|
Name |
Accession |
Description |
Interval |
E-value |
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
21-518 |
0e+00 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 693.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16159 27 TPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASSHGMRVILFTASSGGLPPNETTFAEVLKQQGYSTAL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNCESAGDHCHHPLHHGFDYFYGMPLSMTGDCAHweLSEKRVDLEQKLNFLFQVLALVTLTLAAGKFMHLISI 180
Cdd:cd16159 107 IGKWHLGLHCESRNDFCHHPLNHGFDYFYGLPLTNLKDCGD--GSNGEYDLSFDPLFPLLTAFVLITALTIFLLLYLGAV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 SWMPVIwsALLAVFLLTTSYFAGALIVHAD--CFLMRNHTITEQPMRFQRVTPLILQEVKSFLKRNKLGPFLLLVSFLHV 258
Cdd:cd16159 185 SKRFFV--FLLILSLLFISLFFLLLITNRYfnCILMRNHEVVEQPMSLENLTQRLTKEAISFLERNKERPFLLVMSFLHV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFANSQYGGWNGIYKGGKGM 338
Cdd:cd16159 263 HTALFTSKKFKGRSKHGRYGDNVEEMDWSVGQILDALDELGLKDNTFVYFTSDNGGHLEEISVGGEYGGGNGGIYGGKKM 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 339 GGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLLGTAQHSDHEFLMHYCERF 418
Cdd:cd16159 343 GGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPSDRIIDGRDLMPLLTGQEKRSPHEFLFHYCGAE 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 419 LHAARWHQRDRGTLWKVHFVTPVFQPEGAGaCYGRKVCPCSGEKVVHHDPPLLFDLSRDPSEAHVLTPASEPlFYHVMER 498
Cdd:cd16159 423 LHAVRYRPRDGGAVWKAHYFTPNFYPGTEG-CCGTLLCRCFGDSVTHHDPPLLFDLSADPSESNPLDPTDEP-YQEIIKK 500
|
490 500
....*....|....*....|
gi 1864524949 499 VQQAVWEHQQTLSPVALQLD 518
Cdd:cd16159 501 ILEAVAEHQSSIEPVESQLS 520
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
21-485 |
9.83e-134 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 394.24 E-value: 9.83e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16026 27 TPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGL-----PGVVGPPGSKGGLPPDEITIAEVLKKAGYRTAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGlncesagDH-CHHPLHHGFDYFYGMPLSMTGDCAHWELSEKRVDLeqklnflfqvlalvtltlaagkfmhlis 179
Cdd:cd16026 102 VGKWHLG-------HQpEFLPTRHGFDEYFGIPYSNDMWPFPLYRNDPPGPL---------------------------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 180 iswmpviwsallavfllttsyfagalivhadCFLMRNHTITEQPMRFQRVTPLILQEVKSFLKRNKLGPFLLLVSFLHVH 259
Cdd:cd16026 147 -------------------------------PPLMENEEVIEQPADQSSLTQRYTDEAVDFIERNKDQPFFLYLAHTMPH 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 260 IPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFAN-----------SQY-GG 327
Cdd:cd16026 196 VPLFASEKFKGRSGAGLYGDVVEELDWSVGRILDALKELGLEENTLVIFTSDNGPWLEYGGHGgsagplrggkgTTWeGG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 328 wngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLLGTAQHSD 407
Cdd:cd16026 276 -----------------VRVPFIAWWPGVIPAGTVSDELASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSKSPP 338
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1864524949 408 HEFLMHYCERFLHAARWHQrdrgtlWKVHFVTPVFQPEGAGacygrkvcpcsGEKVVHHDPPLLFDLSRDPSEAHVLT 485
Cdd:cd16026 339 HPFFYYYDGGDLQAVRSGR------WKLHLPTTYRTGTDPG-----------GLDPTKLEPPLLYDLEEDPGETYNVA 399
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
11-503 |
3.07e-119 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 359.05 E-value: 3.07e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 11 GDML---HLQHSWTPnIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSsvGYRV-LQWTgaSGGLPTNETT 86
Cdd:cd16160 15 GDLAsygHPTQERGP-IDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYG--GTRVfLPWD--IGGLPKTEVT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 87 FAKILKEKGYATGLIGKWHLGLNCESAGDHCHHPLHHGFDyFYGMPLSMTGdcaHWELSekrvdleqklnflfqvlalvt 166
Cdd:cd16160 90 MAEALKEAGYTTGMVGKWHLGINENNHSDGAHLPSHHGFD-FVGTNLPFTN---SWACD--------------------- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 167 ltlaagkfmhlisiswmpviwsallavfllTTSYFagalIVHAD---CFLMRNHTITEQPMRFQRVTPLILQEVKSFLKR 243
Cdd:cd16160 145 ------------------------------DTGRH----VDFPDrsaCFLYYNDTIVEQPIQHEHLTETLVGDAKSFIED 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 244 NKLGPFLLLVSFLHVHIPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG---------- 313
Cdd:cd16160 191 NQENPFFLYFSFPQTHTPLFASKRFKGKSKRGRYGDNINEMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGphveyclegg 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 314 --GSLENQFANSQYGGwngiykggkgmggweggIRVPGIFRWPGVLPaGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVID 391
Cdd:cd16160 271 stGGLKGGKGNSWEGG-----------------IRVPFIAYWPGTIK-PRVSHEVVSTMDIFPTFVDLAGGTLPTDRIYD 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 392 GRDLLPLLLGTAQHSDHEFLMHYCERfLHAARWHQrdrgtlWKVHFVT---PVFQPEGAGACYGRKVCP------CSGEK 462
Cdd:cd16160 333 GLSITDLLLGEADSPHDDILYYCCSR-LMAVRYGS------YKIHFKTqplPSQESLDPNCDGGGPLSDyivcydCEDEC 405
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 1864524949 463 VVHHDPPLLFDLSRDPSEAHVLTPAsepLFYHVMERVQQAV 503
Cdd:cd16160 406 VTKHNPPLIFDVEKDPGEQYPLQPS---VYEHMLEAVEKLI 443
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
19-540 |
3.59e-83 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 267.00 E-value: 3.59e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 19 SWTPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYrvlqwTGASGGLPTNETTFAKILKEKGYAT 98
Cdd:cd16158 25 SSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGVFY-----PGSRGGLPLNETTIAEVLKTVGYQT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 99 GLIGKWHLGLNCESAgdhcHHPLHHGFDYFYGMPLSMT-GDCAHwelsekrvdleqklnflfqvlalvtltlaagkfmhl 177
Cdd:cd16158 100 AMVGKWHLGVGLNGT----YLPTHQGFDHYLGIPYSHDqGPCQN------------------------------------ 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 178 isiswmpviwsalLAVFLLTTSYFAGALIVHADCFLMRNHTITEQPMRFQRVTPLILQEVKSFL----KRNKlgPFLLLV 253
Cdd:cd16158 140 -------------LTCFPPNIPCFGGCDQGEVPCPLFYNESIVQQPVDLLTLEERYAKFAKDFIadnaKEGK--PFFLYY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 254 SFLHVHIPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQfansQYGGwNGIYK 333
Cdd:cd16158 205 ASHHTHYPQFAGQKFAGRSSRGPFGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPSTMRK----SRGG-NAGLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 334 GGKGMGGWEGGIRVPGIFRWPGVLPAGRVIgEPTSLMDVFPTVVQLAGGEVPqDRVIDGRDLLPLLLGTAQHSDHEFLMH 413
Cdd:cd16158 280 KCGKGTTYEGGVREPAIAYWPGRIKPGVTH-ELASTLDILPTIAKLAGAPLP-NVTLDGVDMSPILFEQGKSPRQTFFYY 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 414 YC----ERFLHAARWHQrdrgtlWKVHFVT---PVFQPEGAGACYGRKvcpcsgeKVVHHDPPLLFDLSRDPSEAHVLTP 486
Cdd:cd16158 358 PTspdpDKGVFAVRWGK------YKAHFYTqgaAHSGTTPDKDCHPSA-------ELTSHDPPLLFDLSQDPSENYNLLG 424
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864524949 487 ASEplFYHVMERVQQAVWEHQQTLSPVALQLDSLGNlwrPWLQPC----CGPFPLCWC 540
Cdd:cd16158 425 LPE--YNQVLKQIQQVKERFEASMKFGESEINKGED---PALEPCckpgCTPKPSCCQ 477
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
21-485 |
2.67e-80 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 256.63 E-value: 2.67e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYRvlqwtgASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16161 28 TPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPT------SVGGLPLNETTLAEVLRQAGYATGM 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNcesagdHCHHPLHHGFDYFYGMPLSMTGdcahwELSEKRVDleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16161 102 IGKWHLGQR------EAYLPNSRGFDYYFGIPFSHDS-----SLADRYAQ------------------------------ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyFAGAlivhadcFLMRNHTITEqpmrfqrvtplilqevksflkrnklgPFLLLVSFLHVHI 260
Cdd:cd16161 141 --------------------FATD-------FIQRASAKDR--------------------------PFFLYAALAHVHV 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 261 PLITTKNFLGKSAH-GLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG---------GSLENQFANSQyGGWNG 330
Cdd:cd16161 168 PLANLPRFQSPTSGrGPYGDALQEMDDLVGQIMDAVKHAGLKDNTLTWFTSDNGpwevkcelaVGPGTGDWQGN-LGGSV 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 331 IYKGGKGMGgweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLLGTAQhSDHEF 410
Cdd:cd16161 247 AKASTWEGG-----HREPAIVYWPGRIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSK-TGHRC 320
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 411 LMHYCE-----RFLHAARWHQrdrgtlWKVHFVTpvfqpEGAGACYGRKvCPcsgekVVHHDPPLLFDLSRDPSEAHVLT 485
Cdd:cd16161 321 LFHPNSgaagaGALSAVRCGD------YKAHYAT-----GGALACCGST-GP-----KLYHDPPLLFDLEVDPAESFPLT 383
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
21-480 |
7.94e-80 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 254.77 E-value: 7.94e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMvSSVGyrvlqWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16142 29 TPNIDRLAKEGLRFTSFYVEPS-CTPGRAAFITGRHPIRTGL-TTVG-----LPGSPGGLPPWEPTLAELLKDAGYATAQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGlncESAGdhcHHPLHHGFDYFYGMPLsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16142 102 FGKWHLG---DEDG---RLPTDHGFDEFYGNLY----------------------------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyfagalivhadcflmrnHTITEQpmrfqrvtplILQEVKSFLKRNKLG--PFLLLVSFLHV 258
Cdd:cd16142 129 ------------------------------------HTIDEE----------IVDKAIDFIKRNAKAdkPFFLYVNFTKM 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLITTKNFLGKS-AHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLeNQFANSQY------------ 325
Cdd:cd16142 163 HFPTLPSPEFEGKSsGKGKYADSMVELDDHVGQILDALDELGIADNTIVIFTTDNGPEQ-DVWPDGGYtpfrgekgttwe 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 326 GGWngiykggkgmggweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVP------QDRVIDGRDLLPLL 399
Cdd:cd16142 242 GGV-----------------RVPAIVRWPGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPkdkllgKDRHIDGVDQSPFL 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 400 LGTAQHSDHEFLMHYCERFLHAARWHQrdrgtlWKVHFVtpVFQPEGAGACYGRKVCPCsgekvvhhdpPLLFDLSRDPS 479
Cdd:cd16142 305 LGKSEKSRRSEFFYFGEGELGAVRWKN------WKVHFK--AQEDTGGPTGEPFYVLTF----------PLIFNLRRDPK 366
|
.
gi 1864524949 480 E 480
Cdd:cd16142 367 E 367
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
21-482 |
7.11e-73 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 237.48 E-value: 7.11e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVgyrvlqWTGASGGL-PTNETTFAKILKEKGYATG 99
Cdd:cd16143 27 TPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRLKGGV------LGGFSPPLiEPDRVTLAKMLKQAGYRTA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 100 LIGKWHLGLN-CESAGDHCHH---------------PLHHGFDYFYGMPLSmtgdcahwelsekrvdleqklnflfqvla 163
Cdd:cd16143 101 MVGKWHLGLDwKKKDGKKAATgtgkdvdyskpikggPLDHGFDYYFGIPAS----------------------------- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 164 lvtltlaagkfmhlisiswmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqRVTPLILQEVKSFLKR 243
Cdd:cd16143 152 ----------------------------------------------------------------EVLPTLTDKAVEFIDQ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 244 NKLG--PFLLLVSFLHVHIPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQF- 320
Cdd:cd16143 168 HAKKdkPFFLYFALPAPHTPIVPSPEFQGKSGAGPYGDFVYELDWVVGRILDALKELGLAENTLVIFTSDNGPSPYADYk 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 321 --------ANSQY---------GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGE 383
Cdd:cd16143 248 elekfghdPSGPLrgmkadiyeGG-----------------HRVPFIVRWPGKIPAGSVSDQLVSLTDLFATLAAIVGQK 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 384 VPQDRVIDGRDLLPLLLGTAQHSDHEFLMHycerflHAARWHQRDRGTLWKVhfvtpVFQPEGAGACYGRKvcpcsgeKV 463
Cdd:cd16143 311 LPDNAAEDSFSFLPALLGPKKQEVRESLVH------HSGNGSFAIRKGDWKL-----IDGTGSGGFSYPRG-------KE 372
|
490 500
....*....|....*....|
gi 1864524949 464 VHHDPP-LLFDLSRDPSEAH 482
Cdd:cd16143 373 KLGLPPgQLYNLSTDPGESN 392
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
21-518 |
3.04e-72 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 238.14 E-value: 3.04e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYRVLQWTGAS--GGLPTNETTFAKILKEKGYAT 98
Cdd:cd16157 27 TPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQNivGGIPDSEILLPELLKKAGYRN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 99 GLIGKWHLGLNCEsagdhcHHPLHHGFDYFYGMPlsmtgDCaHWelseKRVDLEQKLNflfqvLALVTLTLAAGKFMHLI 178
Cdd:cd16157 107 KIVGKWHLGHRPQ------YHPLKHGFDEWFGAP-----NC-HF----GPYDNKAYPN-----IPVYRDWEMIGRYYEEF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 179 SIswmpviwsallavfllttsyfagalivhadcflmrNHTITEQpmrfqRVTPLILQEVKSFLKR--NKLGPFLLLVSFL 256
Cdd:cd16157 166 KI-----------------------------------DKKTGES-----NLTQIYLQEALEFIEKqhDAQKPFFLYWAPD 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 257 HVHIPLITTKNFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLenqFANSQYGGWNGIYKGGK 336
Cdd:cd16157 206 ATHAPVYASKPFLGTSQRGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAAL---ISAPEQGGSNGPFLCGK 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 337 GMGGWEGgIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLLgtAQHSDHEFLMHYCE 416
Cdd:cd16157 283 QTTFEGG-MREPAIAWWPGHIKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLL--NGKEKDRPIFYYRG 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 417 RFLHAARWHQrdrgtlWKVHFVT----PVFQPEGAGACYGRKVCPCSGEKVVHH-DPPLLFDLSRDPSEAHVLTPASePL 491
Cdd:cd16157 360 DELMAVRLGQ------YKAHFWTwsnsWEEFRKGINFCPGQNVPGVTTHNQTDHtKLPLLFHLGRDPGEKYPISFKS-AE 432
|
490 500
....*....|....*....|....*..
gi 1864524949 492 FYHVMERVQQAVWEHQQTLSPVALQLD 518
Cdd:cd16157 433 YKQAMPRISKVVQQHQKTLVPGEPQLN 459
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
21-482 |
3.26e-72 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 236.67 E-value: 3.26e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGM--VSSVGYRVLQWTGA-----SGGLPTNETTFAKILKE 93
Cdd:cd16144 26 TPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGItdVIPGRRGPPDNTKLipppsTTRLPLEEVTIAEALKD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 94 KGYATGLIGKWHLGlncesaGDHCHHPLHHGFDYFYGmplsmtGDCAHwelsekrvdleqklnflfqvlalvtltlaAGK 173
Cdd:cd16144 106 AGYATAHFGKWHLG------GEGGYGPEDQGFDVNIG------GTGNG-----------------------------GPP 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 174 fmhlisiswmpviwsallavfllttSYFAGALIVHADCFLmrnhtITEQPMRFQRVTplilQEVKSFLKRNKLGPFLLLV 253
Cdd:cd16144 145 -------------------------SYYFPPGKPNPDLED-----GPEGEYLTDRLT----DEAIDFIEQNKDKPFFLYL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 254 SFLHVHIPLITTK----NFLGKSAHGLYGDN-------VEEMDWMVGQILDALDTEGLTNSTLIYFASDHGG-SLENQFA 321
Cdd:cd16144 191 SHYAVHTPIQARPelieKYEKKKKGLRKGQKnpvyaamIESLDESVGRILDALEELGLADNTLVIFTSDNGGlSTRGGPP 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 322 NSQY-----------GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVI 390
Cdd:cd16144 271 TSNAplrggkgslyeGG-----------------IRVPLIVRWPGVIKPGSVSDVPVIGTDLYPTFLELAGGPLPPPQHL 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 391 DGRDLLPLLLGTAQHSDHEFLMhycerflhaarWHQrdrgtlwkvhfvtPVFQPEGAGacygrkvcPCS----GE-KVVH 465
Cdd:cd16144 334 DGVSLVPLLKGGEADLPRRALF-----------WHF-------------PHYHGQGGR--------PASairkGDwKLIE 381
|
490 500
....*....|....*....|
gi 1864524949 466 H---DPPLLFDLSRDPSEAH 482
Cdd:cd16144 382 FyedGRVELYNLKNDIGETN 401
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
21-482 |
9.51e-72 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 234.39 E-value: 9.51e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGyrvlqwtGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:COG3119 49 TPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRYPHRTGVTDNGE-------GYNGGLPPDEPTLAELLKEAGYRTAL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLncesagdhchhplhhgfdyfygmplsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:COG3119 122 FGKWHLYL------------------------------------------------------------------------ 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvTPLILQEVKSFLKRNKLG--PFLLLVSFLHV 258
Cdd:COG3119 130 -------------------------------------------------TDLLTDKAIDFLERQADKdkPFFLYLAFNAP 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLITTKNFLGK-----------------------SAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGS 315
Cdd:COG3119 161 HAPYQAPEEYLDKydgkdiplppnlaprdlteeelrRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPS 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 316 LENQ-FA---NSQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvI 390
Cdd:COG3119 241 LGEHgLRggkGTLYeGG-----------------IRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPED--L 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 391 DGRDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRdrgtlWKVHFvtpvfqpegagaCYGRKvcpcsgekvvhhDPPL 470
Cdd:COG3119 302 DGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGR-----WKLIR------------YYDDD------------GPWE 352
|
490
....*....|..
gi 1864524949 471 LFDLSRDPSEAH 482
Cdd:COG3119 353 LYDLKNDPGETN 364
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
21-482 |
5.74e-58 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 198.59 E-value: 5.74e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgyRVLQWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16145 26 TPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRV------RGNSEPGGQDPLPPDDVTLAEVLKKAGYATAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNcESAGdhchHPLHHGFDYFYGmplsmtgdcahwelsekrvdleqklnFLFQVLAlvtltlaagkfmHlisi 180
Cdd:cd16145 100 FGKWGLGGP-GTPG----HPTKQGFDYFYG--------------------------YLDQVHA------------H---- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttSYFAGALIVHADCFLMRNHTIT-------EQPMRFQRVTPLILQEVKSFLKRNKLGPFLLLV 253
Cdd:cd16145 133 ------------------NYYPEYLWRNGEKVPLPNNVIPpldegnnAGGGGGTYSHDLFTDEALDFIRENKDKPFFLYL 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 254 SFLHVHIPLITTK---NFLGKSAHGLYGDN------------VEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLE- 317
Cdd:cd16145 195 AYTLPHAPLQVPDdgpYKYKPKDPGIYAYLpwpqpekayaamVTRLDRDVGRILALLKELGIDENTLVVFTSDNGPHSEg 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 318 -----NQFANSQ----------Y-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAG 381
Cdd:cd16145 275 gsehdPDFFDSNgplrgykrslYeGG-----------------IRVPFIARWPGKIPAGSVSDHPSAFWDFMPTLADLAG 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 382 GEVPQDrvIDGRDLLPLLLGTAQHSDHEFLmhYCERFLH----AARWHQrdrgtlWKVhfvtpVFQPEGAGacygrkvcp 457
Cdd:cd16145 338 AEPPED--IDGISLLPTLLGKPQQQQHDYL--YWEFYEGggaqAVRMGG------WKA-----VRHGKKDG--------- 393
|
490 500
....*....|....*....|....*
gi 1864524949 458 csgekvvhhdPPLLFDLSRDPSEAH 482
Cdd:cd16145 394 ----------PFELYDLSTDPGETN 408
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
406-540 |
3.28e-56 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 184.44 E-value: 3.28e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 406 SDHEFLMHYCERFLHAARWHQrdrgtlWKVHFVTPVFQPEGAGACYGRKVCpcsgekVVHHDPPLLFDLSRDPSEAHVLT 485
Cdd:pfam14707 1 SPHEFLFHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLS 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1864524949 486 PASePLFYHVMERVQQAVWEHQQTLSPVALQLDSLGNLWRPWLQPCCGPFPLCWC 540
Cdd:pfam14707 69 PDS-PEYPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
21-394 |
2.80e-55 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 186.10 E-value: 2.80e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGmvssvgyrVLQWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16022 26 TPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHG--------VRGNVGNGGGLPPDEPTLAELLKEAGYRTAL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHlglncesagdhchhplhhgfdyfygmplsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16022 98 IGKWH--------------------------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvtplilQEVKSFLKRN-KLGPFLLLVSFLHVH 259
Cdd:cd16022 103 ------------------------------------------------------DEAIDFIERRdKDKPFFLYVSFNAPH 128
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 260 IPLIttknflgksahglYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQfaNSQYGGWNGIYKGgkgmg 339
Cdd:cd16022 129 PPFA-------------YYAMVSAIDDQIGRILDALEELGLLDNTLIVFTSDHGDMLGDH--GLRGKKGSLYEGG----- 188
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864524949 340 gweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRD 394
Cdd:cd16022 189 -----IRVPFIVRWPGKIPAGQVSDALVSLLDLLPTLLDLAGIEPPEG--LDGRS 236
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-424 |
5.60e-53 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 184.34 E-value: 5.60e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTqHISAASLCTPSRAAFLTGRYPVRSGMVSsvgyrvlqwtgasGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16151 26 TPNIDALAAEGVRFN-NAYAQPLCTPSRVQLMTGKYNFRNYVVF-------------GYLDPKQKTFGHLLKDAGYATAI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNcESAGDHchhPLHHGFDYFygmplsmtgdCAhWELSEKRVDLEQKLNFLFQVLALVTLTLAAGKFMhlisi 180
Cdd:cd16151 92 AGKWQLGGG-RGDGDY---PHEFGFDEY----------CL-WQLTETGEKYSRPATPTFNIRNGKLLETTEGDYG----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmPVIWSAllavfllttsyfagalivhadcFLMRnhtiteqpmrfqrvtplilqevksFLKRNKLGPFLLLVSFLHVHI 260
Cdd:cd16151 152 ---PDLFAD----------------------FLID------------------------FIERNKDQPFFAYYPMVLVHD 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 261 PLITT----------KNFLGKSAHglYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLE-NQFANSQY--GG 327
Cdd:cd16151 183 PFVPTpdspdwdpddKRKKDDPEY--FPDMVAYMDKLVGKLVDKLEELGLRENTIIIFTGDNGTHRPiTSRTNGREvrGG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 328 wngiykggkGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLLG-TAQHS 406
Cdd:cd16151 261 ---------KGKTTDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFLPTLAELAGAPLPEDYPLDGRSFAPQLLGkTGSPR 331
|
410 420
....*....|....*....|....*
gi 1864524949 407 DHEFLMHY-------CERFLHAARW 424
Cdd:cd16151 332 REWIYWYYrnphkkfGSRFVRTKRY 356
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
21-482 |
6.48e-52 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 182.36 E-value: 6.48e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQ-HISaaSLCTPSRAAFLTGRYPVRSGMVSSVGYRVLqwtgasggLPTNETTFAKILKEKGYATG 99
Cdd:cd16146 26 TPNLDRLAAESVRFTNfHVS--PVCAPTRAALLTGRYPFRTGVWHTILGRER--------MRLDETTLAEVFKDAGYRTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 100 LIGKWHLGLNcesagdHCHHPLHHGFDYFYGMPLSMTGDCAHWELSEkrvdleqklnflfqvlalvtltlaagkfmhlis 179
Cdd:cd16146 96 IFGKWHLGDN------YPYRPQDRGFDEVLGHGGGGIGQYPDYWGND--------------------------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 180 iswmpviwsallavfllttsYFagalivhaDCFLMRNHTITeqpmRFQR-VTPLILQEVKSFLKRNKLGPFLLLVSFLHV 258
Cdd:cd16146 137 --------------------YF--------DDTYYHNGKFV----KTEGyCTDVFFDEAIDFIEENKDKPFFAYLATNAP 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLITTKNF--------LGKSAHGLYGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG--GSLENQF-AN----- 322
Cdd:cd16146 185 HGPLQVPDKYldpykdmgLDDKLAAFYG-MIENIDDNVGRLLAKLKELGLEENTIVIFMSDNGpaGGVPKRFnAGmrgkk 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 323 -SQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLPLLL 400
Cdd:cd16146 264 gSVYeGG-----------------HRVPFFIRWPGKILAGKDVDTLTAHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLK 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 401 GTAQHSDHEFLmhycerFLHaarWHQRDRGTLWKVHFVtpVFQPEgagacYgRKVCPcsgekvvHHDPPLLFDLSRDPSE 480
Cdd:cd16146 327 GESDPWPERTL------FTH---SGRWPPPPKKKRNAA--VRTGR-----W-RLVSP-------KGFQPELYDIENDPGE 382
|
..
gi 1864524949 481 AH 482
Cdd:cd16146 383 EN 384
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
21-484 |
2.79e-51 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 180.44 E-value: 2.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMVSSVGyrvlqWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16029 26 TPNLDALAADGVILNNYYVQPI-CTPSRAALMTGRYPIHTGMQHGVI-----LAGEPYGLPLNETLLPQYLKELGYATHL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGlncesagdHCHH---PLHHGFDYFYGMPLSMTGdcaHWelsekrvdleqklnflfqvlalvtltlaagkfmhl 177
Cdd:cd16029 100 VGKWHLG--------FYTWeytPTNRGFDSFYGYYGGAED---YY----------------------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 178 isiswmpviwsallavfllttSYFAGALIVHADCFLMRNHTIT-EQPMRFqrVTPLILQEVKSFLKR-NKLGPFLLLVSF 255
Cdd:cd16029 134 ---------------------THTSGGANDYGNDDLRDNEEPAwDYNGTY--STDLFTDRAVDIIENhDPSKPLFLYLAF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 256 LHVHIPLITTKNFL----GKSAHGLYGD------NVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFANSQY 325
Cdd:cd16029 191 QAVHAPLQVPPEYAdpyeDKFAHIKDEDrrtyaaMVSALDESVGNVVDALKAKGMLDNTLIVFTSDNGGPTGGGDGGSNY 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 326 -----------GGwngiykggkgmggweggIRVPGiFRWPGVLP--AGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDG 392
Cdd:cd16029 271 plrggkntlweGG-----------------VRVPA-FVWSPLLPpkRGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 393 RDLLPLLLGTAQHSDHEFLmhycerflhaarwHQRDRGTLWKVHfvtpvfqpegAGACYGRKvcpcsgeKVVHHDPplLF 472
Cdd:cd16029 333 VDQWDALSGGAPSPRTEIL-------------LNIDDITRTTGG----------AAIRVGDW-------KLIVGKP--LF 380
|
490
....*....|..
gi 1864524949 473 DLSRDPSEAHVL 484
Cdd:cd16029 381 NIENDPCERNDL 392
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-482 |
1.24e-50 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 178.53 E-value: 1.24e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYrvlqwtgasggLPTNETTFAKILKEKGYATGL 100
Cdd:cd16034 27 TPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVFGNDVP-----------LPPDAPTIADVLKDAGYRTGY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNCESAGDHCHH----PLHHGFDYFYGMplsmtgDCAH-------WELSEKRVDLEQklnflfqvlalvtltl 169
Cdd:cd16034 96 IGKWHLDGPERNDGRADDYtpppERRHGFDYWKGY------ECNHdhnnphyYDDDGKRIYIKG---------------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 170 aagkfmhlisisWMPvIWSALLAVfllttSYfagalivhadcflMRNHTITEQP-----------MRFQRVtPlilQEVK 238
Cdd:cd16034 154 ------------YSP-DAETDLAI-----EY-------------LENQADKDKPfalvlswnpphDPYTTA-P---EEYL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 239 SFLKRNKLgpflllvsFLHVHIPLIT-TKNFLGKSAHGLYGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG---G 314
Cdd:cd16034 199 DMYDPKKL--------LLRPNVPEDKkEEAGLREDLRGYYA-MITALDDNIGRLLDALKELGLLENTIVVFTSDHGdmlG 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 315 SLENQFANSQYGGwngiykggkgmggwegGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRD 394
Cdd:cd16034 270 SHGLMNKQVPYEE----------------SIRVPFIIRYPGKIKAGRVVDLLINTVDIMPTLLGLCGLPIPDT--VEGRD 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 395 LLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTL----WKvhFVtpvfqpegagacygrkvcpcsgekVVHHDPPL 470
Cdd:cd16034 332 LSPLLLGGKDDEPDSVLLQCFVPFGGGSARDGGEWRGVrtdrYT--YV------------------------RDKNGPWL 385
|
490
....*....|..
gi 1864524949 471 LFDLSRDPSEAH 482
Cdd:cd16034 386 LFDNEKDPYQLN 397
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
21-381 |
8.91e-45 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 159.90 E-value: 8.91e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGyrvlqwtgasGGLPTNETTFAKILKEKGYATGL 100
Cdd:pfam00884 26 TPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTP----------VGLPRTEPSLPDLLKRAGYNTGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGLNCESAgdhchhPLHHGFDYFYGmplsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:pfam00884 96 IGKWHLGWYNNQS------PCNLGFDKFFG-------------------------------------------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavFLLTTSYFAGALIVHADCFLMRNHTiteqpmrfQRVTPLILQevksFLKRNKlGPFLLLVSFLHVHI 260
Cdd:pfam00884 120 -------------RNTGSDLYADPPDVPYNCSGGGVSD--------EALLDEALE----FLDNND-KPFFLVLHTLGSHG 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 261 PLITTKNFLGKSA------------HGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFANSQYGGW 328
Cdd:pfam00884 174 PPYYPDRYPEKYAtfkpsscseeqlLNSYDNTLLYTDDAIGRVLDKLEENGLLDNTLVVYTSDHGESLGEGGGYLHGGKY 253
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1864524949 329 NGIYKGGkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAG 381
Cdd:pfam00884 254 DNAPEGG---------YRVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAG 297
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
21-425 |
9.80e-43 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 156.51 E-value: 9.80e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssvGYRVLQWTgasggLPTNETTFAKILKEKGYATGL 100
Cdd:cd16027 25 TPNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGAH---GLRSRGFP-----LPDGVKTLPELLREAGYYTGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLglNCESAGDHCHHPLHHGFDYFYGMPlsMTGDCAHWElseKRVDLEQklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16027 97 IGKTHY--NPDAVFPFDDEMRGPDDGGRNAWD--YASNAADFL---NRAKKGQ--------------------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmPviwsallavfllttsyFagalivhadcFLMRNHTITEQPMRFQRVTPLI--LQEVKsflkrnkLGPFLllvsflhV 258
Cdd:cd16027 143 ---P----------------F----------FLWFGFHDPHRPYPPGDGEEPGydPEKVK-------VPPYL-------P 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLIttknflgKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGslenQFANS-----QYGgwngiyk 333
Cdd:cd16027 180 DTPEV-------REDLADYYDEIERLDQQVGEILDELEEDGLLDNTIVIFTSDHGM----PFPRAkgtlyDSG------- 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 334 ggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLPLLLG-TAQHSDHEFLM 412
Cdd:cd16027 242 -----------LRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPEY--LQGRSFLPLLKGeKDPGRDYVFAE 308
|
410 420
....*....|....*....|
gi 1864524949 413 H-------YCERFLHAARWH 425
Cdd:cd16027 309 RdrhdetyDPIRSVRTGRYK 328
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
10-425 |
6.46e-41 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 152.37 E-value: 6.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDMLHLQHSW---TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGyrvlqWTGA-SGGLPTNET 85
Cdd:cd16033 12 RYDTLGCYGNPivkTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVE-----NAGAySRGLPPGVE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 86 TFAKILKEKGYATGLIGKWHLGLNcesagdhcHHPLHHGFDYFygMPLSMTGDcaHWeLSEKRVDLEQKLnflfqvlalv 165
Cdd:cd16033 87 TFSEDLREAGYRNGYVGKWHVGPE--------ETPLDYGFDEY--LPVETTIE--YF-LADRAIEMLEEL---------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 166 tltLAAGK-FMHLISIsWMPviwsallavfllttsyfagalivHADCF-------LMRNHTItEQPMRFQRvtPLILqev 237
Cdd:cd16033 144 ---AADDKpFFLRVNF-WGP-----------------------HDPYIppepyldMYDPEDI-PLPESFAD--DFED--- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 238 KSFLKRNKLGPFLLLVSFLHVHIPLIttknflgksAHglYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLE 317
Cdd:cd16033 191 KPYIYRRERKRWGVDTEDEEDWKEII---------AH--YWGYITLIDDAIGRILDALEELGLADDTLVIFTSDHGDALG 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 318 NQfansqyGGWNGIYKGGKGMGgweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLP 397
Cdd:cd16033 260 AH------RLWDKGPFMYEETY------RIPLIIKWPGVIAAGQVVDEFVSLLDLAPTILDLAGVDVPPK--VDGRSLLP 325
|
410 420 430
....*....|....*....|....*....|....*...
gi 1864524949 398 LLLGT----------AQHSDHEFLmhYCERFLHAARWH 425
Cdd:cd16033 326 LLRGEqpedwrdevvTEYNGHEFY--LPQRMVRTDRYK 361
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
17-478 |
1.72e-39 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 146.15 E-value: 1.72e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 17 QHSW------------TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgyrvlqWTGASGgLPTNE 84
Cdd:cd16037 10 EHNPdamgcyghpvvrTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHETGV----------WDNADP-YDGDV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 85 TTFAKILKEKGYATGLIGKWHLglncESAGDHchhplhHGFDYfygmplsmtgdcahwelsekrvDLEqklnflfqvlal 164
Cdd:cd16037 79 PSWGHALRAAGYETVLIGKLHF----RGEDQR------HGFRY----------------------DRD------------ 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 165 vtltlaagkfmhlisiswmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvtplILQEVKSFLKRN 244
Cdd:cd16037 115 --------------------------------------------------------------------VTEAAVDWLREE 126
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 245 KL--GPFLLLVSFLHVHIPLITTKNFLGKSAHGL---YGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGgslENQ 319
Cdd:cd16037 127 AAddKPWFLFVGFVAPHFPLIAPQEFYDLYVRRAraaYYGLVEFLDENIGRVLDALEELGLLDNTLIIYTSDHG---DML 203
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 320 FANSQYGgwngiykggkGMGGWEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRviDGRDLLPLL 399
Cdd:cd16037 204 GERGLWG----------KSTMYEESVRVPMIISGPGI-PAGKRVKTPVSLVDLAPTILEAAGAPPPPDL--DGRSLLPLA 270
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 400 LGTAQHSDHEFlmhyCErfLHAA---------RWHQrdrgtlWK-VHFVtpvfqpegagacygrkvcpcsgekvvhHDPP 469
Cdd:cd16037 271 EGPDDPDRVVF----SE--YHAHgspsgafmlRKGR------WKyIYYV---------------------------GYPP 311
|
....*....
gi 1864524949 470 LLFDLSRDP 478
Cdd:cd16037 312 QLFDLENDP 320
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
21-482 |
2.94e-39 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 148.45 E-value: 2.94e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssvgyrvlqwTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16031 28 TPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVT----------DNNGPLFDASQPTYPKLLRKAGYQTAF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGlncesaGDHCHHPlhHGFDYFYGMPlsmtgdcahwelsekrvdlEQklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16031 98 IGKWHLG------SGGDLPP--PGFDYWVSFP-------------------GQ--------------------------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavflltTSYFAGALIVhadcflMRNHTITEQPmrfqrVTPLILQEVKSFLKRNKLG-PFLLLVSFLHVH 259
Cdd:cd16031 124 -----------------GSYYDPEFIE------NGKRVGQKGY-----VTDIITDKALDFLKERDKDkPFCLSLSFKAPH 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 260 -----------------IPLITT---KNFLGKS-------------------AHGLYGDNVE-------EMDWMVGQILD 293
Cdd:cd16031 176 rpftpaprhrglyedvtIPEPETfddDDYAGRPewareqrnrirgvldgrfdTPEKYQRYMKdylrtvtGVDDNVGRILD 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 294 ALDTEGLTNSTLIYFASDHGGSL-ENQFA-------NSqyggwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGE 365
Cdd:cd16031 256 YLEEQGLADNTIIIYTSDNGFFLgEHGLFdkrlmyeES---------------------IRVPLIIRDPRLIKAGTVVDA 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 366 PTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLPLLLGTAQHS-DHEFLMHYCE--RFLHAARWH--QRDRgtlWK-VHFvt 439
Cdd:cd16031 315 LVLNIDFAPTILDLAGVPIPED--MQGRSLLPLLEGEKPVDwRKEFYYEYYEepNFHNVPTHEgvRTER---YKyIYY-- 387
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 1864524949 440 pvfqpegagacygrkvcpcsgekvvHHDPPL--LFDLSRDPSEAH 482
Cdd:cd16031 388 -------------------------YGVWDEeeLYDLKKDPLELN 407
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
21-482 |
2.45e-35 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 136.80 E-value: 2.45e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQ-HisAASLCTPSRAAFLTGRYPVRSGMvSSVGYRVLQWTGASGGLPTNETTFAKILKEKGYATG 99
Cdd:cd16025 27 TPNLDALAAEGLRFTNfH--TTALCSPTRAALLTGRNHHQVGM-GTMAELATGKPGYEGYLPDSAATIAEVLKDAGYHTY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 100 LIGKWHLGLN----CESAGDH-----------------------CHHPLH--------------HGFDyfygmplsmtgd 138
Cdd:cd16025 104 MSGKWHLGPDdyysTDDLTDKaieyideqkapdkpfflylafgaPHAPLQapkewidkykgkydAGWD------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 139 cahwELSEKRvdLE-QKlnflfqvlalvtltlAAGkfmhlisiswmpviwsallavfllttsyfagalIVHADCFLM-RN 216
Cdd:cd16025 172 ----ALREER--LErQK---------------ELG---------------------------------LIPADTKLTpRP 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 217 HTI-------TEQPMRFQRvtpliLQEVksflkrnklgpflllvsflhvhiplittknflgksahglYGDNVEEMDWMVG 289
Cdd:cd16025 198 PGVpawdslsPEEKKLEAR-----RMEV---------------------------------------YAAMVEHMDQQIG 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 290 QILDALDTEGLTNSTLIYFASDHGGSLENQFAN------------SQYGGwngiykggkgmggweggIRVPGIFRWP-GV 356
Cdd:cd16025 234 RLIDYLKELGELDNTLIIFLSDNGASAEPGWANasntpfrlykqaSHEGG-----------------IRTPLIVSWPkGI 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 357 LPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRV------IDGRDLLPLLLGTAQHSDHEFLmhYCERFLHAARWHQRdrg 430
Cdd:cd16025 297 KAKGGIRHQFAHVIDIAPTILELAGVEYPKTVNgvpqlpLDGVSLLPTLDGAAAPSRRRTQ--YFELFGNRAIRKGG--- 371
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 1864524949 431 tlWKVhfvtpvfqpegagacygrkvcpcsgekVVHHDPPL------LFDLSRDPSEAH 482
Cdd:cd16025 372 --WKA---------------------------VALHPPPGwgdqweLYDLAKDPSETH 400
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
21-478 |
4.54e-35 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 134.24 E-value: 4.54e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgyrvlqWTGASGgLPTNETTFAKILKEKGYATGL 100
Cdd:cd16032 26 TPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIGA----------YDNAAE-FPADIPTFAHYLRAAGYRTAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLglncesagdhCHHPLHHGFDYfygmplsmtgdcahwelsekrvDLEqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16032 95 SGKMHF----------VGPDQLHGFDY----------------------DEE---------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpVIWSALLAVFllttsyfagalivhaDcfLMRNHTiteqpmrfqrvtplilqevksflKRnklgPFLLLVSFLHVHI 260
Cdd:cd16032 115 ----VAFKAVQKLY---------------D--LARGED-----------------------GR----PFFLTVSFTHPHD 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 261 PLITTKNFLG----KSAHGLYGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSL--------ENQFANSqyggw 328
Cdd:cd16032 147 PYVIPQEYWDlyvrRARRAYYG-MVSYVDDKVGQLLDTLERTGLADDTIVIFTSDHGDMLgerglwykMSFFEGS----- 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 329 ngiykggkgmggweggIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRV-IDGRDLLPLLLGTAQHSD 407
Cdd:cd16032 221 ----------------ARVPLIISAPG-RFAPRRVAEPVSLVDLLPTLVDLAGGGTAPHVPpLDGRSLLPLLEGGDSGGE 283
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1864524949 408 HEFLMHYC-ERFLHAARWHQRDRgtlWKvhFVtpvfqpegagacygrkvcpcsgekVVHHDPPLLFDLSRDP 478
Cdd:cd16032 284 DEVISEYLaEGAVAPCVMIRRGR---WK--FI------------------------YCPGDPDQLFDLEADP 326
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
10-397 |
1.82e-32 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 125.35 E-value: 1.82e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDML---HLQHSWTPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPvrsgmvssvgyrvLQWTGASGGLPTNETT 86
Cdd:cd16148 12 RADHLgcyGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYP-------------FYHGVWGGPLEPDDPT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 87 FAKILKEKGYATGLIGkwhlglncesagDHCHHPLHHGFDyfygmplsmtgdcahwelseKRVDleqklnflfqvlalvt 166
Cdd:cd16148 79 LAEILRKAGYYTAAVS------------SNPHLFGGPGFD--------------------RGFD---------------- 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 167 ltlaagkfmhlisiSWMPVIWsallavfllttsyfagalivhadcflMRNHTITEQPMRFQRVTplilQEVKSFLKRNKL 246
Cdd:cd16148 111 --------------TFEDFRG--------------------------QEGDPGEEGDERAERVT----DRALEWLDRNAD 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 247 G-PFlllvsFLHVHIplittknFlgkSAHGLYG-DN-VEEMDWMVGQILDALDTEGLTNSTLIYFASDHGgslENQFANS 323
Cdd:cd16148 147 DdPF-----FLFLHY-------F---DPHEPYLyDAeVRYVDEQIGRLLDKLKELGLLEDTLVIVTSDHG---EEFGEHG 208
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1864524949 324 QYGGWNgiykggkgMGGWEGGIRVPGIFRWPGVLPAGRvIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLP 397
Cdd:cd16148 209 LYWGHG--------SNLYDEQLHVPLIIRWPGKEPGKR-VDALVSHIDIAPTLLDLLGVEPPDY--SDGRSLLP 271
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-397 |
7.80e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 120.42 E-value: 7.80e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYRVLQWTGASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16149 26 TPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIHDWIVEGSHGKTKKPEGYLEGQTTLPEVLQDAGYRCGL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLGlncesagdhchhplhhgfdyfygmplsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlisi 180
Cdd:cd16149 106 SGKWHLG------------------------------------------------------------------------- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyfagaliVHADCFLMRNHtiteqpmrfqrvtplilqevksflKRNKlgPFLLLVSFLHVHI 260
Cdd:cd16149 113 --------------------------DDAADFLRRRA------------------------EAEK--PFFLSVNYTAPHS 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 261 PlittknflgksaHGlYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGgslenqFANSQYGGW---------NGI 331
Cdd:cd16149 141 P------------WG-YFAAVTGVDRNVGRLLDELEELGLTENTLVIFTSDNG------FNMGHHGIWgkgngtfplNMY 201
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864524949 332 YKGgkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDLLP 397
Cdd:cd16149 202 DNS----------VKVPFIIRWPGVVPAGRVVDSLVSAYDFFPTLLELAGVDPPADPRLPGRSFAD 257
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
10-506 |
3.68e-30 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 123.14 E-value: 3.68e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDML-HLQHSW--TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssvgyrvlqWTGASggLPTNETT 86
Cdd:cd16028 12 RADCLsCLGHPLvkTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSV---------WNGTP--LDARHLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 87 FAKILKEKGYATGLIGKWHLglnceSAGDHCHHPLH----------HGFDY-----FYGMPLSmtgDCAHweLSEKrvdl 151
Cdd:cd16028 81 LALELRKAGYDPALFGYTDT-----SPDPRGLAPLDprllsyelamPGFDPvdrldEYPAEDS---DTAF--LTDR---- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 152 eqklnflfqvlALVTLTLAAGK--FMHLISISWMPviwsallavfllttsyfagALIVHADCFLMRNHTITEQPMRfqRV 229
Cdd:cd16028 147 -----------AIEYLDERQDEpwFLHLSYIRPHP-------------------PFVAPAPYHALYDPADVPPPIR--AE 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 230 TPLILQEVKSFLKRnklgpflllvsflhvHIPLITTKNFLGKSAHGLYGDN-------------VEEMDWMVGQILDALD 296
Cdd:cd16028 195 SLAAEAAQHPLLAA---------------FLERIESLSFSPGAANAADLDDeevaqmratylglIAEVDDHLGRLFDYLK 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 297 TEGLTNSTLIYFASDHGGSLENQFANSQyGGWNGIYKggkgmggweggiRVPGIFRWPGVL---PAGRVIGEPTSLMDVF 373
Cdd:cd16028 260 ETGQWDDTLIVFTSDHGEQLGDHWLWGK-DGFFDQAY------------RVPLIVRDPRREadaTRGQVVDAFTESVDVM 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 374 PTVVQLAGGEVPQDrvIDGRDLLPLLLG-------TAQHSDHEFlmhycerFLHAARWHQRDRGTlwkvhfvtpvfQPEG 446
Cdd:cd16028 327 PTILDWLGGEIPHQ--CDGRSLLPLLAGaqpsdwrDAVHYEYDF-------RDVSTRRPQEALGL-----------SPDE 386
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1864524949 447 AGACYGRkvcpcSGE-KVVHHD--PPLLFDLSRDPSEAHVLtpASEPLFYHVMERVQQAVWEH 506
Cdd:cd16028 387 CSLAVIR-----DERwKYVHFAalPPLLFDLKNDPGELRDL--AADPAYAAVVLRYAQKLLSW 442
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-404 |
2.00e-28 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 116.56 E-value: 2.00e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgYRvlqwtgASGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16152 27 TPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGC-----FR------NGIPLPADEKTLAHYFRDAGYETGY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLglncesAGdhchhplhhgfdYfygmplsmtgdcahwelsekRVDleqklnflfqvlalvTLTLAAGKFMHlisi 180
Cdd:cd16152 96 VGKWHL------AG------------Y--------------------RVD---------------ALTDFAIDYLD---- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 swmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvtplilqevksflKRNKLGPFLLLVSFLHVH- 259
Cdd:cd16152 119 -------------------------------------------------------------NRQKDKPFFLFLSYLEPHh 137
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 260 ---------------------IP--LittKNFLGKSAHGL---YGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG 313
Cdd:cd16152 138 qndrdryvapegsaerfanfwVPpdL---AALPGDWAEELpdyLG-CCERLDENVGRIRDALKELGLYDNTIIVFTSDHG 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 314 gsleNQFA--NSQYggwngiykggkGMGGWEGGIRVPGIFRWPGVLpAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvID 391
Cdd:cd16152 214 ----CHFRtrNAEY-----------KRSCHESSIRVPLVIYGPGFN-GGGRVEELVSLIDLPPTLLDAAGIDVPEE--MQ 275
|
410
....*....|...
gi 1864524949 392 GRDLLPLLLGTAQ 404
Cdd:cd16152 276 GRSLLPLVDGKVE 288
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
10-402 |
1.06e-26 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 113.23 E-value: 1.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDMLHLQ-HSW--TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssvGYrvlqwtgASGGLPTNETT 86
Cdd:PRK13759 18 RGDCLGCNgNKAveTPNLDMLASEGYNFENAYSAVPSCTPARAALLTGLSQWHHGRV---GY-------GDVVPWNYKNT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 87 FAKILKEKGYATGLIGKWHLglncesagdhchHPLH--HGFDYfygmplSMTGDcahWELSEKRVDLEQKLNFLFQVLAL 164
Cdd:PRK13759 88 LPQEFRDAGYYTQCIGKMHV------------FPQRnlLGFHN------VLLHD---GYLHSGRNEDKSQFDFVSDYLAW 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 165 VTLTlAAGKFMHLISISWMPVIWSAllavfllttsyfagalivhadcflmRNHTITEQpmrfQRVTPLILQEVKSFLKR- 243
Cdd:PRK13759 147 LREK-APGKDPDLTDIGWDCNSWVA-------------------------RPWDLEER----LHPTNWVGSESIEFLRRr 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 244 NKLGPFLLLVSFLHVHIPLITTKNFL-------------------------GKSAHGLYGD---------------NVEE 283
Cdd:PRK13759 197 DPTKPFFLKMSFARPHSPYDPPKRYFdmykdadipdphigdweyaedqdpeGGSIDALRGNlgeeyarraraayygLITH 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 284 MDWMVGQILDALDTEGLTNSTLIYFASDHGGSL--ENQFANS-QYGGwngiykggkgmggwegGIRVPGIFRWPG---VL 357
Cdd:PRK13759 277 IDHQIGRFLQALKEFGLLDNTIILFVSDHGDMLgdHYLFRKGyPYEG----------------SAHIPFIIYDPGgllAG 340
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1864524949 358 PAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLPLLLGT 402
Cdd:PRK13759 341 NRGTVIDQVVELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIFGQ 383
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
21-408 |
1.86e-26 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 111.90 E-value: 1.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYrvlqWTGASGglptNETTFAKILKEKGYATGL 100
Cdd:cd16030 27 TPNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVYDNNSY----FRKVAP----DAVTLPQYFKENGYTTAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHlglncesagdhchhplHHGFDYFYGMPLSmtgdcahWELSEKRVDLEQKLNFLFQVLALVTLTLAAGKFMHLISI 180
Cdd:cd16030 99 VGKIF----------------HPGIPDGDDDPAS-------WDEPPNPPGPEKYPPGKLCPGKKGGKGGGGGPAWEAADV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 181 --SWMPVIWSALLAVFLLTT------SYFAGA--------LIVHADCFLMRNHTITEQPMRFQRV-TPLI----LQEVks 239
Cdd:cd16030 156 pdEAYPDGKVADEAIEQLRKlkdsdkPFFLAVgfykphlpFVAPKKYFDLYPLESIPLPNPFDPIdLPEVawndLDDL-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 240 flkRNKLGPFLLLVSFLHVHIPLITTKNFLgksaHGLYGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSL-EN 318
Cdd:cd16030 234 ---PKYGDIPALNPGDPKGPLPDEQARELR----QAYYA-SVSYVDAQVGRVLDALEELGLADNTIVVLWSDHGWHLgEH 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 319 Q----FANsqyggWNGIykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGgeVPQDRVIDGRD 394
Cdd:cd16030 306 GhwgkHTL-----FEEA-------------TRVPLIIRAPGVTKPGKVTDALVELVDIYPTLAELAG--LPAPPCLEGKS 365
|
410
....*....|....
gi 1864524949 395 LLPLLLGTAQHSDH 408
Cdd:cd16030 366 LVPLLKNPSAKWKD 379
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
10-514 |
1.46e-24 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 106.16 E-value: 1.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDMLH---LQHSWTPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYP-VRsgmvssvGYRVLQWTgasggLPTNET 85
Cdd:cd16150 12 RADSLGhlgNPAAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPhVN-------GHRTLHHL-----LRPDEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 86 TFAKILKEKGYATGLIGKWHLGLNCESAGDHChhplhhgfdyfygmplsmTGDcahWELSEKRVD-LEQKLN----FLFq 160
Cdd:cd16150 80 NLLKTLKDAGYHVAWAGKNDDLPGEFAAEAYC------------------DSD---EACVRTAIDwLRNRRPdkpfCLY- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 161 vlalVTLTL------AAGKFMHLISISWMPVIWSALLavfllTTSYFAGALIvhadcfLMRNHtiteqpmRFQRVTPLIL 234
Cdd:cd16150 138 ----LPLIFphppygVEEPWFSMIDREKLPPRRPPGL-----RAKGKPSMLE------GIEKQ-------GLDRWSEERW 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 235 QEVKsflkrnklgpflllvsflhvhiplittKNFLGKsahglygdnVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG- 313
Cdd:cd16150 196 RELR---------------------------ATYLGM---------VSRLDHQFGRLLEALKETGLYDDTAVFFFSDHGd 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 314 -----GSLE---NQFANSQyggwngiykggkgmggweggIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVQLAGgeVP 385
Cdd:cd16150 240 ytgdyGLVEkwpNTFEDCL--------------------TRVPLIIKPPG-GPAGGVSDALVELVDIPPTLLDLAG--IP 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 386 QDRVIDGRDLLPLLLG-TAQHSDHEFlmhyCE-RFLHAARWHQRDRGTlwKVHFVTPVFQPEGAGACYGRKVCPCSGE-K 462
Cdd:cd16150 297 LSHTHFGRSLLPVLAGeTEEHRDAVF----SEgGRLHGEEQAMEGGHG--PYDLKWPRLLQQEEPPEHTKAVMIRTRRyK 370
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1864524949 463 VV--HHDPPLLFDLSRDPSEAHVLtpASEPLFYHVMERVQQAVWEHQQTLSPVA 514
Cdd:cd16150 371 YVyrLYEPDELYDLEADPLELHNL--IGDPAYAEIIAEMKQRLLRWMVETSDVV 422
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
16-395 |
1.18e-23 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 100.91 E-value: 1.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 16 LQHSWTPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYrvlqWTGASGGLPTnettFAKILKEKG 95
Cdd:cd16153 32 LGYVESPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVYGFEAA----HPALDHGLPT----FPEVLKKAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 96 YATGLIGKWHLglncesagdhchhplhhgfdyfygmplsmtgdcahwelsekrvdlEQKLNFLFQvlALVTLTLAAGKfm 175
Cdd:cd16153 104 YQTASFGKSHL---------------------------------------------EAFQRYLKN--ANQSYKSFWGK-- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 176 hlisISWMPviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvtplilqevksflKRNKlgPFLLLVSF 255
Cdd:cd16153 135 ----IAKGA---------------------------------------------------------DSDK--PFFVRLSF 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 256 LHVHIPLITTKNFLGKSA-HGL--YGDNveemdwMVGQILDALDTEGLTN---STLIYFASDHGGSLENQFANSQYGGWN 329
Cdd:cd16153 152 LQPHTPVLPPKEFRDRFDyYAFcaYGDA------QVGRAVEAFKAYSLKQdrdYTIVYVTGDHGWHLGEQGILAKFTFWP 225
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1864524949 330 GIykggkgmggweggIRVPGIFRWPGVL--PAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVIDGRDL 395
Cdd:cd16153 226 QS-------------HRVPLIVVSSDKLkaPAGKVRHDFVEFVDLAPTLLAAAGVDVDAPDYLDGRDL 280
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
22-414 |
5.05e-23 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 99.59 E-value: 5.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 22 PNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSVGYRVlQWTgasggLPTNETTFAKILKEKGYATGLI 101
Cdd:cd16035 27 PARERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLGSPM-QPL-----LSPDVPTLGHMLRAAGYYTAYK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 102 GKWHLGlncesagdhchhplhhgfdyfygmplSMTGDCAHwelsekrvdleqklnflfqvlalvtltlaagkfmhlisis 181
Cdd:cd16035 101 GKWHLS--------------------------GAAGGGYK---------------------------------------- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 182 wmpviwsallavfllttsyfagalivhadcflmRNHTITEQPMRFqrvtpliLQEVKSflKRNKLGPFLLLVSFL--H-V 258
Cdd:cd16035 115 ---------------------------------RDPGIAAQAVEW-------LRERGA--KNADGKPWFLVVSLVnpHdI 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLITTKNFlgKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG---GS--LENQFANSqYGgwngiyk 333
Cdd:cd16035 153 MFPPDDEERW--RRFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHGemgGAhgLRGKGFNA-YE------- 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 334 ggkgmggweGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDRVID----GRDLLPLLLGTAQHSDHE 409
Cdd:cd16035 223 ---------EALHVPLIISHPDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARATEApplpGRDLSPLLTDADADAVRD 293
|
....*.
gi 1864524949 410 -FLMHY 414
Cdd:cd16035 294 gILFTY 299
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
21-399 |
2.03e-22 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 100.15 E-value: 2.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssvgyrvlqWTGaSGGLPTNETTFAKILKEKGYATGL 100
Cdd:cd16156 26 TPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGS----------WTN-CMALGDNVKTIGQRLSDNGIHTAY 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 101 IGKWHLglnceSAGDH-----ChhPLHHGFDYFYGMplsmtgDCAHWELSEKRVdleqklnflfqvlalvtltlaagkfm 175
Cdd:cd16156 95 IGKWHL-----DGGDYfgngiC--PQGWDPDYWYDM------RNYLDELTEEER-------------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 176 hlisiswmpVIWSALLAVfllttsyfagalivhadcflMRNHTITEQPMRFQRVTPLILQevksFLKRNKLGPFLLLVSF 255
Cdd:cd16156 136 ---------RKSRRGLTS--------------------LEAEGIKEEFTYGHRCTNRALD----FIEKHKDEDFFLVVSY 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 256 LHVHIPLITTKNF----------LGKSAHglygDNVEE---------------------------------MDWMVGQIL 292
Cdd:cd16156 183 DEPHHPFLCPKPYasmykdfefpKGENAY----DDLENkplhqrlwagakphedgdkgtikhplyfgcnsfVDYEIGRVL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 293 DALDtEGLTNSTLIYfASDHGgslENQFANSQYGgwngiykggKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDV 372
Cdd:cd16156 259 DAAD-EIAEDAWVIY-TSDHG---DMLGAHKLWA---------KGPAVYDEITNIPLIIRGKGGEKAGTVTDTPVSHIDL 324
|
410 420
....*....|....*....|....*..
gi 1864524949 373 FPTVVQLAGgeVPQDRVIDGRDLLPLL 399
Cdd:cd16156 325 APTILDYAG--IPQPKVLEGESILATI 349
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
26-393 |
3.20e-22 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 98.78 E-value: 3.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 26 RLAEFGVKLTQHISAASLCTPSRAAFLTGRYP----VRSGMVSSVGYRVLQWTGAsgglptNETTFAKILKEKGYATGLI 101
Cdd:cd16147 28 LLADQGTTFTNAFVTTPLCCPSRASILTGQYAhnhgVTNNSPPGGGYPKFWQNGL------ERSTLPVWLQEAGYRTAYA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 102 GKWhlgLN-CESAGDHCHHPLhhGFDYFYGMP---------LSMTGDCAHWELSEKR--VDL--EQKLNFLfqvlalvTL 167
Cdd:cd16147 102 GKY---LNgYGVPGGVSYVPP--GWDEWDGLVgnstyynytLSNGGNGKHGVSYPGDylTDViaNKALDFL-------RR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 168 TLAAGKfmhlisiswmPviwsallavFLLTTSYFAgaliVHAdcflmrNHTITEQPMR-FQRVTPL--------ILQEVK 238
Cdd:cd16147 170 AAADDK----------P---------FFLVVAPPA----PHG------PFTPAPRYANlFPNVTAPprpppnnpDVSDKP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 239 SFLKRNKlgpflllvsflhvhiplittknflgksahGLYGDNVEEMDW--------------MVGQILDALDTEGLTNST 304
Cdd:cd16147 221 HWLRRLP-----------------------------PLNPTQIAYIDElyrkrlrtlqsvddLVERLVNTLEATGQLDNT 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 305 LIYFASDHG---GSLENQFANSQ-YggwngiykggkgmggwEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVQLA 380
Cdd:cd16147 272 YIIYTSDNGyhlGQHRLPPGKRTpY----------------EEDIRVPLLVRGPGI-PAGVTVDQLVSNIDLAPTILDLA 334
|
410
....*....|...
gi 1864524949 381 GGEVPQDrvIDGR 393
Cdd:cd16147 335 GAPPPSD--MDGR 345
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-490 |
1.34e-20 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 93.78 E-value: 1.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQ-HI----SAAsLCTPSRAAFLTGRYPVRSGMvssvgyrvlqwtGASGGLPTNETTFAKILKEKG 95
Cdd:cd16155 28 TPNLDRLARRGTSFTNaYNmggwSGA-VCVPSRAMLMTGRTLFHAPE------------GGKAAIPSDDKTWPETFKKAG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 96 YATGLIGKWHLGLnCESAGDHCHHP--------LHHGF----DyfygmPLSMTGdcahwELSEK--RVDLEQKLNFLFQv 161
Cdd:cd16155 95 YRTFATGKWHNGF-ADAAIEFLEEYkdgdkpffMYVAFtaphD-----PRQAPP-----EYLDMypPETIPLPENFLPQ- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 162 lalvtltlaagkfmHlisiswmPviwsallavfllttsyFAGALIVHADcflmrnhtitEQPMRFQRvTPlilQEVKSFL 241
Cdd:cd16155 163 --------------H-------P----------------FDNGEGTVRD----------EQLAPFPR-TP---EAVRQHL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 242 KRNklgpflllvsflhvhiplittknflgksahglYGdNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSL----- 316
Cdd:cd16155 192 AEY--------------------------------YA-MITHLDAQIGRILDALEASGELDNTIIVFTSDHGLAVgshgl 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 317 ---ENQFANSqyggwngiykggkgmggweggIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGR 393
Cdd:cd16155 239 mgkQNLYEHS---------------------MRVPLIISGPGI-PKGKRRDALVYLQDVFPTLCELAGIEIPES--VEGK 294
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 394 DLLPLLLGTAQhsdheflMHYCERFLHAARWHQRDRGTLWKVHFVTPvfqpegagacygrkvcpcsGEKVVhhdppLLFD 473
Cdd:cd16155 295 SLLPVIRGEKK-------AVRDTLYGAYRDGQRAIRDDRWKLIIYVP-------------------GVKRT-----QLFD 343
|
490
....*....|....*..
gi 1864524949 474 LSRDPSEAHVLtpASEP 490
Cdd:cd16155 344 LKKDPDELNNL--ADEP 358
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
21-380 |
2.36e-19 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 87.48 E-value: 2.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKL-TQHISAASLCTPSRAAFLTGRYPVRSGMVSSvGYRVLQWTGASGGLPTNETTFAKILKEKGYATG 99
Cdd:cd00016 26 TPNLKRLASEGATFnFRSVSPPTSSAPNHAALLTGAYPTLHGYTGN-GSADPELPSRAAGKDEDGPTIPELLKQAGYRTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 100 LIGkwhlglncesagdhchhplhhgfdyfygmplsmtgdcahwelsekrvdleqklnflfqvlalvtltlaagkfmhlis 179
Cdd:cd00016 105 VIG----------------------------------------------------------------------------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 180 iswmpviwsallavfllttsyfagalivhadcflmrnhtiteqpmrfqrvtplilqeVKSFLKRNKLG-PFLLLVSFLHV 258
Cdd:cd00016 108 ---------------------------------------------------------LLKAIDETSKEkPFVLFLHFDGP 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 259 HIPLittknFLGKSAHGLYGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLEnqfansqygGWNGIYKGGKGM 338
Cdd:cd00016 131 DGPG-----HAYGPNTPEYYDAVEEIDERIGKVLDALKKAGDADDTVIIVTADHGGIDK---------GHGGDPKADGKA 196
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1864524949 339 GGWEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVQLA 380
Cdd:cd00016 197 DKSHTGMRVPFIAYGPGV-KKGGVKHELISQYDIAPTLADLL 237
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
21-406 |
6.52e-18 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 85.48 E-value: 6.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTqHISAASLCTPSRAAFLTGRYPVRSGmVSSVGYRVLQwtgasgglpTNETTFAKILKE---KGYA 97
Cdd:cd16154 28 TPTLDSLANSGIVFD-NLWATPACSPTRATILTGKYGFRTG-VLAVPDELLL---------SEETLLQLLIKDattAGYS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 98 TGLIGKWHLGlncesaGDHCHHPLHHGFDYFYGMPLSMTGDCAHWELSEKRVDLEQKlnflfqvlalvtlTLAAGKFMHL 177
Cdd:cd16154 97 SAVIGKWHLG------GNDNSPNNPGGIPYYAGILGGGVQDYYNWNLTNNGQTTNST-------------EYATTKLTNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 178 iSISWM-----PviWSALLAvfllttsYFAgalivhadcflmrNHTiteqpmrfqrvtplilqevksflkrnklgPFLLL 252
Cdd:cd16154 158 -AIDWIdqqtkP--WFLWLA-------YNA-------------PHT-----------------------------PFHLP 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 253 VSFLHvhiplitTKNFLGKSAHglYGDN--------VEEMDWMVGQILDALDTEGLTNsTLIYFASDHG--------GSL 316
Cdd:cd16154 186 PAELH-------SRSLLGDSAD--IEANprpyylaaIEAMDTEIGRLLASIDEEEREN-TIIIFIGDNGtpgqvvdlPYT 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 317 ENQFANSQY-GGwngiykggkgmggweggIRVPGIFRWPGVlpaGRVIGEPTSLM---DVFPTVVQLAGGEVPQdrVIDG 392
Cdd:cd16154 256 RNHAKGSLYeGG-----------------INVPLIVSGAGV---ERANERESALVnatDLYATIAELAGVDAAE--IHDS 313
|
410
....*....|....
gi 1864524949 393 RDLLPLLLGTAQHS 406
Cdd:cd16154 314 VSFKPLLSDVNAST 327
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
248-479 |
3.16e-14 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 74.11 E-value: 3.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 248 PFLLlvsFLHVHIPLITTKNFLGKSAHGL------YGDNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHGG-SLEN-Q 319
Cdd:cd16171 166 PFAL---YLGLNLPHPYPSPSMGENFGSIrnirafYYAMCAETDAMLGEIISALKDTGLLDKTYVFFTSDHGElAMEHrQ 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 320 FAN-SQYGGwngiykggkgmggwegGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVQLAGGEVPQDrvIDGRDLLPL 398
Cdd:cd16171 243 FYKmSMYEG----------------SSHVPLLIMGPGI-KAGQQVSDVVSLVDIYPTMLDIAGVPQPQN--LSGYSLLPL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 399 LLGTAQHSDH-----------EFlmHYCErfLHAARWHQRDrgTLWKvhFVTpvfqpegagacYGrkvcpcSGEKVvhhd 467
Cdd:cd16171 304 LSESSIKESPsrvphpdwvlsEF--HGCN--VNASTYMLRT--NSWK--YIA-----------YA------DGNSV---- 354
|
250
....*....|..
gi 1864524949 468 PPLLFDLSRDPS 479
Cdd:cd16171 355 PPQLFDLSKDPD 366
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
21-381 |
1.42e-09 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 59.23 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 21 TPNIDRLAEFGVKLTQHISAASLCTPSRA--AFLTGRYPVRSGMVSSVGYRvlqwtgasgglPTNETTFAKILKEKGYAT 98
Cdd:cd16015 26 TPNLNKLAKEGLYFGNFYSPGFGGGTANGefEVLTGLPPLPLGSGSYTLYK-----------LNPLPSLPSILKEQGYET 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 99 GLIgkwhlglncesagdHCHHP---------LHHGFDYFYG---MPLSMTGDcAHWELSEKrvdleqklnFLFQVLALVT 166
Cdd:cd16015 95 IFI--------------HGGDAsfynrdsvyPNLGFDEFYDledFPDDEKET-NGWGVSDE---------SLFDQALEEL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 167 LTLAAGKFMhlisiswmpviwsallaVFLLTTSyfagalivhadcflmrNHtiteqpmrfqrvtplilqevksflkrnkl 246
Cdd:cd16015 151 EELKKKPFF-----------------IFLVTMS----------------NH----------------------------- 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 247 GPFLLLVSFLHVHIPLITTKNFLGKSAHGLYgdnveEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFANSQYG 326
Cdd:cd16015 169 GPYDLPEEKKDEPLKVEEDKTELENYLNAIH-----YTDKALGEFIEKLKKSGLYENTIIVIYGDHLPSLGSDYDETDED 243
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864524949 327 GWNGIykggkgmggweggiRVPGIFRWPGVLPaGRVIGEPTSLMDVFPTVVQLAG 381
Cdd:cd16015 244 PLDLY--------------RTPLLIYSPGLKK-PKKIDRVGSQIDIAPTLLDLLG 283
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
281-396 |
1.74e-07 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 53.89 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 281 VEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSLENQFANSQYggwngiykggkgmggwEGGIRVPGIFRWPGvLPAG 360
Cdd:COG1368 423 VRYADQALGEFIEKLKKSGWYDNTIFVIYGDHGPRSPGKTDYENP----------------LERYRVPLLIYSPG-LKKP 485
|
90 100 110
....*....|....*....|....*....|....*.
gi 1864524949 361 RVIGEPTSLMDVFPTVVQLAGGEVPQDRVIdGRDLL 396
Cdd:COG1368 486 KVIDTVGSQIDIAPTLLDLLGIDYPSYYAF-GRDLL 520
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
281-378 |
2.17e-06 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 50.29 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 281 VEEMDWMVGQILDALDTEGLTNSTLIYFASDHGGSL-ENQ----FANSQYGGWNgiykggkgmggweggIRVPGIFRWPG 355
Cdd:COG3083 433 VHYVDSQIGRVLDTLEQRGLLENTIVIITADHGEEFnENGqnywGHNSNFSRYQ---------------LQVPLVIHWPG 497
|
90 100
....*....|....*....|...
gi 1864524949 356 VLPagRVIGEPTSLMDVFPTVVQ 378
Cdd:COG3083 498 TPP--QVISKLTSHLDIVPTLMQ 518
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
10-151 |
2.46e-05 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 46.66 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864524949 10 RGDMLHLQHswTPNIDRLAEFGVKLTQHISAA-SLCTPSRAAFLTGRYPVRSGMVSSVGYR--------VLQWTGASGGL 80
Cdd:COG1524 35 RADLLERAH--APNLAALAARGVYARPLTSVFpSTTAPAHTTLLTGLYPGEHGIVGNGWYDpelgrvvnSLSWVEDGFGS 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1864524949 81 PT--NETTFAKILKEKGYATGLIGKWHLGlncESAGDHCHHPLHH-GFDYFYGMPLS--MTGDCAHWELSEKRVDL 151
Cdd:COG1524 113 NSllPVPTIFERARAAGLTTAAVFWPSFE---GSGLIDAARPYPYdGRKPLLGNPAAdrWIAAAALELLREGRPDL 185
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
279-313 |
6.43e-03 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 38.94 E-value: 6.43e-03
10 20 30
....*....|....*....|....*....|....*
gi 1864524949 279 DNVEEMDWMVGQILDALDTEGLTNSTLIYFASDHG 313
Cdd:pfam01663 189 DALRRVDRAIGDLLEALDERGLFEDTNVIVVSDHG 223
|
|
| |
