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Conserved domains on  [gi|1723177|sp|P52761|]
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RecName: Full=RutC family protein slr0709

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-128 1.34e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.83  E-value: 1.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177      3 MKIIQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTIMGeGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLK 82
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVG-GDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1723177     83 DMNDFAAVNAIYGQYFDEaTAPARSCVEVARLPKDVLVEIDCVAVL 128
Cdd:TIGR00004  80 DLNDFAEVNEVYGQYFDE-HYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-128 1.34e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.83  E-value: 1.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177      3 MKIIQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTIMGeGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLK 82
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVG-GDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1723177     83 DMNDFAAVNAIYGQYFDEaTAPARSCVEVARLPKDVLVEIDCVAVL 128
Cdd:TIGR00004  80 DLNDFAEVNEVYGQYFDE-HYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-129 5.50e-55

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 167.66  E-value: 5.50e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177    1 MTMKIIQTAqAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVF 80
Cdd:COG0251   1 MTRELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL--GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 1723177   81 LKDMNDFAAVNAIYGQYFDEAtAPARSCVEVARLPKDVLVEIDCVAVLP 129
Cdd:COG0251  78 LTDMADFAAVNEVYAEYFGEG-RPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-127 4.15e-54

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 165.55  E-value: 4.15e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177     10 QAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImGEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAA 89
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKL-VEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAE 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1723177     90 VNAIYGQYFDEATAPARSCVEVARLPKDVLVEIDCVAV 127
Cdd:pfam01042  80 VNEVYAEYFDADKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-126 7.53e-47

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 146.55  E-value: 7.53e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAAVNAIYGQY 97
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELV--PGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEF 78

                        90       100
                ....*....|....*....|....*....
gi 1723177   98 FDEATAPARSCVEVARLPKDVLVEIDCVA 126
Cdd:cd00448  79 FGEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
4-127 7.51e-36

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 119.79  E-value: 7.51e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177     4 KIIQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKD 83
Cdd:PRK11401   3 KIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEI--PADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 1723177    84 MNDFAAVNAIYGQYFDE--ATAPARSCVEVARLPKDVLVEIDCVAV 127
Cdd:PRK11401  81 LNDFATINEVYKQFFDEhqATYPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 3-128 1.34e-67

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 199.83  E-value: 1.34e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177      3 MKIIQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTIMGeGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLK 82
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVG-GDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1723177     83 DMNDFAAVNAIYGQYFDEaTAPARSCVEVARLPKDVLVEIDCVAVL 128
Cdd:TIGR00004  80 DLNDFAEVNEVYGQYFDE-HYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-129 5.50e-55

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 167.66  E-value: 5.50e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177    1 MTMKIIQTAqAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVF 80
Cdd:COG0251   1 MTRELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL--GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 1723177   81 LKDMNDFAAVNAIYGQYFDEAtAPARSCVEVARLPKDVLVEIDCVAVLP 129
Cdd:COG0251  78 LTDMADFAAVNEVYAEYFGEG-RPARTAVGVAALPKGALVEIEAIAALP 125
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-127 4.15e-54

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 165.55  E-value: 4.15e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177     10 QAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImGEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAA 89
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKL-VEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAE 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1723177     90 VNAIYGQYFDEATAPARSCVEVARLPKDVLVEIDCVAV 127
Cdd:pfam01042  80 VNEVYAEYFDADKAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-126 7.53e-47

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 146.55  E-value: 7.53e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAAVNAIYGQY 97
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGELV--PGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEF 78

                        90       100
                ....*....|....*....|....*....
gi 1723177   98 FDEATAPARSCVEVARLPKDVLVEIDCVA 126
Cdd:cd00448  79 FGEGPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
4-127 7.51e-36

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 119.79  E-value: 7.51e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177     4 KIIQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKD 83
Cdd:PRK11401   3 KIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEI--PADVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 1723177    84 MNDFAAVNAIYGQYFDE--ATAPARSCVEVARLPKDVLVEIDCVAV 127
Cdd:PRK11401  81 LNDFATINEVYKQFFDEhqATYPTRSCVQVARLPKDVKLEIEAIAV 126
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-127 4.63e-27

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 96.45  E-value: 4.63e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPqtmtimgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAAVNAIYGQY 97
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVADDT-------SADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAW 75

                        90       100       110
                ....*....|....*....|....*....|
gi 1723177   98 FDEATAPARSCVEVARLPKDVLVEIDCVAV 127
Cdd:cd06150  76 VPPGHAPARACVEAKLADPGYLVEIVVTAA 105
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 46-126 5.33e-24

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 88.47  E-value: 5.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   46 EGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAAVNAIYGQYFDEATAPARSCVEvARLPKDVLVEIDCV 125
Cdd:cd06155  21 DETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNPPSRVCVE-CGLPEGCDVQLSCV 99


                .
gi 1723177  126 A 126
Cdd:cd06155 100 A 100
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-126 1.36e-20

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 80.29  E-value: 1.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDMNDFAAVNAIYGQY 97
Cdd:cd06154  13 YSRAVRVGNWVFVSGTTGYDYDGMVM--PGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEV 90

                        90       100       110
                ....*....|....*....|....*....|
gi 1723177   98 FDEATaPARSCVEVARLPKD-VLVEIDCVA 126
Cdd:cd06154  91 FGDIR-PAATMVVVSLLVDPeMLVEIEVTA 119
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 18-128 2.74e-18

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 74.22  E-value: 2.74e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTimgEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFLKDM-NDFAAVNAIYGQ 96
Cdd:cd02198   3 YSPAVRVGDTLFVSGQVGSDADGSV---AEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDE 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 1723177   97 YFDEATaPARSCVEVARLPKD-VLVEIDCVAVL 128
Cdd:cd02198  80 YFKEPY-PAWTAVGVAWLARPgLLVEIKVVAVR 111
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 18-122 8.69e-12

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 57.72  E-value: 8.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTIMGEGnVEVQAKQVLTNLGAVLQEAGCGWenVVKTTVFLKDMNDFAAVNAIYGQY 97
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLIPATMTLLEGG-ITLQAVLSLQHLERVAKAMNVQW--VLAAVCYVTDESSVPIARSAWSKY 77

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 1723177   98 FDEATAPARS------------CVEVARLPKDVLVEI 122
Cdd:cd06156  78 CSELDLEDESrnesddvnpplvIVVVPELPRGALVEW 114
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 41-126 4.51e-11

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 56.17  E-value: 4.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   41 MTIMGEGNVEVQAKQVLTNLGAVLQEAGCGWENVVKTTVFL------KDMNDFAAVNAIYGQYFDEA---TAPARSCVEV 111
Cdd:cd06151  31 GSPARYGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGKMDFAGFMKAYRQFFGTAeqpNKPARSTLQV 110

                        90
                ....*....|....*.
gi 1723177  112 ARLPK-DVLVEIDCVA 126
Cdd:cd06151 111 AGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 44-126 1.14e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 54.57  E-value: 1.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   44 MGEGNVEVQAKQVLTNLGAVLQEAGCG-----WENVVKTTVFLKDMNDFAAVNAIYGQYFDEATAPARSCVEVARlpKDV 118
Cdd:cd06153  29 VHPGDVEAQTRETLENIEALLEAAGRGggaqfLADLLRLKVYLRDREDLPAVRAILAARLGPAVPAVFLQADVCR--PDL 106


                ....*...
gi 1723177  119 LVEIDCVA 126
Cdd:cd06153 107 LVEIEAVA 114
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 6-126 8.48e-10

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 52.85  E-value: 8.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177    6 IQTAQAPAPVGPYNQAIAANGFLFTAGQIALDPQTMTIMG----EGNVEV---QAKQVLTNLGAVLQEAGCGW---ENVV 75
Cdd:cd02199   4 LELPPAPAPVGNYVPAVRTGNLLYVSGQLPRVDGKLVYTGkvgaDLSVEEgqeAARLCALNALAALKAALGDLdrvKRVV 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1723177   76 KTTVFLKDMNDF----AAVNA---IYGQYFDEATAPARSCVEVARLPKDVLVEIDCVA 126
Cdd:cd02199  84 RLTGFVNSAPDFteqpKVANGasdLLVEVFGEAGRHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-127 1.68e-05

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 41.14  E-value: 1.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723177   18 YNQAIAANGFLFTAGQIALDPQTMTImgEGNVEVQAKQVLTNLGAVLQEAGC-GWENVVKTTVFLKD-MND--FAAVNAI 93
Cdd:cd06152   3 YSQAVRIGDRIEISGQGGWDPDTGKI--PEDLEEEIDQAFDNVELALKAAGGkGWEQVYKVNSYHVDiKNEeaFGLMVEN 80

                        90       100       110
                ....*....|....*....|....*....|....*
gi 1723177   94 YGQYFDEaTAPARSCVEVARLP-KDVLVEIDCVAV 127
Cdd:cd06152  81 FKKWMPN-HQPIWTCVGVTALGlPGMRVEIEVDAI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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