|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-421 |
1.20e-91 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 281.00 E-value: 1.20e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIG 184
Cdd:cd17319 85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 185 LAGIVVGLCWYVGYRNrrqftlqeeeqqylaseeaarpalkfsewlalfkrrtTWGMILGFSGVNYTGWLYIAWLPGYLQ 264
Cdd:cd17319 165 LLGLLLAVLWWFYLRQ-------------------------------------VWGLALGYFGINYALYGLLTWLPTYLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 265 AQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqakTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMA 344
Cdd:cd17319 208 QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 345 LFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFFI 421
Cdd:cd17319 282 GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-425 |
2.65e-70 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 226.29 E-value: 2.65e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 16 RIRRVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGL 95
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 96 IFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWG 175
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 176 WRTMFVVIGLAGIVVGLCwyvgyrnrrqftlqeeeqqylaseeaarpalkfsewlalfkrrTTWGMILGFSGVNYTGWLY 255
Cdd:COG2271 163 WRAAFLILGLPGLLLALL-------------------------------------------RFWLLALAYFLVYFALYGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 256 IAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTPA 335
Cdd:COG2271 200 LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSPA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 336 QAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHsFNLALVIAAGVTFAGA 415
Cdd:COG2271 273 LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAA 351
|
410
....*....|
gi 1603720766 416 LCYFFIVKTR 425
Cdd:COG2271 352 LLALLLLRET 361
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
30-422 |
1.08e-67 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 220.67 E-value: 1.08e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 30 IAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVN 109
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 110 SFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIV 189
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 190 VGLCWYVGYRNRRQFT-LQEEEQQYLAS-------EEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPG 261
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAkWLTEEEKYIVVggllaeqQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 262 YLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRGYDQAKTRKTAIVIGLVLSaLGTLLVVQSSTPAQAVAFI 341
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLS-LLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 342 SMALFCvHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFFI 421
Cdd:TIGR00893 320 ALGFFG-LGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
.
gi 1603720766 422 V 422
Cdd:TIGR00893 399 V 399
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-421 |
7.77e-53 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 181.23 E-value: 7.77e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 19 RVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFW 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 99 SAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRT 178
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 179 MFVVIGLAGIVVGLCWYVGYRNrrqftlqeeeqqyLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAW 258
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRD-------------PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 259 LPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARrgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAV 338
Cdd:COG2223 228 LPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG--------RRVLLIVFALMALGLLLLALALGSLWLFL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 339 AFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCY 418
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
...
gi 1603720766 419 FFI 421
Cdd:COG2223 380 LLL 382
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
27-420 |
3.38e-41 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 149.63 E-value: 3.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTG 106
Cdd:cd17380 3 LLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 107 MV--NSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIG 184
Cdd:cd17380 83 LLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 185 LAGIVVGLCWYVGYrnrrqftlqeeeqqylaseeaarpalkfsewlalfkrRTTWGMILGFSGVNYTGWLYIAWLPGYLQ 264
Cdd:cd17380 163 LLGLLWALVWLIYL-------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFH 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 265 aQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRGYDQAKTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMA 344
Cdd:cd17380 206 -EVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVA 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 345 LFCVHFagTSAWGLVQVM-VAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17380 285 LGLSAF--SSSGVLVNHQdIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLL 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-398 |
3.70e-40 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 147.14 E-value: 3.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 29 FIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMV 108
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 109 NSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPP-ALVIMQLAWGWRTMFVVIGLAG 187
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPlVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 188 IVVGLCWYVGYRNRRQFTLQ--------EEEQQYLASEEAARPALKFSEWLALFKRRtTWGMILGFSGVNYTGWLYIAWL 259
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLppaeempnEEPDGDAEKKEEELTKKQIFLQYVLLNKV-LWYISLGYVFVYVVRTGILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 260 PGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqakTRKTAIVI---GLVLSALGTLLVVQSSTPAQ 336
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNG------RRGPLAVFfmaLIIVSLLVYWLNPAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 337 AVAFISMALFCvhFAGTSAWGLVQVMVAEHK-VASVAAIQNFGSFVFASFAPIVTGWVVDTTH 398
Cdd:TIGR00881 314 LICLFALGFLV--YGPQMLIGVIASELAPKKaAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-384 |
8.70e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.72 E-value: 8.70e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 18 RRVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIF 97
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 98 WSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWR 177
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 178 TMFVVIGLAGIVVGLCWYVgyrnrrqftlqeeeqqYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIA 257
Cdd:COG2814 165 WVFLVNAVLALLALLLLLR----------------LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 258 WLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrkTAIVIGLVLSALGTLLVVQSSTPAQA 337
Cdd:COG2814 229 YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR---------RLLLIGLLLLALGLLLLALAGSLWLL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1603720766 338 VAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFAS 384
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-419 |
4.97e-35 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 133.90 E-value: 4.97e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIA-PPALVIMQLAWGWRTMFVVI 183
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGyVVGGLVAQATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 184 GLAGIVVG-LCWyvgyrnrrqFTLqeEEQQYLASEEAARPALKFSEWL----ALFKRRTTWGMILGFSGVNYTGWLYIAW 258
Cdd:cd17328 161 GVLGVLLAiLLL---------LFV--REPPRGAAEGGVMAKSTATSFLadlkALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 259 LPGYLQ---AQQGLSLARTGWVA-AIPFLAAAVGMWVNGLVVDALARRGydqAKTRKTAIVIGLVLSA----LGTLLVVQ 330
Cdd:cd17328 230 APTFFLrafGVGDLSSADVGLIFgAITCIAGVLGVLLGGILADRLRRKT---PRADPLVCAVGLLAAApflfLALVLALS 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 331 SSTPAQAVAFISMALFCVHFAGTSAwgLVQVMVAEHKVASVAAIQNFGSFVFASFA-PIVTGWVVDTTH----------- 398
Cdd:cd17328 307 NLLLAWVLLFLGEFLLSLNWAPVFA--ILLYVVIPTRRSTASAIQILLSHLLGDAGsPYLIGLISDLLRqnkdsplaeaa 384
|
410 420
....*....|....*....|.
gi 1603720766 399 SFNLALVIAAGVTFAGALCYF 419
Cdd:cd17328 385 SLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-416 |
1.70e-33 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 129.28 E-value: 1.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAG 187
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 188 IVVGLCWYVGYRNRRQftlqeeeqqylASEEAARPALKFSEWLALFKRRTTWgmILGFSGVNYTG--WLYIAWLPGYLQA 265
Cdd:cd17475 161 ILAAVLFWLFYREPPA-----------ASAATESASTLLRSLKEVLRNRDVW--LIAIAGALLVApqFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 266 QQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFIsMAL 345
Cdd:cd17475 228 HLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGG-------RRRPVLVITAAIAAAALLVLSLLSPGTPLWLL-VLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1603720766 346 FCVHFAGTSAWG-----LVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGAL 416
Cdd:cd17475 300 LILLGLFAIGWNglyltLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-387 |
1.13e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 125.99 E-value: 1.13e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVA-GEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTG 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 107 MVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLA 186
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 187 GIVVGLCWYVgyrnrrqftLQEEEQQYLASEEAARPALKFSEWLALFKRRTTWgMILGFSGVNYTGWLYIAWLPGYLQaQ 266
Cdd:pfam07690 161 SLLAAVLLLL---------PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQE-V 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 267 QGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqakTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALF 346
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1603720766 347 CVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAP 387
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-419 |
3.91e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.84 E-value: 3.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPA--LVIMQLAWGWRTMFVVIGL 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLggILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 186 AGIVVGLCWYVGYRNRRqftlqeeeQQYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQA 265
Cdd:cd06174 161 LALLAAILLLLVVPDPP--------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 266 QQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALarrgydqaKTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMAL 345
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL--------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1603720766 346 FCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYF 419
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-427 |
1.27e-29 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 118.82 E-value: 1.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 40 SSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRI 119
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 120 GLGIGEAPFMPAGVKSINDWYAQReRGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYR 199
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 200 NRRQftlqeeeqqylaseeAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQaQQGLSLARTGWVAA 279
Cdd:COG2807 194 RRPA---------------AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 280 IPFLAAAVGmwvnGLVVDALARRgydqAKTRKTAIVIGLVLSALGTLLVVQSSTPAqavAFISMALFCVHFAGTSAWGLV 359
Cdd:COG2807 258 LFQLAGIPG----SLLVPLLADR----LGDRRPLLLLLGLLGLAGLLGLLLAPGSL---PWLWAVLLGLGQGGLFPLALT 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 360 QVMV---AEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFFIVKTRID 427
Cdd:COG2807 327 LIGLrarTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-422 |
3.41e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.29 E-value: 3.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 51 ADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMP 130
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 131 AGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCwyvgyrnrRQFTLQEEE 210
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL--------ALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 211 QQylASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMW 290
Cdd:cd17325 176 PP--PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 291 VNGLVVDalaRRGydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVAS 370
Cdd:cd17325 254 PAGKLSD---RIG------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 371 VAAIQNFGSFVFASFAPIVTGWVVDTThSFNLALVIAAGVTFAGALCYFFIV 422
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
25-379 |
6.97e-26 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 108.49 E-value: 6.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLS---VAGeaIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAM 101
Cdd:cd17327 7 LPLLCILYFLQYLDKSNISnaaVMG--MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 102 QALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIA---PPALVIMQLA---WG 175
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGgllAYGVFKILGVgglAG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 176 WRTMFVVIGLAGIVVGLCWYVGYRN----RRQFTLQEEEQ--QYLASEEAARPALKF--SEWLALFKRRTTWGMILGFSG 247
Cdd:cd17327 165 WRWLFIIEGLITIIIGLVIFFWLPDnpskAWFLTEEEKELavERLRANQTGKGDQKFkwKQIKEAFKDPRTWLLFLFFFC 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 248 VNYTGWLYIAWLPGyLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRGYdqaktrktAIVIGLVLSALGTLL 327
Cdd:cd17327 245 SQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGL--------FAIFACVLALVGSII 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 328 VVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEH-KVASVAAIQNFGS 379
Cdd:cd17327 316 LLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYtKRATVLAIMLIFY 368
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
39-417 |
1.22e-24 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 104.28 E-value: 1.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 39 RSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLR 118
Cdd:cd17312 19 RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 119 IGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGY 198
Cdd:cd17312 99 GLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 199 RNRrqftlqeeeqqylaseeaarpalkfsewlalfkRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVA 278
Cdd:cd17312 179 RDS---------------------------------PPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 279 AIPFLAAAVGMWVNGLVVDALARrgydqaKTRKTAIVIGLVLSALGTLLVVQSSTPAqAVAFISMALFCVHFAGTSA--W 356
Cdd:cd17312 226 SLYEVGGIAGTILAGLLSDKLFG------GRRAPIAVIYMLLMTLSLALFWFFPHNK-LLSIVLLFLIGFFVGGPINliG 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 357 GLVQVMVAEHKVAS-VAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALC 417
Cdd:cd17312 299 GAAAQDIGRKEAAGtATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-421 |
3.72e-24 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 103.03 E-value: 3.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIApPALVIMQLAWGWRTMFVVIG 184
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 185 LAGIVVGLCWyvgyrnrrqFTLQEEEQqylaSEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQ 264
Cdd:cd17474 160 ALIPVAFLAI---------LFLLPEPK----EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 265 AQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVdalarrgyDQAKTRKTAIVIGLVLSALGTLLVVqsSTPAQAVAFISMA 344
Cdd:cd17474 227 LLYGISPIIIGLLFAGWSVLLALGSLFVGRLL--------KKRFGARRILVIGLLLYALSLLLLG--FVPSLALLLIAIV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 345 LFCVHFAGTSAwgLVQVMVAEHKV----ASVAAIQNFGSFVFASFAPIVTGWVVDtTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17474 297 LFGLGLGLNLP--LLTTLVTELAPeeerGTASSLYNFVRFLGQAVGPLLFGLLLE-IFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 1603720766 421 I 421
Cdd:cd17474 374 L 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
48-420 |
3.40e-21 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 94.56 E-value: 3.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAP 127
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 128 FMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVV-GLCWYvgyrnRRQFTL 206
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLlLLVLL-----FLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 207 QEEEQQylaseeaARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAA 286
Cdd:cd17320 179 PEEKRK-------PLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 287 VGMWVNGLVVdalarRGYDQAKTRKTAIVIgLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEH 366
Cdd:cd17320 252 LGSLLNGRLV-----RRFGPRRLLRLGLLL-LLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1603720766 367 KVASVA-AIQNFGSFVFASFAPIVTGWVVDTTHSfNLALVIAAGVTFAGALCYFF 420
Cdd:cd17320 326 HVAGTAsALLGFLQFLIGALAGALVGLLPNGTAL-PMGLLILVLGLLALLLLILL 379
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-416 |
1.21e-20 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 93.10 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17355 8 TFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGV-KSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLA 186
Cdd:cd17355 88 ATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 187 GIVVGLCWYVGYRNRRqftlqeeEQQYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLqAQ 266
Cdd:cd17355 168 ALLVLVPVLLLLRRRP-------ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-AD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 267 QGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALF 346
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR-------RLLAASYALRALGLALLLLLPFPPLALLLFAALFGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 347 CVHFAGTSAwGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGAL 416
Cdd:cd17355 313 WGATVPLTA-ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-419 |
1.83e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 92.23 E-value: 1.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIG 184
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 185 LAGIVVGLCWYVGYRNRRQFtlqeeeqqylaseeAARPALKFSEWLALFKRRTTWGM----ILGFSGVnYTGWLYIAWlp 260
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPK--------------KPGSLGLLSSLLLLLRNPRLRLAylitFLLFGGF-FALYTYLAP-- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 261 gYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrktAIVIGLVLSALGTLLVVQSSTPAQAVAF 340
Cdd:cd17324 224 -FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR----------ALLIALLLLAAALLLLTLLGPSPLLLLV 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1603720766 341 ISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTThSFNLALVIAAGVTFAGALCYF 419
Cdd:cd17324 293 GLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
49-419 |
1.77e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 89.15 E-value: 1.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 49 IRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPF 128
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 129 MPAGVKSINDwYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVgyrnRRQFTLQE 208
Cdd:cd17478 102 HPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLR----LRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 209 EEQQYLASEEAARPALKFSEWLALfkrrttWGMILGFSGVNYTgwlYIAWLPGYLqAQQGLSLARTGWVAAIPFLAAAVG 288
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLL------LIIVFLRSWVLSS---LTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 289 MWVNGLVVDALARRgydqaktrkTAIVIGLVLSALGTLLVVQSSTPAQAVAFIsMALFCVHFAGTSAWGLVQVMVAEHkv 368
Cdd:cd17478 247 TLIGGPLSDRFGRR---------RVIIASLLLAAPFLLLFLLTPGIWSYILLV-LAGFLLFASFPVTVVLAQELLPGN-- 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 369 ASVAAIQNFG-SFVFASFAPIVTGWVVDTThSFNLALVIAAGVTFAGALCYF 419
Cdd:cd17478 315 VGLASGLMMGlSFGLGGIGAPVLGALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
25-413 |
7.04e-19 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 87.69 E-value: 7.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSA-MQA 103
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 104 LTGMVNSFSHFILLRIGLGIGEAPFMpAGVKSINDWYAQRERGTAVGIF----NSSTVLGQAIAPPALVIMQLAW---GW 176
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLIAGAIVFDGgfvGW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 177 RTMFVVIGLAGIVVGLCWYVGYRNrrqftlqeeeqqylaSEEAARPALKF-SEWLALFKRRTTWGMILGFsGVNYTGWL- 254
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGDD---------------LPTGKASALEFlKVQLAVLKNYRTWILSLLY-GVTFGSFVg 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 255 YIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTP 334
Cdd:cd17341 224 FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGR-------RRLWWLFIVMTIGAALLSLSLPTSG 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 335 AQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVAS------VAAIQNFGSFVFasfaPIVTGWVVDTTHSFNLALVIAA 408
Cdd:cd17341 297 TNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELgavtglVGAIGGLGGFFL----PLLFGSSALMTGSGVGAFSLFG 372
|
....*
gi 1603720766 409 GVTFA 413
Cdd:cd17341 373 VLAVA 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-425 |
3.59e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 85.68 E-value: 3.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 23 ITLTMLFIAGIVNfldrSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQ 102
Cdd:COG0738 12 AIYLLFFLWGFAT----ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 103 ALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYaQRERGTAVGIFNSSTVLGQAIAP---PALVIMQLAWGWRTM 179
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPllgGLLILLGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 180 FVVIGLAGIVVGLCWYvgyrnRRQFTLQEEEQQYLASEEAARpalkfsewLALFKRRTTWGMILGFSGVNYTGWLYIAWL 259
Cdd:COG0738 167 YLILAVLLLLLALLFL-----RSKLPEIEEEEEEAAGSAASL--------KSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 260 PGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrkTAIVIGLVLSALGTLLVVQSSTPAQAVA 339
Cdd:COG0738 234 PLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV---------RLLRLSALLAAVGLLLALLAPGPWLALI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 340 FISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFAsFAPIVTGWVVDTThSFNLALVIAAGVTFAGALCYF 419
Cdd:COG0738 305 GLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGA-IGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLAL 382
|
....*.
gi 1603720766 420 FIVKTR 425
Cdd:COG0738 383 ALKRKR 388
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
29-395 |
4.07e-18 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 85.76 E-value: 4.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 29 FIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMV 108
Cdd:cd17345 9 FIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 109 NSFSH----FILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPaLVIMQLAWG----WRTMF 180
Cdd:cd17345 89 PSATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGP-LAGLGLAIFgdgwWRGAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 181 VVIGLAGIVVGLCWYVGYRNRRQF----TLQEEEQQYLASEEAARPALKFSEWLALFKR--RTTWGMILGFSGVnytgWL 254
Cdd:cd17345 168 IFPAIIAIIVAVIVLFLGKDTPESeglpPIEEYKGDYPEEADGEEEEQELSAWEIFVKYvlKNKLLWYIAIANV----FV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 255 YIA------WLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALarrgydqAKTRKTAIVIGLVLSALGTLLV 328
Cdd:cd17345 244 YLVrygildWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL-------FKGRRAPTGIIFMILVIVALIV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1603720766 329 VQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAA-IQNFGSFVF-ASFAPIVTGWVVD 395
Cdd:cd17345 317 YWLAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAgLTGLFGYLGgSVLATALIGIIVD 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-419 |
2.22e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 83.03 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLDRSSLSVAGEAIRA--DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQ 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 103 ALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAppALVIMQL------AWGW 176
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA--ALVASLLipllsgDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 177 RTMFVVIGLAGIvvglcwyvgyrnrrqftlqeeeqqylaseeaarpalkfsewLALFKRRTTWGMILGFSGVNYTGWLYI 256
Cdd:cd17316 159 RILFLIGALPAL-----------------------------------------LALLLRRRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 257 AWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDalaRRGydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQ 336
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSD---RIG------RKKTLVIGLILSGILALPLFYLLSGSP 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 337 AVAFIsmALFCVHFAGTSAWGLVQVMVAEHKV----ASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTF 412
Cdd:cd17316 269 TLLLL--LLFILSFFVGGVWGALYAYLAELFPtevrATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
....*..
gi 1603720766 413 AGALCYF 419
Cdd:cd17316 347 VALIVAL 353
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
28-194 |
3.55e-17 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 82.45 E-value: 3.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAG 187
Cdd:cd17488 88 SSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIA 167
|
....*....
gi 1603720766 188 IVVG--LCW 194
Cdd:cd17488 168 ILMGivLCW 176
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-421 |
3.96e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 82.22 E-value: 3.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAG 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 188 IVVglcwyvgyrnrrqftlqeeeqqylaseeaarpalkfsewlALFKRRTTWGMILGFSgVNYTGWLYIAWLPGYLQAQQ 267
Cdd:cd17321 161 LVA----------------------------------------LLLARTFSGAVLAAFL-LGAALGGLLFLLPLYLQGVL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 268 GLSLARTGWVaaipFLAAAVGMWVNGLVVDALARRgydqaKTRKTAIVIGLVLSALGTLL---VVQSSTPAQAVAFISMA 344
Cdd:cd17321 200 GYSPLQAGLA----LLPLALAMLVAAPLAGRLADR-----FGPRLVLVAGLLLTAVGLLLlalLGADSSVWLLLPGLVLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 345 LFCVHFAGTSAWGLVQVMVAEHKVASVAAIQN-------------FGSFVFASFAPIVTGWVVDT---------THSFNL 402
Cdd:cd17321 271 GLGLGLFATPLTNAALSSVPKEKAGAASGILNtarqlggalgvalLGALLTAGLSANLGDSGVAAllsaaaaafAAGFHL 350
|
410
....*....|....*....
gi 1603720766 403 ALVIAAGVTFAGALCYFFI 421
Cdd:cd17321 351 AFLVAAALALLAALLALLL 369
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
23-194 |
1.24e-16 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 81.30 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 23 ITLTMlFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQ 102
Cdd:PRK11663 24 ILITM-YLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIIN 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 103 ALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVV 182
Cdd:PRK11663 103 ILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMI 182
|
170
....*....|....
gi 1603720766 183 IGLAGIVVGL--CW 194
Cdd:PRK11663 183 AGIIAIVVGLflCW 196
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
27-418 |
1.44e-16 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 80.74 E-value: 1.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNFLDRSSLSVA------GEAIRADLGLSATEF----------------GVLLSAFSLSYGFAQLPSGILLDR 84
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAivamvnSTATHDNNNTSTDKDtlpveapefdwsektqGIILSSFFYGYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 85 LGPRIVLGAGLIFWSAMQALTGMVNSFSH--FILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAI 162
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLTPLAARGGYgaLIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 163 APPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYvgyrnrrqftlqeeeqqylaseeaarpalkfseWLALfkrrTTWGMI 242
Cdd:cd17318 163 AMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWF---------------------------------FLVL----PVWAIV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 243 LGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRG-YDQAKTRKTAIVIGLVLS 321
Cdd:cd17318 206 VAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGP 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 322 ALGTLLVVQ-SSTPAQAVAFISMALFCvHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVV---DTT 397
Cdd:cd17318 286 GVFLIALGYlGSNATLAVVFLTLSVGL-SGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVkndQTI 364
|
410 420
....*....|....*....|.
gi 1603720766 398 HSFNLALVIAAGVTFAGALCY 418
Cdd:cd17318 365 GQWRIVFFISAAIYILGAIFY 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
49-420 |
2.06e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 80.31 E-value: 2.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 49 IRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPF 128
Cdd:cd17473 26 AQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 129 MPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIApPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRQftlQE 208
Cdd:cd17473 106 MTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARK---SK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 209 EEQQYLASEEAARPALKFSEWLALfkrrTTWGMILGFSGVNYtgwlyiawLPGYLQAQQGLSLARTGWVAAIPFLAAAVG 288
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPIYFL----AFLAMLLFYVIPIQ--------LPFLLQERGGGSAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 289 mwvnGLVVDALARRgydqaKTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKV 368
Cdd:cd17473 250 ----ALLFGRLKRR-----LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 369 ASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17473 321 GRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-304 |
5.05e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 78.31 E-value: 5.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 12 ATPLRIRRVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVL 91
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 92 GAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQ 171
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 172 LAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRQFtlqeeeqqYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYT 251
Cdd:COG0477 163 AALGWRWIFLINAPLGLLALVLRLRLPESRGLL--------LALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 252 GWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRGY 304
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
48-421 |
1.70e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 77.73 E-value: 1.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAP 127
Cdd:cd17371 24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 128 FMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIA----PPALVIMQLAWGWRTMFVvigLAGIVVGLCWYVgyrnRRQ 203
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtllaALLFPLLPPEIAWRVLFL---LGALPALLVLFI----RRF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 204 FTLQEEEQQYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFL 283
Cdd:cd17371 177 VKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTIL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 284 AAAVGMWVNGLVVDALARRgydqaktrkTAIVIGLVLSALGTLLVVQ-SSTPAQAVAFISMALFCVhFAGTSAWG--LVQ 360
Cdd:cd17371 257 GGFLGYLAGGFLADRIGRR---------NNFALFALGSAISILLYFFlPLSPTLILILGFPLGFFA-SGPFSGMGayLTE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 361 VMVAEHKVASVAAIQNFGSFVfASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFFI 421
Cdd:cd17371 327 LFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
48-348 |
2.58e-14 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 73.88 E-value: 2.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVN-SFSHFILLRIGLGIGEA 126
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 127 PFMPAgVKSINDWYAQRERGTAVGIF----NSSTVLGQAIAPP--------ALVIMQLAWGWRTMFVVIGLAGIVVGLCW 194
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPiigslifgGGQPAHLAWGWAFVIVPAGILLLPALLIF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 195 YVGYRNrrqFTLQEEEQqylaseeaarpALKFSEWLALFKRRTTWGMILGFSgVNYTGWL-YIAWLPGYLQAQQGLSLAR 273
Cdd:TIGR00886 186 FVGADT---PPGKPATG-----------KLSFKEALKVFGNRHTWILALLYS-VTFGSFLgVSSIFAMLFKDQFGLSKVQ 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1603720766 274 TGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCV 348
Cdd:TIGR00886 251 AGAYASLGGFLGSLARPAGGAISDRLGGA-------RKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVALFF 318
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-394 |
2.96e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.93 E-value: 2.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 18 RRVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIF 97
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 98 WSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWR 177
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 178 TMFVVIGLAGIVVGLCW---------YVGYRNRRQFTLQ--------EEEQQYLASEEAARPALKFSEWLALFKRRT--- 237
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLLLmrflpesidFLVSKRPETVRRIvnaiapqmQAEAQSALPEQKSTQGTKRSVFKALFQGKTari 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 238 TWGMILGFSGVNYTGWLYIAWLPgYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrktaiVIG 317
Cdd:TIGR00895 252 TVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPR------------VTA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 318 LVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMV----AEHKVASVAAIQNFGSFVfASFAPIVTGWV 393
Cdd:TIGR00895 319 LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMAlfypTAIRATGVGWAIGIGRLG-AIIGPILAGYL 397
|
.
gi 1603720766 394 V 394
Cdd:TIGR00895 398 L 398
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-193 |
1.77e-13 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 67.29 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 61 GVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWY 140
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 141 AQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLC 193
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-422 |
3.79e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 52 DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPA 131
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 132 GVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVI-GLAGIVVGLCWYVGYRNRRQftlqeee 210
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAaVLALLALLLVFLVKDPPPVA------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 211 qqylaseeAARPALKFSEWLALFKRR-TTWGMILGFSGVNYTGwlYIAWLPGYLqAQQGLSlartgwVAAIPFLAAAVGM 289
Cdd:cd17489 178 --------AEEAEAGTRAFRRLVEKKvLPPALILFLASIAYGA--ISTFLPLYA-AERGIS------NAGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 290 wvngLVVDALARRGYDQaKTRKTAIVIGLVLSALGtlLVVQSSTPAQAVAFISMALFCVHFAgtSAWGLVQVMVAEHKVA 369
Cdd:cd17489 241 ----LLSRPFSGKLSDR-KGPKTVIIPGLLLLALG--LLLLSFAGSPWMLLLAAVLYGLGFG--LLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 370 SVAAIQNFGSFVFA----SFAPIVTGWVVDTThSFNLALVIAAGVTFAGALCYFFIV 422
Cdd:cd17489 312 HRRGAANGTFFIFFdlgiGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-421 |
6.31e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.91 E-value: 6.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 30 IAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVN 109
Cdd:cd17503 3 LGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 110 SFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMF---VVIGLA 186
Cdd:cd17503 83 NLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyinLPIGIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 187 GIVVGlcwyvgyrnrrqftlqeeeqqylaseeaarPALKfsewLALFKRRT-TWGMILGF-SGVNYTGWLYIawLPGYLQ 264
Cdd:cd17503 163 ALLLA------------------------------PLLD----LRLFKDRNfTLGLLLSFlLGLGLFGAMFL--LPLYLQ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 265 AQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDalaRRGYdqaktrKTAIVIGLVLSALGTLLVVQSSTPA-----QAVA 339
Cdd:cd17503 207 NVLGYSAFESGLVLAPGGLASAILSPLVGRLLD---KFGP------RLLLLAGLLLLALGTLLLAFLTPDTslwliILPL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 340 FISMALFCVHFAGTSAWGLVQvmVAEHKVASVAAIQNF-----GSFVFASFAPIVTGWV-----------------VDTT 397
Cdd:cd17503 278 FIRGLGMGLVFMPLNTLALNS--LPPEQIGDATALFNTirqlgGSIGTALLATLLTNRTqfhhsrlsellaqqvqkQALI 355
|
410 420
....*....|....*....|....
gi 1603720766 398 HSFNLALVIAAGVTFAGALCYFFI 421
Cdd:cd17503 356 IAFNDAFLVSAILLLVGLLLALFL 379
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
61-410 |
1.29e-12 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 69.39 E-value: 1.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 61 GVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALT--GMVNSFSHFILLRIGLGIGEAPFMPAGVKSIND 138
Cdd:TIGR00894 79 GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIpwAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 139 WYAQRERGTAVGIFNSSTVLGQAIAPPAL-VIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRN--RRQFTLQEEEQQYLA 215
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFLPISgWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADdpSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 216 S--EEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAavgmWVNG 293
Cdd:TIGR00894 239 SslQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFA----WLCS 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 294 LVVDALARrgYDQAKTRKTAIVIGLVLSALGTLLVVQSS--TPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVAS- 370
Cdd:TIGR00894 315 IFAGYLAD--FLKSSKTLSLTAARKIFNGIGGLGPGIFAyaLPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPr 392
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1603720766 371 ----VAAIQNFGSFVFASFAPIVTGWVV--DTTHSFNLALVIAAGV 410
Cdd:TIGR00894 393 flgfIKGITGLPGFIGGLIASTLAGNILsqDSKNVWLIVFLIMAFV 438
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
40-413 |
1.50e-12 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 40 SSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFI---L 116
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLgtaL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 117 LRIGLGIGEApFMPAGVKSindwYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQ--LAWGWRTMFVVIGLAGIVVGLCW 194
Cdd:cd17339 96 AGAGIAVGNV-LLPSLIKR----DFPRRVGLMTGLYTTSMNLGAALASGLSVPLAqaLGGGWRGALAIWALPALLALLIW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 195 YvgyrnrrqftLQEEEQQYLASEEAARPALKfsewlaLFKRRTTWGMILGF---SGVNYTGwlyIAWLPGYLQaQQGLSL 271
Cdd:cd17339 171 L----------PQLRRRKRAAAAAAPLTKIS------VWRSPLAWQVTLFMglqSLLFYTL---MAWLPTILI-DAGLSA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 272 ARTGWVAAIPFLAAAVGmwvnGLVVDALARRGYDQAKTrkTAIVIGLVLSALGTLLVVQSSTPAQAVAFISmalfcvhFA 351
Cdd:cd17339 231 ATAGWLLSLFQLVGIPA----SLLVPILATRLKNQRPI--VVLLAVLFIIGVLGLLFAPTALALLWAVLLG-------LG 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 352 GTSAWGLVQVMVA-----EHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFA 413
Cdd:cd17339 298 GGAAFSLALTLISlrssdPAEAAALSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALTVL 364
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
21-248 |
3.35e-12 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 67.74 E-value: 3.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 21 QKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSA 100
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 101 MQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMF 180
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1603720766 181 VVIGLAGIVVGLCWYVGYRNRRQ-FTLQEEEQQYlASEEAARPALKFSEWLALFKRRTTWGMILGFSGV 248
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSdVGLNNIEEEE-SKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVV 228
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
22-340 |
6.04e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.91 E-value: 6.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 22 KITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAM 101
Cdd:PRK11551 14 ALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 102 QALTGMVNSFSHFILLRI--GLGIGEApfMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTM 179
Cdd:PRK11551 94 SLATAQAWDFPSLLVARLltGVGLGGA--LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 180 FVVIGLAGIVVGLCWYVgyrnrrqftLQEEEQQYLASEEAARPALKFSEwlALF---KRRTTWGMILGFSGVNYTGWLYI 256
Cdd:PRK11551 172 FYVGGVGPLLLVPLLMR---------WLPESRAFAQAAGAGKQRAPVLR--ALFgegRATATLLLWISYFFTLIVLYFLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 257 AWLPGyLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQ 336
Cdd:PRK11551 241 NWLPS-LLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPR-------RVVLLIYAGILASLAALAAAPSFAGML 312
|
....
gi 1603720766 337 AVAF 340
Cdd:PRK11551 313 LAGF 316
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-420 |
4.60e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.17 E-value: 4.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 52 DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVL-----GAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEA 126
Cdd:cd06173 28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladlLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 127 PFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCwyvgyrnrrQFTL 206
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALL---------LLFI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 207 QEEEQQYLASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAipflAAA 286
Cdd:cd06173 179 RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLA----AFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 287 VGMWVNGLVVDALARRgydqaKTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEH 366
Cdd:cd06173 255 VGALLGALLLGRLSKR-----RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1603720766 367 KVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd06173 330 LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
28-421 |
1.08e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.98 E-value: 1.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFmPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAG 187
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 188 IVVGlcwyvgyrnrrqftlqeeeqqylaseeAARPALKfsewLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQ 267
Cdd:cd17504 160 VLLA---------------------------ALVPLID----LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 268 GLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARR-GYdqaktrKTAIVIGLVLSALGTL-LVVQSSTPAQAVAFISMAL 345
Cdd:cd17504 209 PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARvGP------RRVLLIGLVISAVGLLlLALLHSSLWALVVALLLIG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 346 FCVHFAGTSAWGLVQVMVAEHKVASV----AAIQNFGS--------FVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFA 413
Cdd:cd17504 283 IGLGLAFASLPNIVVESVPPDRTGIAtgmnTVLRTIGSaigpaiagAILTTYTVSITSGGVPTEGAYVLAFLIGAALALA 362
|
....*...
gi 1603720766 414 GALCYFFI 421
Cdd:cd17504 363 ALLLSLLI 370
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
54-203 |
1.99e-10 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 62.42 E-value: 1.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 54 GLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMV-----NSFSHFILLRI-----GLGi 123
Cdd:PRK11273 59 GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVpwatsSIAVMFVLLFLcgwfqGMG- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 124 geapfMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPaLVIMQLAW--GWRTMFVVIGLAGIVVGLCWYVGYRNR 201
Cdd:PRK11273 138 -----WPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPL-LFLLGMAWfnDWHAALYMPAFAAILVALFAFAMMRDT 211
|
..
gi 1603720766 202 RQ 203
Cdd:PRK11273 212 PQ 213
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-194 |
2.33e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.82 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 40 SSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRI 119
Cdd:cd17323 16 SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1603720766 120 GLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFvviGLAGIVVGLCW 194
Cdd:cd17323 96 LQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF---WFLAIISGFCL 167
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
53-421 |
3.18e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 3.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRI-----VLGAGLIFWSAMQALTGMVNSFSH----------FILL 117
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPtgkliyalvtYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 118 RIGLGIGEAPFMPAGVKSINDwYAQRERGTAVGIF--NSSTVLGQAIAPPALVIM--QLAWGWRTMFVVIGLAGIVVGLC 193
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTPD-YEERTRLSSWRFAfaGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAFLL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 194 WYVGYRNRRQftlqeeeqqylaseeAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGW-LYIAWLPGYLQAQQGLSLA 272
Cdd:COG2211 200 TFFGTKERPV---------------PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALaLVAALLLYYFKYVLGLSAA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 273 RTGWVAAIPFLAAAVGMwvngLVVDALARRgydqaKTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCvhFAG 352
Cdd:COG2211 265 LVGLLLALYFLAALLGA----PLWPRLAKR-----FGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAG--IGL 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 353 TSAWGLVQVMVAE-----------HKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHsFNLALVIAAGVTFAGALCYFFI 421
Cdd:COG2211 334 GAILVLPWAMLADvvdydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFG-YVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-419 |
5.10e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.68 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAG---EAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGfvaPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFILLRI--GLGIGEApfMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAppALVIMQL--AWGWRTMF 180
Cdd:cd17365 81 TAFAQSVLQLALLRFltGLGLGAA--MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG--GFLAAALipAFGWRSVF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 181 VVIGLAGIVVGLCwyvgyrnrrqftlqeeeqqylaseeaARPALKFseWLALFKrrttwGMILGFsgvnytgwLYIAWLP 260
Cdd:cd17365 157 LLGGVPPLILLPL--------------------------LRGTLLL--WVTFFM-----GLLLVY--------LLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 261 gYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDalaRRGydqaktRKTAIVIGLVLSALGTLLV-VQSSTPAQAVA 339
Cdd:cd17365 196 -KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD---RFG------PKRVLALFFALGAVSLALLgVSPASLVLLYV 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 340 FISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYF 419
Cdd:cd17365 266 LVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVL 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
52-420 |
2.00e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.78 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 52 DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPA 131
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 132 GVKSINDWYAQRERGTAVGIFNSSTVLGQAIApPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRqftlqeeeq 211
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETR--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 212 qylASEEAARPALKFSEWLALFKRRTTWGMILGFSGvnyTGWLYIAW---LPGYLQAQQGLSLARTGWVAAIPFLAAAVG 288
Cdd:cd17329 179 ---PKRRAAEKTEILRGYKIVLRDRAFLLFLLASFL---ISLIYFQLestLPVYVVEILGLGESLLGLLLALNALLIVLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 289 -MWVNGLVvdalarrgydQAKTRKTAIVIGLVLSALGTLLVVQSSTPaqAVAFISMALFCVhfAGTSAWGLVQVMVA--- 364
Cdd:cd17329 253 qFPVARLV----------ERFRLRKILMIGILLFAIGFAVLAFANTL--AVLILAMIVLTL--GEMLVFPAVQTLVAala 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 365 -EHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17329 319 pPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
48-416 |
2.48e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 58.47 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAP 127
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 128 FMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIM-QLAWGWRTMFVVIG-LAGIVVGLCWYVGYRNRRQFT 205
Cdd:cd06180 104 VFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGlGGGLSWRAGWLALAlLSAVLLLLSFLLLRRGPSAPT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 206 LQEeeqqylASEEAARPALKFSEWLALFkrrttwgmilGFSGVNYTgwLYIAWLPGYLqAQQGLSLARTGWVAAIPFLAA 285
Cdd:cd06180 184 EAS------AAESAPGLNRPLWRLALAY----------GLFGFGYI--ITATFLPLIA-RETGAGSLLAGLLWSLFGLAA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 286 AVGMWVNGLVVDALARRgydqaktrkTAIVIGLVLSALGTLLVVQSSTPAQAVafISMALFCVHFAGTSAWglvqVMVAE 365
Cdd:cd06180 245 VPSCFLWGALSDRWGTR---------RALAANLLVQAVGVLLPLLSPGPAGLV--LSAVLFGGTFMAITAL----VMALA 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 366 HKVASVAAIQNFGSFVfASFA------PIVTGWVVDTTHSFNLALVIAAGVTFAGAL 416
Cdd:cd06180 310 RELAPPAAPRALALMT-ASFGvgqilgPLLAGWLADATGGFAPALILAAAALVVAAL 365
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
60-192 |
4.95e-09 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 57.71 E-value: 4.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 60 FGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM-----VNSFSHFILLRIGLGIGEAPFMPAGVK 134
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1603720766 135 SINDWYAQRERGTAVGIFNSST----VLGQAIAPpalVIMQLAWGWRtmFVV----IGLAGIVVGL 192
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNSHTsvgnILGSLIAG---IFVSSAWGLS--FIVpgiiIAAMGVLVFL 204
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
27-421 |
1.40e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 56.46 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNfldrsSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTG 106
Cdd:cd17353 12 MHLILGYQY-----AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 107 MVNSFSHFILLR-----IGLGIGEAPFMPAGVKsindWYAQReRGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFV 181
Cdd:cd17353 87 FAISLPLLFLGYgvlggIGAGIGYITPVSTAVK----WFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 182 VIGL-AGIVVGLCwyvgyrnrrQFTLQEEEQQY-----LASEEAARPALKFSEWLALFKRRTTWGMILGFSGVNYTGWLY 255
Cdd:cd17353 162 ILGIiFLIIIVIG---------AFLIRDPPKGWvppgvDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 256 IAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALArrgydqaktRKTAIVIGLVLSALGTLLVVqsSTPA 335
Cdd:cd17353 233 IGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIG---------RKNTLSIAFLIQGVAMFLLP--FIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 336 QAVAFISMAlFCVHFAGTSAWGLVQVMVAEH---KVASVaaiqNFG----SFVFASFAPIVTGWVVDTTHSFNLALVIAA 408
Cdd:cd17353 302 VAVLFVLGV-ALIGFCYGGGFALFPALTADFfgtKNAGT----NYGllytAKGVGGLIGPIIAAYVLYTGGYNAAFIIAA 376
|
410
....*....|...
gi 1603720766 409 GVTFAGALCYFFI 421
Cdd:cd17353 377 ALSLVALALALLL 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
61-422 |
2.03e-08 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 55.94 E-value: 2.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 61 GVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSF--SHFILLRIGLGIGEAPFMPAGVKSIND 138
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLgaGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 139 WYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYvgyrnrrqftlqeeeqqylasee 218
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWI----------------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 219 aarpalkfseWLALfkrrTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDA 298
Cdd:cd17381 205 ----------WLVM----PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADN 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 299 L-ARRGYDQAKTRKTAIVIGLVLSALGTLLVVQSSTP-AQAVAFISMALFCVHFAgTSAWGLVQVMVAEHKVASVAAIQN 376
Cdd:cd17381 271 LrEKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNySLAVAFLTISSTLGGFS-ASGFNINHLDIAPSYAGILLGITN 349
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1603720766 377 FGSFVFASFAPIVTGWVV--DTTHSFNLALVIAAGVTFAGALcyFFIV 422
Cdd:cd17381 350 TFATIPGMVGPVIAKSLThnNTVEEWQTVFYISAAINVFGAI--FFTI 395
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
25-421 |
2.43e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 55.64 E-value: 2.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNfldrsSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17352 10 LVNFFTDGILN-----SFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMVNSFSHFIL-LRIGLGIGEAPFMPAGVKSINDWYaQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVi 183
Cdd:cd17352 85 SSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 184 gLAGIVVGLCWyvgyrnrrqftlqeeeqqylaseeaarpalkFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYL 263
Cdd:cd17352 163 -LGGLCLNLCV-------------------------------CGLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 264 qAQQGLSLARTGWVAAIPFLAAAVGMWVNGLvvdaLARRGYDQAKTRKTAIVIGLVLSalgTLLVVQSSTPAQAVAFism 343
Cdd:cd17352 211 -KSLGIDESDAAFLLSIIGISDIVGRILLGL----LADKPRIGRLYLYIFTLLILGLS---LLAFPLATTYVGLIVF--- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 344 aLFCVHFAGTSAWGLVQVMVAEH----KVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGALCYF 419
Cdd:cd17352 280 -SVLFGFCSGSYSSLTPVILADLvgleKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLF 358
|
..
gi 1603720766 420 FI 421
Cdd:cd17352 359 LL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-163 |
7.63e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 7.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 4 ETLAARTGATPLRIRRV--QKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGIL 81
Cdd:COG2814 187 ESRPAARARLRGSLRELlrRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 82 LDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQA 161
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
..
gi 1603720766 162 IA 163
Cdd:COG2814 347 LA 348
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
28-197 |
6.58e-07 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 51.20 E-value: 6.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:PRK09556 34 VFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 V-NSFSHFILLRIGL----GIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAppALVIMqlaWGWRT---- 178
Cdd:PRK09556 114 SlGSGSVSLGLMIALwalsGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGA--GGVAL---WGANYffdg 188
|
170 180
....*....|....*....|....
gi 1603720766 179 ----MFVVIGLAGIVVGL-CWYVG 197
Cdd:PRK09556 189 hvigMFIFPSIIALIIGFiGLRYG 212
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
25-415 |
1.08e-06 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 50.49 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFldRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL 104
Cdd:cd17314 7 VSFLLSAMSTGF--ILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 105 TGMV-NSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQReRGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVI 183
Cdd:cd17314 85 LSYVfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 184 GLAGIVVGLCWYVGyRNRRQFTLQEEEQQYLAseeaarpalKFSEWLALFKRRTTWGMILGFSGVNYTGWLYIAWLPGYL 263
Cdd:cd17314 164 GILAAIVLSVVSLL-GFKEPPDNQARLHVQKK---------KTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 264 QAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqakTRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISM 343
Cdd:cd17314 234 RSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGR------LSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 344 ALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIAAGVTFAGA 415
Cdd:cd17314 308 LGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLAS 379
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
56-193 |
2.46e-06 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 49.23 E-value: 2.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 56 SATEF-GVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHF------ILLRIGLGIGEAPF 128
Cdd:cd17342 60 DAALFlGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFynkylyCILWVLNGLLQSTG 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1603720766 129 MPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIApPALVIMQLAWGWRTMFVV---IGLAGIVVGLC 193
Cdd:cd17342 140 WPCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIG-ALLASSVLDYGYEYAFLVtssLLFAGAIVVFF 206
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
51-420 |
7.39e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 7.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 51 ADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPR-IVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFM 129
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 130 PAGVkSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIV-VGLCWYVGYRNRRQFTLQE 208
Cdd:cd17490 104 SFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLgFILSLFIKEERREKKPVLT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 209 EEQQYLasEEAARPALKFSEWLALFKRRTTWGMILGFSGVnytgwlyiawlpgyLQAQQGLSLARTGWVAAIPFLAAAVG 288
Cdd:cd17490 183 ELKELL--SVLKDKKLLFFSLLAILQQMITFSTTFGFTPL--------------IAKQLGASSFQLGLLSIIYLLPNALA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 289 MWVNGLVvdALARRGYdqaktrKTAIVIGLVLSALGTLLVVQSSTPAQavafismaLFCVHFAGTSAWGLVQVM------ 362
Cdd:cd17490 247 SLLSGTL--FYKKLGE------RNTIIIGFLLLGAYCFLIPFAPNLTL--------LYLLQALNGFGTGILFPLlmslsi 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1603720766 363 --VAEHKVASV----AAIQNFGSFVFasfaPIVTGWVVDTThSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17490 311 egVPAEQRSTAmgffQAIYALGMFLG----PVLVGIISEAF-GLQTGFFVIGVIALLAAILSLA 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
53-203 |
7.46e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 7.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPR--IVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMP 130
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 131 AGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRQ 203
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-416 |
7.48e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 7.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYaQRERGTAVGIFNSSTVLGQAIAPP-ALVIMQLAWGWRTMFVVIGLA 186
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLiATSLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 187 GIVVGLCWYvgyrnRRQFTLQEEEQQYLASEEAARPALKFSEWLalfkRRTTWGMILGFSGVNYTGWLYIaWLPGYLQAQ 266
Cdd:cd17333 160 YLLLAILIL-----LTLFPELPSARNPQQSVGAFSASASRLLRN----PSIILGALALFLYVGAETAFSS-WVPSYLVEK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 267 QGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRGYdqaktrktaIVIGLVLSALGTLLVVQSSTPA-QAVAFISMAL 345
Cdd:cd17333 230 KHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL---------LVLSGSGALLGLLILLLAPTLVvGLVATALLGL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1603720766 346 FC-VHFAGTSAWGLVQVMVAEHKVASVAAIqnFGSFVFAsFAPIVTGWVVdttHSFNLALVIAAGVTFAGAL 416
Cdd:cd17333 301 FMaALFPTILSLGISNLPYAKGKGTSVLLA--AGSIGGA-IIPFIMGFIA---EAVGIQTAMLLITILYAII 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-196 |
8.09e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 8.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 15 LRIRRVQKITLTMLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAG 94
Cdd:cd06173 201 LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 95 LIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAW 174
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|..
gi 1603720766 175 GWRTMFVVIGLAGIVVGLCWYV 196
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLL 382
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
48-294 |
1.47e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.82 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGL-IF-WSAMQALTgmVNSFSHFILLRI--GLGI 123
Cdd:PRK11652 33 DMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMsIFiLGTLVALF--AHSLTVLIAASAiqGLGT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 124 GEAPFMpagVKSI-NDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRR 202
Cdd:PRK11652 111 GVGGVM---ARTLpRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 203 qfTLQEEEQQYLASEEAARPALKFSEWL----------ALFKRRT--TWGMILGFSGVNYTgWLYIAWLPGYL-----QA 265
Cdd:PRK11652 188 --PADARRTRVLASYRTLLSNRRFNCYLlmligtlagiAVFEACSgvLMGAVLGLSSMTVS-ILFILPIPAAFfgawfAG 264
|
250 260
....*....|....*....|....*....
gi 1603720766 266 QQGLSLARTGWVAAIPFLAAAVGMWVNGL 294
Cdd:PRK11652 265 RPNKRFSTLMWQSVICCLLAGLLMWIPGW 293
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
52-420 |
1.70e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 46.73 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 52 DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQA--LTGMVNSFSH-FILLRIGL-GIGEAP 127
Cdd:cd17337 26 DLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVlfLAFGLPSHNYpLMLLTYGLrGFGYPL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 128 FMPAGVKSINDWYAQRERGTAVGIFNSS-----TVLGQAIAPPAL-VIMQLAwgwrTMFVVIGLAGIVVGLCWYVgyrNR 201
Cdd:cd17337 106 FAYSFLVWITYRTPAERLGSAVGWFWFAftgglPVLGSYLASFTIpVIGEIG----TLWLSLVFVALGGLIALFL---VR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 202 RQFTLQEEEQqylaSEEAARPALKFSEWLALFKRRTTWGMILGFsgVNYTGWL-YIAWLPGYLQAQQGLSLARTGWVAAI 280
Cdd:cd17337 179 DRTGEQPLAN----PSEEPLKELLSGITILFRNPKIAIGGIVRI--INTLSQFgFPVFMPLYFTDTGGFSTSQWLQIWGI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 281 PFLAAAVGMWVNGLVVDALARrgydqaktRKTAIVIGLVLSALGTLL---VVQSSTPAQAVAFISMALFCVHFAG---TS 354
Cdd:cd17337 253 IFLVNIFFNLIFGILGDKIGW--------RRTVRWFGGVGCAISTLLfyyVPQLFGHNYWAALIAAILFGIGLAGfvpLS 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1603720766 355 AwgLVQVMVAEHKVASVaAIQNFGSFVFASFAPIVTGWVvdtthsfnLALVIAAGVTFAGALCYFF 420
Cdd:cd17337 325 A--LMPSLAPEHKGAAM-SILNLGAGLSNFVGPAIVTLF--------LGSFGAGGVVWIFAGLYLL 379
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
233-426 |
3.39e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 233 FKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDAL-ARRGYdqaktRK 311
Cdd:COG2211 7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrTRWGR-----RR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 312 TAIVIGLVLSALGTLLV--VQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAE-----HKVASVAAIQNFGSFVFAS 384
Cdd:COG2211 82 PWILIGAIPLALSFVLLftAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAEltpdyEERTRLSSWRFAFAGLGGL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1603720766 385 FAPIVTGWVV-----DTTHSFNLALVIAAGVTFAGALCYFFIVKTRI 426
Cdd:COG2211 162 LASVLPPPLVaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKERP 208
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
46-193 |
3.78e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 45.70 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 46 GEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGE 125
Cdd:cd17313 269 TSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGW 348
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 126 A-----PFmPAGVKSINDwyAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLC 193
Cdd:cd17313 349 AtininPY-PLVSDYHSE--SGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
49-192 |
4.04e-05 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 45.69 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 49 IRADLGLSATEFGvLLSAFSLSYG-FAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAP 127
Cdd:PLN00028 62 IRDNLNLTKSDIG-NAGIASVSGSiFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLAT 140
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1603720766 128 FMPAGVksindW----YAQRERGTAVGIFNSSTVLG----QAIAPPALVIMQLAWG-----WRTMFVVIGLAGIVVGL 192
Cdd:PLN00028 141 FVSCQY-----WmstmFNGKIVGTANGIAAGWGNLGggvtQLLMPLVFPLIKDAGApsftaWRIAFFVPGLLHIIMGI 213
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-164 |
5.41e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 5.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPR---IVLGAGLIFWSAMQA 103
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 104 LTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAP 164
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
53-223 |
6.43e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 6.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMV--NSFSHFILLRIGLGIGEAPFMP 130
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 131 ------AGVKSINDW-YAQRERGTAVGIFNSSTVLGQAIAPP-ALVIMQLA-------------WGWRTMFVVIGLAGIV 189
Cdd:COG2211 339 lpwamlADVVDYDEWkTGRRREGLYFGIFTFAIKLGQALAGAlAGLLLALFgyvagaaqspsalTGIRLLFFLLPAVLLL 418
|
170 180 190
....*....|....*....|....*....|....
gi 1603720766 190 VGLCWYVGYRnrrqftLQEEEQQYLASEEAARPA 223
Cdd:COG2211 419 LAALLLLFYP------LTRERHAEIRAELAARRA 446
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
241-423 |
9.21e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 9.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 241 MILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrkTAIVIGLVL 320
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR---------RVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 321 SALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDtTHSF 400
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGW 150
|
170 180
....*....|....*....|...
gi 1603720766 401 NLALVIAAGVTFAGALCYFFIVK 423
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRP 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-192 |
1.07e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNFldrSSLSVAGEAIRA-DLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALT 105
Cdd:cd17370 205 YLLAVALFAL---GNFSFAFLILRAqELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 106 GMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPpalVIMQLAWGWRTMFVVIGL 185
Cdd:cd17370 282 ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAS---LIAGYLWDLISPSAAFLF 358
|
....*..
gi 1603720766 186 AGIVVGL 192
Cdd:cd17370 359 SAVLALI 365
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
172-420 |
1.49e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.67 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 172 LAWGWRTMFVvigLAGIVVGlcwyVGYRNRRQFTLQEEEQQYLASEEAARPALkfsewLALFKR--RTTWGMILGFSGVN 249
Cdd:cd17369 174 LSWGWRIPFL---LSAVLVA----VGLYIRLRLEETPVFRRAKEAGQVVRAPL-----VEVLRRhwRALLLAIGLRLAEN 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 250 YTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaKTRKTAIVIGLVLSALGTLLVV 329
Cdd:cd17369 242 VLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRR-----PVYLAGALLAALFAFPFFWLLD 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 330 QSSTPAQAVAFIsMALFCVHFAGTSAWG--LVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWVVDTTHSFNLALVIA 407
Cdd:cd17369 317 TGSTWLIVLAAV-VVLGVLHGMMYGPQAafLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYL 395
|
250
....*....|...
gi 1603720766 408 AGVTFAGALCYFF 420
Cdd:cd17369 396 AALAVISLVAALF 408
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
233-423 |
2.26e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 233 FKRRTTWGMILGFSGVNYTGWLYIAWLPgYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDALARRgydqaktrkT 312
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRR---------R 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 313 AIVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGW 392
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|.
gi 1603720766 393 VVDTThSFNLALVIAAGVTFAGALCYFFIVK 423
Cdd:COG2814 157 LADLF-GWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
53-203 |
2.28e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAG 132
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 133 VKSINDwYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRQ 203
Cdd:COG0738 321 FSLALD-GLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
30-396 |
2.54e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.02 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 30 IAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVN 109
Cdd:cd17476 5 GAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 110 SFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQ-RERGTAVGIFNSSTVLGQAI-APPALVIMQLAWGWRTMFVVIGLAG 187
Cdd:cd17476 85 NFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALgGVFGGLFAQLAWWPWIFWFLAILAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 188 IVVGLCWYVGYRNRRQFTLqeeeqqylaseeaarpalkfsewlalfkrrttwGMILGFSGVNytGWLYIAWLpgYLQAQQ 267
Cdd:cd17476 165 IVAVAAIFWTSPSFIAVLL---------------------------------AVFLGWASFG--IWVFYATQ--YFQNVR 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 268 GLSLArtgwVAAIPFLAAAVGMWVNGLVVdalarrGYDQAKTRKTAIV-IGLVLSALGTLLVVQSSTPAQAVAFISMALF 346
Cdd:cd17476 208 GYSPL----LTSARFIPMAIGGVLAAITV------GFLIARLPPSYIMaISMVAFLVGPILFATMPVHQTYWAQAFPAMI 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1603720766 347 CVHFAGTSAWGLVQVMVA-----EHK-VAS--VAAIQNFGSFVFASFAPIVTGWVVDT 396
Cdd:cd17476 278 VAPFGMDFSFPAATIIASnavprEYQgLAGslVNTVVNYGISIGLGIAGTVETSVNED 335
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
27-185 |
3.23e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 27 MLFIAGIVNFLDRSSLSVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLP-SGILLDRLGPRIVLGAGLIFWSAMQALT 105
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 106 GMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGL 185
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
53-203 |
3.54e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 42.56 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVL-GAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPA 131
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLlIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1603720766 132 GVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPAL-VIMQLAWGWRTMFVVIGLAGIVVGLCWYVGYRNRRQ 203
Cdd:COG2223 316 VFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFgALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
28-378 |
6.00e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 28 LFIAGIVNFLDRSSLSVAGEAIRADLGlSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGM 107
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 108 VNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMF---VVIG 184
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFyinLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 185 LagivvglcwyvgyrnrrqftlqeeeqqylaseeaarpalkfsewLALFKRRTTW-GMILGF-SGVNYTGWLYiaWLPGY 262
Cdd:cd17502 160 G--------------------------------------------LALALLRTILlSSIFGFlFGGALFGLIY--YLPLY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 263 LQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVvdaLARRGYdqaktRKTAIVIGLVLSALGTLL---VVQSSTPAQAVA 339
Cdd:cd17502 194 FQLVLGDSATKSGVRLLPLIIGLVIGSIISGAL---ISKTGR-----YKPLIVIGTILMSVGAGLlttLTLDTSKWLLIG 265
|
330 340 350
....*....|....*....|....*....|....*....
gi 1603720766 340 FISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFG 378
Cdd:cd17502 266 YLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFF 304
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
234-423 |
7.68e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.40 E-value: 7.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 234 KRRTTWGMILGFsGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVVDalaRRGydqaktRKTA 313
Cdd:COG2223 3 RWRVLLLATLAF-FLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD---RFG------PRRV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 314 IVIGLVLSALGTLLVVQSSTPAQAVAFISMALFCVHFAGTSAWGLVQVMVAEHKVASVAAIQNFGSFVFASFAPIVTGWV 393
Cdd:COG2223 73 LLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL 152
|
170 180 190
....*....|....*....|....*....|
gi 1603720766 394 VdTTHSFNLALVIAAGVTFAGALCYFFIVK 423
Cdd:COG2223 153 I-AAFGWRNAFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
59-420 |
8.23e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 41.56 E-value: 8.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 59 EFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQAL--TGMVNSFSHFILLRIGLGIGEAPFMPAGVKSI 136
Cdd:cd17382 50 TVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLipIAARVHYGCVIFVRILQGLVEGVTYPACHGIW 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 137 NDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGlagiVVGLCWYVGYrnrrqftlqeeeqqylas 216
Cdd:cd17382 130 RKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYG----VFGIIWYMFW------------------ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 217 eeaarpalkfsewlaLFKRRTTWGMILGFSGVNYTGWLYIAWLPGYLQAQQGLSLARTGWVAAIPFLAAAVGMWVNGLVV 296
Cdd:cd17382 188 ---------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 297 DALARRGYDQAKT-RKTAIVIGLVLSALGTLLVVQSSTPAQAVAFISMAlfcVHFAG--TSAWGLVQVMVAEHKVASVAA 373
Cdd:cd17382 253 DYLRSRGILSTTAvRKIFNCGGFGMEATFLLVVAFSHSPTVAISFLVLA---VGFSGfaISGFNVNHLDIAPRYASILMG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1603720766 374 IQNFGSFVFASFAPIVTGWVV--DTTHSFNLALVIAAGVTFAGALCYFF 420
Cdd:cd17382 330 ISNGIGTLSGMVCPVIVGALTkhKTREEWQYVFLIASLVHFFGVIFYAI 378
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
54-163 |
1.08e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 41.07 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 54 GLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFwsamQALTGMVNSFSHFILL-RIGLGIGEAPFMPAG 132
Cdd:cd17336 34 GLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSIL----MGLGCFLLALPHFLFVgQFLLGIGSSPLYTLG 109
|
90 100 110
....*....|....*....|....*....|.
gi 1603720766 133 VKSINDWYAQRERGTAVGIFNSSTVLGQAIA 163
Cdd:cd17336 110 ITYIDDNVSKKNSPLYIGILYAMRVLGPALG 140
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
78-196 |
1.66e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.26 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 78 SGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTV 157
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1603720766 158 LGQAIAPP-ALVIMQlawgWRTMFVVIGLAGIVVGLCWYV 196
Cdd:cd17317 125 LGYMLLALlAYLIRD----WRWLQLAISLPGLLFLLLLWW 160
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
25-351 |
1.72e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 40.39 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 25 LTMLFIAGIVNFLdrsslsVAGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLG--PRIVLGAGLIFWSAMq 102
Cdd:PRK10473 11 LVLLYPAGIDMYL------VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGrkPVAIPGAALFIIASL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 103 aLTGMVNSFSHFILLRIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVV 182
Cdd:PRK10473 84 -LCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 183 IGLAGIVVGLCWYVGYRNRRQftLQEEEQQYLASEEAARPALKFSEWLALFkrrTTWGMILGFSGVNYTgwlyiawlPGY 262
Cdd:PRK10473 163 MAAMGILVLLLSLFILKETRP--ARAPAASSKPRENSESLLNRFFLSRLVI---TTLSVTVILTFVNTS--------PVL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 263 LQAQQGLSlarTGWVAAIPFLAAAVGMWVNGLVVDALARRGYdqaktrKTAIVIGLVLsaLGTLLVVQSSTPAQAVAFIS 342
Cdd:PRK10473 230 LMEQMGFS---RGEYAIIMALTAGVSMTVSFSTPFALGIFKP------RTLMLTSQVL--FLAAGITLALSPSHAVSLFG 298
|
....*....
gi 1603720766 343 MALFCVHFA 351
Cdd:PRK10473 299 ITLICAGFS 307
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-192 |
2.45e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 53 LGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVL-GAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMPA 131
Cdd:cd17477 218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLlGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTL 297
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 132 GVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAWGWRTMFVVIGLAGIVVGL 192
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
54-327 |
5.64e-03 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 39.11 E-value: 5.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 54 GLSATEFGVLLSafslSYGFAQLPSGILLDRLG-----PRIVlGAGLIfwsaMQALTGMVNSFSHFILLRIG---LGIGE 125
Cdd:pfam03137 32 GLPSSLSGLISS----SYDIGNLLLIVFVSYFGgkghrPRWI-GVGAL----LMGLGSLLFALPHFLSFFLGqllLGIGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 126 APFMPAGVKSINDwYAQRERGTA-VGIFNSSTVLGQAIA-------------PPALVIM--------QLAWgWRTmFVVI 183
Cdd:pfam03137 103 TPIYTLGISYIDD-NVKKKNSPLyLGILYAVRVLGPALGfllgslclriyvdIGKVSITltpkdprwVGAW-WLG-FLIA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 184 GLAGIVVG--LCWY----VGYRNRRQFTLQEEEQQYLASEEAARPALKFSEWLALFKrRTTWG-------MILGFSGVNY 250
Cdd:pfam03137 180 GLLLLLTAipFFFFpkslPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLKDFP-KALKRllknpvyMLLTLASVFE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 251 TGWL--YIAWLPGYLQAQQGLSLAR----TGWVaAIPFlaAAVGMWVNGLVVDALarrgydQAKTRKTA--IVIGLVLSA 322
Cdd:pfam03137 259 FLLIagYATFLPKYIETQFGLSASTanllTGVV-AIPG--AALGILLGGLIIKKF------KLSAKGLAkfNVITSLVSL 329
|
....*
gi 1603720766 323 LGTLL 327
Cdd:pfam03137 330 LLSLL 334
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
29-424 |
6.93e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 6.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 29 FIAGIVNFLDRSSLSVAGEAiRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMV 108
Cdd:pfam00083 18 VIGAFLTLIDFFKNFGLSKS-VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 109 NSFSHFILL---RIGLGIGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQ---AIAPPALVIMQLAWGWRTMF-- 180
Cdd:pfam00083 97 KGKWSVYQLivgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGIllaYIFGLGLNKTSNSDGWRIPLgl 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 181 -VVIGLAGIVVGLCW-----------------YVGYRNRRQFTLQEEEQQYLASEEAARPALKFSeWLALFKRRT----- 237
Cdd:pfam00083 177 qLVPALLLIIGLLFLpesprwlvekgrleearEVLAKLRGVPDVDRELDEIKDSLEAGQEAEKAS-WKELFSTKTrrqrl 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 238 -TWGMILGFSgvNYTGWLYIAWLPGYLQAQQGLS--LARTGWVAAIPFLAAAVGMWvnglVVDALARrgydqaktRKTAI 314
Cdd:pfam00083 256 lIGVMLQIFQ--QLTGINAIFYYSTTIFENLGLSdsFLVTIIVGVVNFVFTFIAIF----LVDRFGR--------RPLLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 315 VIGLVLSAL------GTLLVVQSSTPAQAVAFISMALFCVHFAgTSAWGLVQVMVAE-------HKVASVA-AIQNFGSF 380
Cdd:pfam00083 322 LGAAGMAICfvilgiVALLGVSKSDWAGIVAIVFIALFIAFFA-MGWGPVPWVIVSElfplsvrSKAMALAtAANWLANF 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1603720766 381 VFASFAPIVTgwvvDTTHSFNLALVIAAGVTFAGALCYFFIVKT 424
Cdd:pfam00083 401 LIGFLFPIIT----DAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
45-193 |
7.31e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 45 AGEAIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPR--IVLGAGLIFWSAMqaLTGMVNSFSHFILLRIGLG 122
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRktLLISAVLFFISAL--GSAFSPNFTIFIIARIIGG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1603720766 123 IGEAPFMPAGVKSINDWYAQRERGTAVGIFNSSTVLGQ--------AIAPPALVIMQLAWGWRTMFVVIGLAGIVVGLC 193
Cdd:cd17359 101 LAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQllayivnyLIANAGGADWLGAEGWRWMLGLEAIPAILFLLG 179
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-341 |
8.85e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 37.92 E-value: 8.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 51 ADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLRIGLGIGEAPFMP 130
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 131 AGVKSINDWYAQRERGTAVGIFNSSTVLGQAIAPPALVIMQLAwGWR---TMFVVIGLAGIVVGLCWyvgyrnrrqftlq 207
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALpflIAAVLLLLALVPLLLTR------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603720766 208 eeeqqylaseeAARPALKFSEWLALfkRRTTWGMILGFSGVNYTGWL---YIAWLPGYLQaQQGLSLARTGWVAAIPFLA 284
Cdd:cd17477 170 -----------RAAPEIEEAESISL--RRLLRIAPLALLGAFVAGFLegaFYSLLPLYGL-RLGLSVAQAALLLAAFVLG 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1603720766 285 AAVGMWVNGLVVDALARrgydqaktRKTAIVIGLVLSALGTLLVVQSSTPAQAVAFI 341
Cdd:cd17477 236 GLLLQWPLGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLALLVLL 284
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-118 |
9.05e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 37.95 E-value: 9.05e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1603720766 48 AIRADLGLSATEFGVLLSAFSLSYGFAQLPSGILLDRLGPRIVLGAGLIFWSAMQALTGMVNSFSHFILLR 118
Cdd:PRK11043 31 AIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLR 101
|
|
| |
