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Conserved domains on  [gi|164499013|gb|ABY59076|]
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faciogenital dysplasia protein 2, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGEF super family cl47571
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
 5-29 8.24e-06

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


The actual alignment was detected with superfamily member pfam00621:

Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 38.82  E-value: 8.24e-06
                          10        20
                  ....*....|....*....|....*
gi 164499013    5 SSSLTLQHHMLEPVQRIPRYELLLK 29
Cdd:pfam00621 121 CRGLDLNSFLIKPVQRIPRYPLLLK 145
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
 5-29 8.24e-06

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 38.82  E-value: 8.24e-06
                          10        20
                  ....*....|....*....|....*
gi 164499013    5 SSSLTLQHHMLEPVQRIPRYELLLK 29
Cdd:pfam00621 121 CRGLDLNSFLIKPVQRIPRYPLLLK 145
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
 3-29 3.88e-05

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 36.89  E-value: 3.88e-05
                         10        20
                 ....*....|....*....|....*..
gi 164499013   3 EASSSLTLQHHMLEPVQRIPRYELLLK 29
Cdd:cd00160  124 SECGRLKLESLLLKPVQRLTKYPLLLK 150
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
 7-29 1.72e-04

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 34.97  E-value: 1.72e-04
                           10        20
                   ....*....|....*....|...
gi 164499013     7 SLTLQHHMLEPVQRIPRYELLLK 29
Cdd:smart00325 126 RLTLESLLLKPVQRLTKYPLLLK 148
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
 5-29 8.24e-06

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 38.82  E-value: 8.24e-06
                          10        20
                  ....*....|....*....|....*
gi 164499013    5 SSSLTLQHHMLEPVQRIPRYELLLK 29
Cdd:pfam00621 121 CRGLDLNSFLIKPVQRIPRYPLLLK 145
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
 3-29 3.88e-05

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 36.89  E-value: 3.88e-05
                         10        20
                 ....*....|....*....|....*..
gi 164499013   3 EASSSLTLQHHMLEPVQRIPRYELLLK 29
Cdd:cd00160  124 SECGRLKLESLLLKPVQRLTKYPLLLK 150
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
 7-29 1.72e-04

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 34.97  E-value: 1.72e-04
                           10        20
                   ....*....|....*....|...
gi 164499013     7 SLTLQHHMLEPVQRIPRYELLLK 29
Cdd:smart00325 126 RLTLESLLLKPVQRLTKYPLLLK 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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