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Full Results
hypothetical protein EPR50_G00162150 [Perca flavescens]
Protein Classification
MYSc_class_II and Myosin_tail_1 domain-containing protein (domain architecture ID 12036736 )
protein containing domains Myosin_N, MYSc_class_II, and Myosin_tail_1
List of domain hits
Name
Accession
Description
Interval
E-value
Myosin_tail_1
pfam01576 Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
925-2005
0e+00
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 396244 [Multi-domain]
Cd Length: 1081
Bit Score: 1421.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 925 TRQEEEM GQ K D EEL KAA KE VAA K V E T ELK DITQ KH T QL M EE RAQ L EMK L H AETEL Y AEAEEMR V RL E A K KQELEE V LH EM 1004
Cdd:pfam01576 1 TRQEEEM QA K E EEL QKV KE KQQ K A E S ELK ELEK KH Q QL I EE KNI L AEQ L Q AETEL F AEAEEMR A RL A A R KQELEE I LH DL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1005 ESRLEEEE D RS NA L H NE R K E M E Q QL Q LM E AHIA EEE D ARQKLQ M EKV SV E G K V KKLEEDIL MM EDQN N KL Q KERKLLEER 1084
Cdd:pfam01576 81 ESRLEEEE E RS QQ L Q NE K K K M Q Q HI Q DL E EQLE EEE A ARQKLQ L EKV TT E A K I KKLEEDIL LL EDQN S KL S KERKLLEER 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1085 LADMS SNLAEEEEK S K N L S KLK T KHE S MIS E LE L R M KKEEKGR LDM EKAKRK VEA E LG DLQEQ H A D LQAQ LA ELRAQLA A 1164
Cdd:pfam01576 161 ISEFT SNLAEEEEK V K S L N KLK N KHE A MIS D LE D R L KKEEKGR QEL EKAKRK LDG E ST DLQEQ I A E LQAQ IE ELRAQLA K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1165 KEEELQA TQ ARLEEE CN Q RGA A V K RV REL EVL I S ELQEDLE A ERAAR G K V E AA RRDLGEEL N AL R TELED S L GT TAAQQE 1244
Cdd:pfam01576 241 KEEELQA AL ARLEEE GA Q KNN A L K KL REL QAQ I A ELQEDLE S ERAAR A K A E KQ RRDLGEEL E AL K TELED T L DS TAAQQE 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1245 LR A KREQEV SM LKKA M E D E G RSHEAQ V Q DL RQKH S QA V EEL T EQLEQAKR VR A G LEKAKQALE K E SAD L S A D L RS L AS AK 1324
Cdd:pfam01576 321 LR S KREQEV TE LKKA L E E E T RSHEAQ L Q EM RQKH T QA L EEL S EQLEQAKR NK A N LEKAKQALE S E NNE L Q A E L KT L QQ AK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1325 QD V EHK K KK V EGQL N EL NS R FN ESERQR T EL G E RV SKL TT EL D SV T GLL N EAEGK N IKLSKDVSSL S SQLQD A QELL S EE 1404
Cdd:pfam01576 401 QD S EHK R KK L EGQL Q EL QA R LS ESERQR A EL A E KL SKL QS EL E SV S GLL S EAEGK S IKLSKDVSSL E SQLQD T QELL Q EE 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1405 TRQKLNLS G RLRQ T E ED RNSL M EQLEEE T EAKR A VERQ V S S L NM QLS DS KKKL D E MS G T VEALEE G KKRLQRELEA ANSD 1484
Cdd:pfam01576 481 TRQKLNLS S RLRQ L E DE RNSL Q EQLEEE E EAKR N VERQ L S T L QA QLS EM KKKL E E DA G A VEALEE A KKRLQRELEA LTQR 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1485 Y EEKA S AYDKLEK SRG R M QQEL E D V L M DLD S QRQLVSNLEKKQKKFDQMLAEE R A V S CKF AEERDRAEAEAREKETR V L A 1564
Cdd:pfam01576 561 L EEKA A AYDKLEK TKN R L QQEL D D L L V DLD H QRQLVSNLEKKQKKFDQMLAEE K A I S ARY AEERDRAEAEAREKETR A L S 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1565 L A RALEE NQG A L EE A E KTM K G LRA D MEDL I SSKDDVGK S VH D LE KA KR G LE AI V D EM R TQ M EELEDELQ VA EDAKLRL D V 1644
Cdd:pfam01576 641 L S RALEE ALE A K EE L E RQN K Q LRA E MEDL V SSKDDVGK N VH E LE RS KR A LE QQ V E EM K TQ L EELEDELQ AT EDAKLRL E V 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1645 N T QAL R AQ H ER E L H ARDE L GEEKR K QL L KQVRELEAELE E ERKQR G QA SGS KKKLE GE LK DM E D Q LE A TSR GRDEAVKQL 1724
Cdd:pfam01576 721 N M QAL K AQ F ER D L Q ARDE Q GEEKR R QL V KQVRELEAELE D ERKQR A QA VAA KKKLE LD LK EL E A Q ID A ANK GRDEAVKQL 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1725 R K I Q G Q V K D LQR D LE DS RA AQK E V LA SAR ESE RRS K AM EA DIV QL H E M LAA V ERA RK QA EV ERDEL SE E L A SNS SGKS LM 1804
Cdd:pfam01576 801 K K L Q A Q M K E LQR E LE ET RA SRD E I LA QSK ESE KKL K SL EA ELL QL Q E D LAA S ERA KR QA QQ ERDEL AD E I A NGA SGKS AL 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1805 S DEKRRL DTK I S QLEEELEEEQ A N V E S LNDR L RK SQQL VEQL GA EL A AERS T SQ SR E GS RQQLERQN R ELKAK M QEMEG Q 1884
Cdd:pfam01576 881 L DEKRRL EAR I A QLEEELEEEQ S N T E L LNDR Y RK LTLQ VEQL TT EL S AERS F SQ KS E SA RQQLERQN K ELKAK L QEMEG T 960
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1885 GR SK L K A SIAALEAK LREA EEQLE I ESRERQA NG K NL R QK EKKLK DLTI Q M EDER KQ A Q QYKDQAEK G N V R V KQLK H QLE 1964
Cdd:pfam01576 961 VK SK Y K S SIAALEAK IAQL EEQLE Q ESRERQA AN K LV R RT EKKLK EVLL Q V EDER RN A D QYKDQAEK A N S R M KQLK R QLE 1040
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 1593656259 1965 EAEEEA Q R MA AARRKLQRELD E ATE ANDTLS R DMAS LRSKL 2005
Cdd:pfam01576 1041 EAEEEA S R AN AARRKLQRELD D ATE SAESMN R EVST LRSKL 1081
MYSc_class_II
cd01377 class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
169-848
0e+00
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276951
Cd Length: 662
Bit Score: 1308.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NLRERY F S S LIYTYSGLFCV V VNPYK M LPIY S E KI I EM YKGK K R H E V PPHI YS I T DNAYRNM M QDRE D QSIL C TG 248
Cdd:cd01377 1 ASVL H NLRERY Y S D LIYTYSGLFCV A VNPYK R LPIY T E EV I DK YKGK R R E E M PPHI FA I A DNAYRNM L QDRE N QSIL I TG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VA S S H K G KK DATPQ pqqagsla Y G E LE K Q L LQANPILEAFGNAKT IK N D NSSRFGKFI KLN 328
Cdd:cd01377 81 ESGAGKTENTKKVIQYLA S VA A S S K K KK ESGKK -------- K G T LE D Q I LQANPILEAFGNAKT VR N N NSSRFGKFI RIH 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 F DV TG Y I V GA N I D TYLLEKSR CI RQ SMT ER AF HIFY YMVA GA KDK L R E E LLL EDFSC Y R F LVA - G HVE I S G QE D D E M F IE 407
Cdd:cd01377 153 F GS TG K I A GA D I E TYLLEKSR VV RQ AKG ER NY HIFY QLLS GA DPE L K E K LLL TGDPS Y Y F FLS q G ELT I D G VD D A E E F KL 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 408 T L EA ME I M GF T EEE R M GMM K V V STV L Q LGNIKF EKE R NS EQA TMPDDTA A Q K VC HL Q G I N IT D FIR A I L T PRIKVGRE V V 487
Cdd:cd01377 233 T D EA FD I L GF S EEE K M SIF K I V AAI L H LGNIKF KQR R RE EQA ELDGTEE A D K AA HL L G V N SS D LLK A L L K PRIKVGRE W V 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 488 Q K A Q T K Q Q AD F A V E ALAKA M YERLF R W ILA R V NKTLD K s K RQSSS F L G I LDIAGFEIFE D NSFEQLCINYTNE R LQQ L FN 567
Cdd:cd01377 313 T K G Q N K E Q VV F S V G ALAKA L YERLF L W LVK R I NKTLD T - K SKRQY F I G V LDIAGFEIFE F NSFEQLCINYTNE K LQQ F FN 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 568 H T MFVLEQEEYK R EGI Q W S FIDFGLDLQP C I E LIE R PN np P GIL AL LDEEC W FPKATD VS FVEKL LNT H T G HV K - F S KPK 646
Cdd:cd01377 392 H H MFVLEQEEYK K EGI E W T FIDFGLDLQP T I D LIE K PN -- M GIL SI LDEEC V FPKATD KT FVEKL YSN H L G KS K n F K KPK 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 647 QH K DKLM F TVL HYAG K V D YN AAN WL T KN M DPLN D NV T ALL NN SS SNFIQD L W KD ADR vvgletitk MSESSAPP K S K K G M 726
Cdd:cd01377 470 PK K SEAH F ILK HYAG D V E YN IDG WL E KN K DPLN E NV V ALL KK SS DPLVAS L F KD YEE --------- SGGGGGKK K K K G G S 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTV G QL Y KE S L G KLMTTL HN T Q P N FVRCIIPN H EK RA GK M D SN LVL E QLRCNGVLEGIRICR Q GFPNRI V F Q EF R QRY E 806
Cdd:cd01377 541 FRTV S QL H KE Q L N KLMTTL RS T H P H FVRCIIPN E EK KP GK I D AP LVL H QLRCNGVLEGIRICR K GFPNRI I F A EF K QRY S 620
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 ILA A NAIPKGF M DGK Q AC CLMV K H L D LDP N LYRIG QS K M FF R 848
Cdd:cd01377 621 ILA P NAIPKGF D DGK A AC EKIL K A L Q LDP E LYRIG NT K V FF K 662
Myosin_N
pfam02736 Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
104-142
1.32e-12
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
Pssm-ID: 397036
Cd Length: 39
Bit Score: 63.56
E-value: 1.32e-12
10 20 30
....*....|....*....|....*....|....*....
gi 1593656259 104 KK M VW I P SE KEGF EAAS IKEE K GD E V L VE LSN G QKM TV N 142
Cdd:pfam02736 1 KK L VW V P DP KEGF VKGE IKEE E GD K V T VE TED G KTV TV K 39
Name
Accession
Description
Interval
E-value
Myosin_tail_1
pfam01576 Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
925-2005
0e+00
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 396244 [Multi-domain]
Cd Length: 1081
Bit Score: 1421.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 925 TRQEEEM GQ K D EEL KAA KE VAA K V E T ELK DITQ KH T QL M EE RAQ L EMK L H AETEL Y AEAEEMR V RL E A K KQELEE V LH EM 1004
Cdd:pfam01576 1 TRQEEEM QA K E EEL QKV KE KQQ K A E S ELK ELEK KH Q QL I EE KNI L AEQ L Q AETEL F AEAEEMR A RL A A R KQELEE I LH DL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1005 ESRLEEEE D RS NA L H NE R K E M E Q QL Q LM E AHIA EEE D ARQKLQ M EKV SV E G K V KKLEEDIL MM EDQN N KL Q KERKLLEER 1084
Cdd:pfam01576 81 ESRLEEEE E RS QQ L Q NE K K K M Q Q HI Q DL E EQLE EEE A ARQKLQ L EKV TT E A K I KKLEEDIL LL EDQN S KL S KERKLLEER 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1085 LADMS SNLAEEEEK S K N L S KLK T KHE S MIS E LE L R M KKEEKGR LDM EKAKRK VEA E LG DLQEQ H A D LQAQ LA ELRAQLA A 1164
Cdd:pfam01576 161 ISEFT SNLAEEEEK V K S L N KLK N KHE A MIS D LE D R L KKEEKGR QEL EKAKRK LDG E ST DLQEQ I A E LQAQ IE ELRAQLA K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1165 KEEELQA TQ ARLEEE CN Q RGA A V K RV REL EVL I S ELQEDLE A ERAAR G K V E AA RRDLGEEL N AL R TELED S L GT TAAQQE 1244
Cdd:pfam01576 241 KEEELQA AL ARLEEE GA Q KNN A L K KL REL QAQ I A ELQEDLE S ERAAR A K A E KQ RRDLGEEL E AL K TELED T L DS TAAQQE 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1245 LR A KREQEV SM LKKA M E D E G RSHEAQ V Q DL RQKH S QA V EEL T EQLEQAKR VR A G LEKAKQALE K E SAD L S A D L RS L AS AK 1324
Cdd:pfam01576 321 LR S KREQEV TE LKKA L E E E T RSHEAQ L Q EM RQKH T QA L EEL S EQLEQAKR NK A N LEKAKQALE S E NNE L Q A E L KT L QQ AK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1325 QD V EHK K KK V EGQL N EL NS R FN ESERQR T EL G E RV SKL TT EL D SV T GLL N EAEGK N IKLSKDVSSL S SQLQD A QELL S EE 1404
Cdd:pfam01576 401 QD S EHK R KK L EGQL Q EL QA R LS ESERQR A EL A E KL SKL QS EL E SV S GLL S EAEGK S IKLSKDVSSL E SQLQD T QELL Q EE 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1405 TRQKLNLS G RLRQ T E ED RNSL M EQLEEE T EAKR A VERQ V S S L NM QLS DS KKKL D E MS G T VEALEE G KKRLQRELEA ANSD 1484
Cdd:pfam01576 481 TRQKLNLS S RLRQ L E DE RNSL Q EQLEEE E EAKR N VERQ L S T L QA QLS EM KKKL E E DA G A VEALEE A KKRLQRELEA LTQR 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1485 Y EEKA S AYDKLEK SRG R M QQEL E D V L M DLD S QRQLVSNLEKKQKKFDQMLAEE R A V S CKF AEERDRAEAEAREKETR V L A 1564
Cdd:pfam01576 561 L EEKA A AYDKLEK TKN R L QQEL D D L L V DLD H QRQLVSNLEKKQKKFDQMLAEE K A I S ARY AEERDRAEAEAREKETR A L S 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1565 L A RALEE NQG A L EE A E KTM K G LRA D MEDL I SSKDDVGK S VH D LE KA KR G LE AI V D EM R TQ M EELEDELQ VA EDAKLRL D V 1644
Cdd:pfam01576 641 L S RALEE ALE A K EE L E RQN K Q LRA E MEDL V SSKDDVGK N VH E LE RS KR A LE QQ V E EM K TQ L EELEDELQ AT EDAKLRL E V 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1645 N T QAL R AQ H ER E L H ARDE L GEEKR K QL L KQVRELEAELE E ERKQR G QA SGS KKKLE GE LK DM E D Q LE A TSR GRDEAVKQL 1724
Cdd:pfam01576 721 N M QAL K AQ F ER D L Q ARDE Q GEEKR R QL V KQVRELEAELE D ERKQR A QA VAA KKKLE LD LK EL E A Q ID A ANK GRDEAVKQL 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1725 R K I Q G Q V K D LQR D LE DS RA AQK E V LA SAR ESE RRS K AM EA DIV QL H E M LAA V ERA RK QA EV ERDEL SE E L A SNS SGKS LM 1804
Cdd:pfam01576 801 K K L Q A Q M K E LQR E LE ET RA SRD E I LA QSK ESE KKL K SL EA ELL QL Q E D LAA S ERA KR QA QQ ERDEL AD E I A NGA SGKS AL 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1805 S DEKRRL DTK I S QLEEELEEEQ A N V E S LNDR L RK SQQL VEQL GA EL A AERS T SQ SR E GS RQQLERQN R ELKAK M QEMEG Q 1884
Cdd:pfam01576 881 L DEKRRL EAR I A QLEEELEEEQ S N T E L LNDR Y RK LTLQ VEQL TT EL S AERS F SQ KS E SA RQQLERQN K ELKAK L QEMEG T 960
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1885 GR SK L K A SIAALEAK LREA EEQLE I ESRERQA NG K NL R QK EKKLK DLTI Q M EDER KQ A Q QYKDQAEK G N V R V KQLK H QLE 1964
Cdd:pfam01576 961 VK SK Y K S SIAALEAK IAQL EEQLE Q ESRERQA AN K LV R RT EKKLK EVLL Q V EDER RN A D QYKDQAEK A N S R M KQLK R QLE 1040
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 1593656259 1965 EAEEEA Q R MA AARRKLQRELD E ATE ANDTLS R DMAS LRSKL 2005
Cdd:pfam01576 1041 EAEEEA S R AN AARRKLQRELD D ATE SAESMN R EVST LRSKL 1081
MYSc_class_II
cd01377 class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
169-848
0e+00
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276951
Cd Length: 662
Bit Score: 1308.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NLRERY F S S LIYTYSGLFCV V VNPYK M LPIY S E KI I EM YKGK K R H E V PPHI YS I T DNAYRNM M QDRE D QSIL C TG 248
Cdd:cd01377 1 ASVL H NLRERY Y S D LIYTYSGLFCV A VNPYK R LPIY T E EV I DK YKGK R R E E M PPHI FA I A DNAYRNM L QDRE N QSIL I TG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VA S S H K G KK DATPQ pqqagsla Y G E LE K Q L LQANPILEAFGNAKT IK N D NSSRFGKFI KLN 328
Cdd:cd01377 81 ESGAGKTENTKKVIQYLA S VA A S S K K KK ESGKK -------- K G T LE D Q I LQANPILEAFGNAKT VR N N NSSRFGKFI RIH 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 F DV TG Y I V GA N I D TYLLEKSR CI RQ SMT ER AF HIFY YMVA GA KDK L R E E LLL EDFSC Y R F LVA - G HVE I S G QE D D E M F IE 407
Cdd:cd01377 153 F GS TG K I A GA D I E TYLLEKSR VV RQ AKG ER NY HIFY QLLS GA DPE L K E K LLL TGDPS Y Y F FLS q G ELT I D G VD D A E E F KL 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 408 T L EA ME I M GF T EEE R M GMM K V V STV L Q LGNIKF EKE R NS EQA TMPDDTA A Q K VC HL Q G I N IT D FIR A I L T PRIKVGRE V V 487
Cdd:cd01377 233 T D EA FD I L GF S EEE K M SIF K I V AAI L H LGNIKF KQR R RE EQA ELDGTEE A D K AA HL L G V N SS D LLK A L L K PRIKVGRE W V 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 488 Q K A Q T K Q Q AD F A V E ALAKA M YERLF R W ILA R V NKTLD K s K RQSSS F L G I LDIAGFEIFE D NSFEQLCINYTNE R LQQ L FN 567
Cdd:cd01377 313 T K G Q N K E Q VV F S V G ALAKA L YERLF L W LVK R I NKTLD T - K SKRQY F I G V LDIAGFEIFE F NSFEQLCINYTNE K LQQ F FN 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 568 H T MFVLEQEEYK R EGI Q W S FIDFGLDLQP C I E LIE R PN np P GIL AL LDEEC W FPKATD VS FVEKL LNT H T G HV K - F S KPK 646
Cdd:cd01377 392 H H MFVLEQEEYK K EGI E W T FIDFGLDLQP T I D LIE K PN -- M GIL SI LDEEC V FPKATD KT FVEKL YSN H L G KS K n F K KPK 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 647 QH K DKLM F TVL HYAG K V D YN AAN WL T KN M DPLN D NV T ALL NN SS SNFIQD L W KD ADR vvgletitk MSESSAPP K S K K G M 726
Cdd:cd01377 470 PK K SEAH F ILK HYAG D V E YN IDG WL E KN K DPLN E NV V ALL KK SS DPLVAS L F KD YEE --------- SGGGGGKK K K K G G S 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTV G QL Y KE S L G KLMTTL HN T Q P N FVRCIIPN H EK RA GK M D SN LVL E QLRCNGVLEGIRICR Q GFPNRI V F Q EF R QRY E 806
Cdd:cd01377 541 FRTV S QL H KE Q L N KLMTTL RS T H P H FVRCIIPN E EK KP GK I D AP LVL H QLRCNGVLEGIRICR K GFPNRI I F A EF K QRY S 620
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 ILA A NAIPKGF M DGK Q AC CLMV K H L D LDP N LYRIG QS K M FF R 848
Cdd:cd01377 621 ILA P NAIPKGF D DGK A AC EKIL K A L Q LDP E LYRIG NT K V FF K 662
Myosin_head
pfam00063 Myosin head (motor domain);
157-848
0e+00
Myosin head (motor domain);
Pssm-ID: 395017
Cd Length: 674
Bit Score: 1073.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 157 VEDM AA L TF LNE A SVL Q NL RE RY F S S LIYTYSGL FC V V VNPYK M LPIYSE KI I EM Y K GK K R H E V PPHI YS I T D N AYR N M M 236
Cdd:pfam00063 1 VEDM VE L SY LNE P SVL H NL KK RY K S D LIYTYSGL VL V A VNPYK Q LPIYSE DM I KA Y R GK R R G E L PPHI FA I A D E AYR S M L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 237 QD R E D QSIL CT GESGAGKTENTKK VI QYLA V V AS S HKGKK datpqpqqagsla Y G E LE K Q L LQ A NPILEAFGNAKT IK N D 316
Cdd:pfam00063 81 QD K E N QSIL IS GESGAGKTENTKK IM QYLA S V SG S GSAGN ------------- V G R LE E Q I LQ S NPILEAFGNAKT VR N N 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 317 NSSRFGK F I KLN FD VT G Y IVG AN I D TYLLEKSR CIR Q SMT ER AF HIFY YMV AGA KDK L RE EL L L EDFSC Y RF L VA - G HVE 395
Cdd:pfam00063 148 NSSRFGK Y I EIQ FD AK G D IVG GK I E TYLLEKSR VVY Q AEG ER NY HIFY QLL AGA SAQ L KK EL R L TNPKD Y HY L SQ s G CYT 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 396 I S G QE D D E M F IE T LE AM E I M GF TE EE R MG MMKV V STV L Q LGNI K F E KERN S EQA TMP D DTAA QK VCH L Q GI NI T DFIR A I 475
Cdd:pfam00063 228 I D G ID D S E E F KI T DK AM D I L GF SD EE Q MG IFRI V AAI L H LGNI E F K KERN D EQA VPD D TENL QK AAS L L GI DS T ELEK A L 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 476 LTP RIK V GRE V V Q K A Q TKQ QA DF A VE ALAKA M Y E RLF R W ILA R V NK T LD KSKRQSS SF L G I LDI A GFEIFE D NSFEQLCI 555
Cdd:pfam00063 308 CKR RIK T GRE T V S K P Q NVE QA NY A RD ALAKA I Y S RLF D W LVD R I NK S LD VKTIEKA SF I G V LDI Y GFEIFE K NSFEQLCI 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 556 NY T NE R LQQ L FNH T MF V LEQEEY K REGI Q W S FIDFG l D L QPCI E LIE RP nn P P GIL A LLDEEC W FPKATD VS F VE KL LN T 635
Cdd:pfam00063 388 NY V NE K LQQ F FNH H MF K LEQEEY V REGI E W T FIDFG - D N QPCI D LIE KK -- P L GIL S LLDEEC L FPKATD QT F LD KL YS T 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 636 HTG H VK F S KP KQ h KDKLM F TVL HYAG K V D YN AANW L T KN M DPLND NVTA LL NN SS SNFIQD L WK D ADRVV gl ETITKM S E 715
Cdd:pfam00063 465 FSK H PH F Q KP RL - QGETH F IIK HYAG D V E YN VEGF L E KN K DPLND DLVS LL KS SS DPLLAE L FP D YETAE -- SAAANE S G 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 716 S S A P PKS KK GM F R TVG QLY KESLG K LM T TL HN T Q P NFV RCI I PN HE KRAG KM D SN LVL E QLRCNGVLEGIRI C R Q GFPNR 795
Cdd:pfam00063 542 K S T P KRT KK KR F I TVG SQF KESLG E LM K TL NS T N P HYI RCI K PN EK KRAG VF D NS LVL H QLRCNGVLEGIRI R R A GFPNR 621
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1593656259 796 I V FQEF R QRY E ILA ANAI PK GFM D G K QA C CLMVKH L D LD PNL Y RI G QS K M FFR 848
Cdd:pfam00063 622 I T FQEF V QRY R ILA PKTW PK WKG D A K KG C EAILQS L N LD KEE Y QF G KT K I FFR 674
MYSc
smart00242 Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
150-860
0e+00
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.
Pssm-ID: 214580
Cd Length: 677
Bit Score: 990.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 150 NPPKF SK VED MAA LT F LNE AS VL Q NL RE RY FSS LIYTY S GL FC V V VNPYK M LPIY SEKI I EM Y K GK K R H E V PPH IYS I T D 229
Cdd:smart00242 1 NPPKF EG VED LVL LT Y LNE PA VL H NL KK RY LKD LIYTY I GL VL V A VNPYK Q LPIY TDEV I KK Y R GK S R G E L PPH VFA I A D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 230 NAYRNM MQ D R E D QSI LCT GESGAGKTENTKK VI QYLA V V AS S HKGK kdatpqpqqagslay G EL E K Q L L QA NPILEAFGN 309
Cdd:smart00242 81 NAYRNM LN D K E N QSI IIS GESGAGKTENTKK IM QYLA S V SG S NTEV --------------- G SV E D Q I L ES NPILEAFGN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 310 AKT IK N D NSSRFGKFI KLN FD VT G Y I V GA N I D TYLLEKSR CIR Q SMT ER AF HIFY YMV AGA KDK L RE EL L L EDFSC YR F L 389
Cdd:smart00242 146 AKT LR N N NSSRFGKFI EIH FD AK G K I I GA K I E TYLLEKSR VVS Q AKG ER NY HIFY QLL AGA SEE L KK EL G L KSPED YR Y L 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 390 - VA G HVEIS G QE D D E M F I ETL E AM EIM GF T EEE RMGMM K VVSTV L Q LGNI K FE KE RN SEQ A TMPD D T - AAQKVCH L Q G IN 467
Cdd:smart00242 226 n QG G CLTVD G ID D A E E F K ETL N AM RVL GF S EEE QESIF K ILAAI L H LGNI E FE EG RN DNA A STVK D K e ELSNAAE L L G VD 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 468 ITDFIR A ILTPR IK V G R EV VQ K AQTKQ QA DF A VE ALAKA M Y E RLF R W ILA R V N KT L DK s K RQ S SS F L G I LDI A GFEIFE D 547
Cdd:smart00242 306 PEELEK A LTKRK IK T G G EV IT K PLNVE QA LD A RD ALAKA L Y S RLF D W LVK R I N QS L SF - K DG S TY F I G V LDI Y GFEIFE V 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 548 NSFEQLCINY T NE R LQQ L FN HTM F V LEQEEY K REGI Q W S FIDF G l D L Q P CI E LIE rp NN PPGIL A LLDEEC W FPK A TD VS 627
Cdd:smart00242 385 NSFEQLCINY A NE K LQQ F FN QHV F K LEQEEY E REGI D W T FIDF F - D N Q D CI D LIE -- KK PPGIL S LLDEEC R FPK G TD QT 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 628 F V EKL LNT H TG H VK FSKPK Q h K DKLM F TVL HYAG K V D Y NAANW L T KN M D P L N D NVTA LL NN S SSNF I QD L W kdadrvvgl 707
Cdd:smart00242 462 F L EKL NQH H KK H PH FSKPK K - K GRTE F IIK HYAG D V T Y DVTGF L E KN K D T L S D DLIE LL QS S KNPL I AS L F --------- 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 708 etitkms E S SAPPKSK K GM F R TVG QLY KE S L GK LM T TL HN T Q P N F V RCI I PN H EK RA G KM DS N LVL E QLR CN GVLE G IRI 787
Cdd:smart00242 532 ------- P S GVSNAGS K KR F Q TVG SQF KE Q L NE LM D TL NS T N P H F I RCI K PN E EK KP G DF DS S LVL H QLR YL GVLE N IRI 604
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1593656259 788 C R Q GFP N R IV F Q EF R QRY EI L AANAI P KGFM D G K Q AC CLMVKH L D LD PNL Y RI G QS K M F F R T G V LA Q LEE E R D 860
Cdd:smart00242 605 R R A GFP Y R LP F D EF L QRY RV L LPDTW P PWGG D A K K AC EALLQS L G LD EDE Y QL G KT K V F L R P G Q LA E LEE L R E 677
COG5022
COG5022 Myosin heavy chain [General function prediction only];
107-1702
0e+00
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain]
Cd Length: 1463
Bit Score: 888.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 107 V WIP S E KE G FEA A S I KE E --- KG D - EVLVELSN G QKMT V N K DDIQ -- KMNP PKF SK V E D MAA L TF LNE AS VL Q NL RE RY F 180
Cdd:COG5022 12 C WIP D E EK G WIW A E I IK E afn KG K v TEEGKKED G ESVS V K K KVLG nd RIKL PKF DG V D D LTE L SY LNE PA VL H NL EK RY N 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 181 SSL IYTYSGL FCVV VNPY KM L P IY SEK II EM Y K GK K R H E VP PH IYS I TDN AYRN MMQDR E D Q S I LCT GESGAGKTEN T K K 260
Cdd:COG5022 92 NGQ IYTYSGL VLIA VNPY RD L G IY TDD II QS Y S GK N R L E LE PH VFA I AEE AYRN LLSEK E N Q T I IIS GESGAGKTEN A K R 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 261 VI QYLA V V A SS H kgkkda T PQPQQ agslayge L EKQ L L QA NPILEAFGNAKT IK NDNSSRFGK F IK LN FD VT G Y I V GA N I 340
Cdd:COG5022 172 IM QYLA S V T SS S ------ T VEISS -------- I EKQ I L AT NPILEAFGNAKT VR NDNSSRFGK Y IK IE FD EN G E I C GA K I 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 341 D TYLLEKSR CIR Q SMT ER AF HIFY YMV AG AKDK L REE LLL EDFSC Y RF L VA G HV - E I S G QE D DEM F IE TL E A MEIM G FT E 419
Cdd:COG5022 238 E TYLLEKSR VVH Q NKN ER NY HIFY QLL AG DPEE L KKL LLL QNPKD Y IY L SQ G GC d K I D G ID D AKE F KI TL D A LKTI G ID E 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 420 EE RMGMM K VVSTV L QL GNI K F EKE RN s EQ A TMP D DTAAQ K V C H L Q GI NITD F IRAILTPR IK V G R E VVQKAQTKQ QA DFA 499
Cdd:COG5022 318 EE QDQIF K ILAAI L HI GNI E F KED RN - GA A IFS D NSVLD K A C Y L L GI DPSL F VKWLVKRQ IK T G G E WIVVPLNLE QA LAI 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 500 VEA LAKA M Y ER LF R WI LA R V NK T LD K S KRQ s S S F L G I LDI A GFEIFE D NSFEQLCINYTNE R LQQ L FN HT MF V LEQEEY K 579
Cdd:COG5022 397 RDS LAKA L Y SN LF D WI VD R I NK S LD H S AAA - S N F I G V LDI Y GFEIFE K NSFEQLCINYTNE K LQQ F FN QH MF K LEQEEY V 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 580 R EGI Q WSFID F g L D L QPCI E LIE R p N NP P GIL A LLDEEC WF P K ATD V SF VE KL --- LN THTGH v KF S K PKQHKD K lm F T V 656
Cdd:COG5022 476 K EGI E WSFID Y - F D N QPCI D LIE K - K NP L GIL S LLDEEC VM P H ATD E SF TS KL aqr LN KNSNP - KF K K SRFRDN K -- F V V 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 657 L HYAG K V D Y NAANW L T KN M DPLND NVTA LL NN S SSN F IQD L WK D ADR vvgletitkmsessapp KSK KG M F R T V G QLY KE 736
Cdd:COG5022 551 K HYAG D V E Y DVEGF L D KN K DPLND DLLE LL KA S TNE F VST L FD D EEN ----------------- IES KG R F P T L G SRF KE 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 737 SL GK LM T TL HN TQP NFV RCI I PN H EK RAGKM D SNL VL E QLRC N GVLE G IRI C R Q GFP N R IV F Q EF R QRY E IL AANA ---- 812
Cdd:COG5022 614 SL NS LM S TL NS TQP HYI RCI K PN E EK SPWTF D NQM VL S QLRC C GVLE T IRI S R A GFP S R WT F D EF V QRY R IL SPSK swtg 693
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 813 IPKGFM D G K Q A CCLMVKH L DL D PNL Y R IG QS K M FF RT GVLA Q LE EE RD L KL TVVIIAF Q AQA RG FLA R KAFSKRQQQLTA 892
Cdd:COG5022 694 EYTWKE D T K N A VKSILEE L VI D SSK Y Q IG NT K V FF KA GVLA A LE DM RD A KL DNIATRI Q RAI RG RYL R RRYLQALKRIKK 773
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 893 MK VIQ RNCACYLKLKNWQW WRLF T K VK PLL QVTRQEE E MGQKDEELK aakevaa K VETEL K DITQKHTQLME E RAQLEMK 972
Cdd:COG5022 774 IQ VIQ HGFRLRRLVDYELK WRLF I K LQ PLL SLLGSRK E YRSYLACII ------- K LQKTI K REKKLRETEEV E FSLKAEV 846
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 973 L HAETELYAE A EE m R VR L EA K KQELEEVL hemesrleeeedrsnalhnerkemeqqlqlmeahi AEE E D A RQK LQ ME K VS 1052
Cdd:COG5022 847 L IQKFGRSLK A KK - R FS L LK K ETIYLQSA ----------------------------------- QRV E L A ERQ LQ EL K ID 890
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1053 V E g KVKK L EE dilmmed Q N NK L QK E rk LL E ERLADM S SNLAEE E E K SKNLSK LK - TKHESMIS E LELRM -- K KE E KGR L D 1129
Cdd:COG5022 891 V K - SISS L KL ------- V N LE L ES E -- II E LKKSLS S DLIENL E F K TELIAR LK k LLNNIDLE E GPSIE yv K LP E LNK L H 960
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1130 MEKA K rkveae L GDLQ E QHA DL QAQLAE L RAQLAAKEE EL QATQAR L E E ECN Q R GA AVKRVRE L EV L IS E LQ E DLE A ER a 1209
Cdd:COG5022 961 EVES K ------ L KETS E EYE DL LKKSTI L VREGNKANS EL KNFKKE L A E LSK Q Y GA LQESTKQ L KE L PV E VA E LQS A SK - 1033
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1210 argkveaarrdlge ELNALR TEL edslgttaaqqelra KREQEVSM LK KAMED E GRSHE A QVQD L RQKHSQAVEELT e QL 1289
Cdd:COG5022 1034 -------------- IISSES TEL --------------- SILKPLQK LK GLLLL E NNQLQ A RYKA L KLRRENSLLDDK - QL 1083
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1290 E Q AKRVR a G L E K AKQALEK E SADLSADLRSLASAKQDVEHK K KKVEGQLNELN S RFNESERQRT elg ERV S K L TT ELD SV 1369
Cdd:COG5022 1084 Y Q LESTE - N L L K TINVKDL E VTNRNLVKPANVLQFIVAQMI K LNLLQEISKFL S QLVNTLEPVF --- QKL S V L QL ELD GL 1159
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1370 TGLL N EAE gkni KL S KDVSSLS S qlqda QEL L SEETRQKLNLSGRL rqteedrn S LMEQ L EE E TE A KRAVERQVSSLNMQ 1449
Cdd:COG5022 1160 FWEA N LEA ---- LP S PPPFAAL S ----- EKR L YQSALYDEKSKLSS -------- S EVND L KN E LI A LFSKIFSGWPRGDK 1222
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1450 L SDSKKKLDEMSGTVEA L EEGKKRLQRELEA A NSDY E EKA S AYDKLEKS rg RMQQE LE DVLMDL d SQRQ L VSNL ek KQKK 1529
Cdd:COG5022 1223 L KKLISEGWVPTEYSTS L KGFNNLNKKFDTP A SMSN E KLL S LLNSIDNL -- LSSYK LE EEVLPA - TINS L LQYI -- NVGL 1297
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1530 F DQMLAEERAVSC K F A E E -- RDRA E AEAREK E TRVLALARA LEE nqga L EE A E K TMKG L RA D MED L i SSKD D VGK S VHDL 1607
Cdd:COG5022 1298 F NALRTKASSLRW K S A T E vn YNSE E LDDWCR E FEISDVDEE LEE ---- L IQ A V K VLQL L KD D LNK L - DELL D ACY S LNPA 1372
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1608 E KAKRGLE aiv DEMRTQMEE L ED E LQVAED A K L RLDVNTQA L RAQH E R E L H ARDELG EEK RKQL L K qvre LEAELE EE RK 1687
Cdd:COG5022 1373 E IQNLKSR --- YDPADKENN L PK E ILKKIE A L L IKQELQLS L EGKD E T E V H LSEIFS EEK SLIS L D ---- RNSIYK EE VL 1445
1610
....*....|....*
gi 1593656259 1688 QRGQ A SGS K K K LEGE 1702
Cdd:COG5022 1446 SSLS A LLT K E K IALL 1460
PTZ00014
PTZ00014 myosin-A; Provisional
131-891
1.10e-128
myosin-A; Provisional
Pssm-ID: 240229 [Multi-domain]
Cd Length: 821
Bit Score: 425.98
E-value: 1.10e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 131 VELSNGQKMT V NKDDIQKM N PP - KFSKVE D MAA L TFL N EAS VL QN L RE RY FSSL IYT YSGLFC V VV NP Y K M L PIYSEKI I 209
Cdd:PTZ00014 71 IDPPTNSTFE V KPEHAFNA N SQ i DPMTYG D IGL L PHT N IPC VL DF L KH RY LKNQ IYT TADPLL V AI NP F K D L GNTTNDW I 150
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 210 EM Y KGK K RHE - V PPH IYSITDN A YR N MMQDRED Q S I LCT GESGAGKTE N TK KVIQ Y L A vva SS HK G KK D ATP Q pqqagsl 288
Cdd:PTZ00014 151 RR Y RDA K DSD k L PPH VFTTARR A LE N LHGVKKS Q T I IVS GESGAGKTE A TK QIMR Y F A --- SS KS G NM D LKI Q ------- 220
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 289 aygele KQLLQ ANP I LEAFGNAKTI K N D NSSRFG K F IK L NFDVT G Y I VGAN I DTY LLEKSR CIR Q SMT ER AF HIFY YMVA 368
Cdd:PTZ00014 221 ------ NAIMA ANP V LEAFGNAKTI R N N NSSRFG R F MQ L QLGEE G G I RYGS I VAF LLEKSR VVT Q EDD ER SY HIFY QLLK 294
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 369 GA K D KLR E ELL L EDFSC Y RFLVAGHVEIS G QE D DEM F I E TL E AMEI MG FT E EERMGMMKVV S T VL Q LGN IKF E - KE RN -- 445
Cdd:PTZ00014 295 GA N D EMK E KYK L KSLEE Y KYINPKCLDVP G ID D VKD F E E VM E SFDS MG LS E SQIEDIFSIL S G VL L LGN VEI E g KE EG gl 374
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 446 SEQ A TMP D DTAA -- QKV C H L QGINITDFIRAILTPRIKV G REVVQKAQT K QQADFAVEA L A KA M YE R LF R WI LARV N K T L 523
Cdd:PTZ00014 375 TDA A AIS D ESLE vf NEA C E L LFLDYESLKKELTVKVTYA G NQKIEGPWS K DESEMLKDS L S KA V YE K LF L WI IRNL N A T I 454
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 524 DKSK r QSSS F L G I LDI A GFE I F ED NS F EQL C IN Y TNE R LQ QL F NHTM F VL E QEE YK R EGI QWSFIDF g LDLQPC I E L IER 603
Cdd:PTZ00014 455 EPPG - GFKV F I G M LDI F GFE V F KN NS L EQL F IN I TNE M LQ KN F VDIV F ER E SKL YK D EGI STEELEY - TSNESV I D L LCG 532
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 604 PNN pp GI L AL L DEE C WF P KA TD VS FV EKLLNTHTGHV K FSKP K QHKD K l M F TVL H YA G KVD Y N A ANW L T KN M D P L NDNVT 683
Cdd:PTZ00014 533 KGK -- SV L SI L EDQ C LA P GG TD EK FV SSCNTNLKNNP K YKPA K VDSN K - N F VIK H TI G DIQ Y C A SGF L F KN K D V L RPELV 609
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 684 ALLNN S SSNFIQ DL WKDADRVV G letitkmsessapp K SK KG MF rt V G QLYKES L GK LM TTLHN T Q P N F V RCI I PN HE K R 763
Cdd:PTZ00014 610 EVVKA S PNPLVR DL FEGVEVEK G -------------- K LA KG QL -- I G SQFLNQ L DS LM SLINS T E P H F I RCI K PN EN K K 673
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 764 AGKMD S NL VL E QL RCNGV LE GIRICRQ GF PN R IV F Q EF RQRYEI L AANAIPKGFM D G K QACCLMVKHLD L DPNL Y R IG QS 843
Cdd:PTZ00014 674 PLDWN S SK VL I QL HSLSI LE ALQLRQL GF SY R RT F A EF LSQFKY L DLAVSNDSSL D P K EKAEKLLERSG L PKDS Y A IG KT 753
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 1593656259 844 KM F F - RTGV -- L A Q LEE E RDLKLTVVIIAFQ A QARGFLARKAFS K RQQQ L T 891
Cdd:PTZ00014 754 MV F L k KDAA ke L T Q IQR E KLAAWEPLVSVLE A LILKIKKKRKVR K NIKS L V 804
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
934-1805
1.05e-33
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 142.50
E-value: 1.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 934 K D EE LK A AK E V AA -------- KV ETE L K - DI T QKHTQ ----- L M E ERA QL E m K L HAET E LYAEAE E MRVR L EAKK ----- 994
Cdd:TIGR02168 153 K P EE RR A IF E E AA giskyker RK ETE R K l ER T RENLD rledi L N E LER QL K - S L ERQA E KAERYK E LKAE L RELE lallv 231
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 995 --- Q EL E E V L H E MESR L E E E E DRSNA L HN E RK E M E QQ L QLMEAHIA E E E DARQK LQ M E KVSVEGKVKK LE EDILMMEDQN 1071
Cdd:TIGR02168 232 lrl E EL R E E L E E LQEE L K E A E EELEE L TA E LQ E L E EK L EELRLEVS E L E EEIEE LQ K E LYALANEISR LE QQKQILRERL 311
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1072 NK L QKERKL LE ER L ADMS S N L A E EE E KSKN L SKLKTKHESMISE LE LRMKKE E KGRLDM E KAKRKV E AE L GD L QEQH A D L 1151
Cdd:TIGR02168 312 AN L ERQLEE LE AQ L EELE S K L D E LA E ELAE L EEKLEELKEELES LE AELEEL E AELEEL E SRLEEL E EQ L ET L RSKV A Q L 391
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1152 QA Q L A E L RAQLAAK E EE L QATQA R L E EECNQRGAAV K RVR E L E V li S ELQ ED LE AERAARGKVEAARRD L G E E L NA LR T E 1231
Cdd:TIGR02168 392 EL Q I A S L NNEIERL E AR L ERLED R R E RLQQEIEELL K KLE E A E L -- K ELQ AE LE ELEEELEELQEELER L E E A L EE LR E E 469
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1232 LE dslgtt A A Q Q E L R A KR -- EQEVSMLKKAM E DEGRSH E AQVQDLRQ -- K HSQAVEELTEQ L EQAKR V RA G L E K A KQ A LE 1307
Cdd:TIGR02168 470 LE ------ E A E Q A L D A AE re LAQLQARLDSL E RLQENL E GFSEGVKA ll K NQSGLSGILGV L SELIS V DE G Y E A A IE A AL 543
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1308 KESADLSAD l RS L AS AK QDVEHK K KKVE G QLNE L nsrfneserqrtelgervskltt E LDS VT G LLNEAEGKN I KLSKD v 1387
Cdd:TIGR02168 544 GGRLQAVVV - EN L NA AK KAIAFL K QNEL G RVTF L ----------------------- P LDS IK G TEIQGNDRE I LKNIE - 598
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1388 ssls SQ L QD A QE L LSEETRQKLN LS GR L RQTE -- E D RNSLM E QLEEETEAK R A V ERQVSSLNMQLSDSKKKLDEM S GTV E 1465
Cdd:TIGR02168 599 ---- GF L GV A KD L VKFDPKLRKA LS YL L GGVL vv D D LDNAL E LAKKLRPGY R I V TLDGDLVRPGGVITGGSAKTN S SIL E 674
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1466 ALE E g KKR L QREL E AANSDYE E KAS A YDK L E K SRGRMQQ ELE DVLMD L DSQRQLV S N L E K K qkkfdqm LA EER A VSCKFA 1545
Cdd:TIGR02168 675 RRR E - IEE L EEKI E ELEEKIA E LEK A LAE L R K ELEELEE ELE QLRKE L EELSRQI S A L R K D ------- LA RLE A EVEQLE 746
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1546 E ERDRAEA E AR E K E TRVLA L ARA LEE NQGA L E EAE KTMKG L R A DM E D ------- L ISSK D DVGKSVHD L EKAKRG L EAIV 1618
Cdd:TIGR02168 747 E RIAQLSK E LT E L E AEIEE L EER LEE AEEE L A EAE AEIEE L E A QI E Q lkeelka L REAL D ELRAELTL L NEEAAN L RERL 826
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1619 DEMRTQMEEL E DE L QVA E DAKLR L DVNTQA L R A QH E RELHARD EL g E EKRKQ LL KQVRE LE AE L EEE R KQRGQA S GSKKK 1698
Cdd:TIGR02168 827 ESLERRIAAT E RR L EDL E EQIEE L SEDIES L A A EI E ELEELIE EL - E SELEA LL NERAS LE EA L ALL R SELEEL S EELRE 905
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1699 LE GELKDMEDQ LE ATSRGRDEAVKQ L RKIQGQVKD LQ -------- RD LE DSR A AQKEVLASAR E SE RR S K AM E AD I VQ L H 1770
Cdd:TIGR02168 906 LE SKRSELRRE LE ELREKLAQLELR L EGLEVRIDN LQ erlseeys LT LE EAE A LENKIEDDEE E AR RR L K RL E NK I KE L G 985
890 900 910
....*....|....*....|....*....|....*..
gi 1593656259 1771 EM - LAA V E RARKQA E v ER D E L SEELAS - NSSGKS L MS 1805
Cdd:TIGR02168 986 PV n LAA I E EYEELK E - RY D F L TAQKED l TEAKET L EE 1021
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
962-1622
2.76e-20
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 98.21
E-value: 2.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 962 L M E ERAQLEMKLHAETELYAEA E EMRVRLEA K KQ ELEEVL H E MESRLE E EEDRSNA L HNER KE MEQ qlql M E AHIA E E E d 1041
Cdd:PRK03918 167 L G E VIKEIKRRIERLEKFIKRT E NIEELIKE K EK ELEEVL R E INEISS E LPELREE L EKLE KE VKE ---- L E ELKE E I E - 241
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1042 arq K L QM E KV S V EG KVK KLEE D I LMM E DQNNK L Q KE RKL LEE RLADMSS n L A E EE E KSKN LS KLKTKH esmiselelrmk 1121
Cdd:PRK03918 242 --- E L EK E LE S L EG SKR KLEE K I REL E ERIEE L K KE IEE LEE KVKELKE - L K E KA E EYIK LS EFYEEY ------------ 305
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1122 keekgrldm EKAK R KV E AE L GD L Q E QHADLQAQLA E lraq L AA KEE E L QATQAR L E E ECNQRGAAVK R VREL E v LISELQ 1201
Cdd:PRK03918 306 --------- LDEL R EI E KR L SR L E E EINGIEERIK E ---- L EE KEE R L EELKKK L K E LEKRLEELEE R HELY E - EAKAKK 371
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1202 E D LE AERAARG -- KV E AARRD L g EEL NALRT E L E DSLGTTA A Q qel RAKREQ E VSM LKKA M E degrshea QVQDLRQ K HS 1279
Cdd:PRK03918 372 E E LE RLKKRLT gl TP E KLEKE L - EEL EKAKE E I E EEISKIT A R --- IGELKK E IKE LKKA I E -------- ELKKAKG K CP 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1280 QAVE ELTE qleqakrvragl E KA K QA LE KES A D L S adlrslasakq DV E HKK K KV E GQLNE L NSRFN E S E RQRTE l GERV 1359
Cdd:PRK03918 440 VCGR ELTE ------------ E HR K EL LE EYT A E L K ----------- RI E KEL K EI E EKERK L RKELR E L E KVLKK - ESEL 495
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1360 S KL TTELDSVTG L LNEAEGK N IKLSK dvsslssql QD A Q E L ls E ETRQ KL N - L S G RLRQTEED rnsl M E Q LEE ETEAKRA 1438
Cdd:PRK03918 496 I KL KELAEQLKE L EEKLKKY N LEELE --------- KK A E E Y -- E KLKE KL I k L K G EIKSLKKE ---- L E K LEE LKKKLAE 560
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1439 V E RQVSS L NMQ L SDSK K K L D E MS gt V E AL EE GKK RL Q r ELE AANSD Y E E KAS A YDK LE ksrg R MQQ EL EDVLMD LD SQRQ 1518
Cdd:PRK03918 561 L E KKLDE L EEE L AELL K E L E E LG -- F E SV EE LEE RL K - ELE PFYNE Y L E LKD A EKE LE ---- R EEK EL KKLEEE LD KAFE 633
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1519 lvs N L EKKQ K KFDQMLA E ERAVSC K FA EE R - DRAEA E AR E KETRVLA L ARA LEE NQGAL EE AE KT MKG L RADM E DLISS K 1597
Cdd:PRK03918 634 --- E L AETE K RLEELRK E LEELEK K YS EE E y EELRE E YL E LSRELAG L RAE LEE LEKRR EE IK KT LEK L KEEL E EREKA K 710
650 660
....*....|....*....|....*
gi 1593656259 1598 ddvg K SVHD LEKA KRGL E AIVDEMR 1622
Cdd:PRK03918 711 ---- K ELEK LEKA LERV E ELREKVK 731
Myosin_N
pfam02736 Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
104-142
1.32e-12
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.
Pssm-ID: 397036
Cd Length: 39
Bit Score: 63.56
E-value: 1.32e-12
10 20 30
....*....|....*....|....*....|....*....
gi 1593656259 104 KK M VW I P SE KEGF EAAS IKEE K GD E V L VE LSN G QKM TV N 142
Cdd:pfam02736 1 KK L VW V P DP KEGF VKGE IKEE E GD K V T VE TED G KTV TV K 39
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
1033-1349
1.16e-11
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 69.94
E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1033 EA HI A EEED A RQKLQMEKVSV E GKV K KL EE DILMM ED QNN K LQKER K LL EE RLA dmssnla E E EEK S KNLS K LKTKHESM 1112
Cdd:NF033930 33 EA PV A SQSK A EKDYDAAVKKS E AAK K AY EE AKKKA ED AQK K YDEDQ K KT EE KAK ------- K E KKA S EEEQ K ANLAVQKA 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1113 I se LEL R MKKEE K GR l D ME K AKRKVEAELGDLQEQHADLQ A QLAEL RA QLAAKE EEL QA T QARL EE ECNQRGA A V K R V R E 1192
Cdd:NF033930 106 Y -- VKY R KAQRR K KS - D YK K KLAEADKKIDEAKKKQKEAK A EFNKV RA KVVPEA EEL AE T KKKA EE AKAEEPV A K K K V D E 182
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1193 LEVLIS E LQEDL EAE R A ARG K VEAARRD L GEE ---------- L NALRT E LED S LGTTAAQQE LRA KR E Q E VS ----- ML K 1257
Cdd:NF033930 183 AKKKVE E AKKKV EAE E A EIE K LQNEEVA L EAK iaelenqvdn L EKELA E IDE S DSEDYIKEG LRA PL E S E LD akqak LA K 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1258 K AM E D E ---- GRSH E AQV QD LRQ K HS q A V EEL TEQLEQAKRVR A G LEK AKQA LE KESADLSADL rs LASAKQ D VEH KK KK 1333
Cdd:NF033930 263 K QT E L E klld SLDP E GKT QD ELD K EA - A E EEL SKKIDELDNEV A K LEK EVSD LE NSDNNVADYY -- KEALEK D LAT KK AE 339
330
....*....|....*.
gi 1593656259 1334 V E GQLNE L NSRF NE SE 1349
Cdd:NF033930 340 L E KTQKD L DKAL NE LG 355
Streccoc_I_II
NF033804 antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins ...
935-1347
1.59e-11
antigen I/II family LPXTG-anchored adhesin; Members of the antigen I/II family are adhesins with a glucan-binding domain, two types of repetitive regions, an isopeptide bond-forming domain associated with shear resistance, and a C-terminal LPXTG motif for anchoring to the cell wall. They occur in oral Streptococci, and tend to be major cell surface adhesins. Members of this family include SspA and SspB from Streptococcus gordonii, antigen I/II from S. mutans, etc.
Pssm-ID: 411384 [Multi-domain]
Cd Length: 1552
Bit Score: 69.97
E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 935 D EEL K A AK EVAAK V ETE l KDITQKHTQLME E R AQ LEMKLHAE tel YA - E AEE MRVRL EA K K Q E LE evlhemes RLEE E E D 1013
Cdd:NF033804 95 D KAV K D AK SAGVN V VQD - ETVDKGTATTAT E N AQ KQTEIKSD --- YA k Q AEE IKKTT EA Y K K E VA -------- AHQA E T D 162
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1014 RS NA lhn E R K EMEQQL Q L - ME AH I AE E E DARQKLQME K VSV E G K VKKLEE D ILMMEDQ N NKL Q K -- ER KL -- LEER LA DM 1088
Cdd:NF033804 163 KI NA --- E N K AAKDKY Q K d LK AH Q AE V E KINTANATA K AEY E A K LAQYQK D LAAVQKA N EDS Q A dy QN KL sa YQTE LA RV 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1089 - SS N LAEE E EKS K NLSKLKT K HESMIS E L E LRMKKE E KGRLDM E K A KRKV EA E L GDLQEQHA D LQ A qla ELR A Q LAA KEE 1167
Cdd:NF033804 240 q KA N AEAK E AYD K AVKENTA K NAALQA E N E AIKQRN E TAKANY E A A MKQY EA D L AAIKKAKE D ND A --- DYQ A K LAA YQT 316
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1168 EL QAT Q A rle EECNQRG A AV K R V R E LEVLISEL Q EDL EA ER ---- AA RGKV EAA RRDLGEE L N A LRTELEDSL gtt A AQ Q 1243
Cdd:NF033804 317 EL ARV Q K --- ANADAKA A YE K A V E E NTAKNTAI Q AEN EA IK qrna AA KATY EAA LKQYEAD L A A VKKANAANE --- A DY Q 390
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1244 ELR A KREQ E VSMLK KA ME D EGRSH E AQ V Q D LRQ K HS qave E L TEQL E QA K RVR A GLEKAKQ A - L E K ES ADL S --- A DL RS 1319
Cdd:NF033804 391 AKL A AYQT E LARVQ KA NA D AKAAY E KA V E D NKA K NA ---- A L QAEN E AI K QRN A AAKADYE A k L A K YQ ADL A kyk K DL AE 466
410 420
....*....|....*....|....*...
gi 1593656259 1320 LASAKQDV E HKKK K VEGQ L N EL NSRF NE 1347
Cdd:NF033804 467 YPAKLKAY E DEQA K IKAA L A EL EKKK NE 494
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
1417-1764
1.68e-10
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 66.09
E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1417 QT E E D RNSLMEQL E E ete AK R A V E rqvs SLNMQLS D SK KK L DE MSGTV E ALEEGK K RLQR E LEA AN SDYEEKASA Y D K LE 1496
Cdd:NF033930 41 KA E K D YDAAVKKS E A --- AK K A Y E ---- EAKKKAE D AQ KK Y DE DQKKT E EKAKKE K KASE E EQK AN LAVQKAYVK Y R K AQ 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1497 KSRGRM - QQE L EDVLMDL D SQRQ lvs NLEKKQKK F DQML A EERAVSCKF AE ERDR AE - A E A R E KE trvla LARALE E NQG 1574
Cdd:NF033930 114 RRKKSD y KKK L AEADKKI D EAKK --- KQKEAKAE F NKVR A KVVPEAEEL AE TKKK AE e A K A E E PV ----- AKKKVD E AKK 185
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1575 AL EEA E K TMKGLR A DM E D L ISSKDDVGKSVHD LE KAKRG LE AIVD E mrtq ME E LED E lqvaedaklrl D VNTQA LRA QH E 1654
Cdd:NF033930 186 KV EEA K K KVEAEE A EI E K L QNEEVALEAKIAE LE NQVDN LE KELA E ---- ID E SDS E ----------- D YIKEG LRA PL E 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1655 R EL H A R delgee KR K QLL KQ VRELEAELEEERKQRG Q ASGS K KKL E G EL KDME D Q L EATSRGRDEA V KQ L RKIQGQ V K D L 1734
Cdd:NF033930 251 S EL D A K ------ QA K LAK KQ TELEKLLDSLDPEGKT Q DELD K EAA E E EL SKKI D E L DNEVAKLEKE V SD L ENSDNN V A D Y 324
330 340 350
....*....|....*....|....*....|
gi 1593656259 1735 QRD ledsr A AQ K EVLASAR E S E RRS K AMEA 1764
Cdd:NF033930 325 YKE ----- A LE K DLATKKA E L E KTQ K DLDK 349
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
903-1184
2.14e-07
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 56.07
E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 903 Y L K LKNW Q WWRLFTKV K P L LQVTRQEE E MGQ K DE E L KA A - KE V A AKV --- ET EL KDITQ K HTQLME E RAQLEM K LH aet E 978
Cdd:NF033930 106 Y V K YRKA Q RRKKSDYK K K L AEADKKID E AKK K QK E A KA E f NK V R AKV vpe AE EL AETKK K AEEAKA E EPVAKK K VD --- E 182
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 979 LYAEA EE MRVRL EA KKQ E L E evlhemesrleeeedrsn A L H NE RKEM E QQ lqlmeah IAE E E DARQK L qmekvsv E GKVK 1058
Cdd:NF033930 183 AKKKV EE AKKKV EA EEA E I E ------------------ K L Q NE EVAL E AK ------- IAE L E NQVDN L ------- E KELA 230
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1059 KLE E D ilmm EDQNNKLQKE R KL LE ER L ADMSSN LA EEEEKSKN L ------- S K LKTKHESMIS E L EL RM K KE E kgr LD M E 1131
Cdd:NF033930 231 EID E S ---- DSEDYIKEGL R AP LE SE L DAKQAK LA KKQTELEK L ldsldpe G K TQDELDKEAA E E EL SK K ID E --- LD N E 303
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1593656259 1132 K A kr K V E A E LG DL QEQHADLQAQ - LAE L RAQ LA A K EE EL QA TQ AR L EEEC N QR G 1184
Cdd:NF033930 304 V A -- K L E K E VS DL ENSDNNVADY y KEA L EKD LA T K KA EL EK TQ KD L DKAL N EL G 355
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
1022-1320
1.37e-06
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 53.38
E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1022 RK E MEQQ L QLME A HIAEEEDA R Q K LQME K VSVEGKV KK LE E DILMMEDQNNKLQ K E R KLLEERLADMSSNLAEE EE KSKN 1101
Cdd:NF033930 93 EE E QKAN L AVQK A YVKYRKAQ R R K KSDY K KKLAEAD KK ID E AKKKQKEAKAEFN K V R AKVVPEAEELAETKKKA EE AKAE 172
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1102 LSKL K T K HESMISEL E LRM KK eekgrld M E KAKRKV E A elgd LQ EQHAD L Q A QL AEL RA Q LAAK E E EL QATQARLE E E cn 1181
Cdd:NF033930 173 EPVA K K K VDEAKKKV E EAK KK ------- V E AEEAEI E K ---- LQ NEEVA L E A KI AEL EN Q VDNL E K EL AEIDESDS E D -- 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1182 qrga AV K rvrel E V L ISE L QED L E A ER A argkveaarrdlge E L NALR TELE --- DSL GTTAAQ Q ELRA K REQ E VSML KK 1258
Cdd:NF033930 240 ---- YI K ----- E G L RAP L ESE L D A KQ A -------------- K L AKKQ TELE kll DSL DPEGKT Q DELD K EAA E EELS KK 296
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593656259 1259 AM E degrs HEAQ V QD L RQKH S QAVEELTEQLEQA K rvr AG LEK --- A K Q A - LEK ESA DL SAD L RS L 1320
Cdd:NF033930 297 ID E ----- LDNE V AK L EKEV S DLENSDNNVADYY K --- EA LEK dla T K K A e LEK TQK DL DKA L NE L 354
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
1609-1951
5.86e-05
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 47.98
E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1609 KA KRGLE A I V DEMRTQMEEL E DELQV AEDA KLRL D VNTQALRAQHER E LH A RD E LGEEKRKQLLKQ V REL eaeleee RK Q 1688
Cdd:NF033930 41 KA EKDYD A A V KKSEAAKKAY E EAKKK AEDA QKKY D EDQKKTEEKAKK E KK A SE E EQKANLAVQKAY V KYR ------- KA Q 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1689 R GQA S GS KKKL EGEL K DME dql EA TSR g RD EA VKQLR K IQGQ V KDLQRD L EDSR aa Q K EVL A S A R E SERRS K AM EA D ivq 1768
Cdd:NF033930 114 R RKK S DY KKKL AEAD K KID --- EA KKK - QK EA KAEFN K VRAK V VPEAEE L AETK -- K K AEE A K A E E PVAKK K VD EA K --- 184
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1769 lheml AA VE R A R K QA E V E RD E LSEE lasnssgkslm SD E KRR L DT KI sqleeeleeeq A NV E SLN D R L rksqqlv E QLG A 1848
Cdd:NF033930 185 ----- KK VE E A K K KV E A E EA E IEKL ----------- QN E EVA L EA KI ----------- A EL E NQV D N L ------- E KEL A 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1849 E LAAER S TSQSR EG S R QQ LE RQ ---- NRE L KA K MQ E M E GQGR S KLKASIAAL E AKLRE AEE Q L EIESR E RQANGKN L RQK 1924
Cdd:NF033930 231 E IDESD S EDYIK EG L R AP LE SE ldak QAK L AK K QT E L E KLLD S LDPEGKTQD E LDKEA AEE E L SKKID E LDNEVAK L EKE 310
330 340
....*....|....*....|....*..
gi 1593656259 1925 EKK L KDLTIQME D ER K Q A QQ y KD Q A E K 1951
Cdd:NF033930 311 VSD L ENSDNNVA D YY K E A LE - KD L A T K 336
pneumo_PspA
NF033930 pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
1198-1514
7.63e-05
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.
Pssm-ID: 411490 [Multi-domain]
Cd Length: 660
Bit Score: 47.60
E-value: 7.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1198 S ELQE D LE A era A RG K V EAA RRDLG E --- ELNALRTELEDSLGT T aaqq E LR AK R E QEV S M - LK KA MEDEGRSHEAQVQD 1273
Cdd:NF033930 40 S KAEK D YD A --- A VK K S EAA KKAYE E akk KAEDAQKKYDEDQKK T ---- E EK AK K E KKA S E e EQ KA NLAVQKAYVKYRKA 112
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1274 L R Q K H S QAVEE L T E QLEQAKRVRAGLEK AK QALE K ES A DLSADLRS LA ------- S AK QDVEHK KKKV E gqln E LNSRFN 1346
Cdd:NF033930 113 Q R R K K S DYKKK L A E ADKKIDEAKKKQKE AK AEFN K VR A KVVPEAEE LA etkkkae E AK AEEPVA KKKV D ---- E AKKKVE 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1347 E SERQRTELGERVS KL TT E LDSVTGLLN E A E GKNIK L S K DVSSL -- S SQLQDAQ E L L SEETRQK L NL - SGR L RQTEEDRN 1423
Cdd:NF033930 189 E AKKKVEAEEAEIE KL QN E EVALEAKIA E L E NQVDN L E K ELAEI de S DSEDYIK E G L RAPLESE L DA k QAK L AKKQTELE 268
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1424 S L MEQ L ee ET E A K RAV E RQVSSLNMQ LS D skk K L DE MSGT V EA LE EGKKR L QRELEAANSD Y E E kasayd K LEK SRGRMQ 1503
Cdd:NF033930 269 K L LDS L -- DP E G K TQD E LDKEAAEEE LS K --- K I DE LDNE V AK LE KEVSD L ENSDNNVADY Y K E ------ A LEK DLATKK 337
330
....*....|.
gi 1593656259 1504 Q ELE DVLM DLD 1514
Cdd:NF033930 338 A ELE KTQK DLD 348
antiphage_ZorA_3
NF033916 anti-phage defense ZorAB system ZorA; Proteins of this subfamily are putative H+ channel ...
1149-1396
1.13e-03
anti-phage defense ZorAB system ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.
Pssm-ID: 411477 [Multi-domain]
Cd Length: 509
Bit Score: 43.66
E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1149 A D L QA QLAELR A QLAAKEEE LQA TQ AR LEE E CNQR G AAVKRVR E LEVLI SE LQEDLE AE RA a RGK VE AARRDL G EELNAL 1228
Cdd:NF033916 284 S D M QA GQNAMQ A GMNEMLAS LQA SV AR IGS E GEGA G ERIAGQL E KLFAD SE ARQQAM AE QM - QAF VE QIQSSV G QGQSET 362
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1229 RTELED S LGTTAA Q QE lrakre QEV S M L KKAMEDEGR S HEAQV Q D L RQKHSQAVEE L TE Q LE Q akr VR A GLEKAK QA L e K 1308
Cdd:NF033916 363 MEKMAA S VDALGT Q LG ------ GLF S Q L EQQQQQMDE S QQEAQ Q R L HEQTERLIGS L DD Q IK Q --- LL A LVAEQQ QA M - Q 432
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1309 E SAD L S A DL -- R S L A S AKQDVEHKKKKV E gqlnelns RF NES erqrtel G ER VS KLT tel D S VTGL L NEAEGKNIK LS KD 1386
Cdd:NF033916 433 E TIQ L L A GQ te R H L Q S MQAGADKMRLAA E -------- RF DTA ------- G SS VS EAN --- E S TADV L GSVQSASAE LS SA 494
250
....*....|
gi 1593656259 1387 VSS L S S QLQ D 1396
Cdd:NF033916 495 SRE L T S IVA D 504
dapto_LiaX
NF038025 daptomycin-sensing surface protein LiaX; LiaX (lipid-II###interacting antibiotics X), as ...
1026-1163
1.98e-03
daptomycin-sensing surface protein LiaX; LiaX (lipid-II###interacting antibiotics X), as described in Enterococcus faecalis, is expressed under control of the the LiaR response regulator, and is involved in the process of resistance to daptomycin and to antimicrobial peptides of the innate immune response.
Pssm-ID: 411618
Cd Length: 513
Bit Score: 43.08
E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1026 E QQ L Q L M E A h I A E E E D AR Q ------ KLQM EK VSVEGKVKK l E EDILMMEDQNN K LQKERKL LE ER L ADMSSNL ---- AE E 1095
Cdd:NF038025 19 E EA L D L L E N - M A K E K D EK Q ikkaad EVTA EK DDLLDELEN - E QEEEPETFTEQ K EEEDKED LE AI L DELATEA nkas AE L 96
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1096 E E KSKNLSKL K TKHESMISE L ELRMK KEE KGR L DM E KAKRK -- V EAE LGD L QE Q HAD L QAQLA EL RAQ L A 1163
Cdd:NF038025 97 D E VNAEIQGV K EEIKEKQEQ L MVLDT KEE LDE L SE E ELAER qe L EAE IKQ L EA Q LDE L EEEKE EL EEE L K 166
M_group_A_cterm
NF033777 M protein C-terminal domain; M protein (emm) is an important virulence protein and ...
1026-1174
2.02e-03
M protein C-terminal domain; M protein (emm) is an important virulence protein and serology-defining surface antigen of Streptococcus pyogenes (group A Streptococcus). M protein has an amino-terminal YSIRK-type signal sequence (associated with cross-wall targeting in dividing cells), and a C-terminal LPXTG domain for processing by sortase and covalent attachment to the Gram-positive cell wall. Past the signal peptide, M protein has a hypervariable region, but this HMM describes only the well-conserved region C-terminal to the hypervariable region. It discriminates M protein from two related proteins, Enn and Mrp.
Pssm-ID: 411361 [Multi-domain]
Cd Length: 218
Bit Score: 41.74
E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1026 E QQ LQ LM E AHIAEE E DA R QK L QMEKVSVEGKV K KL E E D ILMMEDQNN K LQK E RKLLEERLADMSSN L AEEE E KS K NLS K L 1105
Cdd:NF033777 1 E AE LQ KL E EQNKIS E AS R KG L RRDLDASREAK K QV E K D LANLTAELD K VKE E KQISDASRQGLRRD L DASR E AK K QVE K A 80
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1593656259 1106 KTKHE S MISE LE l RMK KE ekgrld M E KA K RKV E A E LGD LQ eqh A D L Q A QLAE L RA QLA AKE EEL QATQ A 1174
Cdd:NF033777 81 LEEAN S KLAA LE - KLN KE ------ L E ES K KLT E K E KAE LQ --- A K L E A EAKA L KE QLA KQA EEL AKLR A 139
PspC_subgroup_1
NF033838 pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1221-1559
8.75e-03
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 411407 [Multi-domain]
Cd Length: 684
Bit Score: 41.15
E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1221 LG EELN A LRTELEDSLGT T AAQQ E LRAKREQ EV ----- SM L KKAMEDEGRSHEA Q VQD L RQ K H S ---------- QAVE E L 1285
Cdd:NF033838 31 LG GVVH A EEVRGGNNPTV T SSGN E SQKEHAK EV eshle KI L SEIQKSLDKRKHT Q NVA L NK K L S dikteylyel NVLK E K 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1286 T E Q l E QAKRVRAG L EK A KQALE K ESADLS adl RSL A S A KQD VE HKK KK VEG Q LN E -- L N SRF N ESERQRT E LG E --- R V S 1360
Cdd:NF033838 111 S E A - E LTSKTKKE L DA A FEQFK K DTLEPG --- KKV A E A TKK VE EAE KK AKD Q KE E dr R N YPT N TYKTLEL E IA E sdv E V K 186
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1361 K LTT EL DSVTGLLNEA E G K NIKLSKD V S S LSSQLQDAQELLSE ---- E TRQ K LNLSGR L RQTE E DRNSLM EQ LEEETE AK 1436
Cdd:NF033838 187 K AEL EL VKEEAKEPRD E E K IKQAKAK V E S KKAEATRLEKIKTD reka E EEA K RRADAK L KEAV E KNVATS EQ DKPKRR AK 266
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1437 R A V ERQVSSLNMQLS D S K ------------------- KK LD E MSGT VE ALEEGK K RLQR E -------------- LE A A N S 1483
Cdd:NF033838 267 R G V LGEPATPDKKEN D A K ssdssvgeetlpspslkpe KK VA E AEKK VE EAKKKA K DQKE E drrnyptntyktle LE I A E S 346
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1593656259 1484 D YEE K ASAYD -- K L E KSRG R MQQELEDVLMDLD S QRQLVSN LEK kq K K F D QML AEE R A VS c K F AEE RDRA E AE A REKE 1559
Cdd:NF033838 347 D VKV K EAELE lv K E E AKEP R NEEKIKQAKAKVE S KKAEATR LEK -- I K T D RKK AEE E A KR - K A AEE DKVK E KP A EQPQ 421
Name
Accession
Description
Interval
E-value
Myosin_tail_1
pfam01576 Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
925-2005
0e+00
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 396244 [Multi-domain]
Cd Length: 1081
Bit Score: 1421.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 925 TRQEEEM GQ K D EEL KAA KE VAA K V E T ELK DITQ KH T QL M EE RAQ L EMK L H AETEL Y AEAEEMR V RL E A K KQELEE V LH EM 1004
Cdd:pfam01576 1 TRQEEEM QA K E EEL QKV KE KQQ K A E S ELK ELEK KH Q QL I EE KNI L AEQ L Q AETEL F AEAEEMR A RL A A R KQELEE I LH DL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1005 ESRLEEEE D RS NA L H NE R K E M E Q QL Q LM E AHIA EEE D ARQKLQ M EKV SV E G K V KKLEEDIL MM EDQN N KL Q KERKLLEER 1084
Cdd:pfam01576 81 ESRLEEEE E RS QQ L Q NE K K K M Q Q HI Q DL E EQLE EEE A ARQKLQ L EKV TT E A K I KKLEEDIL LL EDQN S KL S KERKLLEER 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1085 LADMS SNLAEEEEK S K N L S KLK T KHE S MIS E LE L R M KKEEKGR LDM EKAKRK VEA E LG DLQEQ H A D LQAQ LA ELRAQLA A 1164
Cdd:pfam01576 161 ISEFT SNLAEEEEK V K S L N KLK N KHE A MIS D LE D R L KKEEKGR QEL EKAKRK LDG E ST DLQEQ I A E LQAQ IE ELRAQLA K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1165 KEEELQA TQ ARLEEE CN Q RGA A V K RV REL EVL I S ELQEDLE A ERAAR G K V E AA RRDLGEEL N AL R TELED S L GT TAAQQE 1244
Cdd:pfam01576 241 KEEELQA AL ARLEEE GA Q KNN A L K KL REL QAQ I A ELQEDLE S ERAAR A K A E KQ RRDLGEEL E AL K TELED T L DS TAAQQE 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1245 LR A KREQEV SM LKKA M E D E G RSHEAQ V Q DL RQKH S QA V EEL T EQLEQAKR VR A G LEKAKQALE K E SAD L S A D L RS L AS AK 1324
Cdd:pfam01576 321 LR S KREQEV TE LKKA L E E E T RSHEAQ L Q EM RQKH T QA L EEL S EQLEQAKR NK A N LEKAKQALE S E NNE L Q A E L KT L QQ AK 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1325 QD V EHK K KK V EGQL N EL NS R FN ESERQR T EL G E RV SKL TT EL D SV T GLL N EAEGK N IKLSKDVSSL S SQLQD A QELL S EE 1404
Cdd:pfam01576 401 QD S EHK R KK L EGQL Q EL QA R LS ESERQR A EL A E KL SKL QS EL E SV S GLL S EAEGK S IKLSKDVSSL E SQLQD T QELL Q EE 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1405 TRQKLNLS G RLRQ T E ED RNSL M EQLEEE T EAKR A VERQ V S S L NM QLS DS KKKL D E MS G T VEALEE G KKRLQRELEA ANSD 1484
Cdd:pfam01576 481 TRQKLNLS S RLRQ L E DE RNSL Q EQLEEE E EAKR N VERQ L S T L QA QLS EM KKKL E E DA G A VEALEE A KKRLQRELEA LTQR 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1485 Y EEKA S AYDKLEK SRG R M QQEL E D V L M DLD S QRQLVSNLEKKQKKFDQMLAEE R A V S CKF AEERDRAEAEAREKETR V L A 1564
Cdd:pfam01576 561 L EEKA A AYDKLEK TKN R L QQEL D D L L V DLD H QRQLVSNLEKKQKKFDQMLAEE K A I S ARY AEERDRAEAEAREKETR A L S 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1565 L A RALEE NQG A L EE A E KTM K G LRA D MEDL I SSKDDVGK S VH D LE KA KR G LE AI V D EM R TQ M EELEDELQ VA EDAKLRL D V 1644
Cdd:pfam01576 641 L S RALEE ALE A K EE L E RQN K Q LRA E MEDL V SSKDDVGK N VH E LE RS KR A LE QQ V E EM K TQ L EELEDELQ AT EDAKLRL E V 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1645 N T QAL R AQ H ER E L H ARDE L GEEKR K QL L KQVRELEAELE E ERKQR G QA SGS KKKLE GE LK DM E D Q LE A TSR GRDEAVKQL 1724
Cdd:pfam01576 721 N M QAL K AQ F ER D L Q ARDE Q GEEKR R QL V KQVRELEAELE D ERKQR A QA VAA KKKLE LD LK EL E A Q ID A ANK GRDEAVKQL 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1725 R K I Q G Q V K D LQR D LE DS RA AQK E V LA SAR ESE RRS K AM EA DIV QL H E M LAA V ERA RK QA EV ERDEL SE E L A SNS SGKS LM 1804
Cdd:pfam01576 801 K K L Q A Q M K E LQR E LE ET RA SRD E I LA QSK ESE KKL K SL EA ELL QL Q E D LAA S ERA KR QA QQ ERDEL AD E I A NGA SGKS AL 880
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1805 S DEKRRL DTK I S QLEEELEEEQ A N V E S LNDR L RK SQQL VEQL GA EL A AERS T SQ SR E GS RQQLERQN R ELKAK M QEMEG Q 1884
Cdd:pfam01576 881 L DEKRRL EAR I A QLEEELEEEQ S N T E L LNDR Y RK LTLQ VEQL TT EL S AERS F SQ KS E SA RQQLERQN K ELKAK L QEMEG T 960
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1885 GR SK L K A SIAALEAK LREA EEQLE I ESRERQA NG K NL R QK EKKLK DLTI Q M EDER KQ A Q QYKDQAEK G N V R V KQLK H QLE 1964
Cdd:pfam01576 961 VK SK Y K S SIAALEAK IAQL EEQLE Q ESRERQA AN K LV R RT EKKLK EVLL Q V EDER RN A D QYKDQAEK A N S R M KQLK R QLE 1040
1050 1060 1070 1080
....*....|....*....|....*....|....*....|.
gi 1593656259 1965 EAEEEA Q R MA AARRKLQRELD E ATE ANDTLS R DMAS LRSKL 2005
Cdd:pfam01576 1041 EAEEEA S R AN AARRKLQRELD D ATE SAESMN R EVST LRSKL 1081
MYSc_class_II
cd01377 class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
169-848
0e+00
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276951
Cd Length: 662
Bit Score: 1308.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NLRERY F S S LIYTYSGLFCV V VNPYK M LPIY S E KI I EM YKGK K R H E V PPHI YS I T DNAYRNM M QDRE D QSIL C TG 248
Cdd:cd01377 1 ASVL H NLRERY Y S D LIYTYSGLFCV A VNPYK R LPIY T E EV I DK YKGK R R E E M PPHI FA I A DNAYRNM L QDRE N QSIL I TG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VA S S H K G KK DATPQ pqqagsla Y G E LE K Q L LQANPILEAFGNAKT IK N D NSSRFGKFI KLN 328
Cdd:cd01377 81 ESGAGKTENTKKVIQYLA S VA A S S K K KK ESGKK -------- K G T LE D Q I LQANPILEAFGNAKT VR N N NSSRFGKFI RIH 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 F DV TG Y I V GA N I D TYLLEKSR CI RQ SMT ER AF HIFY YMVA GA KDK L R E E LLL EDFSC Y R F LVA - G HVE I S G QE D D E M F IE 407
Cdd:cd01377 153 F GS TG K I A GA D I E TYLLEKSR VV RQ AKG ER NY HIFY QLLS GA DPE L K E K LLL TGDPS Y Y F FLS q G ELT I D G VD D A E E F KL 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 408 T L EA ME I M GF T EEE R M GMM K V V STV L Q LGNIKF EKE R NS EQA TMPDDTA A Q K VC HL Q G I N IT D FIR A I L T PRIKVGRE V V 487
Cdd:cd01377 233 T D EA FD I L GF S EEE K M SIF K I V AAI L H LGNIKF KQR R RE EQA ELDGTEE A D K AA HL L G V N SS D LLK A L L K PRIKVGRE W V 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 488 Q K A Q T K Q Q AD F A V E ALAKA M YERLF R W ILA R V NKTLD K s K RQSSS F L G I LDIAGFEIFE D NSFEQLCINYTNE R LQQ L FN 567
Cdd:cd01377 313 T K G Q N K E Q VV F S V G ALAKA L YERLF L W LVK R I NKTLD T - K SKRQY F I G V LDIAGFEIFE F NSFEQLCINYTNE K LQQ F FN 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 568 H T MFVLEQEEYK R EGI Q W S FIDFGLDLQP C I E LIE R PN np P GIL AL LDEEC W FPKATD VS FVEKL LNT H T G HV K - F S KPK 646
Cdd:cd01377 392 H H MFVLEQEEYK K EGI E W T FIDFGLDLQP T I D LIE K PN -- M GIL SI LDEEC V FPKATD KT FVEKL YSN H L G KS K n F K KPK 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 647 QH K DKLM F TVL HYAG K V D YN AAN WL T KN M DPLN D NV T ALL NN SS SNFIQD L W KD ADR vvgletitk MSESSAPP K S K K G M 726
Cdd:cd01377 470 PK K SEAH F ILK HYAG D V E YN IDG WL E KN K DPLN E NV V ALL KK SS DPLVAS L F KD YEE --------- SGGGGGKK K K K G G S 540
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTV G QL Y KE S L G KLMTTL HN T Q P N FVRCIIPN H EK RA GK M D SN LVL E QLRCNGVLEGIRICR Q GFPNRI V F Q EF R QRY E 806
Cdd:cd01377 541 FRTV S QL H KE Q L N KLMTTL RS T H P H FVRCIIPN E EK KP GK I D AP LVL H QLRCNGVLEGIRICR K GFPNRI I F A EF K QRY S 620
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 ILA A NAIPKGF M DGK Q AC CLMV K H L D LDP N LYRIG QS K M FF R 848
Cdd:cd01377 621 ILA P NAIPKGF D DGK A AC EKIL K A L Q LDP E LYRIG NT K V FF K 662
MYSc_Myh10
cd14920 class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
169-848
0e+00
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276952
Cd Length: 673
Bit Score: 1177.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NL RE RY F S S LIYTYSGLFCVV V NPYK M LPIYSE K IIEMY K GKKRHE V PPHIY S I TDN AYR N M M QDREDQSILCTG 248
Cdd:cd14920 1 ASVL H NL KD RY Y S G LIYTYSGLFCVV I NPYK N LPIYSE N IIEMY R GKKRHE M PPHIY A I SES AYR C M L QDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VASSHKG K KD AT pqpqqagsl AY GELE K QLLQANPILE A FGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd14920 81 ESGAGKTENTKKVIQYLA H VASSHKG R KD HN --------- IP GELE R QLLQANPILE S FGNAKT V KNDNSSRFGKFI RI N 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FDVTGYIVGANI D TYLLEKSR CI RQ SMT ER A FHIFY YMVA GA KDK L REE LLLE D F SC YRFL VA G HVE I S GQ E D DEM F I ET 408
Cdd:cd14920 152 FDVTGYIVGANI E TYLLEKSR AV RQ AKD ER T FHIFY QLLS GA GEH L KSD LLLE G F NN YRFL SN G YIP I P GQ Q D KDN F Q ET 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 L EAM E IMGF TE EE RMG M M KVVS T VLQ L GNI K F E KERN SE QA T MP DD T A AQK V CHL Q G I N ITD F I RAILTPRIKVGR EV VQ 488
Cdd:cd14920 232 M EAM H IMGF SH EE ILS M L KVVS S VLQ F GNI S F K KERN TD QA S MP EN T V AQK L CHL L G M N VME F T RAILTPRIKVGR DY VQ 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQTK Q QADFAVEALAKA M YERLFRW ILA R V NK T LD KS KRQ SS SF L GILDIAGFEIFE D NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd14920 312 KAQTK E QADFAVEALAKA T YERLFRW LVH R I NK A LD RT KRQ GA SF I GILDIAGFEIFE L NSFEQLCINYTNE K LQQLFNH 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q W S FIDFGLDLQPCI E LIERP N NPPG I LALLDEECWFPKATD VS FVEKL LNTHTG H V KF S KP K Q H 648
Cdd:cd14920 392 TMF I LEQEEY Q REGI E W N FIDFGLDLQPCI D LIERP A NPPG V LALLDEECWFPKATD KT FVEKL VQEQGS H S KF Q KP R Q L 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KDK LM F TVL HYAGKVDY N A AN WL T KNMDPLNDNV TA LL NN SS SN F IQD LWKD A DR V VGL ETI T K M S E SS -- APP K S KKGM 726
Cdd:cd14920 472 KDK AD F CII HYAGKVDY K A DE WL M KNMDPLNDNV AT LL HQ SS DR F VAE LWKD V DR I VGL DQV T G M T E TA fg SAY K T KKGM 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTVGQLYKESL G KLM T TL H NT Q PNFVRCIIPNHEKRAGK M D SN LVL E QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 806
Cdd:cd14920 552 FRTVGQLYKESL T KLM A TL R NT N PNFVRCIIPNHEKRAGK L D PH LVL D QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 631
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 IL AA NAIPKGFMDGKQAC CL M VKH L D LDPNLYRIGQSK M FFR 848
Cdd:cd14920 632 IL TP NAIPKGFMDGKQAC ER M IRA L E LDPNLYRIGQSK I FFR 673
MYSc_Myh11
cd14921 class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
169-848
0e+00
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276885
Cd Length: 673
Bit Score: 1162.09
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NLRERYFS S LIYTYSGLFCVVVNPYK M LPIYSEKI IE MYKGKKRHE V PPHIY S I T D N AYR N M M QDREDQSILCTG 248
Cdd:cd14921 1 ASVL H NLRERYFS G LIYTYSGLFCVVVNPYK H LPIYSEKI VD MYKGKKRHE M PPHIY A I A D T AYR S M L QDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLAVVASSHKGKKD AT pqpqqagsl AY GELEKQLLQANPILEAFGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd14921 81 ESGAGKTENTKKVIQYLAVVASSHKGKKD TS --------- IT GELEKQLLQANPILEAFGNAKT V KNDNSSRFGKFI RI N 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FDVTGYIVGANI D TYLLEKSR C IRQ SMT ER A FHIFYY MV AGAK D K L R EE LLLE D F SC Y R FL VA G H V E I SGQE DDEMF I ET 408
Cdd:cd14921 152 FDVTGYIVGANI E TYLLEKSR A IRQ ARD ER T FHIFYY LI AGAK E K M R SD LLLE G F NN Y T FL SN G F V P I PAAQ DDEMF Q ET 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 LEAM E IMGF T EEE RMGMM KVVS T VLQLGNI K F E KERN SE QA T MPD D TAAQKVCHL Q GIN I TDF I R A ILTPRIKVGR E VVQ 488
Cdd:cd14921 232 LEAM S IMGF S EEE QLSIL KVVS S VLQLGNI V F K KERN TD QA S MPD N TAAQKVCHL M GIN V TDF T R S ILTPRIKVGR D VVQ 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQTK Q QADFA V EALAKA M YERLFRWIL A RVNK T LDK SK RQ SS SFLGILDIAGFEIFE D NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd14921 312 KAQTK E QADFA I EALAKA T YERLFRWIL T RVNK A LDK TH RQ GA SFLGILDIAGFEIFE V NSFEQLCINYTNE K LQQLFNH 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q W S FIDFGLDLQPCIELIERPNNPPG I LALLDEECWFPKATD V SFVEKL LNTHTG H V KF S KPKQ H 648
Cdd:cd14921 392 TMF I LEQEEY Q REGI E W N FIDFGLDLQPCIELIERPNNPPG V LALLDEECWFPKATD K SFVEKL CTEQGN H P KF Q KPKQ L 471
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KDK LM F TVL HYAGKVDYNA AN WLTKNMDPLNDNVT A LLN N SS SN F IQ DLWKD A DR V VGL ETIT KM S ESS A P -- P K S KKGM 726
Cdd:cd14921 472 KDK TE F SII HYAGKVDYNA SA WLTKNMDPLNDNVT S LLN A SS DK F VA DLWKD V DR I VGL DQMA KM T ESS L P sa S K T KKGM 551
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTVGQLYKE S LGKLMTTL H NT Q PNFVRCIIPNHEKR A GK M D SN LVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 806
Cdd:cd14921 552 FRTVGQLYKE Q LGKLMTTL R NT T PNFVRCIIPNHEKR S GK L D AF LVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYE 631
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 ILAANAIPKGFMDGKQAC C LM V K H L D LDPNLYRIGQSK M FFR 848
Cdd:cd14921 632 ILAANAIPKGFMDGKQAC I LM I K A L E LDPNLYRIGQSK I FFR 673
MYSc_Myh18
cd14932 class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
169-848
0e+00
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276895
Cd Length: 676
Bit Score: 1139.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NL R ERY F S S LIYTYSGLFCVV V NPYK M LPIYSE K I IE MYKGKKRHE V PPHIY S ITD N AYR N MMQDREDQSILCTG 248
Cdd:cd14932 1 ASVL H NL K ERY Y S G LIYTYSGLFCVV I NPYK Y LPIYSE E I VN MYKGKKRHE M PPHIY A ITD T AYR S MMQDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VASS H K G KKD atpqp Q QAGS L AY GELEKQLLQANPILEAFGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd14932 81 ESGAGKTENTKKVIQYLA Y VASS F K T KKD ----- Q SSIA L SH GELEKQLLQANPILEAFGNAKT V KNDNSSRFGKFI RI N 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FDV T GYIVGANI D TYLLEKSR C IRQ SMT ERAFHIFYY MVA GA K DKLR E EL L LED F S C YRFL VA G H V E I S GQ E D D E M F I ET 408
Cdd:cd14932 156 FDV N GYIVGANI E TYLLEKSR A IRQ AKD ERAFHIFYY LLT GA G DKLR S EL C LED Y S K YRFL SN G N V T I P GQ Q D K E L F A ET 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 L EA ME IM GFT EEE RM G MM KVVS T VLQLGN IK F E KERNS E QA T MPDDTAAQKVCHL Q G I N I TDF I RAIL T PRIKVGR EV VQ 488
Cdd:cd14932 236 M EA FR IM SIP EEE QT G LL KVVS A VLQLGN MS F K KERNS D QA S MPDDTAAQKVCHL L G M N V TDF T RAIL S PRIKVGR DY VQ 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQT KQ QA D FAVEALAKA M YER L FRW ILA R V NK T LDK S KRQ SS SF L GILDIAGFEIFE D NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd14932 316 KAQT QE QA E FAVEALAKA S YER M FRW LVM R I NK A LDK T KRQ GA SF I GILDIAGFEIFE L NSFEQLCINYTNE K LQQLFNH 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q WSFIDFGLDLQPCIELIE R PN N PPGILALLDEECWFPKATD V SFVEK LLNTHTGHV KF S KPK QH 648
Cdd:cd14932 396 TMF I LEQEEY Q REGI E WSFIDFGLDLQPCIELIE K PN G PPGILALLDEECWFPKATD K SFVEK VVQEQGNNP KF Q KPK KL 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KD KLM F TVL HYAGKVDY N A AN WL T KNMDPLN D NV TA LLN N S SSN F IQD LWKD A DR V VGL ETITK M S ES - SAPP K SK KGMF 727
Cdd:cd14932 476 KD DAD F CII HYAGKVDY K A NE WL M KNMDPLN E NV AT LLN Q S TDK F VSE LWKD V DR I VGL DKVAG M G ES l HGAF K TR KGMF 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 728 RTVGQLYKE S L GK LMTTL H NT Q PNFVRCIIPNHEK R AGK MDSN LVL E QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 807
Cdd:cd14932 556 RTVGQLYKE Q L MN LMTTL R NT N PNFVRCIIPNHEK K AGK LAHH LVL D QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEI 635
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 1593656259 808 L AA NAIPKGFMDGKQAC C LMVK H L D LDPNLYRIGQSK M FFR 848
Cdd:cd14932 636 L TP NAIPKGFMDGKQAC V LMVK A L E LDPNLYRIGQSK V FFR 676
Myosin_head
pfam00063 Myosin head (motor domain);
157-848
0e+00
Myosin head (motor domain);
Pssm-ID: 395017
Cd Length: 674
Bit Score: 1073.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 157 VEDM AA L TF LNE A SVL Q NL RE RY F S S LIYTYSGL FC V V VNPYK M LPIYSE KI I EM Y K GK K R H E V PPHI YS I T D N AYR N M M 236
Cdd:pfam00063 1 VEDM VE L SY LNE P SVL H NL KK RY K S D LIYTYSGL VL V A VNPYK Q LPIYSE DM I KA Y R GK R R G E L PPHI FA I A D E AYR S M L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 237 QD R E D QSIL CT GESGAGKTENTKK VI QYLA V V AS S HKGKK datpqpqqagsla Y G E LE K Q L LQ A NPILEAFGNAKT IK N D 316
Cdd:pfam00063 81 QD K E N QSIL IS GESGAGKTENTKK IM QYLA S V SG S GSAGN ------------- V G R LE E Q I LQ S NPILEAFGNAKT VR N N 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 317 NSSRFGK F I KLN FD VT G Y IVG AN I D TYLLEKSR CIR Q SMT ER AF HIFY YMV AGA KDK L RE EL L L EDFSC Y RF L VA - G HVE 395
Cdd:pfam00063 148 NSSRFGK Y I EIQ FD AK G D IVG GK I E TYLLEKSR VVY Q AEG ER NY HIFY QLL AGA SAQ L KK EL R L TNPKD Y HY L SQ s G CYT 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 396 I S G QE D D E M F IE T LE AM E I M GF TE EE R MG MMKV V STV L Q LGNI K F E KERN S EQA TMP D DTAA QK VCH L Q GI NI T DFIR A I 475
Cdd:pfam00063 228 I D G ID D S E E F KI T DK AM D I L GF SD EE Q MG IFRI V AAI L H LGNI E F K KERN D EQA VPD D TENL QK AAS L L GI DS T ELEK A L 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 476 LTP RIK V GRE V V Q K A Q TKQ QA DF A VE ALAKA M Y E RLF R W ILA R V NK T LD KSKRQSS SF L G I LDI A GFEIFE D NSFEQLCI 555
Cdd:pfam00063 308 CKR RIK T GRE T V S K P Q NVE QA NY A RD ALAKA I Y S RLF D W LVD R I NK S LD VKTIEKA SF I G V LDI Y GFEIFE K NSFEQLCI 387
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 556 NY T NE R LQQ L FNH T MF V LEQEEY K REGI Q W S FIDFG l D L QPCI E LIE RP nn P P GIL A LLDEEC W FPKATD VS F VE KL LN T 635
Cdd:pfam00063 388 NY V NE K LQQ F FNH H MF K LEQEEY V REGI E W T FIDFG - D N QPCI D LIE KK -- P L GIL S LLDEEC L FPKATD QT F LD KL YS T 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 636 HTG H VK F S KP KQ h KDKLM F TVL HYAG K V D YN AANW L T KN M DPLND NVTA LL NN SS SNFIQD L WK D ADRVV gl ETITKM S E 715
Cdd:pfam00063 465 FSK H PH F Q KP RL - QGETH F IIK HYAG D V E YN VEGF L E KN K DPLND DLVS LL KS SS DPLLAE L FP D YETAE -- SAAANE S G 541
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 716 S S A P PKS KK GM F R TVG QLY KESLG K LM T TL HN T Q P NFV RCI I PN HE KRAG KM D SN LVL E QLRCNGVLEGIRI C R Q GFPNR 795
Cdd:pfam00063 542 K S T P KRT KK KR F I TVG SQF KESLG E LM K TL NS T N P HYI RCI K PN EK KRAG VF D NS LVL H QLRCNGVLEGIRI R R A GFPNR 621
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1593656259 796 I V FQEF R QRY E ILA ANAI PK GFM D G K QA C CLMVKH L D LD PNL Y RI G QS K M FFR 848
Cdd:pfam00063 622 I T FQEF V QRY R ILA PKTW PK WKG D A K KG C EAILQS L N LD KEE Y QF G KT K I FFR 674
MYSc_Myh2_insects_mollusks
cd14911 class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
169-848
0e+00
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276876
Cd Length: 674
Bit Score: 1069.60
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q N LRE RY F S S LIYTYSGLFCVVVNPYK M LPIY S EKI I E M YKG K KRHEVPPH IYS ITD N AYRNM MQ DREDQSILCTG 248
Cdd:cd14911 1 ASVL H N IKD RY Y S G LIYTYSGLFCVVVNPYK K LPIY T EKI M E R YKG I KRHEVPPH VFA ITD S AYRNM LG DREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQ Y LA V VA S S HKGKKD A T P Q P QQAGSLAY GELE K QLLQANPILEAFGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd14911 81 ESGAGKTENTKKVIQ F LA Y VA A S KPKGSG A V P H P AVNPAVLI GELE Q QLLQANPILEAFGNAKT V KNDNSSRFGKFI RI N 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FD VT G Y I V GANI D TYLLEKSR C IRQ SMT ER A FHIFY YMV AGA KDKL RE ELL L E D FSC Y R FL VA G HVEIS G QE D DEM F IE T 408
Cdd:cd14911 161 FD AS G F I S GANI E TYLLEKSR A IRQ AKD ER T FHIFY QLL AGA TPEQ RE KFI L D D VKS Y A FL SN G SLPVP G VD D YAE F QA T 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 LEA M E IMG F T E E ERMGMMKV VS T VL QL G NI KF EK ERN SE QAT M PD D T A AQK VC HL Q G INI TD FI RA I LTPRIKVGR EV V Q 488
Cdd:cd14911 241 VKS M N IMG M T S E DFNSIFRI VS A VL LF G SM KF RQ ERN ND QAT L PD N T V AQK IA HL L G LSV TD MT RA F LTPRIKVGR DF V T 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQTK Q Q AD FAVEA L AKA M YER L F R W ILA R V N KT LD KS KRQ SS SF L GILD I AGFEIFE D NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd14911 321 KAQTK E Q VE FAVEA I AKA C YER M F K W LVN R I N RS LD RT KRQ GA SF I GILD M AGFEIFE L NSFEQLCINYTNE K LQQLFNH 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q W S FIDFGLDLQP C I E LI ER P N npp GI L ALLDEECWFPKATD VS FV E KL LNT H TG H V KF S K p KQH 648
Cdd:cd14911 401 TMF I LEQEEY Q REGI E W K FIDFGLDLQP T I D LI DK P G --- GI M ALLDEECWFPKATD KT FV D KL VSA H SM H P KF M K - TDF 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KDKLM F TVL HYAG K VDY N AA N WL T KNMDPLN D N VTA LL NN S SSN F IQDL WKDA D r V VG LETIT k MSESSAPPKSK KGMFR 728
Cdd:cd14911 477 RGVAD F AIV HYAG R VDY S AA K WL M KNMDPLN E N IVS LL QG S QDP F VVNI WKDA E - I VG MAQQA - LTDTQFGARTR KGMFR 554
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 729 TV GQ LYKE S L G KLM T TL H NT Q PNFVRCIIPNHEKRAGK M D SN LVL E QLRCNGVLEGIRICRQGFPNRI V FQEFRQRYE I L 808
Cdd:cd14911 555 TV SH LYKE Q L A KLM D TL R NT N PNFVRCIIPNHEKRAGK I D AP LVL D QLRCNGVLEGIRICRQGFPNRI P FQEFRQRYE L L 634
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1593656259 809 AA N A IPKGFMDGK Q AC CL M VKH L D LD P NLYR I GQSK M FFR 848
Cdd:cd14911 635 TP N V IPKGFMDGK K AC EK M IQA L E LD S NLYR V GQSK I FFR 674
MYSc_Myh19
cd15896 class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
169-848
0e+00
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276899
Cd Length: 675
Bit Score: 1068.92
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NL R ERY F S S LIYTYSGLFCVV V NPYK M LPIYSE K I I EMYKGKKRHE V PPHIY S ITD N AYR N MMQDREDQSILCTG 248
Cdd:cd15896 1 ASVL H NL K ERY Y S G LIYTYSGLFCVV I NPYK N LPIYSE E I V EMYKGKKRHE M PPHIY A ITD T AYR S MMQDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VASSHK G KKD atpqp Q QAGS L AY GELEKQLLQANPILEAFGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd15896 81 ESGAGKTENTKKVIQYLA H VASSHK T KKD ----- Q NSLA L SH GELEKQLLQANPILEAFGNAKT V KNDNSSRFGKFI RI N 155
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FDV T GYIVGANI D TYLLEKSR C IRQ SMT ER A FHIFYY MVA GA K DKLR E ELLLE DFSC YRFL VA G H V E I S GQ E D DEM F I ET 408
Cdd:cd15896 156 FDV N GYIVGANI E TYLLEKSR A IRQ AKE ER T FHIFYY LLT GA G DKLR S ELLLE NYNN YRFL SN G N V T I P GQ Q D KDL F T ET 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 L EA ME IMG FT E E E RM GM M KVV ST VLQLGN IK F E KER NSE QA T MPD D TAAQKVCHL Q G I N I TDF I RAIL T PRIKVGR EV VQ 488
Cdd:cd15896 236 M EA FR IMG IP E D E QI GM L KVV AS VLQLGN MS F K KER HTD QA S MPD N TAAQKVCHL M G M N V TDF T RAIL S PRIKVGR DY VQ 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQT KQ QA D FAVEALAKA M YER L FRW ILA R V NK T LDK S KRQ SS SF L GILDIAGFEIFE D NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd15896 316 KAQT QE QA E FAVEALAKA T YER M FRW LVM R I NK A LDK T KRQ GA SF I GILDIAGFEIFE L NSFEQLCINYTNE K LQQLFNH 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q WSFIDFGLDLQPCI E LIE R P NN PPGILALLDEECWFPKATD V SFVEK L L NTHTG H V KF S KPK QH 648
Cdd:cd15896 396 TMF I LEQEEY Q REGI E WSFIDFGLDLQPCI D LIE K P AS PPGILALLDEECWFPKATD K SFVEK V L QEQGT H P KF F KPK KL 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KD KLM F TVL HYAGKVDY N A AN WL T KNMDPLNDNV TA LLN N S SSN F IQD LWKD A DR V VGL ETITK MSE SSAPP K SK KGMFR 728
Cdd:cd15896 476 KD EAD F CII HYAGKVDY K A DE WL M KNMDPLNDNV AT LLN Q S TDK F VSE LWKD V DR I VGL DKVSG MSE MPGAF K TR KGMFR 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 729 TVGQLYKE S L G KLM T TL H NT Q PNFVRCIIPNHEK R AGK M D SN LVL E QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 808
Cdd:cd15896 556 TVGQLYKE Q L S KLM A TL R NT N PNFVRCIIPNHEK K AGK L D PH LVL D QLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 635
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1593656259 809 AA NAIPKGFMDGKQAC C LM V K H L D LDPNLYRIGQSK M FFR 848
Cdd:cd15896 636 TP NAIPKGFMDGKQAC V LM I K S L E LDPNLYRIGQSK V FFR 675
MYSc_Myh9
cd14919 class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
169-848
0e+00
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276883
Cd Length: 670
Bit Score: 1060.85
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NL R ERY F S S LIYTYSGLFCVV V NPYK M LPIYSE K I I EMYKGKKRHE V PPHIY S ITD N AYR N MMQDREDQSILCTG 248
Cdd:cd14919 1 ASVL H NL K ERY Y S G LIYTYSGLFCVV I NPYK N LPIYSE E I V EMYKGKKRHE M PPHIY A ITD T AYR S MMQDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VASSHK G KKD A tpqpqqagslay GELE K QLLQANPILEAFGNAKT I KNDNSSRFGKFI KL N 328
Cdd:cd14919 81 ESGAGKTENTKKVIQYLA H VASSHK S KKD Q ------------ GELE R QLLQANPILEAFGNAKT V KNDNSSRFGKFI RI N 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 329 FDV T GYIVGANI D TYLLEKSR C IRQ SMT ER A FHIFYY MVA GA KDK L REE LLLE DFSC YRFL VA GHV E I S GQ E D DE MF I ET 408
Cdd:cd14919 149 FDV N GYIVGANI E TYLLEKSR A IRQ AKE ER T FHIFYY LLS GA GEH L KTD LLLE PYNK YRFL SN GHV T I P GQ Q D KD MF Q ET 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 409 L EAM E IMG FT EEE R MG MMK V V S T VLQLGNI K F E KERN SE QA T MPD D TAAQKV C HL Q GIN I TDF I R A ILTPRIKVGR EV VQ 488
Cdd:cd14919 229 M EAM R IMG IP EEE Q MG LLR V I S G VLQLGNI V F K KERN TD QA S MPD N TAAQKV S HL L GIN V TDF T R G ILTPRIKVGR DY VQ 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 489 KAQTK Q QADFA V EALAKA M YER L FRW ILA R V NK T LDK S KRQ SS SF L GILDIAGFEIF ED NSFEQLCINYTNE R LQQLFNH 568
Cdd:cd14919 309 KAQTK E QADFA I EALAKA T YER M FRW LVL R I NK A LDK T KRQ GA SF I GILDIAGFEIF DL NSFEQLCINYTNE K LQQLFNH 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 569 TMF V LEQEEY K REGI Q W S FIDFGLDLQPCI E LIE R P NN PPGILALLDEECWFPKATD V SFVEK LLNTHTG H V KF S KPKQ H 648
Cdd:cd14919 389 TMF I LEQEEY Q REGI E W N FIDFGLDLQPCI D LIE K P AG PPGILALLDEECWFPKATD K SFVEK VVQEQGT H P KF Q KPKQ L 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 649 KDK LM F TVL HYAGKVDY N A AN WL T KNMDPLNDN VTA LL NN SS SN F IQD LWKD A DR VV GL ETITK MSE SSA P P -- K SK KGM 726
Cdd:cd14919 469 KDK AD F CII HYAGKVDY K A DE WL M KNMDPLNDN IAT LL HQ SS DK F VSE LWKD V DR II GL DQVAG MSE TAL P G af K TR KGM 548
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 727 FRTVGQLYKE S L G KLM T TL H NT Q PNFVRCIIPNHEK R AGK M D SN LVL E QLRCNGVLEGIRICRQGFPNR I VFQEFRQRYE 806
Cdd:cd14919 549 FRTVGQLYKE Q L A KLM A TL R NT N PNFVRCIIPNHEK K AGK L D PH LVL D QLRCNGVLEGIRICRQGFPNR V VFQEFRQRYE 628
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 1593656259 807 IL AA N A IPKGFMDGKQAC C LM V K H L D LD P NLYRIGQSK M FFR 848
Cdd:cd14919 629 IL TP N S IPKGFMDGKQAC V LM I K A L E LD S NLYRIGQSK V FFR 670
MYSc_Myh14_mammals
cd14930 class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
169-848
0e+00
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.
Pssm-ID: 276893
Cd Length: 670
Bit Score: 1003.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 ASVL Q NLRERY F S S LIYTYSGLFCVV V NPYK M LPIY S E K I I EMY K GKKRHEVPPH I Y SI T DN AYR N M M QDREDQSILCTG 248
Cdd:cd14930 1 ASVL H NLRERY Y S G LIYTYSGLFCVV I NPYK Q LPIY T E A I V EMY R GKKRHEVPPH V Y AV T EG AYR S M L QDREDQSILCTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 249 ESGAGKTENTKKVIQYLA V VASS H KG K K D - AT P qpqqagslay GELE K QLLQANPILEAFGNAKT I KNDNSSRFGKFI KL 327
Cdd:cd14930 81 ESGAGKTENTKKVIQYLA H VASS P KG R K E p GV P ---------- GELE R QLLQANPILEAFGNAKT V KNDNSSRFGKFI RI 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 328 NFDV T GYIVGANI D TYLLEKSR C IRQ SMT E RA FHIFY YMVA GA KDK L REE LLLE DF S C YRFL VA G HVEIS GQE D d E M F I E 407
Cdd:cd14930 151 NFDV A GYIVGANI E TYLLEKSR A IRQ AKD E CS FHIFY QLLG GA GEQ L KAD LLLE PC S H YRFL TN G PSSSP GQE R - E L F Q E 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 408 TLE AMEIM GF TE EE RMG M MKV VS T VLQ L GNI KFEK ERN SE QATMPD D TAAQK V C H L Q G INI TDF I RA I LTPRIKVGR EV V 487
Cdd:cd14930 230 TLE SLRVL GF SH EE ITS M LRM VS A VLQ F GNI VLKR ERN TD QATMPD N TAAQK L C R L L G LGV TDF S RA L LTPRIKVGR DY V 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 488 QKAQTK Q QADFA V EALAKA M YERLFRW ILA R V N KT LD K S K RQ SS SFLGILDIAGFEIF ED NSFEQLCINYTNE R LQQLFN 567
Cdd:cd14930 310 QKAQTK E QADFA L EALAKA T YERLFRW LVL R L N RA LD R S P RQ GA SFLGILDIAGFEIF QL NSFEQLCINYTNE K LQQLFN 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 568 HTMFVLEQEEY K REGI Q W S F I DFGLDLQPCI E LIERP N NPPG I LALLDEECWFPKATD V SFVEK LLNTHT GH V KF SK P KQ 647
Cdd:cd14930 390 HTMFVLEQEEY Q REGI P W T F L DFGLDLQPCI D LIERP A NPPG L LALLDEECWFPKATD K SFVEK VAQEQG GH P KF QR P RH 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 648 HK D KLM F T VLHYAGKVDY N A AN WL T KNMDPLNDNV T ALL NN S SSNFIQDL WKD ADRV VGLE TITKMSESSAPPKSKK GMF 727
Cdd:cd14930 470 LR D QAD F S VLHYAGKVDY K A NE WL M KNMDPLNDNV A ALL HQ S TDRLTAEI WKD VEGI VGLE QVSSLGDGPPGGRPRR GMF 549
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 728 RTVGQLYKESL GK LM T TL H NT Q P N FVRCI I PNHEKRAGK MDSN LVL E QLRCNGVLEGIRICRQGFPNRI V FQEFRQRYEI 807
Cdd:cd14930 550 RTVGQLYKESL SR LM A TL S NT N P S FVRCI V PNHEKRAGK LEPR LVL D QLRCNGVLEGIRICRQGFPNRI L FQEFRQRYEI 629
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 1593656259 808 L AA NAIPKGFMDGKQAC CL M VKH L D LDPNLYR I GQSK M FFR 848
Cdd:cd14930 630 L TP NAIPKGFMDGKQAC EK M IQA L E LDPNLYR V GQSK I FFR 670
MYSc
smart00242 Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
150-860
0e+00
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.
Pssm-ID: 214580
Cd Length: 677
Bit Score: 990.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 150 NPPKF SK VED MAA LT F LNE AS VL Q NL RE RY FSS LIYTY S GL FC V V VNPYK M LPIY SEKI I EM Y K GK K R H E V PPH IYS I T D 229
Cdd:smart00242 1 NPPKF EG VED LVL LT Y LNE PA VL H NL KK RY LKD LIYTY I GL VL V A VNPYK Q LPIY TDEV I KK Y R GK S R G E L PPH VFA I A D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 230 NAYRNM MQ D R E D QSI LCT GESGAGKTENTKK VI QYLA V V AS S HKGK kdatpqpqqagslay G EL E K Q L L QA NPILEAFGN 309
Cdd:smart00242 81 NAYRNM LN D K E N QSI IIS GESGAGKTENTKK IM QYLA S V SG S NTEV --------------- G SV E D Q I L ES NPILEAFGN 145
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 310 AKT IK N D NSSRFGKFI KLN FD VT G Y I V GA N I D TYLLEKSR CIR Q SMT ER AF HIFY YMV AGA KDK L RE EL L L EDFSC YR F L 389
Cdd:smart00242 146 AKT LR N N NSSRFGKFI EIH FD AK G K I I GA K I E TYLLEKSR VVS Q AKG ER NY HIFY QLL AGA SEE L KK EL G L KSPED YR Y L 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 390 - VA G HVEIS G QE D D E M F I ETL E AM EIM GF T EEE RMGMM K VVSTV L Q LGNI K FE KE RN SEQ A TMPD D T - AAQKVCH L Q G IN 467
Cdd:smart00242 226 n QG G CLTVD G ID D A E E F K ETL N AM RVL GF S EEE QESIF K ILAAI L H LGNI E FE EG RN DNA A STVK D K e ELSNAAE L L G VD 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 468 ITDFIR A ILTPR IK V G R EV VQ K AQTKQ QA DF A VE ALAKA M Y E RLF R W ILA R V N KT L DK s K RQ S SS F L G I LDI A GFEIFE D 547
Cdd:smart00242 306 PEELEK A LTKRK IK T G G EV IT K PLNVE QA LD A RD ALAKA L Y S RLF D W LVK R I N QS L SF - K DG S TY F I G V LDI Y GFEIFE V 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 548 NSFEQLCINY T NE R LQQ L FN HTM F V LEQEEY K REGI Q W S FIDF G l D L Q P CI E LIE rp NN PPGIL A LLDEEC W FPK A TD VS 627
Cdd:smart00242 385 NSFEQLCINY A NE K LQQ F FN QHV F K LEQEEY E REGI D W T FIDF F - D N Q D CI D LIE -- KK PPGIL S LLDEEC R FPK G TD QT 461
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 628 F V EKL LNT H TG H VK FSKPK Q h K DKLM F TVL HYAG K V D Y NAANW L T KN M D P L N D NVTA LL NN S SSNF I QD L W kdadrvvgl 707
Cdd:smart00242 462 F L EKL NQH H KK H PH FSKPK K - K GRTE F IIK HYAG D V T Y DVTGF L E KN K D T L S D DLIE LL QS S KNPL I AS L F --------- 531
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 708 etitkms E S SAPPKSK K GM F R TVG QLY KE S L GK LM T TL HN T Q P N F V RCI I PN H EK RA G KM DS N LVL E QLR CN GVLE G IRI 787
Cdd:smart00242 532 ------- P S GVSNAGS K KR F Q TVG SQF KE Q L NE LM D TL NS T N P H F I RCI K PN E EK KP G DF DS S LVL H QLR YL GVLE N IRI 604
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1593656259 788 C R Q GFP N R IV F Q EF R QRY EI L AANAI P KGFM D G K Q AC CLMVKH L D LD PNL Y RI G QS K M F F R T G V LA Q LEE E R D 860
Cdd:smart00242 605 R R A GFP Y R LP F D EF L QRY RV L LPDTW P PWGG D A K K AC EALLQS L G LD EDE Y QL G KT K V F L R P G Q LA E LEE L R E 677
COG5022
COG5022 Myosin heavy chain [General function prediction only];
107-1702
0e+00
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain]
Cd Length: 1463
Bit Score: 888.66
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 107 V WIP S E KE G FEA A S I KE E --- KG D - EVLVELSN G QKMT V N K DDIQ -- KMNP PKF SK V E D MAA L TF LNE AS VL Q NL RE RY F 180
Cdd:COG5022 12 C WIP D E EK G WIW A E I IK E afn KG K v TEEGKKED G ESVS V K K KVLG nd RIKL PKF DG V D D LTE L SY LNE PA VL H NL EK RY N 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 181 SSL IYTYSGL FCVV VNPY KM L P IY SEK II EM Y K GK K R H E VP PH IYS I TDN AYRN MMQDR E D Q S I LCT GESGAGKTEN T K K 260
Cdd:COG5022 92 NGQ IYTYSGL VLIA VNPY RD L G IY TDD II QS Y S GK N R L E LE PH VFA I AEE AYRN LLSEK E N Q T I IIS GESGAGKTEN A K R 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 261 VI QYLA V V A SS H kgkkda T PQPQQ agslayge L EKQ L L QA NPILEAFGNAKT IK NDNSSRFGK F IK LN FD VT G Y I V GA N I 340
Cdd:COG5022 172 IM QYLA S V T SS S ------ T VEISS -------- I EKQ I L AT NPILEAFGNAKT VR NDNSSRFGK Y IK IE FD EN G E I C GA K I 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 341 D TYLLEKSR CIR Q SMT ER AF HIFY YMV AG AKDK L REE LLL EDFSC Y RF L VA G HV - E I S G QE D DEM F IE TL E A MEIM G FT E 419
Cdd:COG5022 238 E TYLLEKSR VVH Q NKN ER NY HIFY QLL AG DPEE L KKL LLL QNPKD Y IY L SQ G GC d K I D G ID D AKE F KI TL D A LKTI G ID E 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 420 EE RMGMM K VVSTV L QL GNI K F EKE RN s EQ A TMP D DTAAQ K V C H L Q GI NITD F IRAILTPR IK V G R E VVQKAQTKQ QA DFA 499
Cdd:COG5022 318 EE QDQIF K ILAAI L HI GNI E F KED RN - GA A IFS D NSVLD K A C Y L L GI DPSL F VKWLVKRQ IK T G G E WIVVPLNLE QA LAI 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 500 VEA LAKA M Y ER LF R WI LA R V NK T LD K S KRQ s S S F L G I LDI A GFEIFE D NSFEQLCINYTNE R LQQ L FN HT MF V LEQEEY K 579
Cdd:COG5022 397 RDS LAKA L Y SN LF D WI VD R I NK S LD H S AAA - S N F I G V LDI Y GFEIFE K NSFEQLCINYTNE K LQQ F FN QH MF K LEQEEY V 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 580 R EGI Q WSFID F g L D L QPCI E LIE R p N NP P GIL A LLDEEC WF P K ATD V SF VE KL --- LN THTGH v KF S K PKQHKD K lm F T V 656
Cdd:COG5022 476 K EGI E WSFID Y - F D N QPCI D LIE K - K NP L GIL S LLDEEC VM P H ATD E SF TS KL aqr LN KNSNP - KF K K SRFRDN K -- F V V 550
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 657 L HYAG K V D Y NAANW L T KN M DPLND NVTA LL NN S SSN F IQD L WK D ADR vvgletitkmsessapp KSK KG M F R T V G QLY KE 736
Cdd:COG5022 551 K HYAG D V E Y DVEGF L D KN K DPLND DLLE LL KA S TNE F VST L FD D EEN ----------------- IES KG R F P T L G SRF KE 613
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 737 SL GK LM T TL HN TQP NFV RCI I PN H EK RAGKM D SNL VL E QLRC N GVLE G IRI C R Q GFP N R IV F Q EF R QRY E IL AANA ---- 812
Cdd:COG5022 614 SL NS LM S TL NS TQP HYI RCI K PN E EK SPWTF D NQM VL S QLRC C GVLE T IRI S R A GFP S R WT F D EF V QRY R IL SPSK swtg 693
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 813 IPKGFM D G K Q A CCLMVKH L DL D PNL Y R IG QS K M FF RT GVLA Q LE EE RD L KL TVVIIAF Q AQA RG FLA R KAFSKRQQQLTA 892
Cdd:COG5022 694 EYTWKE D T K N A VKSILEE L VI D SSK Y Q IG NT K V FF KA GVLA A LE DM RD A KL DNIATRI Q RAI RG RYL R RRYLQALKRIKK 773
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 893 MK VIQ RNCACYLKLKNWQW WRLF T K VK PLL QVTRQEE E MGQKDEELK aakevaa K VETEL K DITQKHTQLME E RAQLEMK 972
Cdd:COG5022 774 IQ VIQ HGFRLRRLVDYELK WRLF I K LQ PLL SLLGSRK E YRSYLACII ------- K LQKTI K REKKLRETEEV E FSLKAEV 846
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 973 L HAETELYAE A EE m R VR L EA K KQELEEVL hemesrleeeedrsnalhnerkemeqqlqlmeahi AEE E D A RQK LQ ME K VS 1052
Cdd:COG5022 847 L IQKFGRSLK A KK - R FS L LK K ETIYLQSA ----------------------------------- QRV E L A ERQ LQ EL K ID 890
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1053 V E g KVKK L EE dilmmed Q N NK L QK E rk LL E ERLADM S SNLAEE E E K SKNLSK LK - TKHESMIS E LELRM -- K KE E KGR L D 1129
Cdd:COG5022 891 V K - SISS L KL ------- V N LE L ES E -- II E LKKSLS S DLIENL E F K TELIAR LK k LLNNIDLE E GPSIE yv K LP E LNK L H 960
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1130 MEKA K rkveae L GDLQ E QHA DL QAQLAE L RAQLAAKEE EL QATQAR L E E ECN Q R GA AVKRVRE L EV L IS E LQ E DLE A ER a 1209
Cdd:COG5022 961 EVES K ------ L KETS E EYE DL LKKSTI L VREGNKANS EL KNFKKE L A E LSK Q Y GA LQESTKQ L KE L PV E VA E LQS A SK - 1033
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1210 argkveaarrdlge ELNALR TEL edslgttaaqqelra KREQEVSM LK KAMED E GRSHE A QVQD L RQKHSQAVEELT e QL 1289
Cdd:COG5022 1034 -------------- IISSES TEL --------------- SILKPLQK LK GLLLL E NNQLQ A RYKA L KLRRENSLLDDK - QL 1083
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1290 E Q AKRVR a G L E K AKQALEK E SADLSADLRSLASAKQDVEHK K KKVEGQLNELN S RFNESERQRT elg ERV S K L TT ELD SV 1369
Cdd:COG5022 1084 Y Q LESTE - N L L K TINVKDL E VTNRNLVKPANVLQFIVAQMI K LNLLQEISKFL S QLVNTLEPVF --- QKL S V L QL ELD GL 1159
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1370 TGLL N EAE gkni KL S KDVSSLS S qlqda QEL L SEETRQKLNLSGRL rqteedrn S LMEQ L EE E TE A KRAVERQVSSLNMQ 1449
Cdd:COG5022 1160 FWEA N LEA ---- LP S PPPFAAL S ----- EKR L YQSALYDEKSKLSS -------- S EVND L KN E LI A LFSKIFSGWPRGDK 1222
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1450 L SDSKKKLDEMSGTVEA L EEGKKRLQRELEA A NSDY E EKA S AYDKLEKS rg RMQQE LE DVLMDL d SQRQ L VSNL ek KQKK 1529
Cdd:COG5022 1223 L KKLISEGWVPTEYSTS L KGFNNLNKKFDTP A SMSN E KLL S LLNSIDNL -- LSSYK LE EEVLPA - TINS L LQYI -- NVGL 1297
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1530 F DQMLAEERAVSC K F A E E -- RDRA E AEAREK E TRVLALARA LEE nqga L EE A E K TMKG L RA D MED L i SSKD D VGK S VHDL 1607
Cdd:COG5022 1298 F NALRTKASSLRW K S A T E vn YNSE E LDDWCR E FEISDVDEE LEE ---- L IQ A V K VLQL L KD D LNK L - DELL D ACY S LNPA 1372
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 1608 E KAKRGLE aiv DEMRTQMEE L ED E LQVAED A K L RLDVNTQA L RAQH E R E L H ARDELG EEK RKQL L K qvre LEAELE EE RK 1687
Cdd:COG5022 1373 E IQNLKSR --- YDPADKENN L PK E ILKKIE A L L IKQELQLS L EGKD E T E V H LSEIFS EEK SLIS L D ---- RNSIYK EE VL 1445
1610
....*....|....*
gi 1593656259 1688 QRGQ A SGS K K K LEGE 1702
Cdd:COG5022 1446 SSLS A LLT K E K IALL 1460
MYSc
cd00124 Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
169-848
0e+00
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Pssm-ID: 276950
Cd Length: 633
Bit Score: 885.39
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 169 A SV L Q NLRERY FSS LIYTY S G LFC V V VNP Y K M LP I YSE KII E M Y K GK K R H - EV PPH IYSIT D N AYR N M MQ D RED QSIL CT 247
Cdd:cd00124 1 A AI L H NLRERY ARD LIYTY V G DIL V A VNP F K W LP L YSE EVM E K Y R GK G R S a DL PPH VFAVA D A AYR A M LR D GQN QSIL IS 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 248 GESGAGKTE N TK K V IQ YLA VVAS S HKG K KDAT pqpqqagsla YGEL E K Q L LQ A NPILEAFGNAKT IK NDNSSRFGKFI K L 327
Cdd:cd00124 81 GESGAGKTE T TK L V LK YLA ALSG S GSS K SSSS ---------- ASSI E Q Q I LQ S NPILEAFGNAKT VR NDNSSRFGKFI E L 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 328 N FD V TG YI VGA N I D TYLLEKSR CIR Q SMT ER A FHIFY YMV AG AK D KL REEL L LE DFSC Y RF L V ----- A G HVE I S G QE D D 402
Cdd:cd00124 151 Q FD P TG RL VGA S I E TYLLEKSR VVS Q APG ER N FHIFY QLL AG LS D GA REEL K LE LLLS Y YY L N dylns S G CDR I D G VD D A 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 403 E M F I E T L E A MEIM GF TE EE RMGMMKVVSTV L Q LGNI K FE KERNS E -- Q A TMP DD TAAQKVCH L Q G INIT D FIR A IL T PR I 480
Cdd:cd00124 231 E E F Q E L L D A LDVL GF SD EE QDSIFRILAAI L H LGNI E FE EDEED E ds S A EVA DD ESLKAAAK L L G VDAE D LEE A LT T RT I 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 481 KVG R E VVQ K AQ T KQ QA DF A VE ALAKA M Y E RLF R W ILA R V N KT L D - KSKRQ S S SF L GILDI A GFE I FE D NSFEQLCINY T N 559
Cdd:cd00124 311 KVG G E TIT K PL T VE QA ED A RD ALAKA L Y S RLF D W LVN R I N AA L S p TDAAE S T SF I GILDI F GFE N FE V NSFEQLCINY A N 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 560 E R LQQ L FN HTM F V LEQEEY KR EGI Q WSFIDF g L D L Q P C IE LIE RP nn P P GIL A LLDEEC W FPK A TD VS F V EKL LNT H TG H 639
Cdd:cd00124 391 E K LQQ F FN QHV F K LEQEEY EE EGI D WSFIDF - P D N Q D C LD LIE GK -- P L GIL S LLDEEC L FPK G TD AT F L EKL YSA H GS H 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 640 VK F SKP K Q h K D KL M F TVL HYAG K V D Y N A ANW L T KN M D P L NDNVTA LL NNS S S nfiqdlwkdadrvvgletitkmsessap 719
Cdd:cd00124 468 PR F FSK K R - K A KL E F GIK HYAG D V T Y D A DGF L E KN K D T L PPDLVD LL RSG S Q ---------------------------- 518
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593656259 720 pkskkgmfrtvgql YKES L GK LM T TL HN TQP N FVRCI I PN H EK RA G KM D SN LVLEQLRC N GVLE GI RI C R
