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Conserved domains on  [gi|16326436|gb|AAL17779|]
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pregnancy-associated plasma protein E1 [Homo sapiens]

Protein Classification

Laminin_G_3 and ZnMc_pappalysin_like domain-containing protein( domain architecture ID 11210779)

protein containing domains Laminin_G_3, ZnMc_pappalysin_like, myxo_disulf_rpt, and CCP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 633-830 3.38e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


:

Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  633 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 706
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  707 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 780
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 16326436  781 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 830
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 281-436 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    281 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 360
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436    361 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 436
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1111-1150 4.12e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 4.12e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16326436   1111 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1150
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1524-1590 1.33e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16326436 1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1590
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1721-1757 3.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.23e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 16326436    1721 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1757
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch super family cl02419
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 584-611 3.31e-04

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


The actual alignment was detected with superfamily member smart00004:

Pssm-ID: 470573  Cd Length: 38  Bit Score: 39.62  E-value: 3.31e-04
                            10        20
                    ....*....|....*....|....*...
gi 16326436     584 NCEpSKIGNDHCDPECEHPLTGYDGGDC 611
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1466-1520 8.57e-04

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 8.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436   1466 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1520
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 633-830 3.38e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  633 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 706
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  707 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 780
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 16326436  781 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 830
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 281-436 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    281 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 360
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436    361 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 436
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
285-432 2.89e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 85.55  E-value: 2.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436     285 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 363
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16326436     364 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 432
Cdd:smart00560   64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1111-1150 4.12e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 4.12e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16326436   1111 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1150
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 262-393 4.83e-07

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 54.52  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  262 LYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIiagvfdncshtVSDKGWALGIRSGkdkgkrdARFFfsl 341
Cdd:COG5306  175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNG-------APFV--- 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16326436  342 ctdRVKKATILISHS--RYQPGTWTHVAATYDGRHMALYVDGtQVASSLDQSGP 393
Cdd:COG5306  234 ---EVGGAGGTRSAAgaPLAAGTWHHLAVVADAGKVTLYVNG-VAAGSLDASLP 283
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 678-830 9.49e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 47.22  E-value: 9.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    678 NSTHFLNIYFASSVREDL---AGAATWPWDKDAVTHLGGIVLSPAY-YGMPGHTD---TMIHEVGHVLGLYHVFKGVSER 750
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    751 escndpcketvpsmETGDLCADTaptpksELCREPEPTSDTCGFTRFPGAPF--TNYMSYTDdnCTDNFTPNQVARMHCY 828
Cdd:pfam05572   93 --------------GEGDKVPDT------PSYTGGEVSLRNKDLFNCNGEPInsQNQMDYNG--CYAMFTQDQVDRMVEV 150


                   ..
gi 16326436    829 LD 830
Cdd:pfam05572  151 LA 152
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1524-1590 1.33e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16326436 1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1590
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
1524-1587 2.41e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 2.41e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16326436   1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYvaesaegkvRNKLLKIQCLEGGIWEQG 1587
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---------LVGSPTITCQEDGTWSPP 52
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1721-1757 3.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.23e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 16326436    1721 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1757
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1524-1584 1.92e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 1.92e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16326436    1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW 1584
Cdd:smart00032    1 CPPPPDIENGTV---TSSSGTYSYGDTVTYSCDPGYTLIGSST---------ITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 584-611 3.31e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 3.31e-04
                            10        20
                    ....*....|....*....|....*...
gi 16326436     584 NCEpSKIGNDHCDPECEHPLTGYDGGDC 611
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1466-1520 8.57e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 8.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436   1466 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1520
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1466-1521 6.46e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 6.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 16326436 1466 PDPSLVNYANFSCSEGT-KFLKRCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYCK 1521
Cdd:cd00033    2 PPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVG-SSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 633-830 3.38e-53

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 186.39  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  633 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 706
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  707 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 780
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 16326436  781 lCREPEPTsDTCGFTRFPgAPFTNYMSYTDDNCTDNFTPNQVARMHCYLD 830
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVTRMRSYLD 225
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 281-436 5.50e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 91.29  E-value: 5.50e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    281 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 360
Cdd:pfam13385   14 LPTSDFTVSAWVKPDSLPGWARAIISSS-------GGGGYSLGLDGDG-------RLRFAVNGGNGGWDTV-TSGASVPL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436    361 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 436
Cdd:pfam13385   79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPP----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALSAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
285-432 2.89e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 85.55  E-value: 2.89e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436     285 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 363
Cdd:smart00560    2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16326436     364 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 432
Cdd:smart00560   64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 1111-1150 4.12e-15

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 70.48  E-value: 4.12e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 16326436   1111 APYCGDGKVSErlGEECDDGDLVSGDGCSKVCELEEGFNC 1150
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 262-393 4.83e-07

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 54.52  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436  262 LYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIiagvfdncshtVSDKGWALGIRSGkdkgkrdARFFfsl 341
Cdd:COG5306  175 AQFDGTSPLVVPASPSLALDAGGGFTFSAWIKPAQLDGNAVL-----------YSRRDGANGLDNG-------APFV--- 233

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 16326436  342 ctdRVKKATILISHS--RYQPGTWTHVAATYDGRHMALYVDGtQVASSLDQSGP 393
Cdd:COG5306  234 ---EVGGAGGTRSAAgaPLAAGTWHHLAVVADAGKVTLYVNG-VAAGSLDASLP 283
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 678-830 9.49e-06

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 47.22  E-value: 9.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    678 NSTHFLNIYFASSVREDL---AGAATWPWDKDAVTHLGGIVLSPAY-YGMPGHTD---TMIHEVGHVLGLYHVFKGVSER 750
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEGGCER 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    751 escndpcketvpsmETGDLCADTaptpksELCREPEPTSDTCGFTRFPGAPF--TNYMSYTDdnCTDNFTPNQVARMHCY 828
Cdd:pfam05572   93 --------------GEGDKVPDT------PSYTGGEVSLRNKDLFNCNGEPInsQNQMDYNG--CYAMFTQDQVDRMVEV 150


                   ..
gi 16326436    829 LD 830
Cdd:pfam05572  151 LA 152
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1524-1590 1.33e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.38  E-value: 1.33e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16326436 1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW--EQGSCI 1590
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST---------ITCTENGGWspPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
1524-1587 2.41e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 43.26  E-value: 2.41e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16326436   1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYvaesaegkvRNKLLKIQCLEGGIWEQG 1587
Cdd:pfam00084    1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYR---------LVGSPTITCQEDGTWSPP 52
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1721-1757 3.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 3.23e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 16326436    1721 PDPVLVHC-IQSCEPFQADGWCDTINNRAYCHYDGGDC 1757
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1524-1584 1.92e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 1.92e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16326436    1524 CDAPPIILNANLllpHCLQDNHDVGTICKYECKPGYYVAESAEgkvrnkllkIQCLEGGIW 1584
Cdd:smart00032    1 CPPPPDIENGTV---TSSSGTYSYGDTVTYSCDPGYTLIGSST---------ITCLENGTW 49
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 584-611 3.31e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 3.31e-04
                            10        20
                    ....*....|....*....|....*...
gi 16326436     584 NCEpSKIGNDHCDPECEHPLTGYDGGDC 611
Cdd:smart00004   12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 683-742 6.19e-04

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.79  E-value: 6.19e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16326436  683 LNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYG---MPG--HTDTMIHEVGHVLGLYH 742
Cdd:cd04277   65 IRFGNSSDPDGNTAGYAYYPGSGSGTAYGGDIWFNSSYDTnsdSPGsyGYQTIIHEIGHALGLEH 129
Sushi pfam00084
Sushi repeat (SCR repeat);
1466-1520 8.57e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 39.02  E-value: 8.57e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 16326436   1466 PDPSLVNYANFSCSEGTKFLK-RCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYC 1520
Cdd:pfam00084    2 PPPPDIPNGKVSATKNEYNYGaSVSYECDPGYRLVG-SPTITCQEDGTWSPPFPEC 56
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 702-748 1.31e-03

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.33  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16326436  702 PWDKDAVT---HLGGIVLSPAYYGMPGH--TDTMIHEVGHVLGLYHVFKGVS 748
Cdd:cd04268   65 PSQVDPLTgeiLLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAASD 116
LamG smart00282
Laminin G domain;
347-429 2.46e-03

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 40.02  E-value: 2.46e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436     347 KKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTqvaSSLDQSGPLNSPFMASCRSLLLGG-------DSSEDGHYFR 419
Cdd:smart00282   45 GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG---NRVSGESPGGLTILNLDGPLYLGGlpedlklPPLPVTPGFR 121

                            90
                    ....*....|
gi 16326436     420 GHLGTLVFWS 429
Cdd:smart00282  122 GCIRNLKVNG 131
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1466-1521 6.46e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 6.46e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 16326436 1466 PDPSLVNYANFSCSEGT-KFLKRCSISCVPPAKLQGlSPWLTCLEDGLWSLPEVYCK 1521
Cdd:cd00033    2 PPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVG-SSTITCTENGGWSPPPPTCE 57
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 350-427 9.95e-03

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 38.17  E-value: 9.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16326436    350 TILISHSRYQPGTWTHVAATYDGRHMALYVDGTQVASsldQSGPLNSPFMASCRSLLLGG-------DSSEDGHYFRGHL 422
Cdd:pfam02210   42 SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS---SLPPGESLLLNLNGPLYLGGlppllllPALPVRAGFVGCI 118


                   ....*
gi 16326436    423 GTLVF 427
Cdd:pfam02210  119 RDVRV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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