BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 214 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 293
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720377712 294 SLSPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEE 330
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720377712 327 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 391
Cdd:cd18529     1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 214 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 293
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720377712 294 SLSPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEE 330
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720377712 327 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 391
Cdd:cd18529     1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 224 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNIsLSPEE 299
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKalfsGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 1720377712 300 AVGLLDLATFYSETRLKKLCQQTIKQ 325
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 238 FLVDGKYIYAHKVLLKIRCEHFRSSLED--SEDDIveMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLLDLATFYSETRL 315
Cdd:PHA03098   16 IVNGGGIIKVHKIILSSSSEYFKKMFKNnfKENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720377712 316 KKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVtqtsgfaEMDHDLLK 377
Cdd:PHA03098   94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 214 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 293
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1720377712 294 SLSPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEE 330
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 222 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSP 297
Cdd:cd18298     1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQShwneDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                          90       100
                  ....*....|....*....|....*...
gi 1720377712 298 EEAVGLLDLATFYSETRLKKLCQQTIKQ 325
Cdd:cd18298    81 EDAIGLLDLANSYCEERLKKLCEDIIKQ 108

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184   170 VWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVA 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  93 ALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrIIEIAAcHSAHTSAAKTqGGHVY 172
Cdd:COG5184   247 GLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG-VVAVAA-GSSHTCALLT-DGTVW 321

                  ...
gi 1720377712 173 MWG 175
Cdd:COG5184   322 CWG 324

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  13 VFAWGYNNSGQVGSGSTANQPIPRRVTGclQNKVVMnIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRVA 92
Cdd:COG5184    69 VWCWGNNSYGQLGDGTTTDRTTPVKVPG--LTGVVA-VAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVD 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  93 AlQGIRVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPvVVEKDRIIEIAAchSAHTSAAKTQGGHVY 172
Cdd:COG5184   146 A-GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQ-VGGLSGVVAVAA--GGDHSCALKSDGTVW 221

                  ...
gi 1720377712 173 MWG 175
Cdd:COG5184   222 CWG 224

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  12 QVFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGNGQLGLGSSGNQPTPCRV 91
Cdd:COG5184   219 TVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKV 295

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720377712  92 AALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPT 141
Cdd:COG5184   296 PGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720377712 327 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFK 390
Cdd:cd18498     1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDFIVKAAEAGAFK 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS-----SLEDSEDDIvEMSEFSYPVFRAFLEYLYT---DNISLSPEE 299
Cdd:cd18297     7 VNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSmlssgSTEAQTPVI-EIPDIRYDIFQLMMQYLYTggvESLDVAQDD 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720377712 300 AVGLLDLATFYSETRLKKLCQQTIKQGICEEN 331
Cdd:cd18297    86 ALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712  235 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLLDLATFY 310
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1720377712  311 SETRLKKLCQQTIKQGI 327
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 234 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLLDLATF 309
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRamfsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                  .
gi 1720377712 310 Y 310
Cdd:cd18186    82 L 82

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLL 304
Cdd:cd18352     9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDggyrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                          90       100
                  ....*....|....*....|....*..
gi 1720377712 305 DLATFYSETRLKKLCQQTIKQGICEEN 331
Cdd:cd18352    89 RAADQYLLEGLKRLCEYTIAQDLTLEN 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 217 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVEMSE--FSYPVFRAFLEYLY 289
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndwwSESKQSEIELVEdpECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720377712 290 TDNISLSPEEAVGLLDLATFYSETRLKKLCQQ 321
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVD 112

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720377712 100 QRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrIIEIAAchSAHTSAAKTQGGHVYMWGQ 176
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN-VVAVAA--GGDHTCALKADGTVWCWGN 74

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1720377712  12 QVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNKVVMnIACGQMCSMAV 60
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQ-VACGGDHTVAL 50

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 229 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDSEDDIVEMSEFSYPVFRAFLEYLY---TDNISLSPEE 299
Cdd:cd18350    20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFkslltnKSEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIAD 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1720377712 300 AVGLLDLATFYSETRLKKLCQQTIKQGICEENAI 333
Cdd:cd18350   100 VLELLSAASLFQLDALQRHCEILCSQTINLENAV 133

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEhFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE--AVGLLD 305
Cdd:cd18303    13 FDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSDISYEVVLALLRWLYTDELDLTLDDefLLELMK 91

                          90       100
                  ....*....|....*....|....*...
gi 1720377712 306 LATFYSETRLKKLCQQTIKQGICEENAI 333
Cdd:cd18303    92 AAKRFQLTDLVERCERALMSSVNVDNCI 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 228 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVeMSEFSYPVFRAFLEYLYTDNISLSPEEAVG 302
Cdd:cd18314     1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVT-LEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                          90
                  ....*....|....*..
gi 1720377712 303 LLDLATFYSETRLKKLC 319
Cdd:cd18314    80 LLMLASKYQVPDLEKLC 96

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 224 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDN-ISLSPE 298
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEvmaaMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDScCPASIL 80

                          90       100
                  ....*....|....*....|....*
gi 1720377712 299 EAVGLLDLATFYSETRLKKLCQQTI 323
Cdd:cd18360    81 QAMALLICAEMYQVSRLQHICELYI 105

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30
                  ....*....|....*....|....*....|
gi 1720377712  99 VQRVACGYAHTLVLTDEGQIYAWGANSYGQ 128
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 221 AESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLS 296
Cdd:cd18286     5 GKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGswaeSNSSEITLTGVSHAAVSFVLLFIYGGVLDLP 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720377712 297 PEEAVG-LLDLATFYSETRLKKLCQQTIKQGIC 328
Cdd:cd18286    85 DDVNLGeLLSLADMYGLDGLKDVVAYTLRRDYC 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 223 SLKREFDNPDT--ADLKFLVD-GKYIYAHKVLLKIRCEHFRSSLEDSEDD------------IVEMSEFSYPVFRAFLEY 287
Cdd:cd18310     6 DLENLLDSPDLfySDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEgantkpklelreLIPGGIVGYDAFMLVLSY 85

                          90
                  ....*....|....*...
gi 1720377712 288 LYTDNISLSPEEAVGLLD 305
Cdd:cd18310    86 LYSGRLRLVPKEGSACVD 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 220 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISL 295
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSpvfnAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720377712 296 SPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEEN 331
Cdd:cd18343    88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 217 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDN 292
Cdd:cd18345     2 ECRLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPvfnaMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720377712 293 ISLSPEEAVGLLDLATFYSETRLKKLCQQTIKQGICEENA 332
Cdd:cd18345    82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720377712 235 DLKFLVDGKYIYAHKVLLKIRCEHFRSSL-EDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLLDLATF 309
Cdd:cd18226    24 DLVITVEGKEFSAHKVVVAVGSSYFHACLsKNPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKF 99

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720377712 222 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--SEDDIVEMSE--FSYPVFRAFLEYLYTDNISLSP 297
Cdd:cd18295     8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwKDKREINLKHplVNPDAFRALLQYLYTGRLEIHV 87

                          90       100
                  ....*....|....*....|....
gi 1720377712 298 EEAVGLLDLAtfySETRLKKLCQQ 321
Cdd:cd18295    88 DDVEDCKRLA---KQCRLEELIEE 108