Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.

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gi 17907349 27 VYRCPCRYFESN-VPKSNIKHLKIL-STSNCS-LQIVARLKhNGKQICLDPKTKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLK-NGRKVCLNPEAPWVQKIIKKLLK 64

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.

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gi 17907349 27 VYRCPCRYFESN-VPKSNIKHLKIL-STSNCS-LQIVARLKhNGKQICLDPKTKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLK-NGRKVCLNPEAPWVQKIIKKLLK 64

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.

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gi 17907349   29 RCPCRYFESNVPKSNIKHLKILSTSN-CSLQIVARLKHNGKQICLDPKTKWIQEYLEK 85
Cdd:pfam00048  2 DCCLRYSSKPIPLKRVKSYEIQPASSsCPKPAVIFLTKKGRQVCADPKAKWVQRLIKK 59

Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.

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               ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17907349 27 VYRCPCRYFESN-VPKSNIKHLKIL-STSNCS-LQIVARLKhNGKQICLDPKTKWIQEYLEKALN 88
Cdd:cd00273  1 ELRCRCIKTTSGfVHPKSIKKLEVIpPGPHCPnTEIIATLK-NGRKVCLNPEAPWVQKIIKKLLK 64

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.

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gi 17907349 39 VPKSNIKHLKILSTS--NCSLQIVARLKhNGKQICLDPKTKWIQEYLEKAL 87
Cdd:cd00169 10 IPPKNIKSYRVQEAGghCSIPAVIFTTK-KGRKVCADPKEPWVKDLIQKLD 59

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.

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gi 17907349 30 CPCRYFESNVPKSNIKHLKILStSNCSLQIVARLKHNGKQICLDPKTKWIQEYLEK 85
Cdd:cd00272  1 CCLSYSKKRIPLRVLKSYRRTS-SSCSKPAVIFKTKRGREVCADPKQKWVQRYMKL 55