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Conserved domains on  [gi|16198418|gb|AAH15877|]
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CDH19 protein [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 97-197 6.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.60e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418  97 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 174
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 16198418 175 IGQPgaLSGTTSVLIKLSDVNDN 197
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 206-311 1.20e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418 206 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 284
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 16198418 285 HVPEQlmkyhteASTTFIKIQVEDVDE 311
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 320-390 1.99e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 1.99e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418 320 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 390
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 6-89 1.69e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   6 HHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGRAVEPESEFVIKV 83
Cdd:cd11304  14 TVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITV 92


                ....*.
gi 16198418  84 SDINDN 89
Cdd:cd11304  93 LDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 97-197 6.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.60e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418  97 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 174
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 16198418 175 IGQPgaLSGTTSVLIKLSDVNDN 197
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 116-199 2.97e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 2.97e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    116 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 193
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 16198418    194 VNDNKP 199
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 206-311 1.20e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418 206 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 284
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 16198418 285 HVPEQlmkyhteASTTFIKIQVEDVDE 311
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
98-191 7.80e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 7.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    98 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 175
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 16198418   176 GQPgaLSGTTSVLIKL 191
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 320-390 1.99e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 1.99e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418 320 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 390
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 6-89 1.69e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   6 HHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGRAVEPESEFVIKV 83
Cdd:cd11304  14 TVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITV 92


                ....*.
gi 16198418  84 SDINDN 89
Cdd:cd11304  93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 13-91 3.15e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 3.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418     13 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 91
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
320-388 2.24e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.24e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418   320 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITAT 388
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
206-307 4.73e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   206 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 284
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16198418   285 HVPEQlmkyhteASTTFIKIQVE 307
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
4-66 1.48e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16198418     4 TSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 66
Cdd:pfam00028  11 VGTEVLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 225-313 1.04e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    225 AYDNDIGENAEMDYSIEEDDSQTFDIItnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIKI 304
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSI---DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVTI 71


                   ....*....
gi 16198418    305 QVEDVDEPP 313
Cdd:smart00112  72 TVLDVNDNA 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 338-388 3.06e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 3.06e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418    338 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITAT 388
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT 56
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 97-197 6.60e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 6.60e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418  97 PYEAIVPEMSPEGTLVIQVTASDADdpsSGNNARLLYSLLQGQP--YFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDM 174
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPD---SGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|...
gi 16198418 175 IGQPgaLSGTTSVLIKLSDVNDN 197
Cdd:cd11304  78 GGPP--LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 116-199 2.97e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 2.97e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    116 TASDADdpsSGNNARLLYSLLQG--QPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPgaLSGTTSVLIKLSD 193
Cdd:smart00112   1 SATDAD---SGENGKVTYSILSGndDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 16198418    194 VNDNKP 199
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 206-311 1.20e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 1.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418 206 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 284
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|....*..
gi 16198418 285 HVPEQlmkyhteASTTFIKIQVEDVDE 311
Cdd:cd11304  78 GGPPL-------SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
98-191 7.80e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 7.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    98 YEAIVPEMSPEGTLVIQVTASDADDpssGNNARLLYSLLQGQPY--FSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMI 175
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*.
gi 16198418   176 GQPgaLSGTTSVLIKL 191
Cdd:pfam00028  78 GPP--LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 320-390 1.99e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.27  E-value: 1.99e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418 320 YVFEVFEETPQGSFVGVVSATDPD-NRKSPIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEK 390
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSgneDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 6-89 1.69e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.58  E-value: 1.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   6 HHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIAtGRAVEPESEFVIKV 83
Cdd:cd11304  14 TVVLTVSaTDPDSGENGeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITV 92


                ....*.
gi 16198418  84 SDINDN 89
Cdd:cd11304  93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 13-91 3.15e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 3.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418     13 SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVSDINDNEP 91
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
320-388 2.24e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 2.24e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418   320 YVFEVFEETPQGSFVGVVSATDPD---NRKspIRYSITR---SKVFNIN-DNGTITTSNSLDREISAWYNLSITAT 388
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlgpNGR--IFYSILGggpGGNFRIDpDTGDISTTKPLDRESIGEYELTVEAT 74
Cadherin pfam00028
Cadherin domain;
206-307 4.73e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 4.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   206 YRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSI-EEDDSQTFDIitnhETQEGIVILKKKVDFEHQNHYGIRAKVKNH 284
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 16198418   285 HVPEQlmkyhteASTTFIKIQVE 307
Cdd:pfam00028  77 GGPPL-------SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
4-66 1.48e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 1.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16198418     4 TSHHIGQLR-SDLDNGNNS-FQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVID 66
Cdd:pfam00028  11 VGTEVLTVTaTDPDLGPNGrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 225-313 1.04e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.89  E-value: 1.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418    225 AYDNDIGENAEMDYSIEEDDSQTFDIItnhETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQlmkyhteASTTFIKI 304
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSI---DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATVTI 71


                   ....*....
gi 16198418    305 QVEDVDEPP 313
Cdd:smart00112  72 TVLDVNDNA 80
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 8-89 1.58e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.88  E-value: 1.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16198418   8 IGQLRSDLDNGNNSFqYKLLGAGA---GSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDiATGRAVEPESEFVIKVS 84
Cdd:cd00031  16 RVSIPTDLIASSGEI-IKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAAS-LGANVPQTSSVFSIEVY 93


                ....*
gi 16198418  85 DINDN 89
Cdd:cd00031  94 DENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 338-388 3.06e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.73  E-value: 3.06e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 16198418    338 SATDPD-NRKSPIRYSITRS---KVFNINDN-GTITTSNSLDREISAWYNLSITAT 388
Cdd:smart00112   1 SATDADsGENGKVTYSILSGnddGLFSIDPEtGEITTTKPLDREEQPEYTLTVEAT 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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