NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720389939|ref|XP_030105613|]
View 

zinc finger protein 40 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 8.19e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.19e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389939  33 LLTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-668 7.82e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 7.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 270 KPYKCIECGKCYYHSSFEK-HYRIHSEEESYKCND--CRKSFICCLGLKRHHKIHGGERPYECKQCSKS--FYTSSHLEN 344
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 345 HYRTHRrklhrcNECGKSLSSSSGLQRHQRIHrgekayiCAECNKCFIQKSQLKTHQRIHTGEKSYKCS-------ECEK 417
Cdd:COG5048   112 SSSSNS------NDNNLLSSHSLPPSSRDPQL-------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 418 SFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKCS 497
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 498 DCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKAN 564
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 565 LRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFTVGSDLRKHQKCHTGEKP-- 632
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1720389939 633 YKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 668
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
675-700 1.02e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 675 NLRTHQKIHTGEKPYKCSECDKCFIQ 700
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-727 2.72e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389939 703 HLRTHQRLHTGEKPYKCSECEKSFT 727
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 8.19e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.19e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389939  33 LLTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
34-76 1.32e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.32e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720389939   34 LTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVFVENH 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-72 1.15e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 1.15e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389939  34 LTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVF 72
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-668 7.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 7.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 270 KPYKCIECGKCYYHSSFEK-HYRIHSEEESYKCND--CRKSFICCLGLKRHHKIHGGERPYECKQCSKS--FYTSSHLEN 344
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 345 HYRTHRrklhrcNECGKSLSSSSGLQRHQRIHrgekayiCAECNKCFIQKSQLKTHQRIHTGEKSYKCS-------ECEK 417
Cdd:COG5048   112 SSSSNS------NDNNLLSSHSLPPSSRDPQL-------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 418 SFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKCS 497
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 498 DCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKAN 564
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 565 LRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFTVGSDLRKHQKCHTGEKP-- 632
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1720389939 633 YKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 668
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-476 4.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.30e-04
                          10        20
                  ....*....|....*....|....*
gi 1720389939 452 HLRRHQKIHTGEKPYKCSECEKSFT 476
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
675-700 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 675 NLRTHQKIHTGEKPYKCSECDKCFIQ 700
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-727 2.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389939 703 HLRTHQRLHTGEKPYKCSECEKSFT 727
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-73 8.19e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.19e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1720389939  33 LLTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVFV 73
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
34-76 1.32e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.03  E-value: 1.32e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720389939   34 LTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVFVENH 76
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-72 1.15e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 1.15e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720389939  34 LTFRNVAVDFSKEEWEYLNSSQRALYMDVMWENYSNLVF 72
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-668 7.82e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 7.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 270 KPYKCIECGKCYYHSSFEK-HYRIHSEEESYKCND--CRKSFICCLGLKRHHKIHGGERPYECKQCSKS--FYTSSHLEN 344
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 345 HYRTHRrklhrcNECGKSLSSSSGLQRHQRIHrgekayiCAECNKCFIQKSQLKTHQRIHTGEKSYKCS-------ECEK 417
Cdd:COG5048   112 SSSSNS------NDNNLLSSHSLPPSSRDPQL-------PDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSK 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 418 SFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKCS 497
Cdd:COG5048   179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 498 DCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKAN 564
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 565 LRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFTVGSDLRKHQKCHTGEKP-- 632
Cdd:COG5048   339 LKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPyn 418

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1720389939 633 YKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 668
Cdd:COG5048   419 CKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-763 2.22e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 2.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 382 YICAECNKCFIQKSQLKTHQRIHTGEKSYKCS--ECEKSFTVGSSLRIHQRIHTGEKPYKCSechKCFIQQAHLRRHQKI 459
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 460 htgekpykcSECEKSFTVGSDLRMHQKIHTGEKPYKCSDCDKCFIQKAKLKKHQRIHTGEKPYKCS-------ECEKCFT 532
Cdd:COG5048   111 ---------SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 533 VVSDLRTHQKIHTGEKPYKCSECDKCFIRKANLRRHHRIHTGEKPYKCSDCGKCFIQKANLR-------THERIHTGEKP 605
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslssSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 606 YKCECGKSFTVGSDLRKHQKCHTG-EKPYKCSECNKCFIRKAHLRRHQR--IHTGE--KPYKC--SDCGKCFIQKANLRT 678
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 679 HQKIHTGEKPYKCSEC------DKCFIQKDHLRTHQRLHTGEKPYKC---SECEKSFTGGSVLRKHQKIHTARSLTNAMN 749
Cdd:COG5048   342 HILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKN 421

                         410
                  ....*....|....
gi 1720389939 750 LTNPLSKKPTLELI 763
Cdd:COG5048   422 PPCSKSFNRHYNLI 435
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
194-585 2.87e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 194 HDKFFDSKHKLMIKRMCSGEKPYQCRK--CGKCFRTYSSLYRHRRTHPGEKPYKLTECNKSILY-LSHHKVHYNIHYGEK 270
Cdd:COG5048    40 TDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkASSSSLSSSSSNSND 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 271 PYKCiecgkCYYHSSFEKHYRIHSEEES---------YKCNDCRKSFICCLGLK-RHHKIHGGERPYECKQC----SKSF 336
Cdd:COG5048   120 NNLL-----SSHSLPPSSRDPQLPDLLSisnlrnnplPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLlissNVST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 337 YTSSHLENHYRTHRRKLHRCNECGKSLSSSSGLQRHQRIHRGEKAYICAecnkcfiQKSQLKTHQRIHTGEKSYKCSECE 416
Cdd:COG5048   195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-------SPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 417 KSFTVGSSLRIHQRIHTG-EKPYKCSECHKCFIQQAHLRRHQ--KIHTGE--KPYKCSE--CEKSFTVGSDLRMHQKIHT 489
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 490 GEKPYKC--SDCDKCFIQKAKLKKHQRI--HTGEKPYKCSEC---EKCFTVVSD----LRTHQKIHTGEKPYKCSECDKC 558
Cdd:COG5048   348 SISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnSCIRNFKRDsnlsLHIITHLSFRPYNCKNPPCSKS 427

                         410       420
                  ....*....|....*....|....*..
gi 1720389939 559 FIRKANLRRHHRIHTGEKPYKCSDCGK 585
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
436-758 3.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 436 KPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCS--ECEKSFTVGSDLRMHQKIHTGEKPYKCSdcDKCFIQKAKLKKHQ 513
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 514 RIHTGEKPYKCSECEKCftVVSDLRTHQKIHTGEKPYKCSECD------KCFIRKANLRRHHRIHTGEKpykcsdCGKCF 587
Cdd:COG5048   110 LSSSSSNSNDNNLLSSH--SLPPSSRDPQLPDLLSISNLRNNPlpgnnsSSVNTPQSNSLHPPLPANSL------SKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 588 IQKANLRTHERIHTGEKPYKCECGKSFTVGSDLRKHQKCHTGEKPYKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCG 667
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 668 KCFIQKANLRTHQKIHTGE-------KPYKCSECDKCFIQKDHLRTHQR--LHTGE--KPYKCSE--CEKSFTGGSVLRK 734
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340
                  ....*....|....*....|....
gi 1720389939 735 HQKIHTARSLTNAMNLTNPLSKKP 758
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSP 365
zf-H2C2_2 pfam13465
Zinc-finger double domain;
452-476 4.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.30e-04
                          10        20
                  ....*....|....*....|....*
gi 1720389939 452 HLRRHQKIHTGEKPYKCSECEKSFT 476
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
647-672 4.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 647 HLRRHQRIHTGEKPYKCSDCGKCFIQ 672
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-589 7.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.60e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 564 NLRRHHRIHTGEKPYKCSDCGKCFIQ 589
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
675-700 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 675 NLRTHQKIHTGEKPYKCSECDKCFIQ 700
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 490-573 1.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 490 GEKPYKCS--DCDKCFIQKAKLKKHqRIHtgekpykcSECEKCFTVVSDLRTHQKIHTGEKPYKCSECDKCFiRKANLRR 567
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY-KNLNGLK 415


                  ....*.
gi 1720389939 568 HHRIHT 573
Cdd:COG5189   416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-561 2.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 536 DLRTHQKIHTGEKPYKCSECDKCFIR 561
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
703-727 2.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1720389939 703 HLRTHQRLHTGEKPYKCSECEKSFT 727
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-532 2.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|....
gi 1720389939 509 LKKHQRIHTGEKPYKCSECEKCFT 532
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 2.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 480 DLRMHQKIHTGEKPYKCSDCDKCFIQ 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
424-449 3.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720389939 424 SLRIHQRIHTGEKPYKCSECHKCFIQ 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-420 8.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 8.27e-03
                          10        20
                  ....*....|....*....|....
gi 1720389939 397 LKTHQRIHTGEKSYKCSECEKSFT 420
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 633-655 8.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.46e-03
                          10        20
                  ....*....|....*....|...
gi 1720389939 633 YKCSECNKCFIRKAHLRRHQRIH 655
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 462-542 8.86e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720389939 462 GEKPYKCS--ECEKSFTVGSDLRMHQKI-HTGEKPYKCSDCDKcfiqkaklkkHQRIHTGEKPYKCSECEKCFTVVSDLR 538
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....
gi 1720389939 539 THQK 542
Cdd:COG5189   416 YHRK 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH