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Conserved domains on  [gi|1822684039|gb|QIO23035|]
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IcfA [Haloarcula sp. JP-L23]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 7.67e-28

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 103.35  E-value: 7.67e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   28 DAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAgevVSGDVLYPLAHTGTETAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGLG-PGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1822684039  108 TYDDltdgisEPPGIEHCIGLLKPHLEGGVESLPDDvdragaiNRLVEYNVDRQVEFLVES 168
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTS 125
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 7.67e-28

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 103.35  E-value: 7.67e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   28 DAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAgevVSGDVLYPLAHTGTETAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGLG-PGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1822684039  108 TYDDltdgisEPPGIEHCIGLLKPHLEGGVESLPDDvdragaiNRLVEYNVDRQVEFLVES 168
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTS 125
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-168 1.09e-27

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 102.97  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  34 AVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNrVVQRTDAGevVSGDVLYPLAHTGTETAVVVGHTGCGAVTATYDDlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTG-PGDLFVVRNAGN-LVPPYDLN--VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1822684039 114 DGISEPPGIEHCIGLLKPHLEGGVESLPDDVDRAGAINRLVEYNVDRQVEFLVES 168
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTF 130
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
7-163 2.89e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 100.62  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   7 DLLEGN----ADHAARFDDRFDDVQDAQHPEAVTVCCSDSRVLQDAMFGnEDPGHLFTCGNIGNrVVQRTDAGevVSGDV 82
Cdd:COG0288     6 RLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGN-VVPPYDPG--VLASI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  83 LYPLAHTGTETAVVVGHTGCGAVTATYDDLTDgiSEPPGIEHCIGLLKPHLEgGVESLPDDVDRAGAINRLVEYNVDRQV 162
Cdd:COG0288    82 EYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVE-RVRAELPAADGEERLDRLVELNVREQV 158


                  .
gi 1822684039 163 E 163
Cdd:COG0288   159 E 159
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 8-108 1.73e-16

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 73.71  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   8 LLEGNA-------DHAARFDDRFDDVQDAQHPEAVTVCCSDSRVlqdamfgneDPGHLFTCGnIGNRVVQRTdAGEVVSG 80
Cdd:cd03378     8 LKEGNKrfvsgkpLHPDQDLARRRELAKGQKPFAVILSCSDSRV---------PPEIIFDQG-LGDLFVVRV-AGNIVDD 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1822684039  81 DVL----YPLAHTGTETAVVVGHTGCGAVTAT 108
Cdd:cd03378    77 DVLgsleYAVEVLGVPLVVVLGHESCGAVAAA 108
PLN00416 PLN00416
carbonate dehydratase
 23-105 4.79e-08

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 51.96  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  23 FDDVQDAQHPEAVTVCCSDSRVLQDAMFgNEDPGHLFTCGNIGNRVV---QRTDAGevVSGDVLYPLAHTGTETAVVVGH 99
Cdd:PLN00416   71 FNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVPpfdQKRHSG--VGAAVEYAVVHLKVENILVIGH 147


                  ....*.
gi 1822684039 100 TGCGAV 105
Cdd:PLN00416  148 SCCGGI 153
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 28-168 7.67e-28

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 103.35  E-value: 7.67e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   28 DAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAgevVSGDVLYPLAHTGTETAVVVGHTGCGAVTA 107
Cdd:smart00947   2 KGQHPKALIIGCSDSRVPPELIFGLG-PGDLFVIRNAGNIVPPYDDG---VLASLEYAVEVLGVKEIVVCGHTDCGAVKA 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1822684039  108 TYDDltdgisEPPGIEHCIGLLKPHLEGGVESLPDDvdragaiNRLVEYNVDRQVEFLVES 168
Cdd:smart00947  78 ALDD------EPGLIDNWLERIRPARERALEELGDV-------DALEELNVRDQVENLRTS 125
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 34-168 1.09e-27

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 102.97  E-value: 1.09e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  34 AVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNrVVQRTDAGevVSGDVLYPLAHTGTETAVVVGHTGCGAVTATYDDlT 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTG-PGDLFVVRNAGN-LVPPYDLN--VLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDA-A 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1822684039 114 DGISEPPGIEHCIGLLKPHLEGGVESLPDDVDRAGAINRLVEYNVDRQVEFLVES 168
Cdd:pfam00484  76 GPAELPGFIDNWLRHIRPAVERVAEELESLDDPEERDDALEELNVREQVENLRTF 130
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
7-163 2.89e-26

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 100.62  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   7 DLLEGN----ADHAARFDDRFDDVQDAQHPEAVTVCCSDSRVLQDAMFGnEDPGHLFTCGNIGNrVVQRTDAGevVSGDV 82
Cdd:COG0288     6 RLLEGNrrfvAGKFPQDPERFEELAKGQHPFALVIGCSDSRVPPELIFD-QGPGDLFVVRNAGN-VVPPYDPG--VLASI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  83 LYPLAHTGTETAVVVGHTGCGAVTATYDDLTDgiSEPPGIEHCIGLLKPHLEgGVESLPDDVDRAGAINRLVEYNVDRQV 162
Cdd:COG0288    82 EYAVEVLGVKLIVVLGHSGCGAVKAALDGLEL--EELGLIGNWLRHIRPAVE-RVRAELPAADGEERLDRLVELNVREQV 158


                  .
gi 1822684039 163 E 163
Cdd:COG0288   159 E 159
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 8-108 1.73e-16

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 73.71  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039   8 LLEGNA-------DHAARFDDRFDDVQDAQHPEAVTVCCSDSRVlqdamfgneDPGHLFTCGnIGNRVVQRTdAGEVVSG 80
Cdd:cd03378     8 LKEGNKrfvsgkpLHPDQDLARRRELAKGQKPFAVILSCSDSRV---------PPEIIFDQG-LGDLFVVRV-AGNIVDD 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1822684039  81 DVL----YPLAHTGTETAVVVGHTGCGAVTAT 108
Cdd:cd03378    77 DVLgsleYAVEVLGVPLVVVLGHESCGAVAAA 108
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-107 3.56e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 69.07  E-value: 3.56e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1822684039  30 QHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVvqrTDAGEVVSGDVLYPLAHTGTETAVVVGHTGCGAVTA 107
Cdd:cd00382     1 QKPKALIIGCSDSRVPPELIFGLG-PGDLFVVRNAGNLV---PPYDLDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA 74
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 21-165 5.50e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 70.26  E-value: 5.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  21 DRFDDVQDAQHPEAVTVCCSDSRVLQDAMFGNeDPGHLFTCGNIGNRVVQRTDAGEV--VSGDVLYPLAHTGTETAVVVG 98
Cdd:cd00884    15 ELFEKLAKGQSPKALFIACSDSRVVPALITQT-QPGELFVVRNVGNLVPPYEPDGGFhgTSAAIEYAVAVLKVEHIVVCG 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1822684039  99 HTGCGAVTATYdDLTDGISEPPGIEHCIGLLKPHLEgGVESLPDDVDRAGAINRLVEYNVDRQVEFL 165
Cdd:cd00884    94 HSDCGGIRALL-SPEDLLDKLPFIGKWLRIAEPAKE-VVLAELSHADFDDQLRALEKENVLLSLENL 158
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 30-168 1.07e-11

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 61.43  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  30 QHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNrVVQRTDAGevvSGDVL-YPLAHTGTETAVVVGHTGCGAVTAT 108
Cdd:cd00883    23 QTPEYLWIGCSDSRVPENTILGLL-PGEVFVHRNIAN-LVSPTDLN---CLSVLqYAVDVLKVKHIIVCGHYGCGGVKAA 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039 109 YDDLTDGISEPPgIEHCIGLLKPHLEgGVESLPDDVDRagaINRLVEYNVDRQVEFLVES 168
Cdd:cd00883    98 LTGKRLGLLDNW-LRPIRDVYRLHAA-ELDALEDEEER---VDRLVELNVVEQVKNLCKT 152
PLN00416 PLN00416
carbonate dehydratase
 23-105 4.79e-08

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 51.96  E-value: 4.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  23 FDDVQDAQHPEAVTVCCSDSRVLQDAMFgNEDPGHLFTCGNIGNRVV---QRTDAGevVSGDVLYPLAHTGTETAVVVGH 99
Cdd:PLN00416   71 FNHLAKTQTPKFLVFACSDSRVCPSHIL-NFQPGEAFVVRNIANMVPpfdQKRHSG--VGAAVEYAVVHLKVENILVIGH 147


                  ....*.
gi 1822684039 100 TGCGAV 105
Cdd:PLN00416  148 SCCGGI 153
PLN03006 PLN03006
carbonate dehydratase
 21-107 7.43e-08

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 51.67  E-value: 7.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  21 DRFDDVQDAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAGEVVSGDVLYPLAHTGTETAVVVGHT 100
Cdd:PLN03006  102 EHYKNLADAQAPKFLVIACADSRVCPSAVLGFQ-PGDAFTVRNIANLVPPYESGPTETKAALEFSVNTLNVENILVIGHS 180


                  ....*..
gi 1822684039 101 GCGAVTA 107
Cdd:PLN03006  181 RCGGIQA 187
PRK10437 PRK10437
carbonic anhydrase; Provisional
 23-213 1.79e-07

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 49.93  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  23 FDDVQDAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQrTDAG--EVVSgdvlYPLAHTGTETAVVVGHT 100
Cdd:PRK10437   26 FEKLAQAQKPRFLWIGCSDSRVPAERLTGLE-PGELFVHRNVANLVIH-TDLNclSVVQ----YAVDVLEVEHIIICGHY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039 101 GCGAVTATYDDLTDGISEpPGIEHCIGLLKPHleggvESLPDDVDRAGAINRLVEYNVDRQVEFLVESDDVGEDVDVVGA 180
Cdd:PRK10437  100 GCGGVQAAVENPELGLIN-NWLLHIRDIWFKH-----SSLLGEMPQERRLDTLCELNVMEQVYNLGHSTIMQSAWKRGQK 173

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1822684039 181 VYDFQDVYGGSRGELHVVNVDGeTSVETLRAEY 213
Cdd:PRK10437  174 VTIHGWAYGIHDGLLRDLDVTA-TNRETLEQRY 205
PLN02154 PLN02154
carbonic anhydrase
 21-107 6.09e-07

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 48.97  E-value: 6.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  21 DRFDDVQDAQHPEAVTVCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAGEVVSGDVLYPLAHTGTETAVVVGHT 100
Cdd:PLN02154   96 EKFKALAIAQSPKVMVIGCADSRVCPSYVLGFQ-PGEAFTIRNVANLVTPVQNGPTETNSALEFAVTTLQVENIIVMGHS 174


                  ....*..
gi 1822684039 101 GCGAVTA 107
Cdd:PLN02154  175 NCGGIAA 181
PLN03014 PLN03014
carbonic anhydrase
 23-152 1.83e-06

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 47.81  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  23 FDDVQDAQHPEAVTVCCSDSRVLQDAMFgNEDPGHLFTCGNIGNRV--VQRTDAGEVVSGdVLYPLAHTGTETAVVVGHT 100
Cdd:PLN03014  151 YGELAKGQSPKYMVFACSDSRVCPSHVL-DFQPGDAFVVRNIANMVppFDKVKYGGVGAA-IEYAVLHLKVENIVVIGHS 228

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1822684039 101 GCGAVTATYDDLTDGISEPPGIEHCIGLLKPHLEGGVESLPDDV--DRAGAINR 152
Cdd:PLN03014  229 ACGGIKGLMSFPLDGNNSTDFIEDWVKICLPAKSKVISELGDSAfeDQCGRCER 282
PRK15219 PRK15219
carbonic anhydrase; Provisional
 28-168 2.73e-06

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 46.75  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  28 DAQHPEAVTVCCSDSRVLQDAMFgNEDPGHLFTCgnignRVvqrtdAGEVVSGDVL----YPLAHTGTETAVVVGHTGCG 103
Cdd:PRK15219   86 AGQYPAAVILSCIDSRAPAEIIL-DTGIGETFNS-----RV-----AGNISNDDLLgsmeFACAVAGAKVVLVMGHTACG 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1822684039 104 AVTATYDDLTDGiseppgieHCIGLL---KPhlegGVESLPDDVDRAGAINRLVEYNVDRQVEFLVES 168
Cdd:PRK15219  155 AVKGAIDNVELG--------NLTGLLdriKP----AIEVTEFDGERSSKNYKFVDAVARKNVELTIEN 210
PLN03019 PLN03019
carbonic anhydrase
 23-131 3.37e-05

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 43.98  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  23 FDDVQDAQHPEAVTVCCSDSRVLQDAMFgNEDPGHLFTCGNIGNRV-----VQRTDAGEVVSgdvlYPLAHTGTETAVVV 97
Cdd:PLN03019  146 YGELAKGQSPKYMVFACSDSRVCPSHVL-DFHPGDAFVVRNIANMVppfdkVKYAGVGAAIE----YAVLHLKVENIVVI 220

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1822684039  98 GHTGCGAVTATYDDLTDGISEPPGIEHCIGLLKP 131
Cdd:PLN03019  221 GHSACGGIKGLMSFPLDGNNSTDFIEDWVKICLP 254
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-146 1.78e-04

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 40.31  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1822684039  37 VCCSDSRVLQDAMFGNEdPGHLFTCGNIGNRVVQRTDAGEVVSGDVLyplahtGTETAVVVGHTGCGAVTATYDDLTDGI 116
Cdd:cd03379     8 VTCMDARLDPEKALGLK-LGDAKVIRNAGGRVTDDAIRSLVVSVYLL------GTREIIVIHHTDCGMLTFTDEELKEKM 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1822684039 117 SEpPGIEHCIGLLKPHLEGG-----VESLPDDVDR 146
Cdd:cd03379    81 KE-RGIAEAYGGIDKEFWFLgfddlEESVREDVER 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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