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Conserved domains on  [gi|1826689173|ref|NP_001366260|]
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MHC class II transactivator isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 740-1065 2.16e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.16e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  740 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 817
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  818 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 892
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  893 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 970
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  971 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1050
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1826689173 1051 PHVETLAMWTPTIPF 1065
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 365-534 4.60e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 180.19  E-value: 4.60e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  365 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 443
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  444 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 521
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1826689173  522 MEQAQAYVMRYFE 534
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 664-769 8.64e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.05  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  664 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 732
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1826689173  733 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 769
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 740-1065 2.16e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.16e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  740 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 817
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  818 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 892
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  893 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 970
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  971 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1050
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1826689173 1051 PHVETLAMWTPTIPF 1065
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 365-534 4.60e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 180.19  E-value: 4.60e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  365 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 443
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  444 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 521
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1826689173  522 MEQAQAYVMRYFE 534
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 935-1056 5.02e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 72.52  E-value: 5.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  935 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNcICDVGAES 1014
Cdd:COG5238    264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1826689173 1015 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1056
Cdd:COG5238    340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 664-769 8.64e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.05  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  664 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 732
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1826689173  733 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 769
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
965-990 6.59e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 6.59e-04
                            10        20
                    ....*....|....*....|....*.
gi 1826689173   965 LKSLETLNLSQNNITDLGAYKLAEAL 990
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 936-985 1.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1826689173  936 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 985
Cdd:pfam12799    2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 740-1065 2.16e-80

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 265.37  E-value: 2.16e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  740 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQElpGRLSFLGTRLTPP--DAHVLGKALEAAGqdfslDLRST 817
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGE--EAAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  818 GICPSGLGSLVGLSCVTRFRAALS-DTVALWESLQQ---HGETKLLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 892
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  893 S--SSEDTAGELPAVRDLKKLEFALGPVsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 970
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  971 LNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRRC 1050
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1826689173 1051 PHVETLAMWTPTIPF 1065
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 365-534 4.60e-52

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 180.19  E-value: 4.60e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  365 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPD 443
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  444 RVLLILDGFEELEAQDGFLHStcgpapaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 521
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1826689173  522 MEQAQAYVMRYFE 534
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 935-1056 5.02e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 72.52  E-value: 5.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  935 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNcICDVGAES 1014
Cdd:COG5238    264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1826689173 1015 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1056
Cdd:COG5238    340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 938-1073 1.15e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 71.36  E-value: 1.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  938 QHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALpSLAASLLRLSLYNNCICDVGAESLAR 1017
Cdd:COG5238    180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173 1018 VLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPF----SVQEHLQQ 1073
Cdd:COG5238    259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 927-1078 1.35e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.97  E-value: 1.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  927 LVRILTAFSSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALpSLAASLLRLSLYNNC 1006
Cdd:COG5238    284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL-QENTTLHSLDLSDNQ 359

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1826689173 1007 ICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRcPHVETLAMWTPTIPFSVQEHLQQQDSRI 1078
Cdd:COG5238    360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
280-946 1.76e-10

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 65.21  E-value: 1.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  280 NKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHR 359
Cdd:COG5635     88 ESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERI 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  360 RPRET--------RVIAVLGKAGQGKS----YWAgavSRAWACGRLPQYDFVFSVPCHCLNRPGDaygLQDLLFSLGPQP 427
Cdd:COG5635    168 ESLKRlelleakkKRLLILGEPGSGKTtllrYLA---LELAERYLDAEDPIPILIELRDLAEEAS---LEDLLAEALEKR 241

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  428 LVAADEVFSHILKRpDRVLLILDGFEELeaqdgflhstcgPAPAEPCSLRGLLAGLFQKklLRGCTLLLTARPRGRLVQS 507
Cdd:COG5635    242 GGEPEDALERLLRN-GRLLLLLDGLDEV------------PDEADRDEVLNQLRRFLER--YPKARVIITSRPEGYDSSE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  508 LSKADAlFELSGFSMEQAQAYVMRYFESsgMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLsealleLGEDAKLPST 587
Cdd:COG5635    307 LEGFEV-LELAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNPLLLTLLALL------LRERGELPDT 377

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  588 LTGLYVGLL---------GRAALDSPPGALAE----LAKLAWELgrrHQStlQEDQFPSADVRTWAMAKGLVQHPPRAAE 654
Cdd:COG5635    378 RAELYEQFVelllerwdeQRGLTIYRELSREElrelLSELALAM---QEN--GRTEFAREELEEILREYLGRRKDAEALL 452

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  655 SELAFPSFLLQC---------------FLGALWLAlsgeikdkELPQYLALTPRKKRPYDNWLEGVPRFLAGLI--FQPP 717
Cdd:COG5635    453 DELLLRTGLLVErgegrysfahrsfqeYLAARALV--------EELDEELLELLAEHLEDPRWREVLLLLAGLLddVKQI 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  718 ARCLGALL-GPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDA 796
Cdd:COG5635    525 KELIDALLaRDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLL 604

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  797 HVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGL--SCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAK 874
Cdd:COG5635    605 LLLLLLLLLLLLALALLLALLLLLLLLLLAELLLlaLLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLA 684

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1826689173  875 SLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALS 946
Cdd:COG5635    685 LLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESS 756
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
931-1056 7.56e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.55  E-value: 7.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  931 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGAY-----KLaEALpslaasllrlSLYNN 1005
Cdd:COG4886    109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEPlgnltNL-KSL----------DLSNN 169

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1826689173 1006 CICDVGAEslarvLPDMVSLRVMDVQYNKFTAagaqqLAASLRRCPHVETL 1056
Cdd:COG4886    170 QLTDLPEE-----LGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEEL 210
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 945-1056 1.29e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.02  E-value: 1.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  945 LSENKIGDEGVSQLS-ATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLyNNCICDVGAESLARVLPDMV 1023
Cdd:COG5238    158 LLGLAARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLK-RNPIGDEGAEILAEALKGNK 236

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1826689173 1024 SLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1056
Cdd:COG5238    237 SLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
931-981 1.34e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.78  E-value: 1.34e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1826689173  931 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDL 981
Cdd:COG4886    201 LGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL 243
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 664-769 8.64e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.05  E-value: 8.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826689173  664 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLAGLIFQPPARCLGALLGPsaAAS 732
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGC--KLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1826689173  733 VDRKQKVLaRYLKRLQPGTLRARQLLELLHCAHEAEE 769
Cdd:pfam17776   81 SEIKQELL-QWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
931-983 1.16e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 1.16e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1826689173  931 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNNITDLGA 983
Cdd:COG4886    178 LGNLTNLKELDL---SNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPE 222
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
965-990 6.59e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 6.59e-04
                            10        20
                    ....*....|....*....|....*.
gi 1826689173   965 LKSLETLNLSQNNITDLGAYKLAEAL 990
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1024-1048 1.03e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 1.03e-03
                            10        20
                    ....*....|....*....|....*
gi 1826689173  1024 SLRVMDVQYNKFTAAGAQQLAASLR 1048
Cdd:smart00368    3 SLRELDLSNNKLGDEGARALAEALK 27
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 929-981 1.25e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 1.25e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1826689173  929 RILTAFS-SLQHLDLdalSENKIGDegVSQLSAtfpqLKSLETLNLSQNNITDL 981
Cdd:cd21340    113 RSLAALSnSLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDL 157
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 936-985 1.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1826689173  936 SLQHLDLdalSENKIGDEGVsqlsatFPQLKSLETLNLSQNN-ITDLGAYK 985
Cdd:pfam12799    2 NLEVLDL---SNNQITDIPP------LAKLPNLETLDLSGNNkITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
935-981 5.07e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 5.07e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1826689173  935 SSLQHLDLDAlseNKIgdEGVSQlsATFPQLKSLETLNLSQNNITDL 981
Cdd:pfam13855    1 PNLRSLDLSN---NRL--TSLDD--GAFKGLSNLKVLDLSNNLLTTL 40
LRR_8 pfam13855
Leucine rich repeat;
932-978 8.22e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 8.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1826689173  932 TAFSSLQHL-DLDaLSENKIgdegvSQLSA-TFPQLKSLETLNLSQNNI 978
Cdd:pfam13855   19 GAFKGLSNLkVLD-LSNNLL-----TTLSPgAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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