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Conserved domains on  [gi|1833303510|ref|NP_001368859|]
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solute carrier organic anion transporter family member 1A6 [Mus musculus]

Protein Classification

oat family protein( domain architecture ID 11489679)

oat family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-625 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


:

Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 870.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510   1 MGEPGKRVGIHRVRC------------FAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMG 68
Cdd:TIGR00805   1 MGETEKDIATHESSAglkprprclqslFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  69 NLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLMGRYEYETTISPTSNLSS-NSFLCVENRSQTLKPTQDPA 147
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 148 ECVKEIKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSV 227
Cdd:TIGR00805 161 ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 228 NTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPKEGLQDNGDGTENAKEEKHRDKAKEENQGIIKEFFL 307
Cdd:TIGR00805 241 NTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 308 MMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKA 387
Cdd:TIGR00805 321 FIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 388 AIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTsyEGIQQSFDMENKflSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLA 467
Cdd:TIGR00805 401 AYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENR--TDCNRQCSCDSSIWDPVCGDNGLAYLSPCHA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 468 GCEKSVGTGANMVFQNCSCIRSSGNSSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLG 547
Cdd:TIGR00805 477 GCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLG 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833303510 548 IGLQAFFMRLFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRTYEVSSFRRLYLGLPAALRGSIILPSFFILRLIRK 625
Cdd:TIGR00805 555 LGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-625 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 870.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510   1 MGEPGKRVGIHRVRC------------FAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMG 68
Cdd:TIGR00805   1 MGETEKDIATHESSAglkprprclqslFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  69 NLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLMGRYEYETTISPTSNLSS-NSFLCVENRSQTLKPTQDPA 147
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 148 ECVKEIKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSV 227
Cdd:TIGR00805 161 ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 228 NTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPKEGLQDNGDGTENAKEEKHRDKAKEENQGIIKEFFL 307
Cdd:TIGR00805 241 NTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 308 MMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKA 387
Cdd:TIGR00805 321 FIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 388 AIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTsyEGIQQSFDMENKflSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLA 467
Cdd:TIGR00805 401 AYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENR--TDCNRQCSCDSSIWDPVCGDNGLAYLSPCHA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 468 GCEKSVGTGANMVFQNCSCIRSSGNSSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLG 547
Cdd:TIGR00805 477 GCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLG 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833303510 548 IGLQAFFMRLFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRTYEVSSFRRLYLGLPAALRGSIILPSFFILRLIRK 625
Cdd:TIGR00805 555 LGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-538 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 748.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  18 KIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMG 97
Cdd:cd17458     1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  98 LGCFIISLPHFLMGRYEYETTISPTSNLSSNSFLCVENRSQTLKPTQDPAECVKEIKSLMWIYVLVGNIIRGIGETPIMP 177
Cdd:cd17458    81 LGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 178 LGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNV 257
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 258 LTSIPFFFFPKTLPKEGLQDNGDGTENAK---EEKHRDKAKEENQGIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVAN 334
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGEENETEPSKTLTvelEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 335 IVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTP 414
Cdd:cd17458   321 MISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 415 IAGLTTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSS 494
Cdd:cd17458   401 VAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPS 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1833303510 495 AV---LGLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRC 538
Cdd:cd17458   481 QNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
21-597 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 598.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  21 VFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGC 100
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 101 FIISLPHFlmgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwIYVLVGNIIRGIGETPIMPLGI 180
Cdd:pfam03137  81 LLFALPHF--------------------------------------------------LSFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 181 SYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNtddLTITPTDTRWVGAWWIGFLVCAGVNVLTS 260
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVS---ITLTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 261 IPFFFFPKTLPKEG---LQDNGDGTENAKEEKHRDKAKEENQGIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVI 337
Cdd:pfam03137 188 IPFFFFPKSLPGAAkrrAKKKKEPHSQDIADLKKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 338 YKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAG 417
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 418 LTTSYEGIQQSFdmeNKFLSDCNTRCNCLTKTWDPVCGNNG-LAYMSPCLAGCEKSVGTGANMVFQNCSCI----RSSGN 492
Cdd:pfam03137 348 ITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 493 SSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLGIGLQAFFMRLFAGIPAPIYFGALID 572
Cdd:pfam03137 425 GSATPGKC--PSDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1833303510 573 RTCLHWGTlKCGEPGACRTYEVSSF 597
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-396 3.33e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.46  E-value: 3.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  23 LLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFI 102
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 103 ISL-PHFLMgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyVLVGNIIRGIGETPIMPLGIS 181
Cdd:COG2814    92 CALaPSLWL--------------------------------------------------LLAARFLQGLGAGALFPAALA 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 182 YIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptdtrwvgAWWIGFLVCAGVNVLTSI 261
Cdd:COG2814   122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLALL 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 262 PFFFFpktLPkeglqdngdgtENAKEEKHRDKAKeenqgiikefflmMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPK 341
Cdd:COG2814   180 LLLRL---LP-----------ESRPAARARLRGS-------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPL 232
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303510 342 YLEHHFGISTAKAVFLIGLYttpsvSAGYLISGFIMKKL--KITLKKAAIIALCLFM 396
Cdd:COG2814   233 YLQEVLGLSASAAGLLLALF-----GLGGVLGALLAGRLadRFGRRRLLLIGLLLLA 284
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-625 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 870.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510   1 MGEPGKRVGIHRVRC------------FAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMG 68
Cdd:TIGR00805   1 MGETEKDIATHESSAglkprprclqslFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  69 NLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLMGRYEYETTISPTSNLSS-NSFLCVENRSQTLKPTQDPA 147
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSaNSFLCMENLTQTLRPTQDPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 148 ECVKEIKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSV 227
Cdd:TIGR00805 161 ECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 228 NTDDLTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPKEGLQDNGDGTENAKEEKHRDKAKEENQGIIKEFFL 307
Cdd:TIGR00805 241 NTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 308 MMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKA 387
Cdd:TIGR00805 321 FIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 388 AIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTsyEGIQQSFDMENKflSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLA 467
Cdd:TIGR00805 401 AYFAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENR--TDCNRQCSCDSSIWDPVCGDNGLAYLSPCHA 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 468 GCEKSVGTGANMVFQNCSCIRSSGNSSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLG 547
Cdd:TIGR00805 477 GCRMSVGTGSNMVFTNCSCIQTPGNSSAKKGLC--DPPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLG 554
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1833303510 548 IGLQAFFMRLFAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRTYEVSSFRRLYLGLPAALRGSIILPSFFILRLIRK 625
Cdd:TIGR00805 555 LGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
18-538 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 748.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  18 KIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMG 97
Cdd:cd17458     1 KLKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  98 LGCFIISLPHFLMGRYEYETTISPTSNLSSNSFLCVENRSQTLKPTQDPAECVKEIKSLMWIYVLVGNIIRGIGETPIMP 177
Cdd:cd17458    81 LGCFLASLPHFLMGRYEYESTVSTTSNSSSRVPLCLANQSLSHNVTQLPSECEKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 178 LGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNV 257
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 258 LTSIPFFFFPKTLPKEGLQDNGDGTENAK---EEKHRDKAKEENQGIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVAN 334
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGEENETEPSKTLTvelEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTVLQFNAFSG 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 335 IVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTP 414
Cdd:cd17458   321 MISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWMGCDNSP 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 415 IAGLTTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSS 494
Cdd:cd17458   401 VAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSCVAASGFPS 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1833303510 495 AV---LGLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRC 538
Cdd:cd17458   481 QNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
21-597 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 598.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  21 VFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGC 100
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 101 FIISLPHFlmgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwIYVLVGNIIRGIGETPIMPLGI 180
Cdd:pfam03137  81 LLFALPHF--------------------------------------------------LSFFLGQLLLGIGGTPIYTLGI 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 181 SYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNtddLTITPTDTRWVGAWWIGFLVCAGVNVLTS 260
Cdd:pfam03137 111 SYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVS---ITLTPKDPRWVGAWWLGFLIAGLLLLLTA 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 261 IPFFFFPKTLPKEG---LQDNGDGTENAKEEKHRDKAKEENQGIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVI 337
Cdd:pfam03137 188 IPFFFFPKSLPGAAkrrAKKKKEPHSQDIADLKKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYAT 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 338 YKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAG 417
Cdd:pfam03137 268 FLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFLGCPNSPVAG 347
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 418 LTTSYEGIQQSFdmeNKFLSDCNTRCNCLTKTWDPVCGNNG-LAYMSPCLAGCEKSVGTGANMVFQNCSCI----RSSGN 492
Cdd:pfam03137 348 ITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCScgsqDSGGN 424
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 493 SSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLGIGLQAFFMRLFAGIPAPIYFGALID 572
Cdd:pfam03137 425 GSATPGKC--PSDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPGPILFGALID 502
                         570       580
                  ....*....|....*....|....*
gi 1833303510 573 RTCLHWGTlKCGEPGACRTYEVSSF 597
Cdd:pfam03137 503 STCLLWGK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
19-538 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 585.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17459     1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYETTISPTSNLSSNSFLCVENRSQTLKP-----TQDPAECVKEIKSLMWIYVLVGNIIRGIGET 173
Cdd:cd17459    81 GTFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSiessdSKTGTGCEKEPGSSMWIYVFLGNLLRGIGET 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 174 PIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCA 253
Cdd:cd17459   161 PVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIAG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 254 GVNVLTSIPFFFFPKTLPkeglqdngdgtenakeekhrdkakeenqgiiKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVA 333
Cdd:cd17459   241 VITLLSAVPFWFLPKSLP-------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSLI 289
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 334 NIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTT 413
Cdd:cd17459   290 GMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLSFFAMGCENS 369
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 414 PIAGLTTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRS---- 489
Cdd:cd17459   370 DVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNCSCIGIpssa 449
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1833303510 490 SGNSSAVLGLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLRC 538
Cdd:cd17459   450 SGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
19-537 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 552.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17400     1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYettisptsnlssnsflcvenrsqtlkptqdpaecvkeikSLMWIYVLVGNIIRGIGETPIMPL 178
Cdd:cd17400    81 GCFLKALPHFFMNQYEY---------------------------------------SLMWIYVFVGNILRGIGETPILPL 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17400   122 GISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVL 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPktlpkeglqdngdgtenakeekhrdkakeenqgiikefflmmknlfcnPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17400   202 TAIPFFFLP------------------------------------------------PIYMLFILVSVIQFNSFVGMITY 233
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd17400   234 MPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGL 313
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 419 TTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSSAVLG 498
Cdd:cd17400   314 TTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSCIQTSGNSSANLS 393
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1833303510 499 L----CKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17400   394 LcdggCPRDPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
19-537 1.22e-164

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 480.11  E-value: 1.22e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17457     1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYEttisptsnlssnsflcvenrsqtlkptqdpaeCVKEIKSLMWIYVLVGNIIRGIGETPIMPL 178
Cdd:cd17457    81 GSVLTALPHFFMGYYKYG--------------------------------CLKESGSYMWVYVLMGNMLRGIGETPIVPL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17457   129 GISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSII 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPktlpkeglqdngdgtenakeekhrdkakeenqgiikEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17457   209 SAIPFFFLP------------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTY 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd17457   253 KPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYFFIGCENKSVAGI 332
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 419 TTSYEGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSG----NSS 494
Cdd:cd17457   333 TMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYS 412
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1833303510 495 AVLGLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17457   413 AHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
19-537 3.73e-132

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 395.07  E-value: 3.73e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17336     1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLmgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyvLVGNIIRGIGETPIMPL 178
Cdd:cd17336    81 GCFLLALPHFL----------------------------------------------------FVGQFLLGIGSSPLYTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVntdDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17336   109 GITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRV---PLGITPDDPRWIGAWWLGFLILGILLLI 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPktlpkeglqdngdgtenakeekhrdkakeenqgiikefflmmknlfcnPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17336   186 VSIPLFFFP------------------------------------------------PIFILLLLAIVFESFAISGFSTF 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd17336   218 LPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGCDNPPIAGV 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 419 TTSYEGIqqsfdmENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCI-RSSGNSSAVL 497
Cdd:cd17336   298 TTPYGSS------SSPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSCInSGTATSSGCP 371
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 1833303510 498 GLCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17336   372 PDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
19-537 3.12e-108

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 335.62  E-value: 3.12e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17461     2 IKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYEttisptsnlssnsflcvenrsqtlkptqdpaecvkeikslMWIYVLVGNIIRGIGETPIMPL 178
Cdd:cd17461    82 GAFLLTLPHFLSEPYQYS----------------------------------------MWVLMVVAQLLAGIGTVPIQPF 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17461   122 GISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVL 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPKTLPKEglqdNGDGTENAKEEKHRDKAKEENQ--GIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIV 336
Cdd:cd17461   202 TSLPYFFFPREMLVG----KKPSPEGDMLRKKEDEKKEEGSllDFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLS 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 337 IYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIA 416
Cdd:cd17461   278 TFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFFMGCSTQDVA 357
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 417 GLTTSYEgiqqsfDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSV---GTGANMVFQNCSCIRSSGNS 493
Cdd:cd17461   358 GVYPKTS------NSSDGPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNmdsSTYRQQIYSNCSCIPDLSGE 431
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1833303510 494 SAVlglckKGPDCANKLQYFLIITVFCCFFYSL-ATI---PGYMVFLR 537
Cdd:cd17461   432 KPA-----KTGSCPNSCSHLLLPVMFLISFAGLiACLthnPLYMMVLR 474
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
19-537 3.49e-104

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 325.57  E-value: 3.49e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17460     1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwIYVLVGNIIRGIGETPIMPL 178
Cdd:cd17460    81 AGFLMALPHFISEPYEY-------------------------------------------GILFLGQLLLGIGGVPIQPF 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17460   118 GISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVAL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPKTLPKEGLQD----NGDGTENAKEEKHRDKAKEENQGI--IKEF-FLMMKNLFcNPIYMLCVLTSVLQVNG 331
Cdd:cd17460   198 SAVPYFFFPREMPKEVVELqpreKKLAKTMLKKLKSLSDILQNLSLLqfIKKFpRILLRTLR-NPIYLLVVLAQVNLSAM 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 332 VANIVIYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKK-AAIIALCLFMSEClLSLCNFMLTC 410
Cdd:cd17460   277 VAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGcGAMCVLGMLLCLF-FALPLLFIGC 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 411 DTTPIAGLTTsyegiQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCeKSV----GTGANMVFQNCSC 486
Cdd:cd17460   356 STQKIAGITH-----RTSSSPGLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGC-KSVnvqaLDNSVVNYTDCSC 429
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1833303510 487 IRSSGN-SSAVLGLCkkGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17460   430 VSEGGPvGAASPGTC--GSGCSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
19-537 1.14e-95

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 302.15  E-value: 1.14e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17401     1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEYettisptsnlssnsflcvenrsqtlkptqdpaecvkeikSLMwiyvLVGNIIRGIGETPIMPL 178
Cdd:cd17401    81 GAFLLTLPHFISEPYQY---------------------------------------GIM----VVAQLLLGIGGVPIQPF 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17401   118 GISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPKtlpkeglqdngdgtenakeekhrdkakeenqgIIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17401   198 TSFPYFFFPR--------------------------------FIKRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATF 245
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd17401   246 LNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIGCSTPTIAGV 325
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 419 ---TTSYEGIQQSfdmenkflSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCE----KSVGTGANMVFQNCSCIRsSG 491
Cdd:cd17401   326 yppSSSSSIHPQS--------PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSninmSTSATSKQVIYTNCSCVT-GG 396
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1833303510 492 NSSAVLGLCKKGpdCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17401   397 SASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
19-537 1.21e-90

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 288.00  E-value: 1.21e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISK--ILSGVYmSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVM 96
Cdd:cd17403     1 PKGFLFFLCIFAFLQgmVVNGFV-NVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  97 GLGCFIISLPHFLMgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyVLVGNIIRGIGETPIM 176
Cdd:cd17403    80 GIGSLVFALPHFTV--------------------------------------------------FILAQLLHGAGATPLY 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 177 PLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVnTDDLTITPTDTRWVGAWWIGFLVCAGVN 256
Cdd:cd17403   110 TLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQV-DSELGLTPDDPRWVGAWWLGFLISGALA 188
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 257 VLTSIPFFFFPKTlpkeglqdngdgtenakeekhrdkakeenqgiikefflmmknlfcnpiYMLCVLTSVLQVNGVANIV 336
Cdd:cd17403   189 LIIAFPLLGFPPT------------------------------------------------FMFLNLAGASEGMLLAGFA 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 337 IYKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKitLKKAAIIALCLFMS--ECLLSLCnFMLTCDTTP 414
Cdd:cd17403   221 TFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLK--LKCKGILKFCIVCSivAFLFSFI-LLIYCPNAP 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 415 IAGLTTSYEGiQQSFDMENkFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCI---RSSG 491
Cdd:cd17403   298 FAGVTVPYGN-SPLEGTSN-LTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKVYSNCSCIqsnSSKT 375
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1833303510 492 NSSAVLGlCKKGPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17403   376 STAATGK-ACPCETCCQKLYLFLAVFFLLIVFTFMSSTPALSATLR 420
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
19-537 1.99e-89

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 285.67  E-value: 1.99e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  19 IKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17402     1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMGRYEyettisptsnlssnsflcvenrsqtlkptqdpaecvkeiKSLMWIYVLVGNIIRGIGETPIMPL 178
Cdd:cd17402    81 GALLSALPEFLTHQYK---------------------------------------TNMMYLLLIGAQVLLGIGATPVQPL 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17402   122 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFF 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPKTLpkeglqdngdgtenakeekhrdkakEENQGIIKefflMMKNLFCNPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17402   202 SALLMFGFPQSL-------------------------QQLRVIPK----VTKHLLSNPVFTCIVLAACMEIAVVAGFAAF 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALC--LFMSECLLSLcnFMLTCDTTPIA 416
Cdd:cd17402   253 LGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLvnLVSTACYVSF--LFLGCDTGPVA 330
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 417 GLTTSYEGIQQSFDMENKFLSdCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGanmvfqnCSCIRS--SGNSS 494
Cdd:cd17402   331 GVTVPYGNDTAPGSSLDPYAP-CNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSG-------CACLSSvpAENAT 402
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1833303510 495 AVLGLCKKgPDCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17402   403 VVPGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
20-537 7.55e-89

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 283.47  E-value: 7.55e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  20 KVFLLAL-IWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:cd17404     1 KAFLVCMcLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLPHFLMgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyvlVGNIIRGIGETPIMPL 178
Cdd:cd17404    81 GSFLFSLPHFFI----------------------------------------------------LAQILIGMGGTPIFTL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVntdDLTITPTDTRWVGAWWIGFLVCAGVNVL 258
Cdd:cd17404   109 GTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLST---PPDISPGDPRWIGAWWGGFLLCGIALLL 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPKtlpkeglqdngdgtenakeekhrdkakeenqgiikefflmmknlfcnPIYMLCVLTSVLQVNGVANIVIY 338
Cdd:cd17404   186 VAFPFFTFPK-----------------------------------------------MTFLVVSLGYCMELAIVSGFITF 218
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 339 KPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd17404   219 LPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGCESIKLAGI 298
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 419 TTSY-EGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGC-EKSVGTGANMVFQNCSCIRSSGNSS-- 494
Cdd:cd17404   299 TIPYtTGPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCtSVGNTSTGIRNYTNCACLQSRSSISpp 378
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 1833303510 495 --AVLGLCKKGP--DCANKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17404   379 tvGQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
39-537 2.46e-75

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 248.21  E-value: 2.46e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  39 YMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLMgryeyett 118
Cdd:cd17462    22 FINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHFTV-------- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 119 isptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGI 198
Cdd:cd17462    94 ------------------------------------------FMLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGI 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 199 LEVGKMIGPILGYLMGPFCANIYVDTGSvNTDdltITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPkeglqdn 278
Cdd:cd17462   132 FYTAAIVGPAAGYLLGGFFLNIYTEIGR-QTE---LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQLP------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 279 gdgtenakeekhrdkakeenqGIIKefflmmknlfcNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLI 358
Cdd:cd17462   201 ---------------------GLLK-----------NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLF 248
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 359 GLYTTPSVSAGYLISGFIMKKLKitLKKAAIIALCLFMS-ECLLSLCNFMLTCDTTPIAGLTTSYEGIQQSFDMENkFLS 437
Cdd:cd17462   249 GYLVVPAGGGGTFLGGFIVNKLK--LRCSGIIKFCLICTvVSLLAIFIFSLHCPNVPMAGVTASYRGSVLPEGSLN-LTA 325
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 438 DCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGAN--MVFQNCSCIrsSGNSSAVLGLCKKGPDCA--NKLQYF 513
Cdd:cd17462   326 LCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDIRNgqKVYQDCSCV--AGNLSVGFGEASAGKCTSncNHMPLL 403
                         490       500
                  ....*....|....*....|....
gi 1833303510 514 LIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17462   404 LAFVFLVILFTFLCSIPALTATLR 427
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
23-537 2.85e-68

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 229.63  E-value: 2.85e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  23 LLALIWAYISKILSGVYMSTmltqLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFI 102
Cdd:cd17463    10 LLAVVQGIVVNGLVNISIST----IEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 103 ISLPHFLmgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwIYVLvGNIIRGIGETPIMPLGISY 182
Cdd:cd17463    86 FSLPHFF-------------------------------------------------VFIL-GQLLLGVGGTPLYTLGTAY 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 183 IEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTitPTDTRWVGAWWIGFLVCAGVNVLTSIP 262
Cdd:cd17463   116 IDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGQSVDLT--EEDPRWLGAWWIGFLMCWLIAWCLIAP 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 263 FFFFPKTLPkeglqdngdgtenakeekhrdkakeenqGIIKefflmmknlfcNPIYMLCVLTSVLQVNGVANIVIYKPKY 342
Cdd:cd17463   194 FSCFPKHLP----------------------------GLLK-----------NPVFMCLTISSCSEALITTGFATFLPKF 234
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 343 LEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKaaIIALCLFMSECLLSLCN-FMLT-CDTTPIAGLTT 420
Cdd:cd17463   235 IENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKN--MIKFAIITTTVSLLLLSvFIFAkCGNDPFAGVSE 312
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 421 SYEGIQQSFDMEnkflSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCI-RSSGNSSAVLGL 499
Cdd:cd17463   313 TYNGTGKIGNLT----APCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIgNFTEEFSANTTK 388
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1833303510 500 CKKGPDCA---NKLQYFLIITVFCCFFYSLATIPGYMVFLR 537
Cdd:cd17463   389 CEEGKKCEttcKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
48-537 1.57e-37

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 144.99  E-value: 1.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  48 ERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFlmgryeyettisptsnlss 127
Cdd:cd17405    30 QVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF------------------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 128 nsflcvenrsqtlkptqdpaecvkeikslmwIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGP 207
Cdd:cd17405    91 -------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLGIAHSAYLIGY 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 208 ILGYLMGPFCANIYVDTGSVNTddlTITPTDTRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPkeglqdngdgtenake 287
Cdd:cd17405   140 LLGYVGGLPNFQPPPNEKSVEI---EVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSLP---------------- 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 288 ekhrdkakeenqGIIKEFFLMmknlfcnpIYMLCVLTSVLQVNGVANIViykPKYLEHHFGISTAKAVFLIGLYTTPSVS 367
Cdd:cd17405   201 ------------GLLKNPLLL--------CQAICKATEYLTFIGALEFL---PHYLENQFLLTPGIASLLTGAFLIPGGA 257
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 368 AGYLISGFIMKKLKITLKKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGLTTSYEGIQQSFDMEnkflSDCNTRCNCLT 447
Cdd:cd17405   258 IGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQLGNLT----APCNEYCDCTS 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 448 KTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSS--------AVLGLCKKgpDCAnKLQYFLIITVF 519
Cdd:cd17405   334 SLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCIKEGLAAAddegdfidAIAGKCDS--KCY-KLPLFFAFYFS 410
                         490
                  ....*....|....*...
gi 1833303510 520 CCFFYSLATIPGYMVFLR 537
Cdd:cd17405   411 ATVFSNMCSIPIILIILR 428
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
29-418 1.11e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 100.58  E-value: 1.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  29 AYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHf 108
Cdd:cd06174     4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 109 lmgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslMWIYVLVGNIIRGIGETPIMPLGISYIEDFAK 188
Cdd:cd06174    83 ------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 189 SENSPLYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptdtrwVGAWWIGFLVCAGVNVLTSIPFFFFPK 268
Cdd:cd06174   115 ERERGRALGLLQAFGSVGGILGPLLGGILASSL--------------------GFGWRAVFLIAAALALLAAILLLLVVP 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 269 TLPKEGLQDNGDGTEnakeekhrdkakeenqgiiKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFG 348
Cdd:cd06174   175 DPPESARAKNEEASS-------------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 349 ISTAKAVFLIGLYTTPSVsAGYLISGFIMKKLKITlkKAAIIALCLFMSECLLSLCNFMLTCDTTPIAGL 418
Cdd:cd06174   236 LSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRLIGR--KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
435-487 4.41e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 89.67  E-value: 4.41e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1833303510 435 FLSDCNTRCNCLTKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSCI 487
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCV 53
MFS_1 pfam07690
Major Facilitator Superfamily;
34-397 2.11e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.98  E-value: 2.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  34 ILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLphflmgry 113
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-------- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 114 eyettisptsnlSSNSFLcvenrsqtlkptqdpaecvkeikslmwiyVLVGNIIRGIGETPIMPLGISYIEDFAKSENSP 193
Cdd:pfam07690  82 ------------ASSLWL-----------------------------LLVLRVLQGLGAGALFPAALALIADWFPPEERG 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 194 LYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptDTRWVgawwigFLVCAGVNVLTSIPFFFFpktlpke 273
Cdd:pfam07690 121 RALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAA------FLILAILSLLAAVLLLLP------- 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 274 glqdngdgtenakEEKHRDKAKEENQGIIKEFFLMMKNLFCNPIyMLCVLTSVLQVNGVANIVIYKPKYLEhHFGISTAK 353
Cdd:pfam07690 172 -------------RPPPESKRPKPAEEARLSLIVAWKALLRDPV-LWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALL 236
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1833303510 354 AVFLIGLYTTpSVSAGYLISGFIMKKLKITLKKAAIIALCLFMS 397
Cdd:pfam07690 237 AGLLLGLGGL-LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-396 3.33e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.46  E-value: 3.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  23 LLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFI 102
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 103 ISL-PHFLMgryeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyVLVGNIIRGIGETPIMPLGIS 181
Cdd:COG2814    92 CALaPSLWL--------------------------------------------------LLAARFLQGLGAGALFPAALA 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 182 YIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptdtrwvgAWWIGFLVCAGVNVLTSI 261
Cdd:COG2814   122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLALLALL 179
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 262 PFFFFpktLPkeglqdngdgtENAKEEKHRDKAKeenqgiikefflmMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPK 341
Cdd:COG2814   180 LLLRL---LP-----------ESRPAARARLRGS-------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPL 232
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303510 342 YLEHHFGISTAKAVFLIGLYttpsvSAGYLISGFIMKKL--KITLKKAAIIALCLFM 396
Cdd:COG2814   233 YLQEVLGLSASAAGLLLALF-----GLGGVLGALLAGRLadRFGRRRLLLIGLLLLA 284
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
440-486 1.29e-11

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 59.81  E-value: 1.29e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1833303510 440 NTRCNCLTKTWDPVCGNNGLAYMSPC---LAGCEKSVGTGANMVFQNCSC 486
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
447-486 2.27e-07

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 47.65  E-value: 2.27e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1833303510 447 TKTWDPVCGNNGLAYMSPCLAGCEKSVGTGANMVFQNCSC 486
Cdd:cd00104     2 PKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
49-395 2.25e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  49 RQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIgvgcaVMGLGCFIISlphflmgryeyettisptsnlssn 128
Cdd:cd17325    24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLL-----LLGLLLLAVS------------------------ 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 129 SFLCVENRSqtlkptqdpaecvkeikslmWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPI 208
Cdd:cd17325    75 TLLFAFATS--------------------YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFL 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 209 LGYLMGPFCANIYvdtgsvntddltitptDTRWVgawwigFLVCAGVNVLTSIPFFFFPKtlpkeglqdngdgtENAKEE 288
Cdd:cd17325   135 IGPLLGGLLADAL----------------GYRAP------FLVCAALALLALVLALLLLP--------------EPRPPP 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 289 KHRDKAKEENQGIIKEFFLmmknlfcNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHFGISTAKAVFLIGLYttpsvSA 368
Cdd:cd17325   179 NKRAVSAARLRSGLRLLLR-------DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ-----GL 246
                         330       340
                  ....*....|....*....|....*....
gi 1833303510 369 GYLISGFIMKKL--KITLKKAAIIALCLF 395
Cdd:cd17325   247 ASALSQPPAGKLsdRIGRKPLILIGLLLS 275
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
34-397 7.35e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.69  E-value: 7.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  34 ILSGVymstmLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAV---MGLGC-FIISLPHFL 109
Cdd:cd17328    17 TIAGV-----LPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIwsaATLLSsFAPNFWQLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 110 MGRyeyettisptsnlssnsflcvenrsqtlkptqdpaecvkeikslmwiyvlvgnIIRGIGETPIMPLGISYIEDFAKS 189
Cdd:cd17328    92 LFR-----------------------------------------------------ALVGIGEASYSPIAPTIIADLFPK 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 190 ENSPLYIGILEVGKMIGPILGYLMGPFCANiyvdtgsvntddltitptdtrWVGAWWIGFLVCAGVNVLTSIPFFFFpkt 269
Cdd:cd17328   119 EKRTRALGVFYFAIPLGSGLGYVVGGLVAQ---------------------ATGGWRWAFRVTGVLGVLLAILLLLF--- 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 270 lpkeglqdngdgtenaKEEKHRDKAKEENQGIIK--EFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVIYKPKYLEHHF 347
Cdd:cd17328   175 ----------------VREPPRGAAEGGVMAKSTatSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAF 238
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1833303510 348 GI---STAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKA-AII-ALCLFMS 397
Cdd:cd17328   239 GVgdlSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRAdPLVcAVGLLAA 293
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
21-396 4.21e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  21 VFLLALIWAYISKILSGVymSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGC 100
Cdd:COG2271    12 LALLFLAYFLNYLDRSNL--SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 101 FIISLphflmgryeyettisptsnlsSNSFLcvenrsqtlkptqdpaecvkeikSLMWIYVLVgniirGIGETPIMPLGI 180
Cdd:COG2271    90 LLFGF---------------------ATSFW-----------------------QLLLLRFLL-----GLGEAGFFPAAL 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 181 SYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptdtrwvgAWWIGFLVCAGVNVLTS 260
Cdd:COG2271   121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF----------------------GWRAAFLILGLPGLLLA 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 261 IPFFffpktlpkeglqdngdgtenakeekhrdkakeenqgiikefflmmknlfcnpiyMLCVLTSVLQVNGVANIVIYKP 340
Cdd:COG2271   179 LLRF------------------------------------------------------WLLALAYFLVYFALYGFLTWLP 204
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1833303510 341 KYLEHHFGISTAKAVFLIGLYTTPSVsAGYLISGFIMKKLKITLKKAAIIALCLFM 396
Cdd:COG2271   205 TYLVEVRGLSLAQAGLLLSLPFLAGI-VGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
22-395 1.21e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  22 FLLALIWAYISKILSGVYMS---TMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGL 98
Cdd:COG0738     6 YRRALIAIYLLFFLWGFATAlwgPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  99 GCFIISLphflmgryeyettiSPTsnlssnsflcvenrsqtlkptqdpaecvkeikslmWIYVLVGNIIRGIGETPIMPL 178
Cdd:COG0738    86 GLLLFAL--------------APS-----------------------------------YPLLLLALFLLGLGLGLLDVA 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 179 GISYIEDFAKSENSPLyIGILEVGKMIGPILGYLMGPFCANIYVDTgsvntddltitptdtrwvgAWWIGFLVCAGVNVL 258
Cdd:COG0738   117 ANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSL-------------------SWHLPYLILAVLLLL 176
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 259 TSIPFFFFPktLPKEGlqdngdgtenAKEEKHRDKAKEenqgiikefflmMKNLFCNPIYMLCVLTSVLQV---NGVANI 335
Cdd:COG0738   177 LALLFLRSK--LPEIE----------EEEEEAAGSAAS------------LKSLLKNPRLLLGGLAIFLYVgaeGAIGDW 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1833303510 336 ViykPKYLEHHFGISTAKAVFLIGLYTTpSVSAGYLISGFIMKKL--KITLKKAAIIALCLF 395
Cdd:COG0738   233 L---PLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFgpVRLLRLSALLAAVGL 290
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
4-107 1.32e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510   4 PGKRVGIHRVRCFAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKL 83
Cdd:COG2814   191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
                          90       100
                  ....*....|....*....|....
gi 1833303510  84 HRPIMIGVGCAVMGLGCFIISLPH 107
Cdd:COG2814   271 GRRRLLLIGLLLLALGLLLLALAG 294
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
24-396 6.60e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  24 LALIWAYISKILSGVYM-STMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFI 102
Cdd:COG2223     7 LLLATLAFFLAFGVWYLwSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 103 ISLphflmgryeyettisptsnlsSNSFlcvenrsqtlkptqdpaecvkeikslmWIYVLVGnIIRGIGETPIMPLGISY 182
Cdd:COG2223    87 LAL---------------------AVSY---------------------------WLLLLLG-LLLGIGGGGSFAVGIAL 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 183 IEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYvdtgsvntddltitptdtrwvgAWWIGFLVCAGVNVLTSIP 262
Cdd:COG2223   118 VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF----------------------GWRNAFLILGILLLVVAVL 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 263 FFFFPKTLPKEglqdngdgtenakeekhrdkAKEENQGIIKEFFLMMKNLfcnPIYMLCVLTSVLQVNGVAnIVIYKPKY 342
Cdd:COG2223   176 AWLFLRDPPAG--------------------AAAAAKASLRDQLEALRDP---RFWLLSLLYFGTFGSFIG-FSSWLPPY 231
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1833303510 343 LEHHFGISTAKAVFLIGLYTTPSvSAGYLISGFIMKKL---KITLKKAAIIALCLFM 396
Cdd:COG2223   232 LVDQFGLSAATAGLLAALFALLG-ALGRPLGGWLSDRIggrRVLLIVFALMALGLLL 287
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
35-110 8.05e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.23  E-value: 8.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1833303510  35 LSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFLM 110
Cdd:cd17333    10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
14-109 9.03e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  14 RCFAKIKVFLLALIWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGC 93
Cdd:cd06173   202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
                          90
                  ....*....|....*.
gi 1833303510  94 AVMGLGCFIISLPHFL 109
Cdd:cd06173   282 LLLGLALLVLGLSPSL 297
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
40-395 9.93e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510  40 MSTMLTQLERQFNISTSIVGLINGSFEMGNLLVIVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLphflmgryeyetti 119
Cdd:cd17474    18 VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL-------------- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 120 sptsnlsSNSFlcvenrsqtlkptqdpaecvkeikslmwIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGIL 199
Cdd:cd17474    84 -------SDSF----------------------------ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLY 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 200 E----VGKMIGPILGYLMGpfcaniyvdtgsvntddltitptdtrwvGAWWIG--FLVCAGVNVLTSIPFFFFPKTLPKE 273
Cdd:cd17474   129 EaalgLGIAVGPLLGGLLA----------------------------AISWRYpfFLLAALIPVAFLAILFLLPEPKEKA 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1833303510 274 glqdngdgtENAKEEKHRDKAKEENQGIIKEFFLmmknLFCNPIYML-CVLTsvlqvngvaniviYKPKYLEHHFGISta 352
Cdd:cd17474   181 ---------KSSSATKLRDLKKALRGRGLLTFLV----SAFLYFFLYfAFLT-------------YLPFLLELLYGIS-- 232
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1833303510 353 kaVFLIGL-YTTPSVS--AGYLISGFIMKKlKITLKKAAIIALCLF 395
Cdd:cd17474   233 --PIIIGLlFAGWSVLlaLGSLFVGRLLKK-RFGARRILVIGLLLY 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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