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Conserved domains on  [gi|157831358]
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Chain A, Cd2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 5-103 1.79e-20

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05775:

Pssm-ID: 472250  Cd Length: 98  Bit Score: 81.24  E-value: 1.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358   5 NALETWGALGQDINLDIPSFQmsDDIDDIKWEKTSDKkkIAQFRK-EKETFKE--KDTYKLFKN-GTLKIKHLKTDDQDI 80
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDK--IVEWENnIGPTYFGsfKDRVLLDKEsGSLTIKNLTKEDSGT 76

                         90       100
                 ....*....|....*....|...
gi 157831358  81 YKVSIYDTKGKnVLEKIFDLKIQ 103
Cdd:cd05775   77 YELEITSTNGK-VLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-181 9.16e-15

Immunoglobulin C2-set domain;


:

Pssm-ID: 399065  Cd Length: 80  Bit Score: 65.83  E-value: 9.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358  111 ISWTCINTTLTCEVMNGT-------DPELNLYQDGKH-LKLSQRVITHKWTTSLSAKFKCTA-GNKVSKESSVEPVSCPE 181
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKsLETKKLESTFQPTTEDSGTWVCLAsDNDQKKLESVIEVLVLE 80
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 5-103 1.79e-20

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 81.24  E-value: 1.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358   5 NALETWGALGQDINLDIPSFQmsDDIDDIKWEKTSDKkkIAQFRK-EKETFKE--KDTYKLFKN-GTLKIKHLKTDDQDI 80
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDK--IVEWENnIGPTYFGsfKDRVLLDKEsGSLTIKNLTKEDSGT 76

                         90       100
                 ....*....|....*....|...
gi 157831358  81 YKVSIYDTKGKnVLEKIFDLKIQ 103
Cdd:cd05775   77 YELEITSTNGK-VLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-181 9.16e-15

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 65.83  E-value: 9.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358  111 ISWTCINTTLTCEVMNGT-------DPELNLYQDGKH-LKLSQRVITHKWTTSLSAKFKCTA-GNKVSKESSVEPVSCPE 181
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKsLETKKLESTFQPTTEDSGTWVCLAsDNDQKKLESVIEVLVLE 80
 
Name Accession Description Interval E-value
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 5-103 1.79e-20

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 81.24  E-value: 1.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358   5 NALETWGALGQDINLDIPSFQmsDDIDDIKWEKTSDKkkIAQFRK-EKETFKE--KDTYKLFKN-GTLKIKHLKTDDQDI 80
Cdd:cd05775    1 SSGEVYGALGGNVTLTISSLQ--DDIDEIKWKKTKDK--IVEWENnIGPTYFGsfKDRVLLDKEsGSLTIKNLTKEDSGT 76

                         90       100
                 ....*....|....*....|...
gi 157831358  81 YKVSIYDTKGKnVLEKIFDLKIQ 103
Cdd:cd05775   77 YELEITSTNGK-VLSSKFTLEVL 98
C2-set pfam05790
Immunoglobulin C2-set domain;
111-181 9.16e-15

Immunoglobulin C2-set domain;


Pssm-ID: 399065  Cd Length: 80  Bit Score: 65.83  E-value: 9.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358  111 ISWTCINTTLTCEVMNGT-------DPELNLYQDGKH-LKLSQRVITHKWTTSLSAKFKCTA-GNKVSKESSVEPVSCPE 181
Cdd:pfam05790   1 VTVSCSNNLLTCEVLELTlpkgskmDPSLKLKGQEAKsLETKKLESTFQPTTEDSGTWVCLAsDNDQKKLESVIEVLVLE 80
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 117-173 8.62e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 36.60  E-value: 8.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157831358  117 NTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESS 173
Cdd:pfam13895  16 PVTLTCSAPGNPPPSYTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVARNGRGGKVS 72
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 11-92 6.62e-03

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 34.80  E-value: 6.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157831358  11 GALGQDINLDIPSFQMSDDidDIKWEKTSD---KKKIAQFRKEKETF----KEKDTYKLFKNGTLKIKHLKTDDQDIYKV 83
Cdd:cd05741    7 GAEGKNVLLLVPNLQTPLK--SVSWYKGKQvsrNDEIAEYENSSDEFragsAFSGREYIYTNGSLLIQNITLSDTGFYTL 84


                 ....*....
gi 157831358  84 SIYDTKGKN 92
Cdd:cd05741   85 ESTNIGGKT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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