CMP-sialic acid synthase [Drosophila melanogaster]
acylneuraminate cytidylyltransferase family protein( domain architecture ID 10118501)
acylneuraminate cytidylyltransferase family protein, similar to N-acylneuraminate cytidylyltransferase that catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
CMP-NeuAc_Synthase | cd02513 | CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; ... |
32-240 | 2.09e-62 | ||||
CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm. : Pssm-ID: 133006 Cd Length: 223 Bit Score: 195.06 E-value: 2.09e-62
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Name | Accession | Description | Interval | E-value | ||||
CMP-NeuAc_Synthase | cd02513 | CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; ... |
32-240 | 2.09e-62 | ||||
CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm. Pssm-ID: 133006 Cd Length: 223 Bit Score: 195.06 E-value: 2.09e-62
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NeuA | COG1083 | CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family [Cell wall/membrane/envelope ... |
30-240 | 5.24e-57 | ||||
CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440700 Cd Length: 228 Bit Score: 181.13 E-value: 5.24e-57
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CTP_transf_3 | pfam02348 | Cytidylyltransferase; This family consists of two main Cytidylyltransferase activities: 1) ... |
32-144 | 1.36e-14 | ||||
Cytidylyltransferase; This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase,, EC:2.7.7.38 catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase EC:2.7.7.43,, catalysing the reaction:- CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterized describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand. Pssm-ID: 396773 Cd Length: 217 Bit Score: 70.44 E-value: 1.36e-14
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PRK05450 | PRK05450 | 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional |
30-91 | 5.17e-03 | ||||
3-deoxy-manno-octulosonate cytidylyltransferase; Provisional Pssm-ID: 235473 Cd Length: 245 Bit Score: 37.40 E-value: 5.17e-03
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Name | Accession | Description | Interval | E-value | ||||
CMP-NeuAc_Synthase | cd02513 | CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; ... |
32-240 | 2.09e-62 | ||||
CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm. Pssm-ID: 133006 Cd Length: 223 Bit Score: 195.06 E-value: 2.09e-62
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NeuA | COG1083 | CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family [Cell wall/membrane/envelope ... |
30-240 | 5.24e-57 | ||||
CMP-N-acetylneuraminic acid synthetase, NeuA/PseF family [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440700 Cd Length: 228 Bit Score: 181.13 E-value: 5.24e-57
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CTP_transf_3 | pfam02348 | Cytidylyltransferase; This family consists of two main Cytidylyltransferase activities: 1) ... |
32-144 | 1.36e-14 | ||||
Cytidylyltransferase; This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase,, EC:2.7.7.38 catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase EC:2.7.7.43,, catalysing the reaction:- CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterized describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand. Pssm-ID: 396773 Cd Length: 217 Bit Score: 70.44 E-value: 1.36e-14
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CMP-KDO-Synthetase | cd02517 | CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the ... |
29-91 | 6.45e-06 | ||||
CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; CMP-KDO Synthetase: 3-Deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) catalyzes the conversion of CTP and 3-deoxy-D-manno-octulosonate into CMP-3-deoxy-D-manno-octulosonate (CMP-KDO) and pyrophosphate. KDO is an essential component of the lipopolysaccharide found in the outer surface of gram-negative eubacteria. It is also a constituent of the capsular polysaccharides of some gram-negative eubacteria. Its presence in the cell wall polysaccharides of green algae and plant were also discovered. However, they have not been found in yeast and animals. The absence of the enzyme in mammalian cells makes it an attractive target molecule for drug design. Pssm-ID: 133010 Cd Length: 239 Bit Score: 45.93 E-value: 6.45e-06
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NTP_transf_3 | pfam12804 | MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine ... |
32-161 | 1.10e-04 | ||||
MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain. Pssm-ID: 463715 [Multi-domain] Cd Length: 159 Bit Score: 41.41 E-value: 1.10e-04
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GT_2_like_f | cd04182 | GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; ... |
30-99 | 6.68e-04 | ||||
GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133025 [Multi-domain] Cd Length: 186 Bit Score: 39.47 E-value: 6.68e-04
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PRK05450 | PRK05450 | 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional |
30-91 | 5.17e-03 | ||||
3-deoxy-manno-octulosonate cytidylyltransferase; Provisional Pssm-ID: 235473 Cd Length: 245 Bit Score: 37.40 E-value: 5.17e-03
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PLN02917 | PLN02917 | CMP-KDO synthetase |
33-91 | 5.83e-03 | ||||
CMP-KDO synthetase Pssm-ID: 215495 Cd Length: 293 Bit Score: 37.12 E-value: 5.83e-03
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PRK13368 | PRK13368 | 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional |
32-91 | 6.89e-03 | ||||
3-deoxy-manno-octulosonate cytidylyltransferase; Provisional Pssm-ID: 184007 Cd Length: 238 Bit Score: 36.87 E-value: 6.89e-03
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Blast search parameters | ||||
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