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Conserved domains on  [gi|167013381]
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Chain A, Sialic acid-binding Ig-like lectin 5

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 3-122 3.89e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


:

Pssm-ID: 409377  Cd Length: 119  Bit Score: 201.85  E-value: 3.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   3 YELQVQKSVTVQEGLCVLVPCSFSYPWRSWySSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKN 82
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 167013381  83 CSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVT 122
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 128-213 4.71e-38

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


:

Pssm-ID: 409579  Cd Length: 94  Bit Score: 127.30  E-value: 4.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381 128 PDIHFLEPLESGRPTRLSCSLPGSCEAGPPlTFSWTGNALSPLDP---------ETTRSSELTLTPRPEDHGTNLTCQMK 198
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPALSP-EFSWLGAALTPLPPvlgrleeegTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 167013381 199 RQGAQVTTERTVQLN 213
Cdd:cd20987   80 FPGATVTTERTIQLN 94
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 3-122 3.89e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 201.85  E-value: 3.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   3 YELQVQKSVTVQEGLCVLVPCSFSYPWRSWySSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKN 82
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 167013381  83 CSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVT 122
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 128-213 4.71e-38

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 127.30  E-value: 4.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381 128 PDIHFLEPLESGRPTRLSCSLPGSCEAGPPlTFSWTGNALSPLDP---------ETTRSSELTLTPRPEDHGTNLTCQMK 198
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPALSP-EFSWLGAALTPLPPvlgrleeegTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 167013381 199 RQGAQVTTERTVQLN 213
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 6-122 1.03e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 75.19  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381    6 QVQKSVTVQEGLCVLVPCSFSypwrSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRrVKPETQGRFRLLGDVQKKNCSL 85
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSVYWYRQPPGKGPTFLIAYYSNGS-EEGVKKGRFSGRGDPSNGDGSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 167013381   86 SIGDARMEDTGSYFFRVergRDVKYSYQQNKLNLEVT 122
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAV---IPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 8-111 5.60e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381     8 QKSVTVQEGLCVLVPCSFSypwrswySSPPLYVYWFRDGEIPyyaevvatnnpdrrvkPETQGRFRLLGDvqKKNCSLSI 87
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-------GSPPPEVTWYKQGGKL----------------LAESGRFSVSRS--GSTSTLTI 55

                           90       100
                   ....*....|....*....|....
gi 167013381    88 GDARMEDTGSYFFRVERGRDVKYS 111
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSASS 79
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 132-196 4.29e-04

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 38.17  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381  132 FLEPLESGRPT-----RLSCSlpgSCEAGPPLTFSWTGNaLSPL---------DPET---TRSSELTLTPRPEDHGTNLT 194
Cdd:pfam08205   2 TIEPPASLLEGegpevVATCS---SAGGKPAPRITWYLD-GKPLeaaetsseqDPESglvTVTSELKLVPSRSDHGQSLT 77


                  ..
gi 167013381  195 CQ 196
Cdd:pfam08205  78 CQ 79
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 3-122 3.89e-67

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 201.85  E-value: 3.89e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   3 YELQVQKSVTVQEGLCVLVPCSFSYPWRSWySSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKN 82
Cdd:cd05712    1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYW-VSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKN 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 167013381  83 CSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVT 122
Cdd:cd05712   80 CSLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 128-213 4.71e-38

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 127.30  E-value: 4.71e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381 128 PDIHFLEPLESGRPTRLSCSLPGSCEAGPPlTFSWTGNALSPLDP---------ETTRSSELTLTPRPEDHGTNLTCQMK 198
Cdd:cd20987    1 PNIHVPEELEAGQEVTLTCSVPDNCPALSP-EFSWLGAALTPLPPvlgrleeegTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                         90
                 ....*....|....*
gi 167013381 199 RQGAQVTTERTVQLN 213
Cdd:cd20987   80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 6-122 1.03e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 75.19  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381    6 QVQKSVTVQEGLCVLVPCSFSypwrSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRrVKPETQGRFRLLGDVQKKNCSL 85
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSVYWYRQPPGKGPTFLIAYYSNGS-EEGVKKGRFSGRGDPSNGDGSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 167013381   86 SIGDARMEDTGSYFFRVergRDVKYSYQQNKLNLEVT 122
Cdd:pfam07686  76 TIQNLTLSDSGTYTCAV---IPSGEGVFGKGTRLTVL 109
IgC1_CD22_d2 cd20938
Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 ...
 127-214 4.17e-07

Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains; The members here are composed of the second immunoglobulin domain of clusters of differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C1-set of IgSF domains.


Pssm-ID: 409532  Cd Length: 98  Bit Score: 46.86  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381 127 KPDIHFLEPLESGRPTRLSCSLPGSCEaGPPLTFSW-------TGNALSPLDPETTR---SSELTLTPRPEDHGTNLTCQ 196
Cdd:cd20938    2 QPHIQLPPEIQESQEVTLTCLLNFSCY-GYPIQLQWllegspmRQAAVTSTSLTIKSvftRSELKFQPKWSHHGKIVTCQ 80

                         90
                 ....*....|....*...
gi 167013381 197 MKRQGAQVTTERTVQLNV 214
Cdd:cd20938   81 LQDADGKVLSEDTVQLNV 98
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 6-99 6.70e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 46.49  E-value: 6.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   6 QVQKSVTVQEGLCVLVPCSFSypwrswySSPPLYVYWFRD--GEIPYYAEVVATNNPdrrvkPETQGRFRLLGDVQKKNC 83
Cdd:cd04983    3 QSPQSLSVQEGENVTLNCNYS-------TSTFYYLFWYRQypGQGPQFLIYISSDSG-----NKKKGRFSATLDKSRKSS 70

                         90
                 ....*....|....*.
gi 167013381  84 SLSIGDARMEDTGSYF 99
Cdd:cd04983   71 SLHISAAQLSDSAVYF 86
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 8-111 5.60e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 43.26  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381     8 QKSVTVQEGLCVLVPCSFSypwrswySSPPLYVYWFRDGEIPyyaevvatnnpdrrvkPETQGRFRLLGDvqKKNCSLSI 87
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS-------GSPPPEVTWYKQGGKL----------------LAESGRFSVSRS--GSTSTLTI 55

                           90       100
                   ....*....|....*....|....
gi 167013381    88 GDARMEDTGSYFFRVERGRDVKYS 111
Cdd:smart00410  56 SNVTPEDSGTYTCAATNSSGSASS 79
Ig_Neurocan cd05902
Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), ...
 13-125 1.00e-05

Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan; The members here are composed of the immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan. In CSPGs, the Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, the CSPG aggrecan (not included in this group) forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Unlike aggrecan which is widely distributed in connective tissue and extracellular matrices, neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409483  Cd Length: 121  Bit Score: 43.29  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381  13 VQEGLC--VLVPCSFSYPWRSWYSSPPLYVYWFR---DGEIPYYAEVVATNNPdRRVKPETQGRFRLLGDVQKK-NCSLS 86
Cdd:cd05902    7 VRRPLSssVLLPCVFTLPPSASSPPEGPRIKWTKlstSGGQQQRPVLVARDNV-VRVAKAFQGRVSLPGYPKNRyNASLV 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 167013381  87 IGDARMEDTGSYFFRVERGRDvkysYQQNKLNLEVTALI 125
Cdd:cd05902   86 LSRLRYSDSGTYRCEVVLGIN----DEQDTVPLEVTGVV 120
IgV_CD22_d1 cd20929
First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF ...
 15-105 2.48e-05

First immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the V-set of IgSF domains; The members here are composed of the first immunoglobulin domain in Cluster of Differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the V-set of IgSF domains.


Pssm-ID: 409523  Cd Length: 114  Bit Score: 42.30  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381  15 EGLCVLVPCSFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPEtQGRFRLLGDvQKKNCSLSIGDARMED 94
Cdd:cd20929   13 EGACVWIPCTYRALDGDLESFILFHNPEYNKATSKFDGTRLYESTKDGKVPSE-QKRVQFLGD-KNKNCTLSIHPVHLND 90

                         90
                 ....*....|.
gi 167013381  95 TGSYFFRVERG 105
Cdd:cd20929   91 SGQLGLRMESK 101
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 10-103 1.73e-04

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 39.75  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381  10 SVTVQEGLCVLVPCSFSYPwrswYSSPPLYVYWFRdGEIPYYA---EVVATNNpdRRVKPETQGRFRLLGDVQKKNCSLS 86
Cdd:cd20982    2 EYRAEVGHNAYLPCSYTTA----APGNLVPVCWGK-GACPVSYcgnVLLRTDE--RDVTYQKSSRYQLKGDFSKGDVSLT 74

                         90
                 ....*....|....*..
gi 167013381  87 IGDARMEDTGSYFFRVE 103
Cdd:cd20982   75 IENVTLADSGIYCCRIQ 91
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 6-99 1.97e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 39.62  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   6 QVQKSVTVQEGLCVLVPCSFSYpwrswySSPPLYVYWFR--DGEIPyyaEVVATNNPDRR-VKPETQGRFRLLGDVQKKn 82
Cdd:cd00099    3 QSPRSLSVQEGESVTLSCEVSS------SFSSTYIYWYRqkPGQGP---EFLIYLSSSKGkTKGGVPGRFSGSRDGTSS- 72

                         90
                 ....*....|....*..
gi 167013381  83 CSLSIGDARMEDTGSYF 99
Cdd:cd00099   73 FSLTISNLQPEDSGTYY 89
IGv smart00406
Immunoglobulin V-Type;
21-99 4.04e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.13  E-value: 4.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381    21 VPCSFSYpwrswYSSPPLYVYWFR--DGEIPyyaEVVATNNPDRRVKPETQ--GRFRLLGDVQKKNCSLSIGDARMEDTG 96
Cdd:smart00406   4 LSCKFSG-----STFSSYYVSWVRqpPGKGL---EWLGYIGSNGSSYYQESykGRFTISKDTSKNDVSLTISNLRVEDTG 75


                   ...
gi 167013381    97 SYF 99
Cdd:smart00406  76 TYY 78
IgC1_2_Nectin-2_Necl-5_like cd07703
Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...
 151-195 4.21e-04

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409500  Cd Length: 97  Bit Score: 38.15  E-value: 4.21e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 167013381 151 SCEAG---PPLTFSW----TGNALSPLDPET-----TRSSELTLTPRPEDHGTNLTC 195
Cdd:cd07703   21 RCVSAngrPPARISWsstlNGNANTTQVPGPdsgtvTVTSEYSLVPTPEANGKEVTC 77
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 132-196 4.29e-04

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 38.17  E-value: 4.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381  132 FLEPLESGRPT-----RLSCSlpgSCEAGPPLTFSWTGNaLSPL---------DPET---TRSSELTLTPRPEDHGTNLT 194
Cdd:pfam08205   2 TIEPPASLLEGegpevVATCS---SAGGKPAPRITWYLD-GKPLeaaetsseqDPESglvTVTSELKLVPSRSDHGQSLT 77


                  ..
gi 167013381  195 CQ 196
Cdd:pfam08205  78 CQ 79
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 6-99 6.54e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 35.19  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167013381   6 QVQKSVTVQEGLCVLVPCSFSYPWRSWYsspplyVYWFRdgeIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCSL 85
Cdd:cd07706    4 QAQPDVSVQVGEEVTLNCRYETSWTNYY------LFWYK---QLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISL 74

                         90
                 ....*....|....
gi 167013381  86 SIGDARMEDTGSYF 99
Cdd:cd07706   75 TISALQLEDSAKYF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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