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Conserved domains on  [gi|1720414902|ref|XP_030110685|]
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protein furry homolog-like isoform X17 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2285-3016 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


:

Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2285 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2364
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2365 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2444
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2445 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2524
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2525 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2603
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2604 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2683
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2684 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2763
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2764 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2841
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2842 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 2916
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2917 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 2996
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 1720414902 2997 QSYPLLAQTKPVGNMTSTGF 3016
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 117-649 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  117 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 196
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  197 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 276
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  277 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 356
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  357 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  435 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 512
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  513 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 578
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  579 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 649
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2002-2255 8.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


:

Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.08  E-value: 8.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2002 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2080
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2081 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2158
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2159 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2237
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720414902 2238 PYWKEALNILKLVVSRSA 2255
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid super family cl20509
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 687-1860 2.10e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


The actual alignment was detected with superfamily member pfam14228:

Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.10e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  687 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 766
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  767 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 846
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  847 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 926
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  927 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1000
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1001 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1080
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1081 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1133
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1134 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1176
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1177 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1255
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1256 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1334
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1335 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1412
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1413 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1467
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1468 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1547
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1548 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1613
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1614 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1693
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1694 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1773
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1774 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1852
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 1720414902 1853 LVETVGDP 1860
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2285-3016 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2285 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2364
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2365 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2444
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2445 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2524
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2525 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2603
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2604 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2683
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2684 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2763
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2764 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2841
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2842 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 2916
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2917 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 2996
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 1720414902 2997 QSYPLLAQTKPVGNMTSTGF 3016
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 117-649 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  117 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 196
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  197 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 276
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  277 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 356
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  357 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  435 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 512
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  513 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 578
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  579 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 649
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2002-2255 8.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.08  E-value: 8.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2002 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2080
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2081 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2158
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2159 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2237
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720414902 2238 PYWKEALNILKLVVSRSA 2255
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 687-1860 2.10e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.10e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  687 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 766
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  767 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 846
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  847 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 926
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  927 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1000
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1001 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1080
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1081 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1133
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1134 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1176
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1177 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1255
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1256 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1334
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1335 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1412
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1413 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1467
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1468 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1547
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1548 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1613
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1614 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1693
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1694 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1773
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1774 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1852
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 1720414902 1853 LVETVGDP 1860
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Name Accession Description Interval E-value
Fry_C pfam19421
Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a ...
 2285-3016 0e+00

Furry protein C-terminal; This is the C-terminal domain of Furry (Fry) protein. Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.


Pssm-ID: 466072  Cd Length: 633  Bit Score: 1010.45  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2285 VSKELPGKTLDFHFDISETPIIGNKYGGQHSAAGRNGKAKVIAVTRSTSSTSSGSTSNALVPVSWKRPQLSQRRTREKLM 2364
Cdd:pfam19421    1 SSKELPGKTLDFHFDISETPIIGRRYDELHGSAGRDGKPRVIAVTRSTSSTSSGSNSNVLVPVSWKRPQLSQKRTREKLV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2365 SVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLISTtEDIIQEEEVaVEDNSSEQQFGVFKDFDFLDVELEDAEelqG 2444
Cdd:pfam19421   81 NVLSLCGQEVGLTKNPSVIFSSCGDLDLMDQQTSLVSS-EDGIREEEN-MDDTTSEQQFRVFRDFDFLDVELEDGE---G 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2445 ESMDNFNWGVRRRSLDSIDKGDTPSLQEYPCSSSTPSLTLTNQEDTDESSEEEAaLTASQILSRTQMLNSDCVTEDmmPE 2524
Cdd:pfam19421  156 ESMDNFNWGVRRRSLDSLDKGDTPSLEESQLSGSTPSLNLTNHEDSDESSEEES-LTASQILSHSQLLNSDSPTEE--PN 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2525 HQD-LLQSQDSASSntTEDVLqiRDETPSLEAcldnassQLPEGTSSVlkeehvtafedegsyvipdqqdplvcrgildl 2603
Cdd:pfam19421  233 HVDsLSQSQDSSSA--DEESL--RAETPSLEV-------SLPEDASAR-------------------------------- 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2604 eetdmpeplapesypesiceedvtlalkelderceeeeadfsglssqeedeqdGFPEVQTSPLPTPFLSAIIAAFQPMAY 2683
Cdd:pfam19421  270 -----------------------------------------------------GFPEIQSSPPPSPFFSAILAAFQPVVC 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2684 EDEEEAWRCHVNQTLSDTDGSCAVFTFHVFSRLFQTIQRKFGEITKEAVGFLGESLQRIGTKFKSSLEVMMACSECPTVF 2763
Cdd:pfam19421  297 DDAEEAWRCHVNQLVSDSDGSCAVYTFHVFSSLFQNIQRKFCSLTCDAVSYLGDSLRGIGSKFLSSSQMLTSCSECPTLF 376

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2764 VDAETLMACGLLETLKFGVLELQEHLDTYTTKREAAEQWLDNCKRTF--GANEDIYRMNTNAHQMgilAELELCRRLYRL 2841
Cdd:pfam19421  377 VDAETLMSCGLLEKLKFSVLELQEYLDTYNNKKEAAESWLDNCKATFprGSGDGVITCQPADQEE---KQLELCQRLYKL 453

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2842 HFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLEGILKE-----AEAASENEEIDISKAAQTTIETAIHSLIETLK 2916
Cdd:pfam19421  454 HFQLLLLFQSYCKLIGQVHAISSVPELINMSEELAQLESSLKEaeasvTSDELAQEESASSEPSFSSSEAAVQSILESLR 533

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2917 NKEFVSAVAQVKAFRTLWPNDIFGSCDDDPVQTLLHIYFHHQTLGQTGSFAVISSNLDMSEANCKLMELNLEIRESLRTV 2996
Cdd:pfam19421  534 NKEFSTAIRQIKECRSLWPNDIFGSSSEDEVQTLLNIYFRHQTLGQTGTFALVGSNQDLSEICSKLMELNLEIRDMIRRA 613

                          730       740
                   ....*....|....*....|
gi 1720414902 2997 QSYPLLAQTKPVGNMTSTGF 3016
Cdd:pfam19421  614 QGYRALTAFLPDSSVSGSSL 633
MOR2-PAG1_N pfam14222
Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that ...
 117-649 0e+00

Cell morphogenesis N-terminal; This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464107  Cd Length: 554  Bit Score: 630.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  117 ERRDLAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLYAEVIGVLAQSKFQAVR 196
Cdd:pfam14222    1 ERKSLASIYILCRVLIEIVKQSPLDALTEELGDKLEEIVFGQLKTADPDQLSSSPNRSANWNLFAELLGVLSEIRFVSVS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  197 KKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFEASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPV 276
Cdd:pfam14222   81 DRFIAELEKLPKGLSSKDLEAKIELLIRGMRYLRIKVYPEEAFEESADFMQSLAKFFLNAHGQRVKHAYAEVLVELLLPV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  277 AAAVKNEVNVPCLKNFVEMLYQTTFELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKdpKMSRVAL 356
Cdd:pfam14222  161 AATATAEVNHPKWKEAVELLYPRAAKMASKPRHWNVAFPLVTTLLCVSPKEFFLSNWLSLIESLISKLKDK--TTRPVAL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  357 ESLYRLLWVYVIRIKcESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLDFAMKEIIFDLLSVG-- 434
Cdd:pfam14222  239 QGLSRLLWVYLYRCT-ESLNTTTRKLESILKLLFPPGKKTWLPADPPLDPLVQIIRFIGFKHPDFCFENIIFPLLNADlf 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  435 KSTKTFTINPERMNIGLRVFLVIADSLQQKDGDPPMPTTGVILPSGN--TLRVKKIFLNKTlTDEEAKVIGMSVYYPQVR 512
Cdd:pfam14222  318 NGLKLENLNPERMIIGIRAFLAILSDLEKGEQRPPFPQSFGTLPSPSssALRSKEENLSRP-VDTLALSEGIKDYYERFC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  513 KALDSILRHLDKEVGRPM-------------CMTSVQMSNKEPED-MITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLI 578
Cdd:pfam14222  397 KILGKILILCDNTFGGQAvldekfssptpktPISETFNFSRRPDDnAYDGQRQPFYELLHTAVQAIPRCLPSSIPFNSLI 476

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  579 ELLARLTIHMDEELRALAFNTLQALMLdfPDWREDVLSGFVYFIV---------REVTDVHPTLLDNAVKMLVQLINQWK 649
Cdd:pfam14222  477 ELLCRGTVHVDPNIAESAAQALKRIAR--PSHAQQVITGFARFIFnfddrystmSDGGMLGPGHIESLLKLYVELLEIWI 554
MOR2-PAG1_C pfam14225
Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that ...
 2002-2255 8.74e-75

Cell morphogenesis C-terminal; This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.


Pssm-ID: 464109  Cd Length: 252  Bit Score: 250.08  E-value: 8.74e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2002 ATIFWIATSLLESDYEYEYLLALRLLSKLLTHLPLDKSESREKIENVQSKlKWSN-FPGLQQLFLKGFTSVSTQEMTVHL 2080
Cdd:pfam14225    1 PQLFWTTVACLETIHEHEFLEALRLLEKLLDKLDLDDPDVVEKLLSSQPQ-KWEGkFEGLQPLLLKGLRSSVTLEPTLKL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2081 LSQLISVSKHTLVDPSQvSGFPLNILCLLPHLIQHFDSP--TQFCKETASRIAKVCAEEKCPtlvNLAHMMSLYSTHTYs 2158
Cdd:pfam14225   80 LDRLTKLPDDRLVGPSD-SRLLFLVLANLPRFLHALDDPdiDPDCIETAENLAELAEEQGLP---SLARVLTSYAKGRF- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 2159 RDCSNWINVVCRYLHDSFSEAT-FSLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPVKQFNLEIIKIIGKYVQS 2237
Cdd:pfam14225  155 RTSDDFLKQVVSYLREAYFPDYeFQMLTFLLGLLTNGPPWVKVKTLQILKVLLPEIDMRRPEIAGHGADLISPLLRLLQT 234

                          250
                   ....*....|....*...
gi 1720414902 2238 PYWKEALNILKLVVSRSA 2255
Cdd:pfam14225  235 DLCMQALEVLDEIVTISG 252
MOR2-PAG1_mid pfam14228
Cell morphogenesis central region; This family is the conserved central region of proteins ...
 687-1860 2.10e-38

Cell morphogenesis central region; This family is the conserved central region of proteins that are involved in cell morphogenesis.


Pssm-ID: 433790 [Multi-domain]  Cd Length: 1113  Bit Score: 158.65  E-value: 2.10e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  687 VEGFALVILCSSRPATRRLAVSVLREIRALFALLEVPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSVDLQ 766
Cdd:pfam14228    9 LDAVGLIFLSSVDVQIRHTALELLRCVRALYNDLRDMSSKERSDVSWKNNKEPIFIIDVFEENGDDIVQQCYWDSGRPYD 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  767 TLADWNSSPISHQFDVISPShiwifahvtQGQDPWIISLSSFLKQENlpKHCSTAVSYAWMFAYTRLQLLSPqVDINSpi 846
Cdd:pfam14228   89 MRRESDAIPPDLTLQSILES---------PDKGRWARCLSELVKYAA--ELCPSSVQEARLEVVQRLAQITP-VELGG-- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  847 nakKVNATTSSDSYIGLWRNYLVLCCSAatspspsapagsvrcsPPETlasTPDSGYSidskivgipSPSSLFKHIVPMM 926
Cdd:pfam14228  155 ---KAHQSQDADNKLDQWLLYSMFACSC----------------PPDD---VEDTKSH---------SAKELYHLIFPSL 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902  927 RSESMEITESLVLGLGRTNPGVFRELIEELHPIIKEA---LERRPENMKRRRRRDILRVQLVRIFELLAD---AGVISHS 1000
Cdd:pfam14228  204 KSGSETHIHAATLALGHSHLEVCEPMFGELRSFLDEVateTESKPKWKSQKARREELRVHVANIYRMVAEnfwPGMLIRK 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1001 ASGGLdsetHFLNntLLEyvDLTRQLLEAENEKDSDtLKDIRCHFSALVANIIQNVpVHQRRSIFPQQSlRHSLFMLFSH 1080
Cdd:pfam14228  284 PVFRL----HVLK--FIE--DTVRYITTSPLENFQD-LQPLRFALASVLRSLAPEF-VKSKSERFDPRT-RKRLFDLLAS 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1081 WAGPFSIMFT---------PLDRYS------------------DRNMQINRHQYCALKAMSAVLCcGPVADNVGLSSDGY 1133
Cdd:pfam14228  353 WCDDTGTVWSqdgvsdyrrEVERYKssqnsrskdsvdkisfdkEVNEQVEAIQWIAMNAMAALLY-GPCFDDNARKMSGR 431

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1134 LYKWLDNILD------------------------------SLDKKVHQLGCEAVTL-------LLELNPDqssLMYWAVD 1176
Cdd:pfam14228  432 VIAWINGLFLepaprapfgyspadprtpsyskfagegvrgLGGKDRHRGGPLRVHLakvalknLLQTNLD---LFPACID 508

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1177 RCYTGSRRVAAGCFKAIANVFQNRDY-QCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKmfRYAHKLEVQRTDGVL 1255
Cdd:pfam14228  509 QCYSSDASIADGYFSVLAEVYMRQEIpRCDIQRLLSLILYKVVDPSRRIRDDALQMLETLSVR--EWAEDGEEGTGRYRA 586

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1256 SQLSPLPHLYSVSYYQLSEELARAYPELTLAIFSEISQR-IQTAHPAGRQAMLHYLLPWMNNIELVDLKplpsgrrqded 1334
Cdd:pfam14228  587 AVVGNLPDSYQQFQYKLSAKLAKDHPELSELLCEEIMQRqLDAVDIIAQHQVLTCMAPWIENLNFLKLW----------- 655

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1335 edDSlkdrelmvtsrrwlrgeGWgspqaTAMVLNNLMYMTAKYGDELAwSEVENVWTTLADGwPKNLKIILHFLIS--IC 1412
Cdd:pfam14228  656 --ES-----------------GW-----SERLLKSLYYVTWRHGDQFP-DEIEKLWRTIASK-PRNISPVLDFLISkgIE 709

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1413 GVNSEPS---------LLPYVKKVIVYLGRDKTMQLLEELVSEL---QLTDPV-------------SSGVTHMDNPPYYR 1467
Cdd:pfam14228  710 DCDSNASaeitgafatYFSVAKRVSLYLARICPQQTIDHLVYELaqrMLEESVepsrpsdgafdleSSAVLEFSQGPAPV 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1468 ITSSCKIPSVTSGTTSSSNTMVAPTDGNPDSKALKENFEESyvhldIYGGLNSHLNRQHHRLESRYSSSSGGSYEEEKSD 1547
Cdd:pfam14228  790 QVAQLLDPQPHMSPLLVRSSLEGPLRNASGSLSWRTVTGRS-----MSGPLNTMPEVVAVDTHTGRSGQLFTGSGPLPNM 864

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1548 SMPLY------SNWRLKVMEHNQGEPLPFPPAG---GCWSPLVDyvPETASPGLPLH-----RCNIAVILLTDliIDHSV 1613
Cdd:pfam14228  865 SGPLMgvrsstGSLRSHHVSRDSGDYFIDTPNSveeIRITPVVN--ASELQSALQGHqhwlsRADIALILLAE--IAYEN 940

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1614 KVEWGSYLHLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGpnsdirtvasvllrdkefnePRVLTVKQTAHSDYtfta 1693
Cdd:pfam14228  941 DEDFRSHLPLLFHVTFVSMDSSEDIVLKHCQHLLVNLLYSLA--------------------GRHLELYDVEHGDG---- 996

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1694 gindftpdyqpspmtdsglsssstsssislgnnsaaishlhttllgevdlsvEQDGKVKTLMEFITSRKRGPLWNHEDVS 1773
Cdd:pfam14228  997 ----------------------------------------------------EYKQQVVSLIKYVQSKRGSRMWENEDMT 1024

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414902 1774 SKNPSIKSADQLATFLKHVV-SVFKQSNaegihLERHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLSADTLSDVLSR 1852
Cdd:pfam14228 1025 LTRTELPSAALLSALVLSMVdAIFFQGD-----LREKWGEEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRC 1099


                   ....*...
gi 1720414902 1853 LVETVGDP 1860
Cdd:pfam14228 1100 LHRCLGNP 1107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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