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Conserved domains on  [gi|1720389844|ref|XP_030105594|]
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CSC1-like protein 2 isoform X2 [Mus musculus]

Protein Classification

OSCA/TMEM63 family ion channel( domain architecture ID 10342091)

OSCA/TMEM63 family ion channel is an an osmosensitive calcium-permeable cation channel that converts mechanical stimuli into electric signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-691 1.21e-64

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


:

Pssm-ID: 460661  Cd Length: 273  Bit Score: 217.39  E-value: 1.21e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 420 RCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPI----------ITQFFPTLLLWCFSALLPTIVYYSAFFE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 490 AHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSsldlFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNA 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASS----ASSLIEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 570 MDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYN 649
Cdd:pfam02714 157 GELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720389844 650 LYYAYlpaklDKKIHSGAVNQVVaAPILCLFWLLFFSTMRTG 691
Cdd:pfam02714 237 LLYVY-----VTKYESGGRFWPR-ALNRLLVGLYLFQLCLIG 272
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
227-409 8.21e-44

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


:

Pssm-ID: 464272  Cd Length: 164  Bit Score: 155.56  E-value: 8.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 227 RTLFINGISK-YAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKEnvPAMINPKPCGH 305
Cdd:pfam14703   2 RTVLVTGIPKdLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKN--GKKPKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 306 LCCCVVRGcEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKdfnvckcqgctcrgepraSSC 385
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 1720389844 386 SEALHISNWTVTYAPDPQNIYWEH 409
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
RSN1_TM super family cl16507
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-208 1.31e-08

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


The actual alignment was detected with superfamily member pfam13967:

Pssm-ID: 433613  Cd Length: 158  Bit Score: 54.89  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844  52 FLALLFLFSILRKVAWD--YGRLALVTDadsvasamhgdsHDRYERLtsvsssvdfdqRDNGFCSWLTAIFRIKDDEIRD 129
Cdd:pfam13967  13 ALVFLLLFSILRPKNKRvyAPRTYLAPE------------EERTPPL-----------PGTGLFGWIPPLLKIPDEEILQ 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 130 KCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRT-----TIANLKSGNNLLWLHTSFAFLYLL 204
Cdd:pfam13967  70 HAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTG 149

                  ....
gi 1720389844 205 LTVY 208
Cdd:pfam13967 150 FVLY 153
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-691 1.21e-64

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 217.39  E-value: 1.21e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 420 RCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPI----------ITQFFPTLLLWCFSALLPTIVYYSAFFE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 490 AHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSsldlFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNA 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASS----ASSLIEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 570 MDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYN 649
Cdd:pfam02714 157 GELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720389844 650 LYYAYlpaklDKKIHSGAVNQVVaAPILCLFWLLFFSTMRTG 691
Cdd:pfam02714 237 LLYVY-----VTKYESGGRFWPR-ALNRLLVGLYLFQLCLIG 272
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
227-409 8.21e-44

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 155.56  E-value: 8.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 227 RTLFINGISK-YAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKEnvPAMINPKPCGH 305
Cdd:pfam14703   2 RTVLVTGIPKdLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKN--GKKPKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 306 LCCCVVRGcEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKdfnvckcqgctcrgepraSSC 385
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 1720389844 386 SEALHISNWTVTYAPDPQNIYWEH 409
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
40-743 8.47e-26

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 114.05  E-value: 8.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844  40 GVPTVLALDFMCFLALLFLFSILRKvawdygRLALVTDADSVASamhgdshDRYERLTSVSSSvdfdqrdnGFCSWLTAI 119
Cdd:COG5594    23 AVITQLVFAGLIFLVFLILFLILRK------RWKRLYAPRTNFD-------GQNECLPEPNPS--------SYWGWLEPL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 120 FRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVN--FSGDLLEN--NAYSFGRTTIANLkSGNNLLWLH 195
Cdd:COG5594    82 VKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhFQKATNGNsdSESGLDKLSISNV-SPSNRLYAH 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 196 TS---FAFLYLLLTVYSMRRHTSKMRY--------------KEDDLVKRTLFINGI-SKYAESEKIKKHFEEAYpNCTVL 257
Cdd:COG5594   161 VFlswFFFGYVLFIIFRELRFYVVLRQaylrsplyqqslltLQNNLSSRTVLISGLpSELRSDEELKELFDKLK-VGEID 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 258 EARPCYNVARLMFLDAERKKAER-------------------------GKLYFTNLQSKENVPAMINPKPCGHLCCCVVR 312
Cdd:COG5594   240 SDVLCRDLGTLQELYKERDKILKklekalnellnkllkkshlktnkksGKLTPSRKKEFEILPEYVPDKKRPKHRIKKLN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 313 GC---EQVEAIEYY----TKLEQRLKEdYRREKEkvNEKPLGMAFVTFHNETITAIIlkdfnvckcqgctcrgeprASSC 385
Cdd:COG5594   320 KGifgKKVDAIDYYsaklTKLDAEIEN-ARKSLY--ENTPTKSGFITFKSQASAQIA-------------------AQSQ 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 386 SEALHISNWTVTYAPDPQNIYWEHLSIrgFIWW--LRCLVINVVLFILLFFLTTPAIIITTMDKFN-VTKPVEYLN---- 458
Cdd:COG5594   378 IYSRVLGKLKVEIAPAPNDIIWDNLRL--SRKErlFKRISANILFILLIILWAFPVAFVGTISNLNtLSSLWPFLKfilk 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 459 -----NPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFD 533
Cdd:COG5594   456 dppflAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASSFSSIVWSLLKE 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 534 -KKFLAEAAIRfecvfLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYA 612
Cdd:COG5594   536 pTSIMTLLANN-----LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGKFKDSTPRQKWNRLETPPSFQFGTVLP 610
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 613 WMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYlpaklDKKIHSG------AVNQVVAAPILCLFWLLFFS 686
Cdd:COG5594   611 QPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVS-----NHSPESGggywprALFQIIVGLYLFQVCLLGLF 685
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389844 687 TMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSN 743
Cdd:COG5594   686 SLAKGWGLSVLLFPLIVFTVIFHYYFKKMFDPLSKYIKLSSYKLLIPELEYLSTFSE 742
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-208 1.31e-08

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 54.89  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844  52 FLALLFLFSILRKVAWD--YGRLALVTDadsvasamhgdsHDRYERLtsvsssvdfdqRDNGFCSWLTAIFRIKDDEIRD 129
Cdd:pfam13967  13 ALVFLLLFSILRPKNKRvyAPRTYLAPE------------EERTPPL-----------PGTGLFGWIPPLLKIPDEEILQ 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 130 KCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRT-----TIANLKSGNNLLWLHTSFAFLYLL 204
Cdd:pfam13967  70 HAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTG 149

                  ....
gi 1720389844 205 LTVY 208
Cdd:pfam13967 150 FVLY 153
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
420-691 1.21e-64

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 217.39  E-value: 1.21e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 420 RCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPI----------ITQFFPTLLLWCFSALLPTIVYYSAFFE 489
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 490 AHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSsldlFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNA 569
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASS----ASSLIEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 570 MDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYN 649
Cdd:pfam02714 157 GELLQLGPLILFYIKRKFLDKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720389844 650 LYYAYlpaklDKKIHSGAVNQVVaAPILCLFWLLFFSTMRTG 691
Cdd:pfam02714 237 LLYVY-----VTKYESGGRFWPR-ALNRLLVGLYLFQLCLIG 272
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
227-409 8.21e-44

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 155.56  E-value: 8.21e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 227 RTLFINGISK-YAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKEnvPAMINPKPCGH 305
Cdd:pfam14703   2 RTVLVTGIPKdLRSEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKN--GKKPKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 306 LCCCVVRGcEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKdfnvckcqgctcrgepraSSC 385
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 1720389844 386 SEALHISNWTVTYAPDPQNIYWEH 409
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
40-743 8.47e-26

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 114.05  E-value: 8.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844  40 GVPTVLALDFMCFLALLFLFSILRKvawdygRLALVTDADSVASamhgdshDRYERLTSVSSSvdfdqrdnGFCSWLTAI 119
Cdd:COG5594    23 AVITQLVFAGLIFLVFLILFLILRK------RWKRLYAPRTNFD-------GQNECLPEPNPS--------SYWGWLEPL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 120 FRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVN--FSGDLLEN--NAYSFGRTTIANLkSGNNLLWLH 195
Cdd:COG5594    82 VKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhFQKATNGNsdSESGLDKLSISNV-SPSNRLYAH 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 196 TS---FAFLYLLLTVYSMRRHTSKMRY--------------KEDDLVKRTLFINGI-SKYAESEKIKKHFEEAYpNCTVL 257
Cdd:COG5594   161 VFlswFFFGYVLFIIFRELRFYVVLRQaylrsplyqqslltLQNNLSSRTVLISGLpSELRSDEELKELFDKLK-VGEID 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 258 EARPCYNVARLMFLDAERKKAER-------------------------GKLYFTNLQSKENVPAMINPKPCGHLCCCVVR 312
Cdd:COG5594   240 SDVLCRDLGTLQELYKERDKILKklekalnellnkllkkshlktnkksGKLTPSRKKEFEILPEYVPDKKRPKHRIKKLN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 313 GC---EQVEAIEYY----TKLEQRLKEdYRREKEkvNEKPLGMAFVTFHNETITAIIlkdfnvckcqgctcrgeprASSC 385
Cdd:COG5594   320 KGifgKKVDAIDYYsaklTKLDAEIEN-ARKSLY--ENTPTKSGFITFKSQASAQIA-------------------AQSQ 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 386 SEALHISNWTVTYAPDPQNIYWEHLSIrgFIWW--LRCLVINVVLFILLFFLTTPAIIITTMDKFN-VTKPVEYLN---- 458
Cdd:COG5594   378 IYSRVLGKLKVEIAPAPNDIIWDNLRL--SRKErlFKRISANILFILLIILWAFPVAFVGTISNLNtLSSLWPFLKfilk 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 459 -----NPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFD 533
Cdd:COG5594   456 dppflAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASSFSSIVWSLLKE 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 534 -KKFLAEAAIRfecvfLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYA 612
Cdd:COG5594   536 pTSIMTLLANN-----LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGKFKDSTPRQKWNRLETPPSFQFGTVLP 610
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 613 WMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYlpaklDKKIHSG------AVNQVVAAPILCLFWLLFFS 686
Cdd:COG5594   611 QPILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVS-----NHSPESGggywprALFQIIVGLYLFQVCLLGLF 685
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720389844 687 TMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSN 743
Cdd:COG5594   686 SLAKGWGLSVLLFPLIVFTVIFHYYFKKMFDPLSKYIKLSSYKLLIPELEYLSTFSE 742
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-208 1.31e-08

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 54.89  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844  52 FLALLFLFSILRKVAWD--YGRLALVTDadsvasamhgdsHDRYERLtsvsssvdfdqRDNGFCSWLTAIFRIKDDEIRD 129
Cdd:pfam13967  13 ALVFLLLFSILRPKNKRvyAPRTYLAPE------------EERTPPL-----------PGTGLFGWIPPLLKIPDEEILQ 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389844 130 KCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRT-----TIANLKSGNNLLWLHTSFAFLYLL 204
Cdd:pfam13967  70 HAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFTG 149

                  ....
gi 1720389844 205 LTVY 208
Cdd:pfam13967 150 FVLY 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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