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Conserved domains on  [gi|1575763868|ref|WP_130064165|]
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MULTISPECIES: DciA family protein [Bacteria]

Protein Classification

DUF721 domain-containing protein( domain architecture ID 4474)

uncharacterized DUF721 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DciA super family cl47924
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 59-144 1.62e-06

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


The actual alignment was detected with superfamily member pfam05258:

Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 43.43  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575763868  59 SLLGAILSKLPLDEEGMDPELLRKgWMAAAGPFLGKQACLVSLVKGVATVQVIQPAMRYHLQQWQGALLGKLKEQFGKDA 138
Cdd:pfam05258   4 DLLGRLLSARGLQKALALARLLQA-WPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGREV 82


                  ....*.
gi 1575763868 139 VHSIRI 144
Cdd:pfam05258  83 VRRIRF 88
 
Name Accession Description Interval E-value
DciA pfam05258
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 59-144 1.62e-06

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 43.43  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575763868  59 SLLGAILSKLPLDEEGMDPELLRKgWMAAAGPFLGKQACLVSLVKGVATVQVIQPAMRYHLQQWQGALLGKLKEQFGKDA 138
Cdd:pfam05258   4 DLLGRLLSARGLQKALALARLLQA-WPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGREV 82


                  ....*.
gi 1575763868 139 VHSIRI 144
Cdd:pfam05258  83 VRRIRF 88
 
Name Accession Description Interval E-value
DciA pfam05258
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 59-144 1.62e-06

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 43.43  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575763868  59 SLLGAILSKLPLDEEGMDPELLRKgWMAAAGPFLGKQACLVSLVKGVATVQVIQPAMRYHLQQWQGALLGKLKEQFGKDA 138
Cdd:pfam05258   4 DLLGRLLSARGLQKALALARLLQA-WPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGREV 82


                  ....*.
gi 1575763868 139 VHSIRI 144
Cdd:pfam05258  83 VRRIRF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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