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Conserved domains on  [gi|164420948|ref|YP_001648461|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Amphimedon compressa]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009544)

NADH dehydrogenase subunit 6 (mitochondrion) is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00057
NADH dehydrogenase subunit 6; Provisional
 1-181 4.10e-90

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 177129 [Multi-domain]  Cd Length: 186  Bit Score: 261.47  E-value: 4.10e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   1 MEGLFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPG 80
Cdd:MTH00057   1 MEGLFYLFALGVIISGIMVISALNPVHSVLWLIVAFTSASALFILLEVEFIALIFLIVYVGAIAILFLFVIMMLNLTDLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  81 MGDDMSNYLPAGLIIGIVFLFEA------LSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGA 154
Cdd:MTH00057  81 GGGDMSNYLPAGFIIGVVFLFEVssgislLSSGTKIGQWDFPNWIEKESNIEVLGRVLYTDYYYLFILASFILLVAMIGA 160

                        170       180
                 ....*....|....*....|....*..
gi 164420948 155 IVLTHDEGIEKrKGQDIYIQISRQLWR 181
Cdd:MTH00057 161 IVLTHDLIIEI-KRQDIFIQTSRQLWQ 186
 
Name Accession Description Interval E-value
ND6 MTH00057
NADH dehydrogenase subunit 6; Provisional
 1-181 4.10e-90

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177129 [Multi-domain]  Cd Length: 186  Bit Score: 261.47  E-value: 4.10e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   1 MEGLFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPG 80
Cdd:MTH00057   1 MEGLFYLFALGVIISGIMVISALNPVHSVLWLIVAFTSASALFILLEVEFIALIFLIVYVGAIAILFLFVIMMLNLTDLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  81 MGDDMSNYLPAGLIIGIVFLFEA------LSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGA 154
Cdd:MTH00057  81 GGGDMSNYLPAGFIIGVVFLFEVssgislLSSGTKIGQWDFPNWIEKESNIEVLGRVLYTDYYYLFILASFILLVAMIGA 160

                        170       180
                 ....*....|....*....|....*..
gi 164420948 155 IVLTHDEGIEKrKGQDIYIQISRQLWR 181
Cdd:MTH00057 161 IVLTHDLIIEI-KRQDIFIQTSRQLWQ 186
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 4-161 1.14e-42

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 139.87  E-value: 1.14e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   4 LFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPGMGD 83
Cdd:COG0839    4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEELRE 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164420948  84 DMSNYLPAGLIIGIVFLFE-ALSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVLTHDE 161
Cdd:COG0839   84 GFRKYRPLAALVGLLLLAElAYVLLSTSWAAAPAAAAAAVGNTKALGELLFTDYLLPFELASVLLLVAMIGAIVLARRE 162
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-157 2.73e-29

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 105.28  E-value: 2.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   17 IMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPGMGDDMSNYLPAGLIIG 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164420948   97 IVFLFEALSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVL 157
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00057
NADH dehydrogenase subunit 6; Provisional
 1-181 4.10e-90

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177129 [Multi-domain]  Cd Length: 186  Bit Score: 261.47  E-value: 4.10e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   1 MEGLFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPG 80
Cdd:MTH00057   1 MEGLFYLFALGVIISGIMVISALNPVHSVLWLIVAFTSASALFILLEVEFIALIFLIVYVGAIAILFLFVIMMLNLTDLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  81 MGDDMSNYLPAGLIIGIVFLFEA------LSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGA 154
Cdd:MTH00057  81 GGGDMSNYLPAGFIIGVVFLFEVssgislLSSGTKIGQWDFPNWIEKESNIEVLGRVLYTDYYYLFILASFILLVAMIGA 160

                        170       180
                 ....*....|....*....|....*..
gi 164420948 155 IVLTHDEGIEKrKGQDIYIQISRQLWR 181
Cdd:MTH00057 161 IVLTHDLIIEI-KRQDIFIQTSRQLWQ 186
ND6 MTH00021
NADH dehydrogenase subunit 6; Validated
 8-177 2.12e-46

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 214401 [Multi-domain]  Cd Length: 188  Bit Score: 150.65  E-value: 2.12e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   8 FALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLT--GPGMGD-- 83
Cdd:MTH00021   2 FSLGIIGSGIMVISALNPVHSIFWLVVVFVNSAVFFILLGLDFLALMFLIIYVGAIAILFLFVIMLLNLTdfPPAFGGea 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  84 DMSNYLPAGLIIGIVFLFEALS---FRSTTLGGNW----PLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIV 156
Cdd:MTH00021  82 DMTNYIPIGLIIGTLFFSEIASswlIIGGPYVERWdlafPWFLISYHNIEALGRILYITCYYLFLLASFILLVAMIGAIV 161

                        170       180
                 ....*....|....*....|....
gi 164420948 157 LTHDEGIEK---RKGQDIYIQISR 177
Cdd:MTH00021 162 LTQEPGSEVgplSKKQDIFFQISR 185
PRK06638 PRK06638
NADH-quinone oxidoreductase subunit J;
1-177 1.23e-44

NADH-quinone oxidoreductase subunit J;


Pssm-ID: 235844 [Multi-domain]  Cd Length: 198  Bit Score: 146.13  E-value: 1.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   1 MEGLFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLtGPG 80
Cdd:PRK06638   4 EAIAFYILALLAVLAALGVVTSRNPVHSALFLILTFLSIAGLYFLLGAEFLGVVQIIVYVGAVMVLFLFVVMMLDV-DFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  81 MGDDMSNYLPAGLIIGIVFLFEALSFRSTTLGGNWPLLVEKAP-----NIEVLGRVLYTDYYYLFIIASFILLVAMIGAI 155
Cdd:PRK06638  83 EREQLREWLPGGVLIGLVILLGLLLLLIVGAIIAASGVNAQGIaagegNTKAIGILLFTDYLLPFELASVLLLVAMVGAI 162

                        170       180
                 ....*....|....*....|..
gi 164420948 156 VLTHDEgIEKRKGQDIYIQISR 177
Cdd:PRK06638 163 VLARRE-RARVKRQDVPAQLPD 183
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 4-161 1.14e-42

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 139.87  E-value: 1.14e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   4 LFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPGMGD 83
Cdd:COG0839    4 LFYIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLLDLDKEELRE 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164420948  84 DMSNYLPAGLIIGIVFLFE-ALSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVLTHDE 161
Cdd:COG0839   84 GFRKYRPLAALVGLLLLAElAYVLLSTSWAAAPAAAAAAVGNTKALGELLFTDYLLPFELASVLLLVAMIGAIVLARRE 162
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-157 2.73e-29

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 105.28  E-value: 2.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   17 IMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPGMGDDMSNYLPAGLIIG 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164420948   97 IVFLFEALSFRSTTLGGNWPLLVEKAPNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVL 157
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVGNIEAIGELLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00213
NADH dehydrogenase subunit 6; Provisional
 28-157 1.32e-21

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177256 [Multi-domain]  Cd Length: 239  Bit Score: 88.03  E-value: 1.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  28 SVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLN-------------------------------- 75
Cdd:MTH00213  26 SVFWLILTFIGSSGLFIVLGMEFLGLIFLIVYVGAICIIFLFVIMMIPggakgfkptkgnkkekerkkgeetgrigappa 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  76 ---LTGPGMGDDMSNYLPAGLI----------------------IGIVFLFEALSFRSTTLGGNWPLLVEKA-------- 122
Cdd:MTH00213 106 igiLIGAILAAELASAVPDSFLnnpsgrggaeryeltnilsdrnRGVSSLLGSDKESITTGIQNNIYMRVGAtgapylyn 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 164420948 123 -----------PNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVL 157
Cdd:MTH00213 186 dsfftlngsggTNLEAIGSVLYINYYYAFILVSFILLVAMIGAIVL 231
ndhG CHL00016
NADH dehydrogenase subunit 6
 4-165 2.23e-11

NADH dehydrogenase subunit 6


Pssm-ID: 214335 [Multi-domain]  Cd Length: 182  Bit Score: 59.53  E-value: 2.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   4 LFYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNltGPGMGD 83
Cdd:CHL00016  11 LLVFLGSGLILGSLGVVLLTNPIYSAFSLGLVLVCISLFYILLNADFVAAAQLLIYVGAINVLIIFAVMFMN--GPEYSK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948  84 DMSNYLPAGLIIGIVFLFEALSFRSTTLGGNWP---------LLVEKAP--NIEVLGRVLYTDYYYLFIIASFILLVAMI 152
Cdd:CHL00016  89 DFNLWTVGDGITSLVCTSLFFSLITTILDTSWYgiiwttrsnQIIEQDLisNVQQIGIHLSTDFLLPFELISIILLVALI 168

                        170
                 ....*....|...
gi 164420948 153 GAIVLTHDEGIEK 165
Cdd:CHL00016 169 GAITVARQEQVEE 181
PRK06433 PRK06433
NADH dehydrogenase subunit J; Provisional
 5-73 3.29e-08

NADH dehydrogenase subunit J; Provisional


Pssm-ID: 180562 [Multi-domain]  Cd Length: 88  Bit Score: 48.83  E-value: 3.29e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 164420948   5 FYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMM 73
Cdd:PRK06433   8 FALFALVTVAFSLGVVLSRDVWHSALYLGVALFSVAVLYVMLNAEFLAAVQVLVYVGAVLILITFAVML 76
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 5-158 2.87e-03

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 36.81  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164420948   5 FYLFALGATISGIMVISAFSSVHSVLWLIMVFISASALFILLEVEFIAFIFLIVYVGAIAILFLFVIMMLNLTGPGMGDD 84
Cdd:MTH00045   3 FYLFLILMLFGSTLVFYSLSPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 164420948  85 MSNYLPAGLIIGIVFLfeALSFRSTTLGGNWPLLVEkapNIEVLGRVLYTDYYYLFIIASFILLVAMIGAIVLT 158
Cdd:MTH00045  83 GEVLVLSLLLSLWVFI--SFDNFLELSNNNWSLVSL---SDLVGSSELYNSGGLYLLLGGFILLVALVVALVIS 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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