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Conserved domains on  [gi|1907123087|ref|XP_036016306|]
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protein phosphatase 1B isoform X2 [Mus musculus]

Protein Classification

serine/threonine-protein phosphatase( domain architecture ID 10065643)

serine/threonine-protein phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates; contains a C-terminal PP2C domain that does not seem to play a role in catalysis, but may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-295 2.40e-97

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


:

Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 290.38  E-value: 2.40e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  23 RYGLSSMQGWRVEMEDAHtaVVGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRaadksgsaLEPSVESV 102
Cdd:cd00143     2 SAGVSDKGGDRKTNEDAV--VIKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEET--------LTLSEEDI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 103 KTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNPVEKERIQN 182
Cdd:cd00143    72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCRNGEAVQLTKDHKPVNEEERERIEK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 183 AGGSVMIQRVNGSLAVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEFVKSRL 262
Cdd:cd00143   152 AGGRVSNGRVPGVLAVTRALGDFDLK---------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSEL 222
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907123087 263 EvSDDLENVCNWVVDTCLHKGSRDNMSVVLVCF 295
Cdd:cd00143   223 A-KEDLQEAAQELVDLALRRGSHDNITVVVVRL 254
PP2C_C pfam07830
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
289-368 1.48e-41

Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.


:

Pssm-ID: 429684  Cd Length: 79  Bit Score: 140.72  E-value: 1.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 289 SVVLVCFSNAPKVSEEAVKRDSELDKHLESRVEEIMQKSgEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRHVIEAVYS 368
Cdd:pfam07830   1 SIVLVCFPGAPKVSEEAVKKEAELDKKLEKRVKEIIEQS-DGEEPDLLYVLRVLASEDIPGLPPGGGLASKRSVIEAVYK 79
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-295 2.40e-97

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 290.38  E-value: 2.40e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  23 RYGLSSMQGWRVEMEDAHtaVVGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRaadksgsaLEPSVESV 102
Cdd:cd00143     2 SAGVSDKGGDRKTNEDAV--VIKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEET--------LTLSEEDI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 103 KTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNPVEKERIQN 182
Cdd:cd00143    72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCRNGEAVQLTKDHKPVNEEERERIEK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 183 AGGSVMIQRVNGSLAVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEFVKSRL 262
Cdd:cd00143   152 AGGRVSNGRVPGVLAVTRALGDFDLK---------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSEL 222
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907123087 263 EvSDDLENVCNWVVDTCLHKGSRDNMSVVLVCF 295
Cdd:cd00143   223 A-KEDLQEAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
14-293 1.45e-91

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 275.79  E-value: 1.45e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   14 NAHGAGNGLRYGLSSMQGWRVEMEDAHTAvvgIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKsgs 93
Cdd:smart00332   1 SVSGKNLGLRYGLSSMQGVRKPMEDAHVI---TPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDEL--- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   94 alepsvESVKTGIRTGFLKIDEYMrnfsdLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCN 173
Cdd:smart00332  75 ------EDVEEALRKAFLSTDEEI-----LEELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGKAVQLTEDHKPSN 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  174 PVEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEE 253
Cdd:smart00332 144 EDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK---------PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1907123087  254 LCEFVKSRLevSDDLENVCNWVVDTCLHKGSRDNMSVVLV 293
Cdd:smart00332 215 VVDIVRKHL--SKDPKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
22-288 2.15e-89

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 270.36  E-value: 2.15e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  22 LRYGLSSMQGWRVEMEDAHTAV--VGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFraadksgsalePSV 99
Cdd:pfam00481   1 IDLGGPRMQGWRKSMEDAHIDLpnLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSF-----------LEG 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 100 ESVKTGIRTGFLKIDEYMrnFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQV-CFSTQDHKPCNPVEKE 178
Cdd:pfam00481  70 EKLEDALRKSFLEDTDEV--LRSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNAiKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 179 RIQNAGGSVM-IQRVNGSLAVSRALGDYDYKcvdgkgPTEQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEF 257
Cdd:pfam00481 148 RIRAAGGFVSrNGRVNGVLAVSRAFGDFELK------PGEQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDL 221
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907123087 258 VKSRLEVSDDLENVCNWVVDTCLHKGSRDNM 288
Cdd:pfam00481 222 VRSELSDGGSPMEAAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
1-297 1.21e-56

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 189.98  E-value: 1.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGiphglDNWSFFAVYDGHAGSRVANYCSTHLLEHIT 80
Cdd:PTZ00224    1 MGIMLPKPVLSKLVDRAGNSIFRCASACVNGYRESMEDAHLLYLT-----DDWGFFGVFDGHVNDECSQYLARAWPQALE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  81 T-NEDFRAADKSGSALEpsvesvktgirtgflkID-EYMrnfsdlrNGMDRSGSTAV-GVMVSPTHMYFINCGDSRAVLC 157
Cdd:PTZ00224   76 KePEPMTDERMEELCLE----------------IDeEWM-------DSGREGGSTGTfCVIMKDVHLQVGNVGDSRVLVC 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 158 RNGQVCFSTQDHKPCNPVEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVyEIVRAEEDEF 237
Cdd:PTZ00224  133 RDGKLVFATEDHKPNNPGERQRIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGTGDYLEQKVIAVPDV-THLTCQSNDF 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907123087 238 VVLACDGIWD-VMSNEELCEFVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSVVLVCFSN 297
Cdd:PTZ00224  212 IILACDGVFEgNFSNEEVVAFVKEQLETCDDLAVVAGRVCDEAIRRGSKDNISCLIVQLKD 272
PP2C_C pfam07830
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
289-368 1.48e-41

Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.


Pssm-ID: 429684  Cd Length: 79  Bit Score: 140.72  E-value: 1.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 289 SVVLVCFSNAPKVSEEAVKRDSELDKHLESRVEEIMQKSgEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRHVIEAVYS 368
Cdd:pfam07830   1 SIVLVCFPGAPKVSEEAVKKEAELDKKLEKRVKEIIEQS-DGEEPDLLYVLRVLASEDIPGLPPGGGLASKRSVIEAVYK 79
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
33-299 2.18e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 97.59  E-value: 2.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  33 RVEMEDAHTAVVGiphglDNWSFFAVYDG---HAGSRVAnycSTHLLEHITtnEDFRAADKsgsalePSVESVKTGIRTG 109
Cdd:COG0631    13 RENNEDAFLVALD-----PGGGLFVVADGmggHAAGEVA---SRLAVETLA--ELFQEALA------PDPEDLEEALREA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 110 FLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHkpcNPV----EKERIQNAGG 185
Cdd:COG0631    77 IRAANRAILELAQEDPELAGMGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQLTRDH---SLVqelvDAGRITPEEA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 186 SVMIQRvNgslAVSRALGDYDykcvdgkgpteqlvSPEPEVYEiVRAEEDEFVVLACDGIWDVMSNEELCEFVKSrlevS 265
Cdd:COG0631   154 RTHPQR-N---VLTRALGTDD--------------DVEPDISP-LELEPGDRLLLCSDGLTDMVSDEEIAEILAS----A 210
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1907123087 266 DDLENVCNWVVDTCLHKGSRDNMSVVLVCFSNAP 299
Cdd:COG0631   211 GDPQEAAEALIELALEAGGPDNITVVLVRVEDAD 244
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
23-295 2.40e-97

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 290.38  E-value: 2.40e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  23 RYGLSSMQGWRVEMEDAHtaVVGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRaadksgsaLEPSVESV 102
Cdd:cd00143     2 SAGVSDKGGDRKTNEDAV--VIKPNLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEET--------LTLSEEDI 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 103 KTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNPVEKERIQN 182
Cdd:cd00143    72 EEALRKAFLRADEEILEEAQDEPDDARSGTTAVVALIRGNKLYVANVGDSRAVLCRNGEAVQLTKDHKPVNEEERERIEK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 183 AGGSVMIQRVNGSLAVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEFVKSRL 262
Cdd:cd00143   152 AGGRVSNGRVPGVLAVTRALGDFDLK---------PGVSAEPDVTVVKLTEDDDFLILASDGLWDVLSNQEAVDIVRSEL 222
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907123087 263 EvSDDLENVCNWVVDTCLHKGSRDNMSVVLVCF 295
Cdd:cd00143   223 A-KEDLQEAAQELVDLALRRGSHDNITVVVVRL 254
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
14-293 1.45e-91

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 275.79  E-value: 1.45e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   14 NAHGAGNGLRYGLSSMQGWRVEMEDAHTAvvgIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAADKsgs 93
Cdd:smart00332   1 SVSGKNLGLRYGLSSMQGVRKPMEDAHVI---TPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIKEKDEL--- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   94 alepsvESVKTGIRTGFLKIDEYMrnfsdLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCN 173
Cdd:smart00332  75 ------EDVEEALRKAFLSTDEEI-----LEELEALSGSTAVVALISGNKLYVANVGDSRAVLCRNGKAVQLTEDHKPSN 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  174 PVEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKcvdgkgpteQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEE 253
Cdd:smart00332 144 EDERARIEAAGGFVINGRVNGVLALSRAIGDFFLK---------PYVSAEPDVTVVELTEKDDFLILASDGLWDVLSNQE 214
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1907123087  254 LCEFVKSRLevSDDLENVCNWVVDTCLHKGSRDNMSVVLV 293
Cdd:smart00332 215 VVDIVRKHL--SKDPKEAAKRLIDLALARGSKDNITVVVV 252
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
22-288 2.15e-89

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 270.36  E-value: 2.15e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  22 LRYGLSSMQGWRVEMEDAHTAV--VGIPHGLDNWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFraadksgsalePSV 99
Cdd:pfam00481   1 IDLGGPRMQGWRKSMEDAHIDLpnLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTILALRRSF-----------LEG 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 100 ESVKTGIRTGFLKIDEYMrnFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQV-CFSTQDHKPCNPVEKE 178
Cdd:pfam00481  70 EKLEDALRKSFLEDTDEV--LRSAEKEDLDSGCTAVVALISGNKLYVANVGDSRAVLCRNGNAiKRLTKDHKPSDEDERR 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 179 RIQNAGGSVM-IQRVNGSLAVSRALGDYDYKcvdgkgPTEQLVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSNEELCEF 257
Cdd:pfam00481 148 RIRAAGGFVSrNGRVNGVLAVSRAFGDFELK------PGEQAVSAEPDITSHTITEDDEFLILACDGLWDVLSDQEVVDL 221
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1907123087 258 VKSRLEVSDDLENVCNWVVDTCLHKGSRDNM 288
Cdd:pfam00481 222 VRSELSDGGSPMEAAEELRDEAIAYGSEDNI 252
PTZ00224 PTZ00224
protein phosphatase 2C; Provisional
1-297 1.21e-56

protein phosphatase 2C; Provisional


Pssm-ID: 240318 [Multi-domain]  Cd Length: 381  Bit Score: 189.98  E-value: 1.21e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087   1 MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGiphglDNWSFFAVYDGHAGSRVANYCSTHLLEHIT 80
Cdd:PTZ00224    1 MGIMLPKPVLSKLVDRAGNSIFRCASACVNGYRESMEDAHLLYLT-----DDWGFFGVFDGHVNDECSQYLARAWPQALE 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  81 T-NEDFRAADKSGSALEpsvesvktgirtgflkID-EYMrnfsdlrNGMDRSGSTAV-GVMVSPTHMYFINCGDSRAVLC 157
Cdd:PTZ00224   76 KePEPMTDERMEELCLE----------------IDeEWM-------DSGREGGSTGTfCVIMKDVHLQVGNVGDSRVLVC 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 158 RNGQVCFSTQDHKPCNPVEKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVyEIVRAEEDEF 237
Cdd:PTZ00224  133 RDGKLVFATEDHKPNNPGERQRIEACGGRVVSNRVDGDLAVSRAFGDRSFKVKGTGDYLEQKVIAVPDV-THLTCQSNDF 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907123087 238 VVLACDGIWD-VMSNEELCEFVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSVVLVCFSN 297
Cdd:PTZ00224  212 IILACDGVFEgNFSNEEVVAFVKEQLETCDDLAVVAGRVCDEAIRRGSKDNISCLIVQLKD 272
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
22-299 1.84e-45

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 160.46  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  22 LRYGLSSMQGWRVEMEDAHTAVVGI--PHGLDNW-----SFFAVYDGHAGSRVANYCSTHLLEHITTNEDFraadksgsa 94
Cdd:PLN03145   65 VRSGAWADIGSRSSMEDVYICVDNFmsDFGLKNSedgpsAFYGVFDGHGGKHAADFACYHLPRFIVEDEDF--------- 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  95 lePSveSVKTGIRTGFLKIDEYMRNFSDLrNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHKPCNP 174
Cdd:PLN03145  136 --PR--EIEKVVSSAFLQTDTAFAEACSL-DASLASGTTALAALVVGRSLVVANAGDCRAVLCRRGKAIEMSRDHKPMCS 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 175 VEKERIQNAGGSVMIQRVNGSLAVSRALGDYDY---KCVDGkGPteqlVSPEPEVYEIVRAEEDEFVVLACDGIWDVMSN 251
Cdd:PLN03145  211 KERKRIEASGGYVYDGYLNGQLNVARALGDWHMegmKGSDG-GP----LSAEPELMTTQLTEEDEFLIIGCDGIWDVFRS 285
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1907123087 252 EELCEFVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSVVLVCFSNAP 299
Cdd:PLN03145  286 QNAVDFARRRLQEHNDPVMCSKELVDEALKRKSGDNLAVVVVCFQSQP 333
PP2C_C pfam07830
Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is ...
289-368 1.48e-41

Protein serine/threonine phosphatase 2C, C-terminal domain; Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteriztic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.


Pssm-ID: 429684  Cd Length: 79  Bit Score: 140.72  E-value: 1.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 289 SVVLVCFSNAPKVSEEAVKRDSELDKHLESRVEEIMQKSgEEGMPDLAHVMRILSAENIPNLPPGGGLAGKRHVIEAVYS 368
Cdd:pfam07830   1 SIVLVCFPGAPKVSEEAVKKEAELDKKLEKRVKEIIEQS-DGEEPDLLYVLRVLASEDIPGLPPGGGLASKRSVIEAVYK 79
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
33-299 2.18e-23

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 97.59  E-value: 2.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  33 RVEMEDAHTAVVGiphglDNWSFFAVYDG---HAGSRVAnycSTHLLEHITtnEDFRAADKsgsalePSVESVKTGIRTG 109
Cdd:COG0631    13 RENNEDAFLVALD-----PGGGLFVVADGmggHAAGEVA---SRLAVETLA--ELFQEALA------PDPEDLEEALREA 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 110 FLKIDEYMRNFSDLRNGMDRSGSTAVGVMVSPTHMYFINCGDSRAVLCRNGQVCFSTQDHkpcNPV----EKERIQNAGG 185
Cdd:COG0631    77 IRAANRAILELAQEDPELAGMGTTLVAALIAGGRLYIAHVGDSRAYLLRDGELEQLTRDH---SLVqelvDAGRITPEEA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 186 SVMIQRvNgslAVSRALGDYDykcvdgkgpteqlvSPEPEVYEiVRAEEDEFVVLACDGIWDVMSNEELCEFVKSrlevS 265
Cdd:COG0631   154 RTHPQR-N---VLTRALGTDD--------------DVEPDISP-LELEPGDRLLLCSDGLTDMVSDEEIAEILAS----A 210
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1907123087 266 DDLENVCNWVVDTCLHKGSRDNMSVVLVCFSNAP 299
Cdd:COG0631   211 GDPQEAAEALIELALEAGGPDNITVVLVRVEDAD 244
PRK14559 PRK14559
serine/threonine phosphatase;
61-304 3.58e-05

serine/threonine phosphatase;


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 45.82  E-value: 3.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087  61 GHAGSRVANYCSTHLL-----EHITTNEdfraadksgsalePSVESVKTGIRTGFLKIdeYMRNFSDLRNGMDRSGSTAV 135
Cdd:PRK14559  425 GHAAGEVASALAVETLqqyfqQHWQDEL-------------PDEETIREAIYLANEAI--YDLNQQNARSGSGRMGTTLV 489
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 136 GVMVSPTHMYFINCGDSRAVLC--RNG--QVcfsTQDHkpcnpvekERIQNAggsvmIQR-VNGSLAVSR--------AL 202
Cdd:PRK14559  490 MALVQDTQVAVAHVGDSRLYRVtrKGGleQL---TVDH--------EVGQRE-----IQRgVEPQIAYARpdayqltqAL 553
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907123087 203 GDYDYKCVdgkgpteqlvspEPEVyEIVRAEEDEFVVLACDGIWDVMSNEELCE-FVKSRLEVSDDLENVCNWVVDTCLH 281
Cdd:PRK14559  554 GPRDNSAI------------QPDI-QFLEIEEDTLLLLCSDGLSDNDLLETHWQtHLLPLLSSSANLDQGLNKLIDLANQ 620
                         250       260
                  ....*....|....*....|...
gi 1907123087 282 KGSRDNMSVVLVCFSNAPKVSEE 304
Cdd:PRK14559  621 YNGHDNITAILVRLKVRPQLSLE 643
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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