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Conserved domains on  [gi|160707973|ref|NP_034100|]
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granulocyte-macrophage colony-stimulating factor receptor subunit alpha precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 132-223 8.84e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 110.19  E-value: 8.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973  132 NLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVI-TQCIANDLSLLGS---EAYLVVTGRSG 207
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTrIGCQFDDLEGLSSsfhQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 160707973  208 AGPVRFLDDVVATKAL 223
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
IL3Ra_N super family cl39930
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 42-108 6.69e-12

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


The actual alignment was detected with superfamily member pfam18611:

Pssm-ID: 436618  Cd Length: 76  Bit Score: 60.82  E-value: 6.69e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707973   42 LNLTFDPWTRTLTWACDtaaGNVTVTSCTVTSREAG-IHRRVSPFGCRCWFrRMMALHHGVTLDVNGT 108
Cdd:pfam18611   2 LNLRVDPRKRRLTWDCH---GNVTEIECFLNSKENSpIEKKVAEKNCYCTF-PDLSLHEGANLTVRVT 65
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 227-315 1.92e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973 227 GPPRDVTASCNSSH-CTVSWAPPSTWASltaRDFQFEVQWQSAEPGSTPR-KVLVVEETRLAFPSPAPHGGHKVKVRAgd 304
Cdd:cd00063    2 SPPTNLRVTDVTSTsVTLSWTPPEDDGG---PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRA-- 76

                         90
                 ....*....|.
gi 160707973 305 TRMKHWGEWSP 315
Cdd:cd00063   77 VNGGGESPPSE 87
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 132-223 8.84e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 110.19  E-value: 8.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973  132 NLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVI-TQCIANDLSLLGS---EAYLVVTGRSG 207
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTrIGCQFDDLEGLSSsfhQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 160707973  208 AGPVRFLDDVVATKAL 223
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 42-108 6.69e-12

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 60.82  E-value: 6.69e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707973   42 LNLTFDPWTRTLTWACDtaaGNVTVTSCTVTSREAG-IHRRVSPFGCRCWFrRMMALHHGVTLDVNGT 108
Cdd:pfam18611   2 LNLRVDPRKRRLTWDCH---GNVTEIECFLNSKENSpIEKKVAEKNCYCTF-PDLSLHEGANLTVRVT 65
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 227-315 1.92e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973 227 GPPRDVTASCNSSH-CTVSWAPPSTWASltaRDFQFEVQWQSAEPGSTPR-KVLVVEETRLAFPSPAPHGGHKVKVRAgd 304
Cdd:cd00063    2 SPPTNLRVTDVTSTsVTLSWTPPEDDGG---PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRA-- 76

                         90
                 ....*....|.
gi 160707973 305 TRMKHWGEWSP 315
Cdd:cd00063   77 VNGGGESPPSE 87
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 132-223 8.84e-30

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 110.19  E-value: 8.84e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973  132 NLTCEIRAARFLSCAWREGPAAPADVRYSLRVLNSTGHDVARCMADPGDDVI-TQCIANDLSLLGS---EAYLVVTGRSG 207
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTrIGCQFDDLEGLSSsfhQVYICVNGSSS 80

                          90
                  ....*....|....*.
gi 160707973  208 AGPVRFLDDVVATKAL 223
Cdd:pfam09240  81 AGPIRSSDQTFQLQNI 96
IL3Ra_N pfam18611
IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell ...
 42-108 6.69e-12

IL-3 receptor alpha chain N-terminal domain; Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Structure of IL-3 receptor alpha chain (IL3Ra) in complex with the anti-leukemia antibody CSL362 reveals that the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), contains the CSL362 binding epitope. Furthermore, NTD of IL3Ra adopts a typical fibronectin type III (FnIII) fold.


Pssm-ID: 436618  Cd Length: 76  Bit Score: 60.82  E-value: 6.69e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160707973   42 LNLTFDPWTRTLTWACDtaaGNVTVTSCTVTSREAG-IHRRVSPFGCRCWFrRMMALHHGVTLDVNGT 108
Cdd:pfam18611   2 LNLRVDPRKRRLTWDCH---GNVTEIECFLNSKENSpIEKKVAEKNCYCTF-PDLSLHEGANLTVRVT 65
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 227-315 1.92e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.17  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160707973 227 GPPRDVTASCNSSH-CTVSWAPPSTWASltaRDFQFEVQWQSAEPGSTPR-KVLVVEETRLAFPSPAPHGGHKVKVRAgd 304
Cdd:cd00063    2 SPPTNLRVTDVTSTsVTLSWTPPEDDGG---PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRA-- 76

                         90
                 ....*....|.
gi 160707973 305 TRMKHWGEWSP 315
Cdd:cd00063   77 VNGGGESPPSE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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