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Conserved domains on  [gi|1810956792|gb|QIC34206|]
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variable lymphocyte receptor B, partial [Lampetra planeri]

Protein Classification

LRR_8 and DUF3439 domain-containing protein( domain architecture ID 12156423)

LRR_8 and DUF3439 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3439 super family cl13373
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 47-95 3.85e-10

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


The actual alignment was detected with superfamily member pfam11921:

Pssm-ID: 288750  Cd Length: 122  Bit Score: 52.65  E-value: 3.85e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1810956792  47 ACSDILYLSRWISQHPGVVRDGEHRVDPDQARCSGTNTPVRAVTEASTS 95
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTT 49
LRR_8 pfam13855
Leucine rich repeat;
1-43 3.64e-08

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 3.64e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRGAFDNLKSLTHIWLYDNP 43
Cdd:pfam13855  18 DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 47-95 3.85e-10

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 52.65  E-value: 3.85e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1810956792  47 ACSDILYLSRWISQHPGVVRDGEHRVDPDQARCSGTNTPVRAVTEASTS 95
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTT 49
LRR_8 pfam13855
Leucine rich repeat;
1-43 3.64e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 3.64e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRGAFDNLKSLTHIWLYDNP 43
Cdd:pfam13855  18 DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-42 7.80e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 7.80e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPrGAFDNLKSLTHIWLYDN 42
Cdd:COG4886   175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 15-81 2.07e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 2.07e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1810956792   15 LNNNQLTTVPRGAFDNLKSLTHIWLYDNPWDCACSdILYLSRWISQHPGVVRdgehrvDPDQARCSG 81
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCG-LARLPRWAEEKGVKVR------QPEAALCAG 61
LRR smart00370
Leucine-rich repeats, outliers;
7-30 4.44e-06

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.64  E-value: 4.44e-06
                           10        20
                   ....*....|....*....|....
gi 1810956792    7 LTQLTYLTLNNNQLTTVPRGAFDN 30
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRCT smart00082
Leucine rich repeat C-terminal domain;
42-100 6.95e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.71  E-value: 6.95e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810956792   42 NPWDCACsDILYLSRWIsqhpgvvRDGEHRVDPDQARC---SGTNTPVRavtEASTSPSKCP 100
Cdd:smart00082   1 NPFICDC-ELRWLLRWL-------QANEHLQDPVDLRCaspSSLRGPLL---ELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-42 3.77e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 34.76  E-value: 3.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1810956792   7 LTQLTYLTLNNNQLTTVprGAFDNLKSLTHIWLYDN 42
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDN 34
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 47-95 3.85e-10

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 52.65  E-value: 3.85e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1810956792  47 ACSDILYLSRWISQHPGVVRDGEHRVDPDQARCSGTNTPVRAVTEASTS 95
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDSSGYVDPDSAKCSGSGKPVRSIICPTTT 49
LRR_8 pfam13855
Leucine rich repeat;
1-43 3.64e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 3.64e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRGAFDNLKSLTHIWLYDNP 43
Cdd:pfam13855  18 DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-42 7.80e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 7.80e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPrGAFDNLKSLTHIWLYDN 42
Cdd:COG4886   175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-43 9.03e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 9.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRgAFDNLKSLTHIWLYDNP 43
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-42 2.49e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 2.49e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRgAFDNLKSLTHIWLYDN 42
Cdd:COG4886   198 PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-42 2.91e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 2.91e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPRgAFDNLKSLTHIWLYDN 42
Cdd:COG4886   129 PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN 169
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 15-81 2.07e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 44.30  E-value: 2.07e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1810956792   15 LNNNQLTTVPRGAFDNLKSLTHIWLYDNPWDCACSdILYLSRWISQHPGVVRdgehrvDPDQARCSG 81
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCG-LARLPRWAEEKGVKVR------QPEAALCAG 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-42 2.27e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1810956792   1 PGVFDKLTQLTYLTLNNNQLTTVPrgAFDNLKSLTHIWLYDN 42
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN 260
LRR smart00370
Leucine-rich repeats, outliers;
7-30 4.44e-06

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.64  E-value: 4.44e-06
                           10        20
                   ....*....|....*....|....
gi 1810956792    7 LTQLTYLTLNNNQLTTVPRGAFDN 30
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
7-30 4.44e-06

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.64  E-value: 4.44e-06
                           10        20
                   ....*....|....*....|....
gi 1810956792    7 LTQLTYLTLNNNQLTTVPRGAFDN 30
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-43 5.62e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 5.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1810956792   6 KLTQLTYLTLNNNQLTTVPRGAfdNLKSLTHIWLYDNP 43
Cdd:COG4886   248 NLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
8-42 8.48e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 8.48e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1810956792   8 TQLTYLTLNNNQLTTVPRGAFDNLKSLTHIWLYDN 42
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 8-43 1.09e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1810956792   8 TQLTYLTLNNNQLTTVPrgAFDNLKSLTHIWLYDNP 43
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
6-43 1.47e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 1.47e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1810956792   6 KLTQLTYLTLNNNQLTTVPRgAFDNLKSLTHIWLYDNP 43
Cdd:COG4886   111 NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ 147
LRRCT smart00082
Leucine rich repeat C-terminal domain;
42-100 6.95e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.71  E-value: 6.95e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1810956792   42 NPWDCACsDILYLSRWIsqhpgvvRDGEHRVDPDQARC---SGTNTPVRavtEASTSPSKCP 100
Cdd:smart00082   1 NPFICDC-ELRWLLRWL-------QANEHLQDPVDLRCaspSSLRGPLL---ELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 7-42 3.77e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 34.76  E-value: 3.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1810956792   7 LTQLTYLTLNNNQLTTVprGAFDNLKSLTHIWLYDN 42
Cdd:cd21340     1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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