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Conserved domains on  [gi|18138256|ref|NP_542467|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepidosiren paradoxa]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009582)

NADH dehydrogenase subunit 6 (mitochondrion) is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-168 1.34e-49

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 177196  Cd Length: 173  Bit Score: 157.61  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIM-LGGVTVWWWVFLEVGVDVMSGM--EYMELMV--KDFIGLGWVYGVCGGLLILSVWALFLALLVVLE 155
Cdd:MTH00138  81 SWGSWSVLGYVVGyLVGVVLAAGLFWGGWYEGSWVVvdELKEFSVlrGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                        170
                 ....*....|...
gi 18138256  156 VTRGVSRGALRSV 168
Cdd:MTH00138 161 LTRGLSRGALRAV 173
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-168 1.34e-49

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 157.61  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIM-LGGVTVWWWVFLEVGVDVMSGM--EYMELMV--KDFIGLGWVYGVCGGLLILSVWALFLALLVVLE 155
Cdd:MTH00138  81 SWGSWSVLGYVVGyLVGVVLAAGLFWGGWYEGSWVVvdELKEFSVlrGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                        170
                 ....*....|...
gi 18138256  156 VTRGVSRGALRSV 168
Cdd:MTH00138 161 LTRGLSRGALRAV 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-100 6.12e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    17 IGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPEAWMDWPVMMNFIMLGG 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80


                  ....
gi 18138256    97 VTVW 100
Cdd:pfam00499  81 LLLA 84
 
Name Accession Description Interval E-value
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-168 1.34e-49

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 157.61  E-value: 1.34e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIM-LGGVTVWWWVFLEVGVDVMSGM--EYMELMV--KDFIGLGWVYGVCGGLLILSVWALFLALLVVLE 155
Cdd:MTH00138  81 SWGSWSVLGYVVGyLVGVVLAAGLFWGGWYEGSWVVvdELKEFSVlrGDVGGVALMYSSGGGMLVICAWVLLLTLFVVLE 160

                        170
                 ....*....|...
gi 18138256  156 VTRGVSRGALRSV 168
Cdd:MTH00138 161 LTRGLSRGALRAV 173
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-168 1.04e-38

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 129.58  E-value: 1.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIM-LGGVTVWWWVFLEVGVDVMSGMEY---MELMVKDFIGLGWVYGVCGGLLILSVWALFLALLVVLEV 156
Cdd:MTH00065  81 AWGSWSVLVYVLFyLLLLIVGYILFGCNFSLEFLFTNYdteFSVVGYDWGGVGLMYSSGGWFLMISGWVLLLTLFVVLEV 160

                        170
                 ....*....|..
gi 18138256  157 TRGVSRGALRSV 168
Cdd:MTH00065 161 TRGLSRGSLRAV 172
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-168 9.37e-32

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 112.15  E-value: 9.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPV-------MMNFIMLGGVTVWWWVFLEVGVDVMSGMEyMELMVKDFIGLGWVYGVCGGLLILSVWALFLALLVV 153
Cdd:MTH00115  81 AWGDWGVvgyvvgfVLVVVVVGVVVGGLWGMEGVGVVTVDSGG-LFVVRLDFSGVSLFYSSGGGGLLVCGWGLLLTLFVV 159

                        170
                 ....*....|....*
gi 18138256  154 LEVTRGVSRGALRSV 168
Cdd:MTH00115 160 LELVRGLSRGALRAF 174
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-159 3.02e-25

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 95.25  E-value: 3.02e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIMLG---GVTVWWWVFLEVGVDVMSGMEYME-----------LMVKDFIGLGWVYGVCGGLLILSVWAL 146
Cdd:MTH00109  82 TWVSNKVVLGALLLGllmELLLVLYVLKDDEVEVVFNFNGLGdwviydtggsgFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 18138256  147 FLALLVVLEVTRG 159
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-168 3.02e-22

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 87.35  E-value: 3.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   81 AWMDWPVMMNFIMLGGVTVWWWVFLEVGVDVMSGMEYMELMVKDFIGLGWVYGVCGGLLILSVWALFLALLVVLEVTRGV 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVLFLVLFVVLELVRGL 160


                 ....*...
gi 18138256  161 SRGALRSV 168
Cdd:MTH00214 161 SRGALRVV 168
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 24-166 3.97e-13

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 63.39  E-value: 3.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256   24 SPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPeawmDWPVMMNFIMLGGVTVWWWV 103
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP----SVSNLGEVLVLSLLLSLWVF 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18138256  104 FLEVGVDVMSGMEYMELMVKDFIGLGWVYGVCGGLLILSVWALFLALLVVLEVTRGVSRGALR 166
Cdd:MTH00045  98 ISFDNFLELSNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVISFGHEYSSLR 160
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-100 6.12e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 6.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18138256    17 IGVASNPSPMFAALGLVCGAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSSEEYPEAWMDWPVMMNFIMLGG 96
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80


                  ....
gi 18138256    97 VTVW 100
Cdd:pfam00499  81 LLLA 84
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-75 5.34e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.33  E-value: 5.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18138256    1 MSYIFVMLLVGFIISLIGVASNPSPMFAALGLVcgAAFGCGILVWLGGSFLSLVLFLIYLGGMLVVFAYSVALSS 75
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSKQPLSLGLVLLLL--SLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSP 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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