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Conserved domains on  [gi|1621341373|dbj|GDY69760|]
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hypothetical protein SAV14893_091530 [Streptomyces avermitilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tox-HNH-HHH pfam15637
HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH ...
 252-355 9.55e-56

HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteriztic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.


:

Pssm-ID: 434827  Cd Length: 103  Bit Score: 184.21  E-value: 9.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621341373 252 PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQSYGSAISLANAQLIASGQAPRVDATWIEHFPGHAAYVNDTLEHH 331
Cdd:pfam15637   1 PRLEVDMRYVGKGKSGSNSA-GWLRNSKYFWKEMLKSNPEYFSKKNRQLIRAGQSPIVDKAWIKEFPQHAGYSNDTLVHH 79

                          90       100
                  ....*....|....*....|....
gi 1621341373 332 HVGQGSRAVPLPSRLHDAYTVFHP 355
Cdd:pfam15637  80 HIGQGGQAVPIPASLHPGSGGVHP 103
DUF4157 pfam13699
Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. ...
 25-102 1.88e-30

Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteriztic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.


:

Pssm-ID: 433412 [Multi-domain]  Cd Length: 79  Bit Score: 114.24  E-value: 1.88e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1621341373  25 PLDAGIRQTMEMAFGHDFSQVRVHSDPQAHALTRRMNARALTLGDHIALGQDWYSPDSADELRALAHELAHVVQQRSG 102
Cdd:pfam13699   1 PLPAAVRARMERAFGADFSDVRVHTGPAAARAARALGARAFTVGNDIFFGPGRYQPGSAAGRELLAHELTHVVQQRGG 78
 
Name Accession Description Interval E-value
Tox-HNH-HHH pfam15637
HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH ...
 252-355 9.55e-56

HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteriztic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.


Pssm-ID: 434827  Cd Length: 103  Bit Score: 184.21  E-value: 9.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621341373 252 PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQSYGSAISLANAQLIASGQAPRVDATWIEHFPGHAAYVNDTLEHH 331
Cdd:pfam15637   1 PRLEVDMRYVGKGKSGSNSA-GWLRNSKYFWKEMLKSNPEYFSKKNRQLIRAGQSPIVDKAWIKEFPQHAGYSNDTLVHH 79

                          90       100
                  ....*....|....*....|....
gi 1621341373 332 HVGQGSRAVPLPSRLHDAYTVFHP 355
Cdd:pfam15637  80 HIGQGGQAVPIPASLHPGSGGVHP 103
DUF4157 pfam13699
Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. ...
 25-102 1.88e-30

Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteriztic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.


Pssm-ID: 433412 [Multi-domain]  Cd Length: 79  Bit Score: 114.24  E-value: 1.88e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1621341373  25 PLDAGIRQTMEMAFGHDFSQVRVHSDPQAHALTRRMNARALTLGDHIALGQDWYSPDSADELRALAHELAHVVQQRSG 102
Cdd:pfam13699   1 PLPAAVRARMERAFGADFSDVRVHTGPAAARAARALGARAFTVGNDIFFGPGRYQPGSAAGRELLAHELTHVVQQRGG 78
 
Name Accession Description Interval E-value
Tox-HNH-HHH pfam15637
HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH ...
 252-355 9.55e-56

HNH/Endo VII superfamily nuclease toxin with a HHH motif; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteriztic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.


Pssm-ID: 434827  Cd Length: 103  Bit Score: 184.21  E-value: 9.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621341373 252 PAEGVDMPWVGRGKGISSSElGYLRDSKYFWPRFQQSYGSAISLANAQLIASGQAPRVDATWIEHFPGHAAYVNDTLEHH 331
Cdd:pfam15637   1 PRLEVDMRYVGKGKSGSNSA-GWLRNSKYFWKEMLKSNPEYFSKKNRQLIRAGQSPIVDKAWIKEFPQHAGYSNDTLVHH 79

                          90       100
                  ....*....|....*....|....
gi 1621341373 332 HVGQGSRAVPLPSRLHDAYTVFHP 355
Cdd:pfam15637  80 HIGQGGQAVPIPASLHPGSGGVHP 103
DUF4157 pfam13699
Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. ...
 25-102 1.88e-30

Domain of unknown function (DUF4157); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteriztic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.


Pssm-ID: 433412 [Multi-domain]  Cd Length: 79  Bit Score: 114.24  E-value: 1.88e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1621341373  25 PLDAGIRQTMEMAFGHDFSQVRVHSDPQAHALTRRMNARALTLGDHIALGQDWYSPDSADELRALAHELAHVVQQRSG 102
Cdd:pfam13699   1 PLPAAVRARMERAFGADFSDVRVHTGPAAARAARALGARAFTVGNDIFFGPGRYQPGSAAGRELLAHELTHVVQQRGG 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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