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Conserved domains on  [gi|1635909443|ref|NP_001357482|]
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monocarboxylate transporter 11 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
14-372 1.62e-124

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17423:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 383  Bit Score: 364.41  E-value: 1.62e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17423    81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVvggeeswGGPLLAAAVAYGLSAGSYA 333
Cdd:cd17423   241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKV-------YGSLLALAVAYGFCAGALA 313
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17423   314 PLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSG 352
 
Name Accession Description Interval E-value
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
14-372 1.62e-124

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 364.41  E-value: 1.62e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17423    81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVvggeeswGGPLLAAAVAYGLSAGSYA 333
Cdd:cd17423   241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKV-------YGSLLALAVAYGFCAGALA 313
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17423   314 PLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSG 352
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
1-373 1.50e-52

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 181.09  E-value: 1.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443   1 MTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGA 80
Cdd:TIGR00892   4 ALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  81 RPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPAL 160
Cdd:TIGR00892  84 RPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 161 QLLLDTFGWRGALLLLGAITLHLTPCGALLLPL-------------VLPGDPPAPPRSPLAA-------LGLSLFTRRAF 220
Cdd:TIGR00892 164 QYLFESFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskskskeGLPPDGSTKKLSKKSTaekinrfLDFSLFTHRGF 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 221 SIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPlPRLLAVFGA---LTGL 297
Cdd:TIGR00892 244 LVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIR-PHVQYLFSFallFNGL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1635909443 298 glwvvgLVPVVGGEESWGGpLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:TIGR00892 323 ------THLLCALAGDYTG-LVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGR 391
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
15-372 1.29e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 77.61  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  15 WVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLG 94
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  95 FVFSAFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFSRRRV-LAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGG-GGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPlVLPGDPPAPPRSPLAALgLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDR-GLGG 252
Cdd:COG2223   163 LILGILLLVVAVLAWLFLR-DPPAGAAAAAKASLRDQ-LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 253 YGAALVVAVAAMGDAGARLVCGWLADqgWVPLPRLLAVFGALTGLGLWVVGLVPVVGgeeswgGPLLAAAVAYGLSAGSY 332
Cdd:COG2223   241 ATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALMALGLLLLALALGSL------WLFLVLFLLLGLALGGG 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 333 APLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:COG2223   313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
MFS_1 pfam07690
Major Facilitator Superfamily;
19-368 1.70e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  19 AAAFAINGLSYGLLrsLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFS 98
Cdd:pfam07690   2 FLAAFLAALGRSLL--GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  99 AFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFSR-RRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLG 177
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGA-GALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 178 AITLHLTPCGALLL-PLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAA 256
Cdd:pfam07690 159 ILSLLAAVLLLLPRpPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 257 LVVAVAAMGDAGARLVCGWLADQ-GWVPLPRLLAVFGALTGLGLWVVGLVPVVGGeeswggpLLAAAVAYGLSAGSYAPL 335
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLW-------LLLALLLLGFGFGLVFPA 311
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1635909443 336 VFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGP 368
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
14-372 1.62e-124

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 364.41  E-value: 1.62e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17423     1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17423    81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17423   161 LLLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVvggeeswGGPLLAAAVAYGLSAGSYA 333
Cdd:cd17423   241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKV-------YGSLLALAVAYGFCAGALA 313
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17423   314 PLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSG 352
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
1-373 1.50e-52

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 181.09  E-value: 1.50e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443   1 MTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGA 80
Cdd:TIGR00892   4 ALPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  81 RPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPAL 160
Cdd:TIGR00892  84 RPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 161 QLLLDTFGWRGALLLLGAITLHLTPCGALLLPL-------------VLPGDPPAPPRSPLAA-------LGLSLFTRRAF 220
Cdd:TIGR00892 164 QYLFESFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskskskeGLPPDGSTKKLSKKSTaekinrfLDFSLFTHRGF 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 221 SIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPlPRLLAVFGA---LTGL 297
Cdd:TIGR00892 244 LVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIR-PHVQYLFSFallFNGL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1635909443 298 glwvvgLVPVVGGEESWGGpLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:TIGR00892 323 ------THLLCALAGDYTG-LVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGR 391
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
14-373 2.18e-47

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 165.03  E-value: 2.18e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17352     1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17352    81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLplvlpgdppapprsplaalglsLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17352   161 LILGGLCLNLCVCGLLLR----------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDES 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLlaVFGALTGLGLwvvGLVPVVGGEESWGgpLLAAAVAYGLSAGSYA 333
Cdd:cd17352   219 DAAFLLSIIGISDIVGRILLGLLADKPRIGRLYL--YIFTLLILGL---SLLAFPLATTYVG--LIVFSVLFGFCSGSYS 291
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:cd17352   292 SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGL 331
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
14-373 2.91e-39

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 143.72  E-value: 2.91e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17430     1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17430    81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPlvlpgdppapprsplaaLGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17430   161 LILGGLLLNCCTCGAVMRP-----------------LDFSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDT 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPlPRLLAVFG-ALTGLGLwvvgLVPVVGGEESWGGpLLAAAVAYGLSAGSY 332
Cdd:cd17430   224 EAAFLLSILGFIDIFARPACGVVAGLKWVR-PRVVYLFSfAMLFNGL----TDLCSATAADYGG-LVVFCVFFGISYGMV 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1635909443 333 APLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:cd17430   298 GALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGR 338
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
14-372 6.56e-39

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 142.58  E-value: 6.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17422     1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17422    81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVLPGdppapprsplaalglsLFTRRAFSIFAlgtalvGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17422   161 LVVGALQLNIVVCGALLRVLKEPG----------------FICYALFGLFA------TLGFFAPQLYIIPLSLSLGIDQD 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLwvvglVPVVGGEESWGgpLLAAAVAYGL----SA 329
Cdd:cd17422   219 WAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVL-----LLFPFAYGFWS--LLVCSIFYGFmfgtVA 291
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1635909443 330 GSYAPLVfgVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17422   292 GTHIPLL--AEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGG 332
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
14-373 1.67e-32

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 125.70  E-value: 1.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17427     1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17427    81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVlpgdppapprsplaalglSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17427   161 LILGGLLLNCCVAGSLMRPLG------------------PLFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEY 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPlPRLLAVFGALTglgLWVVGLVPVVGGEESWGGpLLAAAVAYGLSAGSYA 333
Cdd:cd17427   223 SAAFLLSILAFVDMFARPSMGLVANSKWIR-PRIQYFFSFAV---MYNGVCHLLCPLAEDYTG-LVIYAVFFGFAFGMVS 297
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:cd17427   298 SVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGK 337
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
14-373 3.20e-29

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 116.52  E-value: 3.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17426     1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17426    81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLvlpgdppapprSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17426   161 LILGGLLLNCCVAGSLMRPI-----------GPKPFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNE 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPlPRLLAVFGALTglgLWVVGLVPVVGGEESWGGpLLAAAVAYGLSAGSYA 333
Cdd:cd17426   230 SAAFLLSILAFVDMVARPSMGIVANTKWVR-PRIQYFFAASV---LYNGVCHLLAPLSTSYVG-FCIYAIFFGFAFGWLS 304
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:cd17426   305 SVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGR 344
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
14-372 4.74e-27

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 110.28  E-value: 4.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17424     1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17424    81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVLPGdppapprsplaalglslftrraFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17424   161 LILGGFVLNLCVCGALMRFLLMPD----------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQ 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGeeswggPLLAA-AVAYGLSAGSY 332
Cdd:cd17424   219 QAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTF------PLLVPfSFTFGYFDGAY 292
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 333 APLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17424   293 VALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAG 332
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
14-372 6.07e-26

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 107.16  E-value: 6.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17425     1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17425    81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPlvlpgdppapprsplaalglsLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17425   161 LVFGGVLLNCCVCGAVMRP---------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDES 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEEswggpLLAAAVAYGLSAGSYA 333
Cdd:cd17425   220 KAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPV-----LLVYCLLYSISMSGIG 294
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17425   295 SLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAG 333
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
14-372 2.59e-23

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 99.90  E-value: 2.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17421     1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGAsSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17421    81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPlvlpgdppapprsplaaLGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGY 253
Cdd:cd17421   160 LIFGGIMLNLVASGMLLRP-----------------IDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPM 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 254 GAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVggeeswgGPLLAAAVAYGLSAGSYA 333
Cdd:cd17421   223 DASFIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTY-------PLLMTYAVFFAIFCGGYL 295
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 334 PLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17421   296 ALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAG 334
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
14-241 2.14e-21

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 94.51  E-value: 2.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17429     1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17429    81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1635909443 174 LLLGAITLHLTPCGALllplvlpgdppapprsplaalgLSLFTRRAFSIFALGTALVGGGYFVPYVHL 241
Cdd:cd17429   161 FIQGAVSLNLCVCGAL----------------------MRLFTNKVFVAFIFWALFAYCSFVIPFIHL 206
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
14-372 2.27e-19

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 89.13  E-value: 2.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHF-----DRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGG 88
Cdd:cd17420     1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  89 VLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFG 168
Cdd:cd17420    81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 169 WRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRS-----------PLAALGLSLFTRRAFSIFALGTALVGGGYFVP 237
Cdd:cd17420   161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGrrtlhsrinlfLRKIFNVEIFKRKRYVIWALGIPLALFGYFVP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 238 YVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQgwvpLPRLLAVFgaLTGLGLWVVGLVPVVGGEESWGGP 317
Cdd:cd17420   241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADM----PPGVKKMY--LQVLSFVSIGLMSMMIPLCNSFGI 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1635909443 318 LLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17420   315 LISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAG 369
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
14-372 1.48e-16

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 80.39  E-value: 1.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17355     1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWA-LVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGA 172
Cdd:cd17355    81 GLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 173 LLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLS----LFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDR 248
Cdd:cd17355   161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGStlkeALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 249 GLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGgeeswggpLLAAAVAYGLS 328
Cdd:cd17355   241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLA--------LLLFAALFGLG 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1635909443 329 AGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17355   313 WGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
14-372 3.39e-16

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 79.09  E-value: 3.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17428     1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17428    81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALllplvlpgdppapprsplaalgLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLG-G 252
Cdd:cd17428   161 LIVGALALNLLACGSL----------------------MRLFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIeE 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 253 YGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLwvvglVPVVGGEESWGGPLLAAAVAYGLSAGSY 332
Cdd:cd17428   219 IALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAAL-----LAIPFAKSYLTLAVLSAILGFLSGNWSI 293
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 333 APLVfgvLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17428   294 FPYV---TTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVG 330
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
15-372 1.29e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 77.61  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  15 WVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLG 94
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  95 FVFSAFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFSRRRV-LAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:COG2223    84 LLLLALAVSYWLLLLLGLLLGIGG-GGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPlVLPGDPPAPPRSPLAALgLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDR-GLGG 252
Cdd:COG2223   163 LILGILLLVVAVLAWLFLR-DPPAGAAAAAKASLRDQ-LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 253 YGAALVVAVAAMGDAGARLVCGWLADqgWVPLPRLLAVFGALTGLGLWVVGLVPVVGgeeswgGPLLAAAVAYGLSAGSY 332
Cdd:COG2223   241 ATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALMALGLLLLALALGSL------WLFLVLFLLLGLALGGG 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1635909443 333 APLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:COG2223   313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
2-372 2.37e-14

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 73.75  E-value: 2.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443   2 TPQPAGPPDGGWGWVVAAAAFAINgLSYGLLrSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGAR 81
Cdd:COG2807     6 SSARRSRRAGRWLLLLAIVLVALN-LRPAIT-SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLE 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  82 PVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFgWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQ 161
Cdd:COG2807    84 RTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 162 LLLDTFGWRGALLLLGAITLhltpCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHL 241
Cdd:COG2807   163 PLAAALGWRGALAVWALLAL----LALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 242 APHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQgWVPLPRLLAVFGALTGLGLWVVGLVpvvggeesWGGPLLAA 321
Cdd:COG2807   239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADR-LGDRRPLLLLLGLLGLAGLLGLLLA--------PGSLPWLW 309
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1635909443 322 AVAYGLSAGSYAPLVFGVLPG-LVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:COG2807   310 AVLLGLGQGGLFPLALTLIGLrARTPAEAAALSGMAQSVGYLLAALGPLLVG 361
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
8-364 4.28e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.62  E-value: 4.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443   8 PPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVG 87
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  88 GVLASLGFVFSAFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFS-RRRVLAVGLALTGNGASSLLLAPALQLLLDT 166
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGA-GALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 167 FGWRGALLLLGAITLhltpCGALLLPLVLPGDPPAPPRSPLAALgLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHAL 246
Cdd:COG2814   161 FGWRWVFLVNAVLAL----LALLLLLRLLPESRPAARARLRGSL-RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 247 DR-GLGGYGAALVVAVAAMGDAGARLVCGWLADqgWVPLPRLLAVFGALTGLGLWVVGLVPVVGGeeswggpLLAAAVAY 325
Cdd:COG2814   236 EVlGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWL-------LLLALFLL 306
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1635909443 326 GLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGG 364
Cdd:COG2814   307 GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
14-373 4.57e-13

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 69.75  E-value: 4.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASL 93
Cdd:cd17314     1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  94 GFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGAL 173
Cdd:cd17314    81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 174 LLLGAITLHLTPCGALLLPLVlPGDPPAPPRSPLAALG--LSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHA-LDRGL 250
Cdd:cd17314   161 TILGILAAIVLSVVSLLGFKE-PPDNQARLHVQKKKTQtmGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVrSLQLD 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 251 GGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGAltgLGLWVVGLVPVVGGEESWGGPLLAAAvayGLSAG 330
Cdd:cd17314   240 APSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTI---LGLGLCAFLFLLKMTPVGLVLTGSLL---GFSYG 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1635909443 331 SYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGK 373
Cdd:cd17314   314 GLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAK 356
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-372 2.05e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 64.89  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  11 GGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVL 90
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  91 ASLGFVFSAFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFS-RRRVLAVGLALTGNGASSLLLAPALQLLLDTFGW 169
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLRFLLGLGE-AGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 170 RGALLLLGAItlhltpcGALLLPLvlpgdppapprsplaalglslftrrAFSIFALGTALVGGGYFVPYVHLAPHALD-R 248
Cdd:COG2271   164 RAAFLILGLP-------GLLLALL-------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEvR 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 249 GLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGeeswggpLLAAAVAYGLS 328
Cdd:COG2271   212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL-------AIALLFLAGFG 284
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1635909443 329 AGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:COG2271   285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVG 328
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
14-372 2.58e-11

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 64.43  E-value: 2.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQD-----TAWISALALAVQQAASPVGSALSTRWGARPVVMVGG 88
Cdd:cd17464     1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  89 VLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFG 168
Cdd:cd17464    81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 169 WRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRS------PLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLA 242
Cdd:cd17464   161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKKRkfkcppLKKIFNFNIWKSTGYRIWAFGIPAALFGYFVPYVHLM 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 243 PHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQgwvpLPRLLAVFgaLTGLGLWVVGLVPVVGGEESWGGPLLAAA 322
Cdd:cd17464   241 NHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADY----IPGVKKVY--LQVSSFFFIGLMSMMIPLCHVFGGLIAVC 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1635909443 323 VAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSG 372
Cdd:cd17464   315 LFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAG 364
MFS_1 pfam07690
Major Facilitator Superfamily;
19-368 1.70e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  19 AAAFAINGLSYGLLrsLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFS 98
Cdd:pfam07690   2 FLAAFLAALGRSLL--GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  99 AFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFSR-RRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLG 177
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGA-GALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 178 AITLHLTPCGALLL-PLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAA 256
Cdd:pfam07690 159 ILSLLAAVLLLLPRpPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 257 LVVAVAAMGDAGARLVCGWLADQ-GWVPLPRLLAVFGALTGLGLWVVGLVPVVGGeeswggpLLAAAVAYGLSAGSYAPL 335
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLW-------LLLALLLLGFGFGLVFPA 311
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1635909443 336 VFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGP 368
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
14-241 2.05e-10

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 61.74  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  14 GWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQ-----DTAWISALALAVQQAASPVGSALSTRWGARPVVMVGG 88
Cdd:cd17465     1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  89 VLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFG 168
Cdd:cd17465    81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1635909443 169 WRGALLLLGAITLHLTpcgalllplvlpgdppapprspLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHL 241
Cdd:cd17465   161 LAHTFQVLSLFMFIQI----------------------FLSLTYKVFRRKTYRIWAFGIATAVLGYFVPYVHL 211
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
15-203 6.66e-09

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 57.23  E-value: 6.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  15 WVVAAAAFAINGLSyGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLG 94
Cdd:cd17353     3 WLVLLGAVLMHLIL-GYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  95 FVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALL 174
Cdd:cd17353    82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
                         170       180
                  ....*....|....*....|....*....
gi 1635909443 175 LLGAITLHLTPCGALLlpLVLPGDPPAPP 203
Cdd:cd17353   162 ILGIIFLIIIVIGAFL--IRDPPKGWVPP 188
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
34-383 8.65e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 8.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  34 SLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGL 113
Cdd:cd06174    14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 114 LAGFGwALVFAPALGTLSRYF---SRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALL 190
Cdd:cd06174    94 LGLGS-GLIDPAVLALIADLFperERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 191 LPLVLPGDPPAPPRSPLAALGLSLFT---RRAFSIFALGTALVGGGYFVPYVHLAPHALDRG-LGGYGAALVVAVAAMGD 266
Cdd:cd06174   173 VPDPPESARAKNEEASSKSVLKLLKRvlkNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGgLSVAVAGLLLSLFGLAG 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 267 AGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGgeeswggpLLAAAVAYGLSAGSYAPLVFGVLPGLVGV 346
Cdd:cd06174   253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLL--------LLLLLLLLGFGLGGLLPLSFALIAELFPP 324
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1635909443 347 GGVVQATGLVMMLMSLGGLLGPPLSGKDLSSQICLQL 383
Cdd:cd06174   325 EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
15-300 1.26e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  15 WVVAAAAFAINGLSY---GLLrslglafPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLA 91
Cdd:cd17324     2 LALALAAFAIGTTEYviqGLL-------PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443  92 SLGFVFSAFASDLLHLYLGLGLLAGFGwALVFAPALGTLSRYFS-RRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWR 170
Cdd:cd17324    75 ILGNLLAALAPSFALLLLARALAGLAH-GGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635909443 171 GALLLLGAITLhltpCGALLLPLVLPGDPPAPPRSPLAALG-LSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRG 249
Cdd:cd17324   154 AAFLAIAVLAL----LAALLLWRLLPSLPPKKPGSLGLLSSlLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1635909443 250 lGGYGAALVVAVAAMGDAGA--RLVCGWLADQGWVplPRLLAVFGALTGLGLW 300
Cdd:cd17324   230 -GFSSSAIIGLLLLFGVAGVvgSPLAGRLADRGGR--RALLIALLLLAAALLL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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