTIQDFESAI 244
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 245 HP---VFINPEYLIKLSKFW-HAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFgihpFNFKNLTNHYYDDMKPNTN- 319
Cdd:pfam00777 159 DPdkvLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 1570485847 320 ---FHSMPVEFSILLQLHRNGV 338
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 73-343 4.08e-101

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 299.18  E-value: 4.08e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  73 EKFRLDLRVNVNGFDEaIITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGK 152
Cdd:cd23963     4 DKFRKELERLLNTRKL-FLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 153 MINSADFVIRCNLPPLsDGYEKDVGTKTNLVTANPTILFKKFESLVGRRRP--LMEKLSSYGNSMLLLPAFSFGMNTAVC 230
Cdd:cd23963    83 EIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRdkFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 231 MRTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLkEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPFNfKNLTNHY 310
Cdd:cd23963   162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPYHY 239

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1570485847 311 YDDMKPNT--NFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23963   240 YDDLSPSTknKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 91-343 1.31e-94

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 282.49  E-value: 1.31e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  91 ITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSnKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSD 170
Cdd:cd23989    22 VTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSR 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 171 GYEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVCMRTLYTIQDFESAIHPVFIN 250
Cdd:cd23989   101 EYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFAN 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 251 PEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPFNfKNLTNHYYDDMKPNTNFHSMPVEFSIL 330
Cdd:cd23989   181 PNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNVLPDSGFHAMPEEFLQL 259

                         250
                  ....*....|...
gi 1570485847 331 LQLHRNGVLRLHL 343
Cdd:cd23989   260 WHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 92-342 2.39e-93

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 279.41  E-value: 2.39e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  92 TQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSDG 171
Cdd:cd23990    23 TQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 172 YEKDVGTKTNLVTANPTILFKKFESLVGRRRPLMEKLSSYGNSMLLLPAFSFGMNTAVCMRTLYTIQDFESAIHPVFINP 251
Cdd:cd23990   103 YVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVKYVLDDFESQQAVYYFHP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 252 EYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPFNFkNLTNHYYDDMKPNTNFHSMPVEFSILL 331
Cdd:cd23990   183 QYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGI-FITHHYYDNVKPRPGFHAMPSEIFNFL 261

                         250
                  ....*....|.
gi 1570485847 332 QLHRNGVLRLH 342
Cdd:cd23990   262 HMHSRGILRVH 272
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 91-342 5.83e-74

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 229.99  E-value: 5.83e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  91 ITQTNTPVGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLsD 170
Cdd:cd23969    22 VLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-E 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 171 GYEKDVGTKTNLVTANPTILFKKFESLVGR--RRPLMEKLSSYGNSMLLLPAFsfgMNTAVCMRTLYT---IQDFESAIH 245
Cdd:cd23969   101 GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAF---VSKGGEEHVQWTneiILKHKLNVK 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 246 PVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHpFNFKNLTNHYYDDMKPNTNF--HSM 323
Cdd:cd23969   178 TAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSED-GNGRAVKYHYYDNRKYLTTArpHKM 256

                         250
                  ....*....|....*....
gi 1570485847 324 PVEFSILLQLHRNGVLRLH 342
Cdd:cd23969   257 PEEFRALRSLHQRGALRLH 275
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 70-343 1.86e-72

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 226.51  E-value: 1.86e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  70 FN---YEKFRLDLRVNVNGFDEAIITQTNTPVGSRLVYD-GERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIV 145
Cdd:cd23970     1 FNktaLLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 146 ANSSCGKMINSADFVIRCNLPPLsDGYEKDVGTKTNLVTANPTILFKKFESL--VGRRRPLMEKLSSYGNSMLLLPAFSF 223
Cdd:cd23970    81 TNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSILEKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFFF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 224 GMNTAVcMRTL--YTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPF 301
Cdd:cd23970   160 HTSATV-TRTLvdFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1570485847 302 NfKNLTNHYYD--DMKPNTN---FHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23970   239 G-TPLPYHYYDkkGTKFTTKwqeSHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 87-343 6.92e-58

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 188.61  E-value: 6.92e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  87 DEAIITQTNTPvGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLP 166
Cdd:cd23987    19 DISVLKGTLKP-GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 167 PLSDgYEKDVGTKTNLVTANPTILFKKFESLVGR--RRPLMEKLSSYGNSMLLLPAFsfgMNTAVCMRTLYT---IQDFE 241
Cdd:cd23987    98 PVEE-YAKDVGTKTDLVTMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAF---MAKGGEERVEWVndlILKHH 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 242 SAIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGIHPfNFKNLTNHYYDDMK----PN 317
Cdd:cd23987   174 INVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQ-NQNPVKYHYYDSLKygytSQ 252

                         250       260
                  ....*....|....*....|....*.
gi 1570485847 318 TNFHSMPVEFSILLQLHRNGVLRLHL 343
Cdd:cd23987   253 ASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 87-341 1.74e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 180.15  E-value: 1.74e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847  87 DEAIITQTNTPvGSRLVYDGERKRILNVTQQIYDLFPKGHPFSNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLP 166
Cdd:cd23988    19 DVSVVKSSFKP-GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLA 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 167 PLsDGYEKDVGTKTNLVTANPTILFKKFESLVGR--RRPLMEKLSSYGNSMLLLPAFSF--GMNTAVCMRTLytIQDFES 242
Cdd:cd23988    98 PV-VEFAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVkgGEKHVEWVNAL--ILKNKL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 243 AIHPVFINPEYLIKLSKFWHAHGLKEARLSTGVMMTSLALELCDDVHLYGFWPFGiHPFNFKNLTNHYYDDMK----PNT 318
Cdd:cd23988   175 KVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFP-KDANGNPVKYHYYDDLKyryfSNA 253

                         250       260
                  ....*....|....*....|...
gi 1570485847 319 NFHSMPVEFSILLQLHRNGVLRL 341
Cdd:cd23988   254 GPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 136-333 2.42e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 108.99  E-value: 2.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNLVTANPTILfkkfESLVGRRRPLMEKLSSYGNSM 215
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTK-GFEKDVGSKTTFRVLNSKWA----GFYLRGPRCGCHPLPLEEEVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 216 LLLPAFSFGMNTAVcmrtlyTIQDFESAIHPVFINP----------EYLIKLSKFWHAHGLKearLSTGVMMTSLALELC 285
Cdd:cd19952    76 LILSRAAAADFKRL------KRRKKRHDNAVLLLTDpapdllsyvrKRLEKLGLKSFFGGNA---PSSGLLAVLLALQLC 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1570485847 286 DDVHLYGFWPFGIHPfnfKNLTNHYYDDMKPN--TNFHSMPVEFSILLQL 333
Cdd:cd19952   147 DSVDLYGFGVDSGHA---PKVPYHYYDLVEAEegTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 110-342 5.51e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 102.34  E-value: 5.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 110 RILNVTQQIYDLFPKGHPfsnKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLpPLSDGYEKDVGTKTNLVTANPti 189
Cdd:cd23964    62 RNLNLTSSRYMFVLRGGR---PRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFP-- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 190 lfkkfESLVGRRRPLMekLSSYGNSMLLLPAFSFG---MNTAVCMRTLYTIQDFESA----------------IHPVFIn 250
Cdd:cd23964   136 -----ESLHNSLLKHV--PQDKDTKYLFIPFKIRDydyLDAVLSGKPVPDGCDKGKRppplfgpklnatnvrlLHPDFI- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 251 pEYLiklskfwHAHGLKEA---RLSTGVMMTSLALELCDDVHLYGfwpFGIHPfnfkNLTNHYYDD-MKPNTNF---HSM 323
Cdd:cd23964   208 -RYL-------FNRWLNSStsyRPTTGALMLLTALHTCDQVSVYG---FGYDP----RFSLHYYDKtFVKFTVFyanHDF 272

                         250
                  ....*....|....*....
gi 1570485847 324 PVEFSILLQLHRNGVLRLH 342
Cdd:cd23964   273 TNERKLWRKLHEEGIINLY 291
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 106-342 1.67e-20

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 89.65  E-value: 1.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 106 GERKRILNVTQQIY-DLFPKGHPFSNKRWD---TCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTn 181
Cdd:cd23966    46 SSKNSDLREVLEKLfQVVPGENPYRTRDPNrcrRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTK-GFEKDVGSKT- 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 182 lvtanpTILFKKFESLVGRRRplmeklssyGNSMLLLP-----------AFSFGMNTavcmRTLYTIQDFESAI-HPV-F 248
Cdd:cd23966   124 ------THHFMYPESAVDLDP---------GVHLVLVPfkvldlqwlisALTTGEIT----RTYTPVKRFIKADkDKVlV 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 249 INPEYLIKLSKFW-HAHGlkeaRL-STGVMMTSLALELCDDVHLYGF-------WpfgihpfnfknltNHYYDDMKPNTN 319
Cdd:cd23966   185 INPAFIKYVHDNWtEHHG----RYpSTGFLALIFALHICDEVSVFGFgadskgnW-------------HHYWEKNRSAGA 247

                         250       260
                  ....*....|....*....|....*...
gi 1570485847 320 F-----HSMPVEFSILLQLHRNGVLRLH 342
Cdd:cd23966   248 FrktgvHDADFESDIIKKLAKEGKIRVY 275
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 136-316 4.89e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 83.88  E-value: 4.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNLVTANPTILFKKFESLvgrrrplmeklssYGNSM 215
Cdd:cd23967     5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVK-GYEKDVGSKTTFRMFYPESAFRDPEEY-------------DSDWL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 216 LLLPAFSfgmntAVCMRTLYTI-QD---------FESAIHPVFINPE-------YLIKLSKFWHaHGLKEA------RLS 272
Cdd:cd23967    71 LVLVPFK-----SMDLLWLQAViKGkkpngkggfWKKIATSVPKPPKkirilnpYILQEAAFDL-IGLPMNgkqgknVPT 144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1570485847 273 TGVMMTSLALELCDDVHLYGfwpFGiHPFNFKNLTNHYYDD--MKP 316
Cdd:cd23967   145 TGIIAIVMALHYCDEVDIAG---FG-YDPSDPNAPLHYYDSltMKA 186
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 136-343 1.59e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 81.72  E-value: 1.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNlPPLSDGYEKDVGTKTNLVTANPTILFKKFESL--VGRRRPLMEK------ 207
Cdd:cd23974    87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYagVGFNGPPQSKetryif 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 208 LSSYGNSMLLL------------------PAFSFGMNTAVCMRTLYtiqdfesaiHPVFInpEYLikLSKFWHAHGLKEA 269
Cdd:cd23974   166 LPDHDRDYLLVkaalthtpidrgrdkskrPSKYFGKDVTAEKFKIY---------HPDFI--RYL--RNRFLWSPILNTK 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 270 -----RLSTGVMMTSLALELCDDVHLYGFwpfgIHPfNFKNLTNHYYDDMKPNTNF---HSMPVEFSILLQLHRNGVLRL 341
Cdd:cd23974   233 qrdiyRPSTGAVMLLAALHTCDQVSAYGF----MTP-DYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKL 307


                  ..
gi 1570485847 342 HL 343
Cdd:cd23974   308 YM 309
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 135-333 3.67e-15

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 73.16  E-value: 3.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 135 TCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNL-------------VTANPTIL-----FKK--- 193
Cdd:cd23982     4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIrlfypesaqfdpgIENDPDTLlvlvpFKPldf 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 194 ---FESLVGRRRPLMEKLSSYGNSMLLLPAFsfgmntavcMRTLytiqdfesaihpvfiNPEYL-IKLSKFWHAHGL--K 267
Cdd:cd23982    83 ywlYEILSNEKRVRKGFWKQPPRIWDANPKQ---------IRIL---------------NPYYTyVAATKLLQVPGQrkK 138

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 268 EARLSTGVMMTSLALELCDDVHLYGFWpfgiHPFNF-KNLTNHYYDD--MKPNTNF-HSMPVEFSILLQL 333
Cdd:cd23982   139 KQKPTTGLLAITLALHLCDEVHIAGFG----YPDNGnSNQPIHYYNQitLKSMANSgHNLNAEAQAIQRL 204
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 116-344 3.84e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 74.79  E-value: 3.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 116 QQIYDLFPKGhpfsNKRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNlPPLSDGYEKDVGTKTNL-------VTANPT 188
Cdd:cd23973    70 QQLLALSPPG----GDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFyvhtahsITSSLM 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 189 IL----FKKFESLVGRRRPLM-EKLSSYGNSMLLLpafsfgMNTAVcMRTLYTIQD----FESAIHP---VFINPEYLIK 256
Cdd:cd23973   145 ILqkrgFKNIPQDKDIKYILFpEGPRDYQWLEALL------KNKTI-PSGAYYGRRprsyFSGDFTEdkyLVLHPDFLRY 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 257 L-SKFWHAHGLKEA-----RLSTGVMMTSLALELCDDVHLYGFWPFGihpfnFKNLTNHYYDDMKPNTNF---HSMPVEF 327
Cdd:cd23973   218 VkNRFLRSKTLKGKywaiyRPTTGAFLLLTALHLCDTVSAYGFITED-----YRKYPDHYYDKKKTKLVFyinHDFRLEK 292

                         250
                  ....*....|....*..
gi 1570485847 328 SILLQLHRNGVLRLHLG 344
Cdd:cd23973   293 KLWKRLHDEKIIKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 135-333 4.50e-15

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.86  E-value: 4.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 135 TCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNLVTANPTILFKkfeslvgrrrplmEKLSSYGNS 214
Cdd:cd23984     4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPESIFS-------------DPSHYDPNT 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 215 MLLLPAF------------------SFGMNTAVCMRTLYTIQDFEsaihpvFINPEYLIKLS----KFWHAHGLKEARL- 271
Cdd:cd23984    70 TVVLIPFkphdlrwlldllmgkkvsAKGFWKKPALNLIYKPNQIR------ILNPFILRIAAyellHFPKRFPKEKKPKh 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 272 -STGVMMTSLALELCDDVHLYGFwpfgihPFNFKNLTN--HYYDD-----MKPNTnFHSMPVEFSILLQL 333
Cdd:cd23984   144 pTTGIIAITLALHICNEVHIAGF------KYDFSNLNStlHYYGNetmsvMTKNE-YHNISAEQKFLKDL 206
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 131-341 8.36e-14

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 70.38  E-value: 8.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 131 KRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLsDGYEKDVGTKTNLVTANPTILFK-KFESLvgrrrplmeKLS 209
Cdd:cd23968    43 KRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTTLRLINSQILSKpEFNFL---------TDP 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 210 SYGNSMLLlpAFSFGMNTAVCMRTLYtiqdfeSAIHPVFIN--------PE---YLIKLSKFWHA-HGLKE---ARL--- 271
Cdd:cd23968   113 LYRNVTLL--VWDPSSYNVNLEKWYK------KPDFDFFPNyikyrrrhPEepfYLIDPRFLWRLwDILQEytpEKIkpn 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 272 --STGVMMTSLALELCDDVHLYGFWPfgihpfnFKNLTN--HYYDDMKPNT----NFHSMPVEFSILLQLH--------R 335
Cdd:cd23968   185 ppSSGFIGIVLMLHLCDWVDVYEYVP-------SVRQTDrcHYYDVEKDLActlgAWHPLAAEKLLVRHLNvgsdddifR 257


                  ....*.
gi 1570485847 336 NGVLRL 341
Cdd:cd23968   258 KGRATL 263
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 136-342 1.45e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.24  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNlPPLSDGYEKDVGTKTNL------VTANPTILFKKFeslvGRRRPLMEKLS 209
Cdd:cd23972    85 CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygftvnTMKNSLISYWNL----GFTRTPQGQDL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 210 SYgnsmLLLPAfsfgmntavcmrtlyTIQDF---ESAIH--PV------------FINPEYLIKLSKFWHA---HGLKEA 269
Cdd:cd23972   160 QY----IFIPS---------------DIRDYvmlRSAILgvPVpegldkgdrphkYFGPEASAKKFKLLHPdfiSYLTDR 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 270 RL---------------STGVMMTSLALELCDDVHLYGFwpfgIHPfNFKNLTNHYYDDMKPNTNF---HSMPVEFSILL 331
Cdd:cd23972   221 FLkskllnthyghlympSTGALMLLTALHTCDQVSAYGF----ITS-NYWKFSDHYYERKKKPLVFyanHDMLLEAALWR 295

                         250
                  ....*....|.
gi 1570485847 332 QLHRNGVLRLH 342
Cdd:cd23972   296 RLHKAGILQLY 306
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 134-313 2.30e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 65.73  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 134 DTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNL-VTAnptilFKKFESLVGRRRPLMEKLSSYG 212
Cdd:cd23965     2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTR-GYEKDVGRRTTIrVVS-----HSSLPRLLRNAILLLAGTRAPT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 213 NSMLLLPAFSFGMNTAVCMRTLYTIQDFESAIHPVFINPEYLIKLSKFWHAHGLKEAR-----LSTGVMMTSLALELCDD 287
Cdd:cd23965    76 VVVFWGPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIksgtwLSTGWFTMLLALDVCDE 155

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1570485847 288 VHLYGFwpfgIHPFNFKNLTN-----HYYDD 313
Cdd:cd23965   156 IKVYGM----VPENYCREHPNskvpyHYYEP 182
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 136-317 4.86e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 61.79  E-value: 4.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNL-VTANPTIlfkkFESLvgrRRPlMEKLSSYGNS 214
Cdd:cd23978     4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV----YRVL---RRP-QEFLNRTPET 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 215 MLLL--PAFSFGMNTavcMRTLYTIQDFESAIHP---VF-INPEYLIKLSKFWHAHGLKEAR-----LSTGVMMTSLALE 283
Cdd:cd23978    75 TLIFwgPPNKMQKDG---KSNLFRIIQRASMTFPnmsAFvVSPRRMRQFDDLFRGETGRDRKkshswLSTGWFTMVIAVE 151

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1570485847 284 LCDDVHLYGFWP--FGIHPFNFKNLTNHYYDDMKPN 317
Cdd:cd23978   152 LCDNVHVYGMVPpnYCSKRPTPKKMPYHYYEPKGPD 187
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 109-293 1.37e-10

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 61.05  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 109 KRILNVTQQIYDLFPKGHPFSNKRwdtCAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKTnlvtanpT 188
Cdd:cd23980    60 RELFQVVPGNVDPLLEKRLVSCRR---CAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKT-------T 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 189 ILFKKFESLvgrrRPLMEKLssygnSMLLLPAFSFGMNTAVCMRTLYTI--------------QDFESAIHPVFINPEYl 254
Cdd:cd23980   129 HHFVYPESF----RELAQNV-----SMILVPFKTLDLEWVISATTTGTIshtyvpvprkikvkKEKILIYHPAFIKYVF- 198

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1570485847 255 iklSKFWHAHGLKEarlSTGVMMTSLALELCDDVHLYGF 293
Cdd:cd23980   199 ---DRWLQGHGRYP---STGILSVIFSLHVCDEVDLYGF 231
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 136-315 1.43e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 59.94  E-value: 1.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNLVTANPTILFKKFESlvgrrrplMEKlssygNSM 215
Cdd:cd23981     5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVK-GFEKDVGSKTTLRITYPEGAIQKPEQ--------YEK-----DSL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 216 LLLPAF-------------------SFGMNTAVCMRTLYTIQDFEsAIHPVFINPEYLIKLSKFWHAHGLKEARLST-GV 275
Cdd:cd23981    71 FVLAGFkwqdfkwlkyivykekvsaSDGFWKSVATRVPREPHEIR-ILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTlGS 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1570485847 276 MMTSLALELCDDVHLYGFWpfgiHPFNFKNLTNHYYDDMK 315
Cdd:cd23981   150 VAITMALHNCDEVAVAGFG----YDMNTPNAPLHYYETIK 185
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 135-190 2.34e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 57.54  E-value: 2.34e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1570485847 135 TCAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKTNLVTANPTIL 190
Cdd:cd23986    51 SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQIL 105
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 136-323 2.45e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 56.67  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPLSdGYEKDVGTKTNLVTANP-----------------TILFKK----- 193
Cdd:cd23983     5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQ-GYSQDVGNKTTIRMTYPegapkseqeydptslfvAVLFKSvdfaw 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 194 FESLVGRRR-PLMEKL---SSYGNSMLLLPAFSFGMNTAVCMRTLYTIQDFesaihpvfinPEyliKLSKFWhahGLKEA 269
Cdd:cd23983    84 LKAMVKKEPlSFWSRLffwKEVADSIPLKPSQFRILNPLIIKETALDILQY----------PE---PQSRLW---GWDKN 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1570485847 270 RLSTGVMMTSLALELCDDVHLYGFWpfgiHPFNFKNLTNHYYDDMKPNT-NFHSM 323
Cdd:cd23983   148 VPTLGVTAVVLATHLCDEVSLAGFG----YDLSQPHAPLHYYDSVCMAAmNTQTM 198
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 113-293 1.15e-08

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 55.26  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 113 NVTQQIYDLFPKGHPFsnKRWDT-----CAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKT------- 180
Cdd:cd23979    57 EVLSKLFQIIPGENPY--RSWDPsrcrrCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTthhfmyp 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 181 ----NLvTANPTILFKKFESLvgrrrplmeklssygNSMLLLPAFSFGM--NTAVCMRTLYTIQDFESAIHpvfiNPEYL 254
Cdd:cd23979   134 esakNL-PANVSFVLVPFKTL---------------DLLWITSALSTGQirFTYAPVKQFLRVDKDKVQIY----NPAFF 193

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1570485847 255 IKLSKFWHAHGLKEArlSTGVMMTSLALELCDDVHLYGF 293
Cdd:cd23979   194 KYIHDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGF 230
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 131-295 3.61e-08

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 53.94  E-value: 3.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 131 KRWDTCAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKTNLVTANPTILfkkfesLVGRRRPLMEKLSS 210
Cdd:cd23985    43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAP-TAGFQQDVGTKTTIRLINSQLV------TTEKHKFLKDSLYN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 211 YGNSMLLLPAFSFGMNTAVCMRTLYTIqdFESAIHPVFINPE---YLIKLSKFWH---------AHGLKEARLSTGVMMT 278
Cdd:cd23985   116 EGILIVWDPAPYHSDIPEWYKNPDYNF--FENYKTYRRLNPNqpfYILHPQMQWElwdiiqensPEEIQPNPPSSGMLGI 193

                         170
                  ....*....|....*..
gi 1570485847 279 SLALELCDDVHLYGFWP 295
Cdd:cd23985   194 ILMMTLCDQVDVYEFLP 210
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 135-317 1.61e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.71  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 135 TCAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKTNL-VTANPTIlfkkfESLVGRRRPLMEklSSYGn 213
Cdd:cd23976    17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSI-----QRILRNRNELLN--VSQG- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 214 smlllPAFSFGMNTAVCMRT----LYTIQDFESAIHPVF----INPEYLIKLSKFWHAHGLKEAR-----LSTGVMMTSL 280
Cdd:cd23976    88 -----TVFIFWGPSNYMRRDgkglVYNNLQLMNQILPKLkvytITRHKMLQFDELFKRETGKDRKisntwLSTGWFTMII 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1570485847 281 ALELCDDVHLYGFWP--FGIHPfNFKNLTNHYYDDMKPN 317
Cdd:cd23976   163 ALELCDRINVYGMVPpdFCRDP-NHPSVPYHYYEPSGPD 200
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 136-292 4.35e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 44.08  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 136 CAVIGNGGIVANSSCGKMINSADFVIRCNLPPlSDGYEKDVGTKTNLVTANPTILfkkfeslvgrrrPLMEKLSSYgnsm 215
Cdd:cd23977     4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVSHTSV------------PLLLRNQGY---- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1570485847 216 lllpafsFGMNTAvcmRTLYTIQDFESAIHPVFINPEY--LIKLSKFW---HAHGLKEAR-------------------- 270
Cdd:cd23977    67 -------FFQQSR---DTKYVIWGPERNMDRDGGGKTYraLLTLAKMYphlQVYTLTEEKmaycdgvfqnetgknrmksg 136

                         170       180
                  ....*....|....*....|....
gi 1570485847 271 --LSTGVMMTSLALELCDDVHLYG 292
Cdd:cd23977   137 sfLSTGWFTMILALELCEEILVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH