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Conserved domains on  [gi|1720378130|ref|XP_030103505|]
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S-formylglutathione hydrolase isoform X2 [Mus musculus]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 2-248 2.10e-132

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member PLN02442:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 283  Bit Score: 374.88  E-value: 2.10e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130   2 ALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAP 81
Cdd:PLN02442    4 ALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSGKVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIALVAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  82 DTSPRGCNIKGEDDSWDFGTGAGFYVNATEDPWKaNYRMYSYVTEELPQLINANFP-VDPQRMSIFGHSMGGHGALICAL 160
Cdd:PLN02442   84 DTSPRGLNVEGEADSWDFGVGAGFYLNATQEKWK-NWRMYDYVVKELPKLLSDNFDqLDTSRASIFGHSMGGHGALTIYL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 161 KNPGKYRA---------------------------------YDATCLVKAYSGSQIDILIDQGKDDEFLSNgQLLPDNFI 207
Cdd:PLN02442  163 KNPDKYKSvsafapianpincpwgqkaftnylgsdkadweeYDATELVSKFNDVSATILIDQGEADKFLKE-QLLPENFE 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1720378130 208 AACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLN 248
Cdd:PLN02442  242 EACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQALK 282
 
Name Accession Description Interval E-value
PLN02442 PLN02442
S-formylglutathione hydrolase
 2-248 2.10e-132

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 374.88  E-value: 2.10e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130   2 ALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAP 81
Cdd:PLN02442    4 ALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSGKVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIALVAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  82 DTSPRGCNIKGEDDSWDFGTGAGFYVNATEDPWKaNYRMYSYVTEELPQLINANFP-VDPQRMSIFGHSMGGHGALICAL 160
Cdd:PLN02442   84 DTSPRGLNVEGEADSWDFGVGAGFYLNATQEKWK-NWRMYDYVVKELPKLLSDNFDqLDTSRASIFGHSMGGHGALTIYL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 161 KNPGKYRA---------------------------------YDATCLVKAYSGSQIDILIDQGKDDEFLSNgQLLPDNFI 207
Cdd:PLN02442  163 KNPDKYKSvsafapianpincpwgqkaftnylgsdkadweeYDATELVSKFNDVSATILIDQGEADKFLKE-QLLPENFE 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1720378130 208 AACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLN 248
Cdd:PLN02442  242 EACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQALK 282
fghA_ester_D TIGR02821
S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and ...
 6-247 1.30e-128

S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification]


Pssm-ID: 131868  Cd Length: 275  Bit Score: 364.87  E-value: 1.30e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130   6 ISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDTSP 85
Cdd:TIGR02821   3 ISSHACFGGTQGFYRHKSETCGVPMTFGVFLPPQAAAGPVPVLWYLSGLTCTHENFMIKAGAQRFAAEHGLALVAPDTSP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  86 RGCNIKGEDDSWDFGTGAGFYVNATEDPWKANYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGK 165
Cdd:TIGR02821  83 RGTGIAGEDDAWDFGKGAGFYVDATEEPWSQHYRMYSYIVQELPALVAAQFPLDGERQGITGHSMGGHGALVIALKNPDR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 166 YR---------------------------------AYDATCLVKAySGSQIDILIDQGKDDEFLSNgQLLPDNFIAACTE 212
Cdd:TIGR02821 163 FKsvsafapivapsrcpwgqkafsaylgadeaawrSYDASLLVAD-GGRHSTILIDQGTADQFLDE-QLRPDAFEQACRA 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1720378130 213 KKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYL 247
Cdd:TIGR02821 241 AGQALTLRRQAGYDHSYYFIASFIADHLRHHAERL 275
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
13-248 8.68e-88

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 260.53  E-value: 8.68e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  13 GGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDtsprgcnikg 92
Cdd:COG0627     1 GGRVVRVTVPSPALGREMPVSVYLPPGYDGRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPD---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  93 eddswdfGTGAGFYVNATEDPWKaNYRMYSYVTEELPQLINANFPVDPQR--MSIFGHSMGGHGALICALKNPGKYRA-- 168
Cdd:COG0627    71 -------GGQASFYVDWTQGPAG-HYRWETYLTEELPPLIEANFPVSADRerRAIAGLSMGGHGALTLALRHPDLFRAva 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 169 --------------------------------YDATCLVKAYsGSQIDILIDQGKDDEFLSNGQLlpdNFIAACTEKKIP 216
Cdd:COG0627   143 afsgildpsqppwgekafdayfgppdraawaaNDPLALAEKL-RAGLPLYIDCGTADPFFLEANR---QLHAALRAAGIP 218

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1720378130 217 VVFRLQEGYdHSYYFIATFIADHIRHHAKYLN 248
Cdd:COG0627   219 HTYRERPGG-HSWYYWASFLEDHLPFLARALG 249
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 23-242 1.23e-64

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 201.54  E-value: 1.23e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  23 SVELKCKMRFAVYLP-PQAESGKCPALYWLSGlTCTEQNFISKSGYQQAASEHGLVVIAPDTSPRGCNIKGeDDSWDFGt 101
Cdd:pfam00756   1 SNSLGREMKVQVYLPeDYPPGRKYPVLYLLDG-TGWFQNGPAKEGLDRLAASGEIPPVIIVGSPRGGEVSF-YSDWDRG- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 102 gagfyVNATEDPWKANYRmySYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKY--------------- 166
Cdd:pfam00756  78 -----LNATEGPGAYAYE--TFLTQELPPLLDANFPTAPDGRALAGQSMGGLGALYLALKYPDLFgsvssfspilnpsns 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 167 ----------RAYDATCLVKA--YSGSQIDILIDQGKDDEFLsNGQLLPDNFIAACTEKKIP--VVFRLQEGYDHSY--- 229
Cdd:pfam00756 151 mwgpeddpawQEGDPVLLAVAlsANNTRLRIYLDVGTREDFL-GDQLPVEILEELAPNRELAeqLAYRGVGGYDHEYygg 229

                         250
                  ....*....|....*..
gi 1720378130 230 ----YFIATFIADHIRH 242
Cdd:pfam00756 230 hdwaYWRAQLIAALIDL 246
 
Name Accession Description Interval E-value
PLN02442 PLN02442
S-formylglutathione hydrolase
 2-248 2.10e-132

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 374.88  E-value: 2.10e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130   2 ALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAP 81
Cdd:PLN02442    4 ALKEISVNKMFGGFNRRYKHFSSTLGCSMTFSVYFPPASDSGKVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIALVAP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  82 DTSPRGCNIKGEDDSWDFGTGAGFYVNATEDPWKaNYRMYSYVTEELPQLINANFP-VDPQRMSIFGHSMGGHGALICAL 160
Cdd:PLN02442   84 DTSPRGLNVEGEADSWDFGVGAGFYLNATQEKWK-NWRMYDYVVKELPKLLSDNFDqLDTSRASIFGHSMGGHGALTIYL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 161 KNPGKYRA---------------------------------YDATCLVKAYSGSQIDILIDQGKDDEFLSNgQLLPDNFI 207
Cdd:PLN02442  163 KNPDKYKSvsafapianpincpwgqkaftnylgsdkadweeYDATELVSKFNDVSATILIDQGEADKFLKE-QLLPENFE 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1720378130 208 AACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLN 248
Cdd:PLN02442  242 EACKEAGAPVTLRLQPGYDHSYFFIATFIDDHINHHAQALK 282
fghA_ester_D TIGR02821
S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and ...
 6-247 1.30e-128

S-formylglutathione hydrolase; This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification]


Pssm-ID: 131868  Cd Length: 275  Bit Score: 364.87  E-value: 1.30e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130   6 ISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDTSP 85
Cdd:TIGR02821   3 ISSHACFGGTQGFYRHKSETCGVPMTFGVFLPPQAAAGPVPVLWYLSGLTCTHENFMIKAGAQRFAAEHGLALVAPDTSP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  86 RGCNIKGEDDSWDFGTGAGFYVNATEDPWKANYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGK 165
Cdd:TIGR02821  83 RGTGIAGEDDAWDFGKGAGFYVDATEEPWSQHYRMYSYIVQELPALVAAQFPLDGERQGITGHSMGGHGALVIALKNPDR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 166 YR---------------------------------AYDATCLVKAySGSQIDILIDQGKDDEFLSNgQLLPDNFIAACTE 212
Cdd:TIGR02821 163 FKsvsafapivapsrcpwgqkafsaylgadeaawrSYDASLLVAD-GGRHSTILIDQGTADQFLDE-QLRPDAFEQACRA 240

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1720378130 213 KKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYL 247
Cdd:TIGR02821 241 AGQALTLRRQAGYDHSYYFIASFIADHLRHHAERL 275
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
13-248 8.68e-88

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 260.53  E-value: 8.68e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  13 GGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDtsprgcnikg 92
Cdd:COG0627     1 GGRVVRVTVPSPALGREMPVSVYLPPGYDGRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPD---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  93 eddswdfGTGAGFYVNATEDPWKaNYRMYSYVTEELPQLINANFPVDPQR--MSIFGHSMGGHGALICALKNPGKYRA-- 168
Cdd:COG0627    71 -------GGQASFYVDWTQGPAG-HYRWETYLTEELPPLIEANFPVSADRerRAIAGLSMGGHGALTLALRHPDLFRAva 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 169 --------------------------------YDATCLVKAYsGSQIDILIDQGKDDEFLSNGQLlpdNFIAACTEKKIP 216
Cdd:COG0627   143 afsgildpsqppwgekafdayfgppdraawaaNDPLALAEKL-RAGLPLYIDCGTADPFFLEANR---QLHAALRAAGIP 218

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1720378130 217 VVFRLQEGYdHSYYFIATFIADHIRHHAKYLN 248
Cdd:COG0627   219 HTYRERPGG-HSWYYWASFLEDHLPFLARALG 249
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 23-242 1.23e-64

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 201.54  E-value: 1.23e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  23 SVELKCKMRFAVYLP-PQAESGKCPALYWLSGlTCTEQNFISKSGYQQAASEHGLVVIAPDTSPRGCNIKGeDDSWDFGt 101
Cdd:pfam00756   1 SNSLGREMKVQVYLPeDYPPGRKYPVLYLLDG-TGWFQNGPAKEGLDRLAASGEIPPVIIVGSPRGGEVSF-YSDWDRG- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 102 gagfyVNATEDPWKANYRmySYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKY--------------- 166
Cdd:pfam00756  78 -----LNATEGPGAYAYE--TFLTQELPPLLDANFPTAPDGRALAGQSMGGLGALYLALKYPDLFgsvssfspilnpsns 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 167 ----------RAYDATCLVKA--YSGSQIDILIDQGKDDEFLsNGQLLPDNFIAACTEKKIP--VVFRLQEGYDHSY--- 229
Cdd:pfam00756 151 mwgpeddpawQEGDPVLLAVAlsANNTRLRIYLDVGTREDFL-GDQLPVEILEELAPNRELAeqLAYRGVGGYDHEYygg 229

                         250
                  ....*....|....*..
gi 1720378130 230 ----YFIATFIADHIRH 242
Cdd:pfam00756 230 hdwaYWRAQLIAALIDL 246
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
13-229 8.52e-18

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 80.67  E-value: 8.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  13 GGLQKVFEHSSVeLKCKMRFAVYLPPQAESG--KCPALYWLSGLTCTEQNFISKSGYQQAA----SEHGL---VVIAPDt 83
Cdd:COG2382    79 GTVETVTYPSKA-LGRTRRVWVYLPPGYDNPgkKYPVLYLLDGGGGDEQDWFDQGRLPTILdnliAAGKIppmIVVMPD- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  84 sprgcNIKGEDDSWDFGTGAGFyvnatedpwkanyrmYSYVTEELPQLINANFPV--DPQRMSIFGHSMGGHGALICALK 161
Cdd:COG2382   157 -----GGDGGDRGTEGPGNDAF---------------ERFLAEELIPFVEKNYRVsaDPEHRAIAGLSMGGLAALYAALR 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 162 NPGKYRA-----------------YDATCLVKAYS-GSQIDILIDQGKDDEFLSNGQllpdNFIAACTEKKIPVVFRLQE 223
Cdd:COG2382   217 HPDLFGYvgsfsgsfwwppgdadrGGWAELLAAGApKKPLRFYLDVGTEDDLLEANR----ALAAALKAKGYDVEYREFP 292


                  ....*.
gi 1720378130 224 GyDHSY 229
Cdd:COG2382   293 G-GHDW 297
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
34-169 1.32e-08

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 53.84  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  34 VYLPP--QAESGKCPALYWLSGltctEQNFISKSGYQQAASEHG-----LVVIA----PDTSPR-----GCNIKGEDDSW 97
Cdd:COG2819    25 VYLPPgyDAPEKRYPVLYMLDG----QNLFDALAGAVGTLSRLEggippAIVVGigngDDGERRlrdytPPPAPGYPGPG 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720378130  98 DFGTGAgfyvnatedpwkANYRmySYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYRAY 169
Cdd:COG2819   101 GPGGGA------------DAFL--RFLEEELKPYIDKRYRTDPERTGLIGHSLGGLFSLYALLKYPDLFGRY 158
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 31-169 2.20e-07

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 50.77  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  31 RFAVYLPPQAESGK-CPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDTSPRGCNIkgeddSWDFGTGAGFYVNA 109
Cdd:COG3509    38 TYRLYVPAGYDGGApLPLVVALHGCGGSAADFAAGTGLNALADREGFIVVYPEGTGRAPGR-----CWNWFDGRDQRRGR 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720378130 110 TEdpwkanyrmYSYVTeelpQLIN---ANFPVDPQRMSIFGHSMGGHGALICALKNPGKYRAY 169
Cdd:COG3509   113 DD---------VAFIA----ALVDdlaARYGIDPKRVYVTGLSAGGAMAYRLACEYPDVFAAV 162
COG4099 COG4099
Predicted peptidase [General function prediction only];
30-173 5.54e-07

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 49.20  E-value: 5.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  30 MRFAVYLPPQAESG-KCPALYWLSG-------LTCTEQNFISKSGYQQAASEHGLVVIAPDTSprgcnikgEDDSWdfgt 101
Cdd:COG4099    33 LPYRLYLPKGYDPGkKYPLVLFLHGagergtdNEKQLTHGAPKFINPENQAKFPAIVLAPQCP--------EDDYW---- 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720378130 102 gagfyvnatedpwkanyrMYSYVTEELPQLIN---ANFPVDPQRMSIFGHSMGGHGALICALKNPGKYRAYDATC 173
Cdd:COG4099   101 ------------------SDTKALDAVLALLDdliAEYRIDPDRIYLTGLSMGGYGTWDLAARYPDLFAAAVPIC 157
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
30-245 4.90e-06

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 46.02  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  30 MRfaVYLPPQAEsGKCPAL------YWLSGltcteqnfiSKSGY----QQAASEHGLVVIAPDtsprgcnikgeddswdf 99
Cdd:COG0657     1 MD--VYRPAGAK-GPLPVVvyfhggGWVSG---------SKDTHdplaRRLAARAGAAVVSVD----------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 100 gtgagfYVNATEDPWKAN----YRMYSYVTEELpqlinANFPVDPQRMSIFGHSMGGH--GALICALKNPGK-------- 165
Cdd:COG0657    52 ------YRLAPEHPFPAAledaYAALRWLRANA-----AELGIDPDRIAVAGDSAGGHlaAALALRARDRGGprpaaqvl 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 166 -YRAYDATclvkaYSGSQIDI------LIDQGKDDEFLSNGQLlpdnFIAACTEKKIPVVFRLQEGYDHSYYFIATF--- 235
Cdd:COG0657   121 iYPVLDLT-----ASPLRADLaglpptLIVTGEADPLVDESEA----LAAALRAAGVPVELHVYPGGGHGFGLLAGLpea 191

                         250
                  ....*....|....*.
gi 1720378130 236 ------IADHIRHHAK 245
Cdd:COG0657   192 raalaeIAAFLRRALA 207
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
34-168 8.32e-06

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 45.39  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  34 VYLPPqaESGKCPALYWLSGLTCTEQNFISksGYQQAASEHGLVVIAPDtsPRGC----NIKGEDDSWDFGTGAGFyvnA 109
Cdd:COG1506    14 LYLPA--DGKKYPVVVYVHGGPGSRDDSFL--PLAQALASRGYAVLAPD--YRGYgesaGDWGGDEVDDVLAAIDY---L 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720378130 110 TEDPWkanyrmysyvteelpqlinanfpVDPQRMSIFGHSMGGHGALICALKNPGKYRA 168
Cdd:COG1506    85 AARPY-----------------------VDPDRIGIYGHSYGGYMALLAAARHPDRFKA 120
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
73-229 1.85e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 44.57  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  73 EHGLVVIAPDTsprgcnikgeddswdFGTGAGfyvnaTEDPWKANYRMYSYVTEELPQLINA-------NFPVDPQRMSI 145
Cdd:COG0412    54 AAGYVVLAPDL---------------YGRGGP-----GDDPDEARALMGALDPELLAADLRAaldwlkaQPEVDAGRVGV 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130 146 FGHSMGGHGALICALKNPGkyraYDATClvkAYSGSQID-------------ILIDQGKDDEFLSNGQLlpDNFIAACTE 212
Cdd:COG0412   114 VGFCFGGGLALLAAARGPD----LAAAV---SFYGGLPAddlldlaarikapVLLLYGEKDPLVPPEQV--AALEAALAA 184

                         170
                  ....*....|....*..
gi 1720378130 213 KKIPVVFRLQEGYDHSY 229
Cdd:COG0412   185 AGVDVELHVYPGAGHGF 201
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 34-156 1.19e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.13  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  34 VYLPPqAESGKCPALYWLSGLTcteQNFISKSGYQQAASEHGLVVIAPDtsPRGcnikgeddswdFGTGAGFYVNAtEDP 113
Cdd:COG1073    27 LYLPA-GASKKYPAVVVAHGNG---GVKEQRALYAQRLAELGFNVLAFD--YRG-----------YGESEGEPREE-GSP 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1720378130 114 WKANYR-MYSYVTEeLPQlinanfpVDPQRMSIFGHSMGGHGAL 156
Cdd:COG1073    89 ERRDARaAVDYLRT-LPG-------VDPERIGLLGISLGGGYAL 124
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
73-159 1.99e-03

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 38.93  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  73 EHGLVVIAPDtsPRGCNikgEDDSWDFGTGAGFYVNATEdpWKANYRMYSYVTEELpQLINANFP-----VDPQRMSIFG 147
Cdd:COG4188    87 SHGYVVAAPD--HPGSN---AADLSAALDGLADALDPEE--LWERPLDLSFVLDQL-LALNKSDPplagrLDLDRIGVIG 158

                          90
                  ....*....|..
gi 1720378130 148 HSMGGHGALICA 159
Cdd:COG4188   159 HSLGGYTALALA 170
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 46-168 9.02e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 36.52  E-value: 9.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378130  46 PALYWLSGLTCTEQNFisksGYQQAASEHGLVVIAPDtsPRGcnikgeddswdFGtgagfyvnATEDPWkANYRMYSYVt 125
Cdd:COG0596    24 PPVVLLHGLPGSSYEW----RPLIPALAAGYRVIAPD--LRG-----------HG--------RSDKPA-GGYTLDDLA- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720378130 126 EELPQLINAnfpVDPQRMSIFGHSMGGHGALICALKNPGKYRA 168
Cdd:COG0596    77 DDLAALLDA---LGLERVVLVGHSMGGMVALELAARHPERVAG 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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