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Conserved domains on  [gi|1880321585|gb|QLY71948|]
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CRB1-B [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 141-276 2.42e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.25  E-value: 2.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  141 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 218
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1880321585  219 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 276
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 370-487 2.32e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  370 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 445
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1880321585  446 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 487
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 607-732 1.55e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 73.99  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  607 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 685
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1880321585  686 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 732
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
EGF_CA smart00179
Calcium-binding EGF-like domain;
24-65 5.72e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 5.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1880321585    24 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 65
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 924-960 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  924 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 960
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 303-334 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.35e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1880321585  303 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 334
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-839 2.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  804 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 839
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  768 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 802
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 841-876 2.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1880321585  841 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 876
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 516-550 3.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  516 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 550
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 73-108 3.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585   73 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 108
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 141-276 2.42e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.25  E-value: 2.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  141 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 218
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1880321585  219 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 276
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 370-487 2.32e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  370 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 445
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1880321585  446 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 487
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 112-276 1.55e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.55e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  112 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 189
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  190 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 268
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1880321585  269 CLQDIRFD 276
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 607-732 1.55e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 73.99  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  607 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 685
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1880321585  686 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 732
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 347-485 3.63e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  347 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 422
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1880321585  423 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 485
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 579-729 4.95e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 4.95e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  579 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 656
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  657 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 729
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
602-731 1.36e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 1.36e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   602 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 679
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1880321585   680 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 731
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
136-276 4.73e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 64.28  E-value: 4.73e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   136 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 212
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1880321585   213 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 276
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
365-487 4.30e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 4.30e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   365 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 437
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1880321585   438 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 487
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
24-65 5.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 5.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1880321585    24 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 65
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 924-960 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  924 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 960
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 24-51 5.17e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 5.17e-06
                           10        20
                   ....*....|....*....|....*....
gi 1880321585   24 DVDECLL-HPCLNGGTCENLPGNYACHCP 51
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 303-334 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.35e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1880321585  303 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 334
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-839 2.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  804 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 839
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  768 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 802
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 303-333 2.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 2.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1880321585  303 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 333
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
924-960 4.01e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.01e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1880321585   924 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 960
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 841-876 2.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1880321585  841 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 876
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 516-550 3.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  516 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 550
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 518-547 4.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.58e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1880321585  518 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 547
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 928-958 6.15e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 6.15e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1880321585  928 CASDPCINGGLCRDLVNRFLCICDVAFAGER 958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 28-51 8.85e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 8.85e-04
                           10        20
                   ....*....|....*....|....
gi 1880321585   28 CLLHPCLNGGTCENLPGNYACHCP 51
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
804-839 9.79e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.79e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1880321585   804 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 839
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
773-802 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1880321585   773 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 802
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 770-798 1.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*....
gi 1880321585  770 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 798
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
303-334 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1880321585   303 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 334
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 808-882 2.75e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.24  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  808 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 879
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1880321585  880 RLP 882
Cdd:PHA03099   130 KLP 132
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 73-108 3.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585   73 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 108
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 141-276 2.42e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.25  E-value: 2.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  141 FHTVQPNALLLIRGN-KDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLALvggsckEKC 218
Cdd:pfam02210    1 FRTRQPNGLLLYAGGgGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERnGNTLTLSV------DGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1880321585  219 TTKSSVPVENHQSICALQDSFLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 276
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLP--------PLLLLPALPVRAGFVGCIRDVRVN 124
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 370-487 2.32e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 82.08  E-value: 2.32e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  370 VRTRQPLGLLLALENSTYQYVSVWLEHGSLALQTPGSPKFMVNFF----LSDGNVHLISLRIKPNEIELYQSSQNLGFIS 445
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSsgknLNDGQWHSVRVERNGNTLTLSVDGQTVVSSL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1880321585  446 VPTW--TIRRGDVIFIGGLP--DREKTEVYGGFFKGCVQDVRLNSQ 487
Cdd:pfam02210   81 PPGEslLLNLNGPLYLGGLPplLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 112-276 1.55e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 1.55e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  112 TLSFGSNGFLWVTSGSHTGigPECNISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVwNQLKVLLSISHNT 189
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPR--TRLSISFSFRTTSPNGLLLYAGSQNGGdfLALELEDGRLVLRYDL-GSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  190 SDGEWHFVEVTI-AETLTLALVGGSCKEKCTTKSSVPVENHQSIcalqdsFLGGLPMGTANNSVsvlniynvPSTPSFVG 268
Cdd:cd00110     78 NDGQWHSVSVERnGRSVTLSVDGERVVESGSPGGSALLNLDGPL------YLGGLPEDLKSPGL--------PVSPGFVG 143


                   ....*...
gi 1880321585  269 CLQDIRFD 276
Cdd:cd00110    144 CIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 607-732 1.55e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 73.99  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  607 FRTHDTNVMILHAE-KEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLvNDGTWHQVTFSMidpvaQTSRWQMEVNDQ 685
Cdd:pfam02210    1 FRTRQPNGLLLYAGgGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNL-NDGQWHSVRVER-----NGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1880321585  686 TpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGGI 732
Cdd:pfam02210   75 T--VVSSLPPGESLLLNLNGPLYLGglpplllLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 347-485 3.63e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.91  E-value: 3.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  347 DSTGYAAFSVNDNYGQNFSLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ---TPGSPKFMVNFFLSDGNVHL 422
Cdd:cd00110      5 SGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgDFLALELEDGRLVLRydlGSGSLVLSSKTPLNDGQWHS 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1880321585  423 ISLRIKPNEIEL-------YQSSQNLGFISVPTwtirrGDVIFIGGLPDREKT--EVYGGFFKGCVQDVRLN 485
Cdd:cd00110     85 VSVERNGRSVTLsvdgervVESGSPGGSALLNL-----DGPLYLGGLPEDLKSpgLPVSPGFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 579-729 4.95e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 4.95e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  579 AVFSGLSReILFRSNGNITRElTNITFAFRTHDTNVMILHAEKEP--EFLNISIQDARLFFQLRSGNSfyTLHLMGSQLV 656
Cdd:cd00110      2 VSFSGSSY-VRLPTLPAPRTR-LSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGRLVLRYDLGSG--SLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  657 NDGTWHQVTFSMIDPVAqtsrwQMEVNDQTpfVISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEI 729
Cdd:cd00110     78 NDGQWHSVSVERNGRSV-----TLSVDGER--VVESGSPGGSALLNLDGPLYLGglpedlkSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
602-731 1.36e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 65.82  E-value: 1.36e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   602 NITFAFRTHDTNVMILHA--EKEPEFLNISIQDARLFFQLRSGNSFYTLHLmGSQLVNDGTWHQVTFSMIDPVAqtsrwQ 679
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgsKGGGDYLALELRDGRLVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSV-----T 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1880321585   680 MEVNDQTPfvISEVATGSLNFLKDNTDIYVG-------DQSVDNPKGLQGCLSTIEIGG 731
Cdd:smart00282   75 LSVDGGNR--VSGESPGGLTILNLDGPLYLGglpedlkLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
136-276 4.73e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 64.28  E-value: 4.73e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   136 NISLRFHTVQPNALLLIRGNKDVS--MKLELLNGCVHLSIEVWNQLKVLLSISHNTSDGEWHFVEVTI-AETLTLalvgg 212
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGdyLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERnGRSVTL----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1880321585   213 sckekcttksSVPVENHQSICALQDS---------FLGGLPmgtannsvSVLNIYNVPSTPSFVGCLQDIRFD 276
Cdd:smart00282   76 ----------SVDGGNRVSGESPGGLtilnldgplYLGGLP--------EDLKLPPLPVTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
365-487 4.30e-10

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 58.50  E-value: 4.30e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585   365 SLSMFVRTRQPLGLLLALENSTY-QYVSVWLEHGSLALQ--TPGSPKFMVNFF--LSDGNVHLISLRIKPNEIELY--QS 437
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRydLGSGPARLTSDPtpLNDGQWHRVAVERNGRSVTLSvdGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1880321585   438 SQNLGFISVPTWTIRRGDVIFIGGLPD--REKTEVYGGFFKGCVQDVRLNSQ 487
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEdlKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
607-731 1.65e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  607 FRTHDTNVMILHAEK--EPEFLNISIQDARLFFQLRSGNSfyTLHLMGSQLVNDGTWHQVTFSMIdpvaqTSRWQMEVND 684
Cdd:pfam00054    1 FRTTEPSGLLLYNGTqtERDFLALELRDGRLEVSYDLGSG--AAVVRSGDKLNDGKWHSVELERN-----GRSGTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1880321585  685 QTPFVISEVaTGSLNFLKDNTDIYVG---DQSVDNP-----KGLQGCLSTIEIGG 731
Cdd:pfam00054   74 EARPTGESP-LGATTDLDVDGPLYVGglpSLGVKKRrlaisPSFDGCIRDVIVNG 127
EGF_CA smart00179
Calcium-binding EGF-like domain;
24-65 5.72e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 5.72e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1880321585    24 DVDECLL-HPCLNGGTCENLPGNYACHCPfddtsRTFYGGENC 65
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECP-----PGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 924-960 1.45e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  924 DINECAS-DPCINGGLCRDLVNRFLCICDVAFAGERCE 960
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
141-276 3.14e-06

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 3.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  141 FHTVQPNALLLIRG--NKDVSMKLELLNGCVHLSIEVWNQlKVLLSISHNTSDGEWHFVEVTIAET-LTLALVGGSckek 217
Cdd:pfam00054    1 FRTTEPSGLLLYNGtqTERDFLALELRDGRLEVSYDLGSG-AAVVRSGDKLNDGKWHSVELERNGRsGTLSVDGEA---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1880321585  218 cTTKSSVPVENHQSICALQDSFLGGLPmgtannSVSVLNiYNVPSTPSFVGCLQDIRFD 276
Cdd:pfam00054   76 -RPTGESPLGATTDLDVDGPLYVGGLP------SLGVKK-RRLAISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 24-51 5.17e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 5.17e-06
                           10        20
                   ....*....|....*....|....*....
gi 1880321585   24 DVDECLL-HPCLNGGTCENLPGNYACHCP 51
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCP 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 303-334 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.35e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1880321585  303 CESQ-PCQNRGRCINLWQGYQCECDRPYTGSNC 334
Cdd:cd00054      5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-839 2.13e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1880321585  804 NIDECFS-SPC-IHGNCSDGVAAYHCRCEPGYTGVNCE 839
Cdd:cd00054      1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 768-802 2.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  768 NACHS-SPCLHGGNCEDSYSSYRCACLSGWSGTHCE 802
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 303-333 2.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 2.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1880321585  303 CESQPCQNRGRCINLWQGYQCECDRPYTGSN 333
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
924-960 4.01e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 4.01e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1880321585   924 DINECAS-DPCINGGLCRDLVNRFLCICDVAF-AGERCE 960
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 841-876 2.76e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1880321585  841 DVDNCKS-HQCANGATCVPEAHGYSCLCFGNFTGRFC 876
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 516-550 3.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585  516 NTCKS-NPCHNGGVCHSLWDDFSCSCPTNTAGRACE 550
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 518-547 4.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 4.58e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1880321585  518 CKSNPCHNGGVCHSLWDDFSCSCPTNTAGR 547
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 928-958 6.15e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 6.15e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1880321585  928 CASDPCINGGLCRDLVNRFLCICDVAFAGER 958
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 28-51 8.85e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 8.85e-04
                           10        20
                   ....*....|....*....|....
gi 1880321585   28 CLLHPCLNGGTCENLPGNYACHCP 51
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP 24
EGF_CA smart00179
Calcium-binding EGF-like domain;
804-839 9.79e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 9.79e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1880321585   804 NIDECFS-SPCIHG-NCSDGVAAYHCRCEPGYT-GVNCE 839
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
773-802 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1880321585   773 SPCLHGGNCEDSYSSYRCACLSGWS-GTHCE 802
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 770-798 1.66e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|....*....
gi 1880321585  770 CHSSPCLHGGNCEDSYSSYRCACLSGWSG 798
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
Laminin_G_1 pfam00054
Laminin G domain;
370-490 2.17e-03

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  370 VRTRQPLGLLLALENSTY-QYVSVWLEHGSL----------ALQTPGSPkfmvnffLSDGNVHLI---------SLRIKP 429
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErDFLALELRDGRLevsydlgsgaAVVRSGDK-------LNDGKWHSVelerngrsgTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1880321585  430 NEIELYQS-SQNLGFISVPTwtirrgdVIFIGGLPDREKTE---VYGGFFKGCVQDVRLNSQTLE 490
Cdd:pfam00054   74 EARPTGESpLGATTDLDVDG-------PLYVGGLPSLGVKKrrlAISPSFDGCIRDVIVNGKPLD 131
EGF_CA smart00179
Calcium-binding EGF-like domain;
303-334 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1880321585   303 CES-QPCQNRGRCINLWQGYQCECDRPYT-GSNC 334
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 808-882 2.75e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 39.24  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1880321585  808 CFSSPCIHGNCSDGVaayHCRCEPGYTGVNCE--VDVDNCKSHQCANGATCVPEAH------GYSCLCFGNFTGRFCRHS 879
Cdd:PHA03099    53 CLHGDCIHARDIDGM---YCRCSHGYTGIRCQhvVLVDYQRSEKPNTTTSYIPSPGivlvlvGIIITCCLLSVYRFTRRT 129


                   ...
gi 1880321585  880 RLP 882
Cdd:PHA03099   130 KLP 132
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 772-802 2.98e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 2.98e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1880321585  772 SSPCLHGGNCEDSYSSYRCACLSGWSG-THCE 802
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 73-108 3.86e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1880321585   73 THHQCLNNGKCIphfqNGQHGFTCQCLSGYAGPLCE 108
Cdd:cd00054      7 SGNPCQNGGTCV----NTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 304-333 6.12e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 6.12e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1880321585  304 ESQPCQNRGRCINLWQGYQCECDRPYTGSN 333
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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