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Conserved domains on  [gi|1852011981|gb|QKO01740|]
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mating type protein 1-1-1, partial [Neonectria neomacrospora]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATalpha_HMGbox super family cl07856
Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating ...
 1-114 5.21e-40

Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating type protein alpha 1. Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes. MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes. Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (pfam04648) response pathway. In silico modelling of the MAT_Alpha1 domain indicates that its best scoring templates were structures of HMG-box proteins, and DOI: 10.4236/ojbiphy.2013.31001. Phylogenetic analysis suggests that the MAT_Alpha1 domain diverged from the MATA_HMG-box subfamily. The name of MATalpha_HMG-box was proposed for the MAT_alpha1 domain.


The actual alignment was detected with superfamily member pfam04769:

Pssm-ID: 398438  Cd Length: 186  Bit Score: 131.48  E-value: 5.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852011981   1 YYLKLFPDLQQKTASGLLTTLWSQDPFRNKWALVAKVYSFVRDEVGRSNISLKRFLDVCCPVMNIIQPNLYLGIFGWIVQ 80
Cdd:pfam04769  48 YYSPLFSQLPQKELSPFITQLWEHDPFRNEWDLMAKVYSAIRDQLGKDKAPLQKFLHIACPHLKVVEPENYLETLGWKLV 127

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1852011981  81 FDENGPCDLVQddnaVYLDHFQGENVPSTEMDLL 114
Cdd:pfam04769 128 TNPEGTPTLQR----TAMPGVGNNLQPMNGLDLL 157
 
Name Accession Description Interval E-value
MATalpha_HMGbox pfam04769
Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating ...
 1-114 5.21e-40

Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating type protein alpha 1. Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes. MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes. Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (pfam04648) response pathway. In silico modelling of the MAT_Alpha1 domain indicates that its best scoring templates were structures of HMG-box proteins, and DOI: 10.4236/ojbiphy.2013.31001. Phylogenetic analysis suggests that the MAT_Alpha1 domain diverged from the MATA_HMG-box subfamily. The name of MATalpha_HMG-box was proposed for the MAT_alpha1 domain.


Pssm-ID: 398438  Cd Length: 186  Bit Score: 131.48  E-value: 5.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852011981   1 YYLKLFPDLQQKTASGLLTTLWSQDPFRNKWALVAKVYSFVRDEVGRSNISLKRFLDVCCPVMNIIQPNLYLGIFGWIVQ 80
Cdd:pfam04769  48 YYSPLFSQLPQKELSPFITQLWEHDPFRNEWDLMAKVYSAIRDQLGKDKAPLQKFLHIACPHLKVVEPENYLETLGWKLV 127

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1852011981  81 FDENGPCDLVQddnaVYLDHFQGENVPSTEMDLL 114
Cdd:pfam04769 128 TNPEGTPTLQR----TAMPGVGNNLQPMNGLDLL 157
 
Name Accession Description Interval E-value
MATalpha_HMGbox pfam04769
Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating ...
 1-114 5.21e-40

Mating-type protein MAT alpha 1 HMG-box; This family includes Saccharomyces cerevisiae mating type protein alpha 1. Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes. MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes. Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (pfam04648) response pathway. In silico modelling of the MAT_Alpha1 domain indicates that its best scoring templates were structures of HMG-box proteins, and DOI: 10.4236/ojbiphy.2013.31001. Phylogenetic analysis suggests that the MAT_Alpha1 domain diverged from the MATA_HMG-box subfamily. The name of MATalpha_HMG-box was proposed for the MAT_alpha1 domain.


Pssm-ID: 398438  Cd Length: 186  Bit Score: 131.48  E-value: 5.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1852011981   1 YYLKLFPDLQQKTASGLLTTLWSQDPFRNKWALVAKVYSFVRDEVGRSNISLKRFLDVCCPVMNIIQPNLYLGIFGWIVQ 80
Cdd:pfam04769  48 YYSPLFSQLPQKELSPFITQLWEHDPFRNEWDLMAKVYSAIRDQLGKDKAPLQKFLHIACPHLKVVEPENYLETLGWKLV 127

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1852011981  81 FDENGPCDLVQddnaVYLDHFQGENVPSTEMDLL 114
Cdd:pfam04769 128 TNPEGTPTLQR----TAMPGVGNNLQPMNGLDLL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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